Cell-based in vitro blood-brain barrier model can rapidly evaluate nanoparticles' brain permeability in association with particle size and surface modification

International Journal of Molecular Sciences

Volumn 15, Issue 2, 2014, Pages 1812-1825

  Hanada, Sanshiro ^a   Fujioka, Kouki ^b   Inoue, Yuriko ^c   Kanaya, Fumihide ^a   Manome, Yoshinobu ^b   Yamamoto, Kenji ^a  

^a NATIONAL CENTER FOR GLOBAL HEALTH AND MEDICINE   (Japan)

^b JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^c TOHO UNIVERSITY   (Japan)

Author keywords

Blood brain barrier; Cell based assay; Nanoparticles; Permeability coefficient

Indexed keywords

MIDAZOLAM; NANOPARTICLE; QUANTUM DOT; SILICA NANOPARTICLE; SULPIRIDE; UNCLASSIFIED DRUG; SILICON DIOXIDE;

ANIMAL CELL; APICAL MEMBRANE; ARTICLE; BASOLATERAL MEMBRANE; BLOOD BRAIN BARRIER; BRAIN PERMEABILITY; CONTROLLED STUDY; DRUG UPTAKE; ELECTRIC RESISTANCE; FLUORESCENCE MICROSCOPY; HISTOLOGY; LIGHT SCATTERING; MEMBRANE PERMEABILITY; NONHUMAN; PARTICLE SIZE; RAT; SURFACE CHARGE; ANIMAL; CHEMISTRY; CULTURE TECHNIQUE; CYTOLOGY; ENDOTHELIUM CELL; METABOLISM; PERICYTE; PERMEABILITY; SURFACE PROPERTY;

ANIMALS; BLOOD-BRAIN BARRIER; CELL CULTURE TECHNIQUES; ENDOTHELIAL CELLS; NANOPARTICLES; PARTICLE SIZE; PERICYTES; PERMEABILITY; RATS; SILICON DIOXIDE; SURFACE PROPERTIES;

EID: 84892956242     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms15021812     Document Type: Article

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