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Loss of angiotensin-converting enzyme-2 exacerbates diabetic cardiovascular complications and leads to systolic and vascular dysfunction: A critical role of the angiotensin II/AT1 receptor axis
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This study pinpoints the crucial role of ACE2 in development of diabetic cardiomyopathy through Ang II-dependent mechanisms
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This comprehensive study provides critical evidence for beneficial effects of hrACE2 in Ang II- and pressure overload-induced cardiac remodeling and dysfunction. The cardioprotection was associated with attenuation of signaling pathways and molecules relevant for hypertrophy, fibrosis, and oxidative stress and correlated with reduction in Ang II and elevation in Ang-(1-7)
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