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Volumn 16, Issue 3, 2014, Pages

ACE2: Angiotensin II/angiotensin-(1-7) balance in cardiac and renal injury

Author keywords

Angiotensin II; Angiotensin (1 7); Angiotensin converting enzyme 2; Diabetes; Heart; Heart failure; Hypertension; Kidney; Left ventricular remodeling; Renal disease

Indexed keywords

ANGIOTENSIN 1 RECEPTOR ANTAGONIST; ANGIOTENSIN CONVERTING ENZYME 2; ANGIOTENSIN[1-7]; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; ANGIOTENSIN I; ANGIOTENSIN I (1 7); ANGIOTENSIN I (1-7); ANGIOTENSIN II; DIPEPTIDYL CARBOXYPEPTIDASE; PEPTIDE FRAGMENT;

EID: 84893161111     PISSN: 15226417     EISSN: 15343111     Source Type: Journal    
DOI: 10.1007/s11906-014-0420-5     Document Type: Review
Times cited : (101)

References (108)
  • 1
    • 83255175529 scopus 로고    scopus 로고
    • Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue
    • The first paper to show the chymase-dependent generation of Ang II from the novel intermediate precursor Ang-(1-12) in atrial tissue from patients undergoing cardiac surgery for primary control of atrial fibrillation
    • • Ahmad S, Simmons T, Varagic J, Moniwa N, Chappell MC, Ferrario CM. Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue. PLoS One. 2011;6(12):e28501. The first paper to show the chymase-dependent generation of Ang II from the novel intermediate precursor Ang-(1-12) in atrial tissue from patients undergoing cardiac surgery for primary control of atrial fibrillation.
    • (2011) PLoS One , vol.6 , Issue.12
    • Ahmad, S.1    Simmons, T.2    Varagic, J.3    Moniwa, N.4    Chappell, M.C.5    Ferrario, C.M.6
  • 3
    • 84891403514 scopus 로고    scopus 로고
    • An evolving story of angiotensin II-forming pathways in rodents and humans
    • Ferrario CM, Ahmad S, Nagata S, Simington S, Varagic J, Kon N, et al. An evolving story of angiotensin II-forming pathways in rodents and humans. Clin Sci. 2013;156(7):461-9.
    • (2013) Clin Sci , vol.156 , Issue.7 , pp. 461-469
    • Ferrario, C.M.1    Ahmad, S.2    Nagata, S.3    Simington, S.4    Varagic, J.5    Kon, N.6
  • 4
    • 77952689893 scopus 로고    scopus 로고
    • The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function
    • Ferrario CM, Varagic J. The ANG-(1-7)/ACE2/mas axis in the regulation of nephron function. Am J Physiol Renal Physiol. 2010;298(6):F1297-305.
    • (2010) Am J Physiol Renal Physiol , vol.298 , Issue.6
    • Ferrario, C.M.1    Varagic, J.2
  • 6
    • 68849105984 scopus 로고    scopus 로고
    • Soluble angiotensin-converting enzyme 2 in human heart failure: Relation with myocardial function and clinical outcomes
    • Epelman S, Shrestha K, Troughton RW, Francis GS, Sen S, Klein AL, et al. Soluble angiotensin-converting enzyme 2 in human heart failure: relation with myocardial function and clinical outcomes. J Card Fail. 2009;15(7):565-71.
    • (2009) J Card Fail , vol.15 , Issue.7 , pp. 565-571
    • Epelman, S.1    Shrestha, K.2    Troughton, R.W.3    Francis, G.S.4    Sen, S.5    Klein, A.L.6
  • 7
    • 84881651138 scopus 로고    scopus 로고
    • Regulation of urinary ACE2 in diabetic mice
    • In db/db mice and STZ-induced diabetes serum, urinary, and renal cortex ACE2 were increased. This study suggests that urinary ACE2 reflected renal rather than systemic source
    • • Wysocki J, Garcia-Halpin L, Ye M, Maier C, Sowers K, Burns KD, et al. Regulation of urinary ACE2 in diabetic mice. Am J Physiol Renal Physiol. 2013;305(4):F600-11. In db/db mice and STZ-induced diabetes serum, urinary, and renal cortex ACE2 were increased. This study suggests that urinary ACE2 reflected renal rather than systemic source.
    • (2013) Am J Physiol Renal Physiol , vol.305 , Issue.4
    • Wysocki, J.1    Garcia-Halpin, L.2    Ye, M.3    Maier, C.4    Sowers, K.5    Burns, K.D.6
  • 8
    • 24044444558 scopus 로고    scopus 로고
    • Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2)
    • DOI 10.1074/jbc.M505111200
    • Lambert DW, Yarski M, Warner FJ, Thornhill P, Parkin ET, Smith AI, et al. Tumor necrosis factor-alpha convertase (ADAM17) mediates regulated ectodomain shedding of the severe-acute respiratory syndrome-coronavirus (SARS-CoV) receptor, angiotensin-converting enzyme-2 (ACE2). J Biol Chem. 2005;280(34):30113-9. (Pubitemid 41216188)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.34 , pp. 30113-30119
    • Lambert, D.W.1    Yarski, M.2    Warner, F.J.3    Thornhill, P.4    Parkin, E.T.5    Smith, A.I.6    Hooper, N.M.7    Turner, A.J.8
  • 9
    • 6344246036 scopus 로고    scopus 로고
    • Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism
    • DOI 10.1042/BJ20040634
    • Rice GI, Thomas DA, Grant PJ, Turner AJ, Hooper NM. Evaluation of angiotensin-converting enzyme (ACE), its homologue ACE2 and neprilysin in angiotensin peptide metabolism. Biochem J. 2004;383(Pt 1):45-51. (Pubitemid 39389449)
    • (2004) Biochemical Journal , vol.383 , Issue.1 , pp. 45-51
    • Rice, G.I.1    Thomas, D.A.2    Grant, P.J.3    Turner, A.J.4    Hooper, N.M.5
  • 10
    • 84862284803 scopus 로고    scopus 로고
    • Targeting the ACE2 and Apelin Pathways Are Novel Therapies for Heart Failure: Opportunities and Challenges
    • Kazemi-Bajestani SM, Patel VB, Wang W, Oudit GY. Targeting the ACE2 and Apelin Pathways Are Novel Therapies for Heart Failure: Opportunities and Challenges. Cardiol Res Pract. 2012;2012:823193.
    • (2012) Cardiol Res Pract , vol.2012 , pp. 823193
    • Kazemi-Bajestani, S.M.1    Patel, V.B.2    Wang, W.3    Oudit, G.Y.4
  • 11
    • 0038053724 scopus 로고    scopus 로고
    • A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9
    • Donoghue M, Hsieh F, Baronas E, Godbout K, Gosselin M, Stagliano N, et al. A novel angiotensin-converting enzyme-related carboxypeptidase (ACE2) converts angiotensin I to angiotensin 1-9. Circ Res. 2000;87(5):E1-9.
    • (2000) Circ Res , vol.87 , Issue.5
    • Donoghue, M.1    Hsieh, F.2    Baronas, E.3    Godbout, K.4    Gosselin, M.5    Stagliano, N.6
  • 12
    • 0034721906 scopus 로고    scopus 로고
    • A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase
    • Tipnis SR, Hooper NM, Hyde R, Karran E, Christie G, Turner AJ. A human homolog of angiotensin-converting enzyme. Cloning and functional expression as a captopril-insensitive carboxypeptidase. J Biol Chem. 2000;275(43):33238-43.
    • (2000) J Biol Chem , vol.275 , Issue.43 , pp. 33238-33243
    • Tipnis, S.R.1    Hooper, N.M.2    Hyde, R.3    Karran, E.4    Christie, G.5    Turner, A.J.6
  • 15
    • 77952511816 scopus 로고    scopus 로고
    • Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats
    • Trask AJ, Groban L, Westwood BM, Varagic J, Ganten D, Gallagher PE, et al. Inhibition of angiotensin-converting enzyme 2 exacerbates cardiac hypertrophy and fibrosis in Ren-2 hypertensive rats. Am J Hypertens. 2010;23(6):687-93.
    • (2010) Am J Hypertens , vol.23 , Issue.6 , pp. 687-693
    • Trask, A.J.1    Groban, L.2    Westwood, B.M.3    Varagic, J.4    Ganten, D.5    Gallagher, P.E.6
  • 16
    • 70350457666 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction
    • Kassiri Z, Zhong J, Guo D, Basu R, Wang X, Liu PP, et al. Loss of angiotensin-converting enzyme 2 accelerates maladaptive left ventricular remodeling in response to myocardial infarction. Circ Heart Fail. 2009;2(5):446-55.
    • (2009) Circ Heart Fail , vol.2 , Issue.5 , pp. 446-455
    • Kassiri, Z.1    Zhong, J.2    Guo, D.3    Basu, R.4    Wang, X.5    Liu, P.P.6
  • 17
    • 77956184446 scopus 로고    scopus 로고
    • Effects of ACE2 inhibition in the post-myocardial infarction heart
    • Kim MA, Yang D, Kida K, Molotkova N, Yeo SJ, Varki N, et al. Effects of ACE2 inhibition in the post-myocardial infarction heart. J Card Fail. 2010;16(9):777-85.
    • (2010) J Card Fail , vol.16 , Issue.9 , pp. 777-785
    • Kim, M.A.1    Yang, D.2    Kida, K.3    Molotkova, N.4    Yeo, S.J.5    Varki, N.6
  • 18
    • 84861099242 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: A critical role of the angiotensin II/AT1 receptor axis
    • This study pinpoints the crucial role of ACE2 in development of diabetic cardiomyopathy through Ang II-dependent mechanisms
    • • Patel VB, Bodiga S, Basu R, Das SK, Wang W, Wang Z, et al. Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: a critical role of the angiotensin II/AT1 receptor axis. Circ Res. 2012;110(10):1322-35. This study pinpoints the crucial role of ACE2 in development of diabetic cardiomyopathy through Ang II-dependent mechanisms.
    • (2012) Circ Res , vol.110 , Issue.10 , pp. 1322-1335
    • Patel, V.B.1    Bodiga, S.2    Basu, R.3    Das, S.K.4    Wang, W.5    Wang, Z.6
  • 20
    • 77955981900 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction
    • This comprehensive study provides critical evidence for beneficial effects of hrACE2 in Ang II- and pressure overload-induced cardiac remodeling and dysfunction. The cardioprotection was associated with attenuation of signaling pathways and molecules relevant for hypertrophy, fibrosis, and oxidative stress and correlated with reduction in Ang II and elevation in Ang-(1-7)
    • • Zhong J, Basu R, Guo D, Chow FL, Byrns S, Schuster M, et al. Angiotensin-converting enzyme 2 suppresses pathological hypertrophy, myocardial fibrosis, and cardiac dysfunction. Circulation. 2010;122(7):717-28. This comprehensive study provides critical evidence for beneficial effects of hrACE2 in Ang II- and pressure overload-induced cardiac remodeling and dysfunction. The cardioprotection was associated with attenuation of signaling pathways and molecules relevant for hypertrophy, fibrosis, and oxidative stress and correlated with reduction in Ang II and elevation in Ang-(1-7).
    • (2010) Circulation , vol.122 , Issue.7 , pp. 717-728
    • Zhong, J.1    Basu, R.2    Guo, D.3    Chow, F.L.4    Byrns, S.5    Schuster, M.6
  • 21
    • 79958820082 scopus 로고    scopus 로고
    • Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit
    • Bodiga S, Zhong JC, Wang W, Basu R, Lo J, Liu GC, et al. Enhanced susceptibility to biomechanical stress in ACE2 null mice is prevented by loss of the p47(phox) NADPH oxidase subunit. Cardiovasc Res. 2011;91(1):151-61.
    • (2011) Cardiovasc Res , vol.91 , Issue.1 , pp. 151-161
    • Bodiga, S.1    Zhong, J.C.2    Wang, W.3    Basu, R.4    Lo, J.5    Liu, G.C.6
  • 23
    • 84861528870 scopus 로고    scopus 로고
    • Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin-converting enzyme 2-null mice
    • When ACE2 is absent, a blockade of Ang II action or Ang-(1-7) supplementation provides comparable cardioprotection in an experimental model of heart failure due to pressure overload revealing striking redundancy of these two counterregulatory mechanisms
    • • Patel VB, Bodiga S, Fan D, Das SK, Wang Z, Wang W, et al. Cardioprotective effects mediated by angiotensin II type 1 receptor blockade and enhancing angiotensin 1-7 in experimental heart failure in angiotensin- converting enzyme 2-null mice. Hypertension. 2012;59(6):1195-203. When ACE2 is absent, a blockade of Ang II action or Ang-(1-7) supplementation provides comparable cardioprotection in an experimental model of heart failure due to pressure overload revealing striking redundancy of these two counterregulatory mechanisms.
    • (2012) Hypertension , vol.59 , Issue.6 , pp. 1195-1203
    • Patel, V.B.1    Bodiga, S.2    Fan, D.3    Das, S.K.4    Wang, Z.5    Wang, W.6
  • 24
    • 0141988865 scopus 로고    scopus 로고
    • Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: Evidence for upregulation of the angiotensin-converting enzyme homologue ACE2
    • DOI 10.1161/01.CIR.0000094734.67990.99
    • Zisman LS, Keller RS, Weaver B, Lin Q, Speth R, Bristow MR, et al. Increased angiotensin-(1-7)-forming activity in failing human heart ventricles: evidence for upregulation of the angiotensin-converting enzyme Homologue ACE2. Circulation. 2003;108(14):1707-12. (Pubitemid 37243658)
    • (2003) Circulation , vol.108 , Issue.14 , pp. 1707-1712
    • Zisman, L.S.1    Keller, R.S.2    Weaver, B.3    Lin, Q.4    Speth, R.5    Bristow, M.R.6    Canver, C.C.7
  • 26
    • 4243105120 scopus 로고    scopus 로고
    • ACE2 gene expression is up-regulated in the human failing heart
    • Goulter AB, Goddard MJ, Allen JC, Clark KL. ACE2 gene expression is up-regulated in the human failing heart. BMC Med. 2004;2:19.
    • (2004) BMC Med , vol.2 , pp. 19
    • Goulter, A.B.1    Goddard, M.J.2    Allen, J.C.3    Clark, K.L.4
  • 27
    • 77957326124 scopus 로고    scopus 로고
    • Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure
    • Ohtsuki M, Morimoto S, Izawa H, Ismail TF, Ishibashi-Ueda H, Kato Y, et al. Angiotensin converting enzyme 2 gene expression increased compensatory for left ventricular remodeling in patients with end-stage heart failure. Int J Cardiol. 2010;145(2):333-4.
    • (2010) Int J Cardiol , vol.145 , Issue.2 , pp. 333-334
    • Ohtsuki, M.1    Morimoto, S.2    Izawa, H.3    Ismail, T.F.4    Ishibashi-Ueda, H.5    Kato, Y.6
  • 28
    • 75349101263 scopus 로고    scopus 로고
    • Plasma ACE2 activity is an independent prognostic marker in Chagas' disease and equally potent as BNP
    • This study suggests thatmeasurements of both ACE2 activity and BNP may be of greater value in prediction morbidity and mortality in patients with heart failure
    • • Wang Y, Moreira MC, Heringer-Walther S, Ebermann L, Schultheiss HP, Wessel N, et al. Plasma ACE2 activity is an independent prognostic marker in Chagas' disease and equally potent as BNP. J Card Fail. 2010;16(2):157-63. This study suggests thatmeasurements of both ACE2 activity and BNP may be of greater value in prediction morbidity and mortality in patients with heart failure.
    • (2010) J Card Fail , vol.16 , Issue.2 , pp. 157-163
    • Wang, Y.1    Moreira, M.C.2    Heringer-Walther, S.3    Ebermann, L.4    Schultheiss, H.P.5    Wessel, N.6
  • 29
    • 78649337583 scopus 로고    scopus 로고
    • ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction
    • Zhao YX, Yin HQ, Yu QT, Qiao Y, Dai HY, Zhang MX, et al. ACE2 overexpression ameliorates left ventricular remodeling and dysfunction in a rat model of myocardial infarction. Hum Gene Ther. 2010;21(11):1545-54.
    • (2010) Hum Gene Ther , vol.21 , Issue.11 , pp. 1545-1554
    • Zhao, Y.X.1    Yin, H.Q.2    Yu, Q.T.3    Qiao, Y.4    Dai, H.Y.5    Zhang, M.X.6
  • 30
    • 2342620869 scopus 로고    scopus 로고
    • Upregulation of Angiotensin-Converting Enzyme 2 after Myocardial Infarction by Blockade of Angiotensin II Receptors
    • DOI 10.1161/01.HYP.0000124667.34652.1a
    • Ishiyama Y, Gallagher PE, Averill DB, Tallant EA, Brosnihan KB, Ferrario CM. Upregulation of angiotensin-converting enzyme 2 after myocardial infarction by blockade of angiotensin II receptors. Hypertension. 2004;43(5):970-6. (Pubitemid 38579900)
    • (2004) Hypertension , vol.43 , Issue.5 , pp. 970-976
    • Ishiyama, Y.1    Gallagher, P.E.2    Averill, D.B.3    Tallant, E.A.4    Brosnihan, K.B.5    Ferrario, C.M.6
  • 31
    • 80054090183 scopus 로고    scopus 로고
    • Role of angiotensin-converting enzyme 2 in cardiac hypertrophy induced by nitric oxide synthase inhibition
    • Inaba S, Iwai M, Furuno M, Kanno H, Senba I, Okayama H, et al. Role of angiotensin-converting enzyme 2 in cardiac hypertrophy induced by nitric oxide synthase inhibition. J Hypertens. 2011;29(11):2236-45.
    • (2011) J Hypertens , vol.29 , Issue.11 , pp. 2236-2245
    • Inaba, S.1    Iwai, M.2    Furuno, M.3    Kanno, H.4    Senba, I.5    Okayama, H.6
  • 32
    • 80052693325 scopus 로고    scopus 로고
    • Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis
    • Sukumaran V, Veeraveedu PT, Gurusamy N, Yamaguchi K, Lakshmanan AP, Ma M, et al. Cardioprotective effects of telmisartan against heart failure in rats induced by experimental autoimmune myocarditis through the modulation of angiotensin-converting enzyme-2/angiotensin 1-7/mas receptor axis. Int J Biol Sci. 2011;7(8):1077-92.
    • (2011) Int J Biol Sci , vol.7 , Issue.8 , pp. 1077-1092
    • Sukumaran, V.1    Veeraveedu, P.T.2    Gurusamy, N.3    Yamaguchi, K.4    Lakshmanan, A.P.5    Ma, M.6
  • 34
    • 19644384705 scopus 로고    scopus 로고
    • Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2
    • DOI 10.1161/CIRCULATIONAHA.104.510461
    • Ferrario CM, Jessup J, Chappell MC, Averill DB, Brosnihan KB, Tallant EA, et al. Effect of angiotensin-converting enzyme inhibition and angiotensin II receptor blockers on cardiac angiotensin-converting enzyme 2. Circulation. 2005;111(20):2605-10. (Pubitemid 40740859)
    • (2005) Circulation , vol.111 , Issue.20 , pp. 2605-2610
    • Ferrario, C.M.1    Jessup, J.2    Chappell, M.C.3    Averill, D.B.4    Brosnihan, K.B.5    Tallant, E.A.6    Diz, D.I.7    Gallagher, P.E.8
  • 35
    • 33644861536 scopus 로고    scopus 로고
    • Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes
    • Gallagher PE, Chappell MC, Ferrario CM, Tallant EA. Distinct roles for ANG II and ANG-(1-7) in the regulation of angiotensin-converting enzyme 2 in rat astrocytes. Am J Physiol Cell Physiol. 2006;290(2):C420-6.
    • (2006) Am J Physiol Cell Physiol , vol.290 , Issue.2
    • Gallagher, P.E.1    Chappell, M.C.2    Ferrario, C.M.3    Tallant, E.A.4
  • 39
    • 80051949470 scopus 로고    scopus 로고
    • Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology
    • Qi Y, Shenoy V, Wong F, Li H, Afzal A, Mocco J, et al. Lentivirus-mediated overexpression of angiotensin-(1-7) attenuated ischaemia-induced cardiac pathophysiology. Exp Physiol. 2011;96(9):863-74.
    • (2011) Exp Physiol , vol.96 , Issue.9 , pp. 863-874
    • Qi, Y.1    Shenoy, V.2    Wong, F.3    Li, H.4    Afzal, A.5    Mocco, J.6
  • 40
    • 77952547547 scopus 로고    scopus 로고
    • Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts
    • Lin CS, Pan CH, Wen CH, Yang TH, Kuan TC. Regulation of angiotensin converting enzyme II by angiotensin peptides in human cardiofibroblasts. Peptides. 2010;31(7):1334-40.
    • (2010) Peptides , vol.31 , Issue.7 , pp. 1334-1340
    • Lin, C.S.1    Pan, C.H.2    Wen, C.H.3    Yang, T.H.4    Kuan, T.C.5
  • 42
    • 84856042570 scopus 로고    scopus 로고
    • Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes
    • Patel SK, Wai B, Ord M, MacIsaac RJ, Grant S, Velkoska E, et al. Association of ACE2 genetic variants with blood pressure, left ventricular mass, and cardiac function in Caucasians with type 2 diabetes. Am J Hypertens. 2012;25(2):216-22.
    • (2012) Am J Hypertens , vol.25 , Issue.2 , pp. 216-222
    • Patel, S.K.1    Wai, B.2    Ord, M.3    MacIsaac, R.J.4    Grant, S.5    Velkoska, E.6
  • 43
    • 46949084963 scopus 로고    scopus 로고
    • Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy
    • van der Merwe L, Cloete R, Revera M, Heradien M, Goosen A, Corfield VA, et al. Genetic variation in angiotensin-converting enzyme 2 gene is associated with extent of left ventricular hypertrophy in hypertrophic cardiomyopathy. Hum Genet. 2008;124(1):57-61.
    • (2008) Hum Genet , vol.124 , Issue.1 , pp. 57-61
    • Van Der Merwe, L.1    Cloete, R.2    Revera, M.3    Heradien, M.4    Goosen, A.5    Corfield, V.A.6
  • 44
    • 38349159262 scopus 로고    scopus 로고
    • Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy
    • Wang SX, Fu CY, Zou YB, Wang H, Shi Y, Xu XQ, et al. Polymorphisms of angiotensin-converting enzyme 2 gene associated with magnitude of left ventricular hypertrophy in male patients with hypertrophic cardiomyopathy. Chin Med J (Engl). 2008;121(1):27-31.
    • (2008) Chin Med J (Engl) , vol.121 , Issue.1 , pp. 27-31
    • Wang, S.X.1    Fu, C.Y.2    Zou, Y.B.3    Wang, H.4    Shi, Y.5    Xu, X.Q.6
  • 45
    • 33750733884 scopus 로고    scopus 로고
    • Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population
    • DOI 10.1042/CS20060020
    • Yang W, Huang W, Su S, Li B, Zhao W, Chen S, et al. Association study of ACE2 (angiotensin I-converting enzyme 2) gene polymorphisms with coronary heart disease and myocardial infarction in a Chinese Han population. Clin Sci (Lond). 2006;111(5):333-40. (Pubitemid 44696255)
    • (2006) Clinical Science , vol.111 , Issue.5 , pp. 333-340
    • Yang, W.1    Huang, W.2    Su, S.3    Li, B.4    Zhao, W.5    Chen, S.6    Gu, D.7
  • 46
    • 84892826747 scopus 로고    scopus 로고
    • The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease
    • Chaoxin J, Daili S, Yanxin H, Ruwei G, Chenlong W, Yaobin T. The influence of angiotensin-converting enzyme 2 gene polymorphisms on type 2 diabetes mellitus and coronary heart disease. Eur Rev Med Pharmacol Sci. 2013;17(19):2654-9.
    • (2013) Eur Rev Med Pharmacol Sci , vol.17 , Issue.19 , pp. 2654-2659
    • Chaoxin, J.1    Daili, S.2    Yanxin, H.3    Ruwei, G.4    Chenlong, W.5    Yaobin, T.6
  • 47
    • 33751251070 scopus 로고    scopus 로고
    • Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese
    • DOI 10.1038/sj.jhh.1002090, PII 1002090
    • Huang W, Yang W, Wang Y, Zhao Q, Gu D, Chen R. Association study of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms and essential hypertension in northern Han Chinese. J Hum Hypertens. 2006;20(12):968-71. (Pubitemid 44782831)
    • (2006) Journal of Human Hypertension , vol.20 , Issue.12 , pp. 968-971
    • Huang, W.1    Yang, W.2    Wang, Y.3    Zhao, Q.4    Gu, D.5    Chen, R.6
  • 48
    • 31944448010 scopus 로고    scopus 로고
    • Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome
    • DOI 10.1016/j.lab.2005.10.001, PII S0022214305003495
    • Zhong J, Yan Z, Liu D, Ni Y, Zhao Z, Zhu S, et al. Association of angiotensin-converting enzyme 2 gene A/G polymorphism and elevated blood pressure in Chinese patients with metabolic syndrome. J Lab Clin Med. 2006;147(2):91-5. (Pubitemid 43189001)
    • (2006) Journal of Laboratory and Clinical Medicine , vol.147 , Issue.2 , pp. 91-95
    • Zhong, J.1    Yan, Z.2    Liu, D.3    Ni, Y.4    Zhao, Z.5    Zhu, S.6    Tepel, M.7    Zhu, Z.8
  • 49
    • 84864286293 scopus 로고    scopus 로고
    • ACE2 gene polymorphism and essential hypertension: An updated meta-analysis involving 11,051 subjects
    • Lu N, Yang Y, Wang Y, Liu Y, Fu G, Chen D, et al. ACE2 gene polymorphism and essential hypertension: an updated meta-analysis involving 11,051 subjects. Mol Biol Rep. 2012;39(6):6581-9.
    • (2012) Mol Biol Rep , vol.39 , Issue.6 , pp. 6581-6589
    • Lu, N.1    Yang, Y.2    Wang, Y.3    Liu, Y.4    Fu, G.5    Chen, D.6
  • 51
    • 3042596693 scopus 로고    scopus 로고
    • No association of angiotensin-converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension
    • DOI 10.1016/j.amjhyper.2004.02.022, PII S0895706104007502
    • Benjafield AV, Wang WY, Morris BJ. No association of angiotensin- converting enzyme 2 gene (ACE2) polymorphisms with essential hypertension. Am J Hypertens. 2004;17(7):624-8. (Pubitemid 38844990)
    • (2004) American Journal of Hypertension , vol.17 , Issue.7 , pp. 624-628
    • Benjafield, A.V.1    Wang, W.Y.S.2    Morris, B.J.3
  • 52
    • 67650508044 scopus 로고    scopus 로고
    • Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension
    • Zhou JB, Yang JK. Meta-analysis of association of ACE2 G8790A polymorphism with Chinese Han essential hypertension. J Renin Angiotensin Aldosterone Syst. 2009;10(1):31-4.
    • (2009) J Renin Angiotensin Aldosterone Syst , vol.10 , Issue.1 , pp. 31-34
    • Zhou, J.B.1    Yang, J.K.2
  • 53
    • 68949200176 scopus 로고    scopus 로고
    • Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk
    • Sotoodehnia N, Li G, Johnson CO, Lemaitre RN, Rice KM, Rea TD, et al. Genetic variation in angiotensin-converting enzyme-related pathways associated with sudden cardiac arrest risk. Heart Rhythm. 2009;6(9):1306-14.
    • (2009) Heart Rhythm , vol.6 , Issue.9 , pp. 1306-1314
    • Sotoodehnia, N.1    Li, G.2    Johnson, C.O.3    Lemaitre, R.N.4    Rice, K.M.5    Rea, T.D.6
  • 54
    • 8344230109 scopus 로고    scopus 로고
    • Renal ACE2 expression in human kidney disease
    • DOI 10.1002/path.1670
    • Lely AT, Hamming I, van GH, Navis GJ. Renal ACE2 expression in human kidney disease. J Pathol. 2004;204(5):587-93. (Pubitemid 39585958)
    • (2004) Journal of Pathology , vol.204 , Issue.5 , pp. 587-593
    • Lely, A.T.1    Hamming, I.2    Van Goor, H.3    Navis, G.J.4
  • 55
    • 60549095157 scopus 로고    scopus 로고
    • Localization of ACE2 in the renal vasculature: Amplification by angiotensin II type 1 receptor blockade using telmisartan
    • Soler MJ, Ye M, Wysocki J, William J, Lloveras J, Batlle D. Localization of ACE2 in the renal vasculature: amplification by angiotensin II type 1 receptor blockade using telmisartan. Am J Physiol Renal Physiol. 2009;296(2):F398-405.
    • (2009) Am J Physiol Renal Physiol , vol.296 , Issue.2
    • Soler, M.J.1    Ye, M.2    Wysocki, J.3    William, J.4    Lloveras, J.5    Batlle, D.6
  • 56
    • 33750722109 scopus 로고    scopus 로고
    • Glomerular localization and expression of angiotensin-converting enzyme 2 and angiotensin-converting enzyme: Implications for albuminuria in diabetes
    • DOI 10.1681/ASN.2006050423
    • Ye M, Wysocki J, William J, Soler MJ, Cokic I, Batlle D. Glomerular localization and expression of Angiotensin-converting enzyme 2 and Angiotensin-converting enzyme: implications for albuminuria in diabetes. J Am Soc Nephrol. 2006;17(11):3067-75. (Pubitemid 44707767)
    • (2006) Journal of the American Society of Nephrology , vol.17 , Issue.11 , pp. 3067-3075
    • Ye, M.1    Wysocki, J.2    William, J.3    Soler, M.J.4    Cokic, I.5    Batlle, D.6
  • 58
    • 0037341501 scopus 로고    scopus 로고
    • Characterization of renal angiotensin - Converting enzyme 2 in diabetic nephropathy
    • DOI 10.1161/01.HYP.0000060689.38912.CB
    • Tikellis C, Johnston CI, Forbes JM, Burns WC, Burrell LM, Risvanis J, et al. Characterization of renal angiotensin-converting enzyme 2 in diabetic nephropathy. Hypertension. 2003;41(3):392-7. (Pubitemid 36314606)
    • (2003) Hypertension , vol.41 , Issue.3 I , pp. 392-397
    • Tikellis, C.1    Johnston, C.I.2    Forbes, J.M.3    Burns, W.C.4    Burrell, L.M.5    Risvanis, J.6    Cooper, M.E.7
  • 62
    • 84860296188 scopus 로고    scopus 로고
    • Loss of angiotensin-converting enzyme 2 enhances TGF-beta/Smad-mediated renal fibrosis and NF-kappaB-driven renal inflammation in a mouse model of obstructive nephropathy
    • Liu Z, Huang XR, Chen HY, Penninger JM, Lan HY. Loss of angiotensin-converting enzyme 2 enhances TGF-beta/Smad-mediated renal fibrosis and NF-kappaB-driven renal inflammation in a mouse model of obstructive nephropathy. Lab Invest. 2012;92(5):650-61.
    • (2012) Lab Invest , vol.92 , Issue.5 , pp. 650-661
    • Liu, Z.1    Huang, X.R.2    Chen, H.Y.3    Penninger, J.M.4    Lan, H.Y.5
  • 64
    • 79551485466 scopus 로고    scopus 로고
    • Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2
    • Zhong J, Guo D, Chen CB, Wang W, Schuster M, Loibner H, et al. Prevention of angiotensin II-mediated renal oxidative stress, inflammation, and fibrosis by angiotensin-converting enzyme 2. Hypertension. 2011;57(2):314-22.
    • (2011) Hypertension , vol.57 , Issue.2 , pp. 314-322
    • Zhong, J.1    Guo, D.2    Chen, C.B.3    Wang, W.4    Schuster, M.5    Loibner, H.6
  • 65
    • 34548153521 scopus 로고    scopus 로고
    • ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice
    • DOI 10.1038/sj.ki.5002373, PII 5002373
    • Soler MJ, Wysocki J, Ye M, Lloveras J, Kanwar Y, Batlle D. ACE2 inhibition worsens glomerular injury in association with increased ACE expression in streptozotocin-induced diabetic mice. Kidney Int. 2007;72(5):614-23. (Pubitemid 47312795)
    • (2007) Kidney International , vol.72 , Issue.5 , pp. 614-623
    • Soler, M.J.1    Wysocki, J.2    Ye, M.3    Lloveras, J.4    Kanwar, Y.5    Batlle, D.6
  • 66
    • 79954459188 scopus 로고    scopus 로고
    • Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats
    • Prieto MC, Gonzalez-Villalobos RA, Botros FT, Martin VL, Pagan J, Satou R, et al. Reciprocal changes in renal ACE/ANG II and ACE2/ANG 1-7 are associated with enhanced collecting duct renin in Goldblatt hypertensive rats. Am J Physiol Renal Physiol. 2011;300(3):F749-55.
    • (2011) Am J Physiol Renal Physiol , vol.300 , Issue.3
    • Prieto, M.C.1    Gonzalez-Villalobos, R.A.2    Botros, F.T.3    Martin, V.L.4    Pagan, J.5    Satou, R.6
  • 67
    • 9644258509 scopus 로고    scopus 로고
    • Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats
    • Zhong JC, Huang DY, Yang YM, Li YF, Liu GF, Song XH, et al. Upregulation of angiotensin-converting enzyme 2 by all-trans retinoic acid in spontaneously hypertensive rats. Hypertension. 2004;44(6):907-12.
    • (2004) Hypertension , vol.44 , Issue.6 , pp. 907-912
    • Zhong, J.C.1    Huang, D.Y.2    Yang, Y.M.3    Li, Y.F.4    Liu, G.F.5    Song, X.H.6
  • 69
    • 84864751446 scopus 로고    scopus 로고
    • High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese Zucker rats
    • Samuel P, Ali Q, Sabuhi R, Wu Y, Hussain T. High Na intake increases renal angiotensin II levels and reduces expression of the ACE2-AT(2)R-MasR axis in obese Zucker rats. Am J Physiol Renal Physiol. 2012;303(3):F412-9.
    • (2012) Am J Physiol Renal Physiol , vol.303 , Issue.3
    • Samuel, P.1    Ali, Q.2    Sabuhi, R.3    Wu, Y.4    Hussain, T.5
  • 70
    • 84871867177 scopus 로고    scopus 로고
    • High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage
    • Bernardi S, Toffoli B, Zennaro C, Tikellis C, Monticone S, Losurdo P, et al. High-salt diet increases glomerular ACE/ACE2 ratio leading to oxidative stress and kidney damage. Nephrol Dial Transplant. 2012;27(5):1793-800.
    • (2012) Nephrol Dial Transplant , vol.27 , Issue.5 , pp. 1793-1800
    • Bernardi, S.1    Toffoli, B.2    Zennaro, C.3    Tikellis, C.4    Monticone, S.5    Losurdo, P.6
  • 71
    • 34249774906 scopus 로고    scopus 로고
    • Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio
    • DOI 10.1210/en.2006-1287
    • Wakahara S, Konoshita T, Mizuno S, Motomura M, Aoyama C, Makino Y, et al. Synergistic expression of angiotensin-converting enzyme (ACE) and ACE2 in human renal tissue and confounding effects of hypertension on the ACE to ACE2 ratio. Endocrinology. 2007;148(5):2453-7. (Pubitemid 46997072)
    • (2007) Endocrinology , vol.148 , Issue.5 , pp. 2453-2457
    • Wakahara, S.1    Konoshita, T.2    Mizuno, S.3    Motomura, M.4    Aoyama, C.5    Makino, Y.6    Kato, N.7    Koni, I.8    Miyamori, I.9
  • 72
    • 77955098970 scopus 로고    scopus 로고
    • Increased ACE and decreased ACE2 expression in kidneys from patients with IgA nephropathy
    • Mizuiri S, Hemmi H, Arita M, Aoki T, Ohashi Y, Miyagi M, et al. Increased ACE and decreased ACE2 expression in kidneys from patients with IgA nephropathy. Nephron Clin Pract. 2011;117(1):c57-66.
    • (2011) Nephron Clin Pract , vol.117 , Issue.1
    • Mizuiri, S.1    Hemmi, H.2    Arita, M.3    Aoki, T.4    Ohashi, Y.5    Miyagi, M.6
  • 73
    • 57049086924 scopus 로고    scopus 로고
    • Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease
    • Reich HN, Oudit GY, Penninger JM, Scholey JW, Herzenberg AM. Decreased glomerular and tubular expression of ACE2 in patients with type 2 diabetes and kidney disease. Kidney Int. 2008;74(12):1610-6.
    • (2008) Kidney Int , vol.74 , Issue.12 , pp. 1610-1616
    • Reich, H.N.1    Oudit, G.Y.2    Penninger, J.M.3    Scholey, J.W.4    Herzenberg, A.M.5
  • 74
    • 84863802059 scopus 로고    scopus 로고
    • Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice
    • This study provides critical evidence that podocyte-specific overexpression of hACE2 transiently attenuated the development of diabetic nephropathy
    • • Nadarajah R, Milagres R, Dilauro M, Gutsol A, Xiao F, Zimpelmann J, et al. Podocyte-specific overexpression of human angiotensin-converting enzyme 2 attenuates diabetic nephropathy in mice. Kidney Int. 2012;82(3):292-303. This study provides critical evidence that podocyte-specific overexpression of hACE2 transiently attenuated the development of diabetic nephropathy.
    • (2012) Kidney Int , vol.82 , Issue.3 , pp. 292-303
    • Nadarajah, R.1    Milagres, R.2    Dilauro, M.3    Gutsol, A.4    Xiao, F.5    Zimpelmann, J.6
  • 75
    • 77956853546 scopus 로고    scopus 로고
    • Investigation of ACE, ACE2 and AGTR1 genes for association with nephropathy in Type 1 diabetes mellitus
    • Currie D, McKnight AJ, Patterson CC, Sadlier DM, Maxwell AP. Investigation of ACE, ACE2 and AGTR1 genes for association with nephropathy in Type 1 diabetes mellitus. Diabet Med. 2010;27(10):1188-94.
    • (2010) Diabet Med , vol.27 , Issue.10 , pp. 1188-1194
    • Currie, D.1    McKnight, A.J.2    Patterson, C.C.3    Sadlier, D.M.4    Maxwell, A.P.5
  • 78
    • 70549098001 scopus 로고    scopus 로고
    • Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition
    • Lond
    • Velkoska E, Dean RG, Burchill L, Levidiotis V, Burrell LM. Reduction in renal ACE2 expression in subtotal nephrectomy in rats is ameliorated with ACE inhibition. Clin Sci (Lond). 2010;118(4):269-79.
    • (2010) Clin Sci , vol.118 , Issue.4 , pp. 269-279
    • Velkoska, E.1    Dean, R.G.2    Burchill, L.3    Levidiotis, V.4    Burrell, L.M.5
  • 79
    • 79951779192 scopus 로고    scopus 로고
    • Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy
    • Lond
    • Velkoska E, Dean RG, Griggs K, Burchill L, Burrell LM. Angiotensin-(1-7) infusion is associated with increased blood pressure and adverse cardiac remodelling in rats with subtotal nephrectomy. Clin Sci (Lond). 2011;120(8):335-45.
    • (2011) Clin Sci , vol.120 , Issue.8 , pp. 335-345
    • Velkoska, E.1    Dean, R.G.2    Griggs, K.3    Burchill, L.4    Burrell, L.M.5
  • 80
    • 60549095158 scopus 로고    scopus 로고
    • Angiotensin-(1-7) activates growth-stimulatory pathways in human mesangial cells
    • Zimpelmann J, Burns KD. Angiotensin-(1-7) activates growth-stimulatory pathways in human mesangial cells. Am J Physiol Renal Physiol. 2009;296(2):F337-46.
    • (2009) Am J Physiol Renal Physiol , vol.296 , Issue.2
    • Zimpelmann, J.1    Burns, K.D.2
  • 81
    • 84862128283 scopus 로고    scopus 로고
    • Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remote kidney injury in a mouse hindlimb ischemia-reperfusion model
    • Yang XH, Wang YH, Wang JJ, Liu YC, Deng W, Qin C, et al. Role of angiotensin-converting enzyme (ACE and ACE2) imbalance on tourniquet-induced remote kidney injury in a mouse hindlimb ischemia-reperfusion model. Peptides. 2012;36(1):60-70.
    • (2012) Peptides , vol.36 , Issue.1 , pp. 60-70
    • Yang, X.H.1    Wang, Y.H.2    Wang, J.J.3    Liu, Y.C.4    Deng, W.5    Qin, C.6
  • 82
    • 84888375977 scopus 로고    scopus 로고
    • Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats
    • This is the first study to show a contribution of AT2 receptor in the regulation of renal ACE2 of obese Zuker rats. ACE2 and related Ang-(1-7) upregulation was associated with reduction of blood pressure and increased urinary sodium excretion. AT2 receptor agonist increased ACE2 activity in HK-2 cells confirming a direct effect of AT2 activation in enhancing ACE2/Ang-(1-7) axis
    • • Ali Q, Wu Y, Hussain T. Chronic AT2 receptor activation increases renal ACE2 activity, attenuates AT1 receptor function and blood pressure in obese Zucker rats. Kidney Int. 2013;84(5):931-9. This is the first study to show a contribution of AT2 receptor in the regulation of renal ACE2 of obese Zuker rats. ACE2 and related Ang-(1-7) upregulation was associated with reduction of blood pressure and increased urinary sodium excretion. AT2 receptor agonist increased ACE2 activity in HK-2 cells confirming a direct effect of AT2 activation in enhancing ACE2/Ang-(1-7) axis.
    • (2013) Kidney Int , vol.84 , Issue.5 , pp. 931-939
    • Ali, Q.1    Wu, Y.2    Hussain, T.3
  • 83
    • 43449084360 scopus 로고    scopus 로고
    • Angiotensin II up-regulates Angiotensin I-Converting Enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway
    • DOI 10.2353/ajpath.2008.070762
    • Koka V, Huang XR, Chung AC, Wang W, Truong LD, Lan HY. Angiotensin II up-regulates angiotensin I-converting enzyme (ACE), but down-regulates ACE2 via the AT1-ERK/p38 MAP kinase pathway. Am J Pathol. 2008;172(5):1174-83. (Pubitemid 351671532)
    • (2008) American Journal of Pathology , vol.172 , Issue.5 , pp. 1174-1183
    • Koka, V.1    Xiao, R.H.2    Chung, A.C.K.3    Wang, W.4    Truong, L.D.5    Lan, H.Y.6
  • 84
    • 84876588807 scopus 로고    scopus 로고
    • Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2. Lewis rats
    • Varagic J, Ahmad S, VonCannon JL, Moniwa N, Brosnihan KB, Wysocki J, et al. Predominance of AT(1) blockade over mas-mediated angiotensin-(1-7) mechanisms in the regulation of blood pressure and renin-angiotensin system in mRen2. Lewis rats. Am J Hypertens. 2013;26(5):583-90.
    • (2013) Am J Hypertens , vol.26 , Issue.5 , pp. 583-590
    • Varagic, J.1    Ahmad, S.2    VonCannon, J.L.3    Moniwa, N.4    Brosnihan, K.B.5    Wysocki, J.6
  • 85
    • 42449140640 scopus 로고    scopus 로고
    • ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes
    • Tikellis C, Bialkowski K, Pete J, Sheehy K, Su Q, Johnston C, et al. ACE2 deficiency modifies renoprotection afforded by ACE inhibition in experimental diabetes. Diabetes. 2008;57(4):1018-25.
    • (2008) Diabetes , vol.57 , Issue.4 , pp. 1018-1025
    • Tikellis, C.1    Bialkowski, K.2    Pete, J.3    Sheehy, K.4    Su, Q.5    Johnston, C.6
  • 86
    • 42649095968 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor
    • DOI 10.1113/expphysiol.2007.040352
    • Lew RA, Warner FJ, Hanchapola I, Yarski MA, Manohar J, Burrell LM, et al. Angiotensin-converting enzyme 2 catalytic activity in human plasma is masked by an endogenous inhibitor. Exp Physiol. 2008;93(5):685-93. (Pubitemid 351595050)
    • (2008) Experimental Physiology , vol.93 , Issue.5 , pp. 685-693
    • Lew, R.A.1    Warner, F.J.2    Hanchapola, I.3    Yarski, M.A.4    Manohar, J.5    Burrell, L.M.6    Smith, A.I.7
  • 87
    • 84880968521 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 activity in patients with chronic kidney disease
    • Roberts MA, Velkoska E, Ierino FL, Burrell LM. Angiotensin-converting enzyme 2 activity in patients with chronic kidney disease. Nephrol Dial Transplant. 2013;28(9):2287-94.
    • (2013) Nephrol Dial Transplant , vol.28 , Issue.9 , pp. 2287-2294
    • Roberts, M.A.1    Velkoska, E.2    Ierino, F.L.3    Burrell, L.M.4
  • 88
    • 49349093061 scopus 로고    scopus 로고
    • Detection of soluble angiotensin-converting enzyme 2 in heart failure: Insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system
    • Epelman S, Tang WH, Chen SY, Van LF, Francis GS, Sen S. Detection of soluble angiotensin-converting enzyme 2 in heart failure: insights into the endogenous counter-regulatory pathway of the renin-angiotensin-aldosterone system. J Am Coll Cardiol. 2008;52(9):750-4.
    • (2008) J Am Coll Cardiol , vol.52 , Issue.9 , pp. 750-754
    • Epelman, S.1    Tang, W.H.2    Chen, S.Y.3    Van, L.F.4    Francis, G.S.5    Sen, S.6
  • 89
    • 84876432226 scopus 로고    scopus 로고
    • Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: A prospective controlled study
    • Ortiz-Perez JT, Riera M, Bosch X, De Caralt TM, Perea RJ, Pascual J, et al. Role of circulating angiotensin converting enzyme 2 in left ventricular remodeling following myocardial infarction: a prospective controlled study. PLoS One. 2013;8(4):e61695.
    • (2013) PLoS One , vol.8 , Issue.4
    • Ortiz-Perez, J.T.1    Riera, M.2    Bosch, X.3    De Caralt, T.M.4    Perea, R.J.5    Pascual, J.6
  • 90
    • 84884539433 scopus 로고    scopus 로고
    • Increasing serum soluble angiotensin-converting enzyme 2 activity after intensive medical therapy is associated with better prognosis in acute decompensated heart failure
    • Shao Z, Shrestha K, Borowski AG, Kennedy DJ, Epelman S, Thomas JD, et al. Increasing serum soluble angiotensin-converting enzyme 2 activity after intensive medical therapy is associated with better prognosis in acute decompensated heart failure. J Card Fail. 2013;19(9):605-10.
    • (2013) J Card Fail , vol.19 , Issue.9 , pp. 605-610
    • Shao, Z.1    Shrestha, K.2    Borowski, A.G.3    Kennedy, D.J.4    Epelman, S.5    Thomas, J.D.6
  • 91
    • 84855860581 scopus 로고    scopus 로고
    • Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications
    • Soro-Paavonen A, Gordin D, Forsblom C, Rosengard-Barlund M, Waden J, Thorn L, et al. Circulating ACE2 activity is increased in patients with type 1 diabetes and vascular complications. J Hypertens. 2012;30(2):375-83.
    • (2012) J Hypertens , vol.30 , Issue.2 , pp. 375-383
    • Soro-Paavonen, A.1    Gordin, D.2    Forsblom, C.3    Rosengard-Barlund, M.4    Waden, J.5    Thorn, L.6
  • 92
    • 43049103449 scopus 로고    scopus 로고
    • Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy
    • Wang G, Lai FM, Lai KB, Chow KM, Kwan CH, Li KT, et al. Urinary mRNA expression of ACE and ACE2 in human type 2 diabetic nephropathy. Diabetologia. 2008;51(6):1062-7.
    • (2008) Diabetologia , vol.51 , Issue.6 , pp. 1062-1067
    • Wang, G.1    Lai, F.M.2    Lai, K.B.3    Chow, K.M.4    Kwan, C.H.5    Li, K.T.6
  • 93
    • 84874538781 scopus 로고    scopus 로고
    • High urinary ACE2 concentrations are associated with severity of glucose intolerance and microalbuminuria
    • Park SE, Kim WJ, Park SW, Park JW, Lee N, Park CY, et al. High urinary ACE2 concentrations are associated with severity of glucose intolerance and microalbuminuria. Eur J Endocrinol. 2013;168(2):203-10.
    • (2013) Eur J Endocrinol , vol.168 , Issue.2 , pp. 203-210
    • Park, S.E.1    Kim, W.J.2    Park, S.W.3    Park, J.W.4    Lee, N.5    Park, C.Y.6
  • 95
    • 84871204126 scopus 로고    scopus 로고
    • Circulating angiotensin-converting enzyme 2 activity in kidney transplantation: A longitudinal pilot study
    • Soler MJ, Riera M, Crespo M, Mir M, Marquez E, Pascual MJ, et al. Circulating angiotensin-converting enzyme 2 activity in kidney transplantation: a longitudinal pilot study. Nephron Clin Pract. 2012;121(3-4):c144-50.
    • (2012) Nephron Clin Pract , vol.121 , Issue.3-4
    • Soler, M.J.1    Riera, M.2    Crespo, M.3    Mir, M.4    Marquez, E.5    Pascual, M.J.6
  • 96
    • 84867406075 scopus 로고    scopus 로고
    • Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain
    • Barretti DL, Magalhaes FC, Fernandes T, do Carmo EC, Rosa KT, Irigoyen MC, et al. Effects of aerobic exercise training on cardiac renin-angiotensin system in an obese Zucker rat strain. PLoS One. 2012;7(10):e46114.
    • (2012) PLoS One , vol.7 , Issue.10
    • Barretti, D.L.1    Magalhaes, F.C.2    Fernandes, T.3    Do Carmo, E.C.4    Rosa, K.T.5    Irigoyen, M.C.6
  • 97
    • 80051473367 scopus 로고    scopus 로고
    • Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7)
    • This study suggests a regulatory role for specific microRNAs in reciprocal regulation of cardiac ACE and ACE2 as an underlying cardioprotective molecular mechanism for the development of non-pathological left ventricular hypertrophy in response to aerobic exercise
    • • Fernandes T, Hashimoto NY, Magalhaes FC, Fernandes FB, Casarini DE, Carmona AK, et al. Aerobic exercise training-induced left ventricular hypertrophy involves regulatory MicroRNAs, decreased angiotensin-converting enzyme-angiotensin ii, and synergistic regulation of angiotensin-converting enzyme 2-angiotensin (1-7). Hypertension. 2011;58(2):182-9. This study suggests a regulatory role for specific microRNAs in reciprocal regulation of cardiac ACE and ACE2 as an underlying cardioprotective molecular mechanism for the development of non-pathological left ventricular hypertrophy in response to aerobic exercise.
    • (2011) Hypertension , vol.58 , Issue.2 , pp. 182-189
    • Fernandes, T.1    Hashimoto, N.Y.2    Magalhaes, F.C.3    Fernandes, F.B.4    Casarini, D.E.5    Carmona, A.K.6
  • 98
    • 77449160523 scopus 로고    scopus 로고
    • Human recombinant ACE2 reduces the progression of diabetic nephropathy
    • Oudit GY, Liu GC, Zhong J, Basu R, Chow FL, Zhou J, et al. Human recombinant ACE2 reduces the progression of diabetic nephropathy. Diabetes. 2010;59(2):529-38.
    • (2010) Diabetes , vol.59 , Issue.2 , pp. 529-538
    • Oudit, G.Y.1    Liu, G.C.2    Zhong, J.3    Basu, R.4    Chow, F.L.5    Zhou, J.6
  • 99
    • 84872178401 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats
    • Lo J, Patel VB, Wang Z, Levasseur J, Kaufman S, Penninger JM, et al. Angiotensin-converting enzyme 2 antagonizes angiotensin II-induced pressor response and NADPH oxidase activation in Wistar-Kyoto rats and spontaneously hypertensive rats. Exp Physiol. 2013;98(1):109-22.
    • (2013) Exp Physiol , vol.98 , Issue.1 , pp. 109-122
    • Lo, J.1    Patel, V.B.2    Wang, Z.3    Levasseur, J.4    Kaufman, S.5    Penninger, J.M.6
  • 100
    • 73849101073 scopus 로고    scopus 로고
    • Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: Prevention of angiotensin II-dependent hypertension
    • Wysocki J, Ye M, Rodriguez E, Gonzalez-Pacheco FR, Barrios C, Evora K, et al. Targeting the degradation of angiotensin II with recombinant angiotensin-converting enzyme 2: prevention of angiotensin II-dependent hypertension. Hypertension. 2010;55(1):90-8.
    • (2010) Hypertension , vol.55 , Issue.1 , pp. 90-98
    • Wysocki, J.1    Ye, M.2    Rodriguez, E.3    Gonzalez-Pacheco, F.R.4    Barrios, C.5    Evora, K.6
  • 101
    • 84865556205 scopus 로고    scopus 로고
    • Murine recombinant angiotensin-converting enzyme 2: Effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2
    • Ye M, Wysocki J, Gonzalez-Pacheco FR, Salem M, Evora K, Garcia-Halpin L, et al. Murine recombinant angiotensin-converting enzyme 2: effect on angiotensin II-dependent hypertension and distinctive angiotensin-converting enzyme 2 inhibitor characteristics on rodent and human angiotensin-converting enzyme 2. Hypertension. 2012;60(3):730-40.
    • (2012) Hypertension , vol.60 , Issue.3 , pp. 730-740
    • Ye, M.1    Wysocki, J.2    Gonzalez-Pacheco, F.R.3    Salem, M.4    Evora, K.5    Garcia-Halpin, L.6
  • 103
    • 84863116259 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy
    • Dong B, Yu QT, Dai HY, Gao YY, Zhou ZL, Zhang L, et al. Angiotensin-converting enzyme-2 overexpression improves left ventricular remodeling and function in a rat model of diabetic cardiomyopathy. J Am Coll Cardiol. 2012;59(8):739-47.
    • (2012) J Am Coll Cardiol , vol.59 , Issue.8 , pp. 739-747
    • Dong, B.1    Yu, Q.T.2    Dai, H.Y.3    Gao, Y.Y.4    Zhou, Z.L.5    Zhang, L.6
  • 104
    • 78651497653 scopus 로고    scopus 로고
    • Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: A comparison with ACE inhibition
    • Liu CX, Hu Q, Wang Y, Zhang W, Ma ZY, Feng JB, et al. Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: a comparison with ACE inhibition. Mol Med. 2011;17(1-2):59-69.
    • (2011) Mol Med , vol.17 , Issue.1-2 , pp. 59-69
    • Liu, C.X.1    Hu, Q.2    Wang, Y.3    Zhang, W.4    Ma, Z.Y.5    Feng, J.B.6
  • 106
    • 84862770709 scopus 로고    scopus 로고
    • Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction
    • Murca TM, Moraes PL, Capuruco CA, Santos SH, Melo MB, Santos RA, et al. Oral administration of an angiotensin-converting enzyme 2 activator ameliorates diabetes-induced cardiac dysfunction. Regul Pept. 2012;177(1-3):107-15.
    • (2012) Regul Pept , vol.177 , Issue.1-3 , pp. 107-115
    • Murca, T.M.1    Moraes, P.L.2    Capuruco, C.A.3    Santos, S.H.4    Melo, M.B.5    Santos, R.A.6
  • 107
    • 84867351874 scopus 로고    scopus 로고
    • Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: Implications for future therapeutic directions
    • Lond
    • Burchill LJ, Velkoska E, Dean RG, Griggs K, Patel SK, Burrell LM. Combination renin-angiotensin system blockade and angiotensin-converting enzyme 2 in experimental myocardial infarction: implications for future therapeutic directions. Clin Sci (Lond). 2012;123(11):649-58.
    • (2012) Clin Sci , vol.123 , Issue.11 , pp. 649-658
    • Burchill, L.J.1    Velkoska, E.2    Dean, R.G.3    Griggs, K.4    Patel, S.K.5    Burrell, L.M.6
  • 108
    • 77951171609 scopus 로고    scopus 로고
    • Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents
    • Wei CC, Hase N, Inoue Y, Bradley EW, Yahiro E, Li M, et al. Mast cell chymase limits the cardiac efficacy of Ang I-converting enzyme inhibitor therapy in rodents. J Clin Invest. 2010;120(4):1229-39.
    • (2010) J Clin Invest , vol.120 , Issue.4 , pp. 1229-1239
    • Wei, C.C.1    Hase, N.2    Inoue, Y.3    Bradley, E.W.4    Yahiro, E.5    Li, M.6


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