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Volumn 40, Issue 3, 2014, Pages 390-404

Targeted therapies for squamous cell carcinoma of the head and neck: Current knowledge and future directions

Author keywords

Head neck cancer; Molecular biology; Squamous cell carcinoma; Targeted therapies; Treatment

Indexed keywords

ABT 806; AFATINIB; ANGIOGENESIS INHIBITOR; BEVACIZUMAB; CEDIRANIB; CETUXIMAB; DACOMITINIB; DASATINIB; EPIDERMAL GROWTH FACTOR RECEPTOR; EPIDERMAL GROWTH FACTOR RECEPTOR KINASE INHIBITOR; ERLOTINIB; FUTUXIMAB; GEFITINIB; HEAT SHOCK PROTEIN; HISTONE DEACETYLASE; LAPATINIB; MAMMALIAN TARGET OF RAPAMYCIN; NIMOTUZUMAB; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEASOME; PROTEIN KINASE B; SARACATINIB; SCATTER FACTOR RECEPTOR; SOMATOMEDIN C RECEPTOR; SORAFENIB; STAT PROTEIN; SUNITINIB; UNCLASSIFIED DRUG; VANDETANIB; ZALUTUMUMAB;

EID: 84892848118     PISSN: 03057372     EISSN: 15321967     Source Type: Journal    
DOI: 10.1016/j.ctrv.2013.09.007     Document Type: Review
Times cited : (69)

References (187)
  • 1
    • 84892890534 scopus 로고    scopus 로고
    • http://www.globoscan.iarc.fr.
  • 2
    • 77954190940 scopus 로고    scopus 로고
    • Human papillomavirus and survival of patients with oropharyngeal cancer
    • Ang K.K., Harris J., Wheeler R., et al. Human papillomavirus and survival of patients with oropharyngeal cancer. N Engl J Med 2010, 363:24-35.
    • (2010) N Engl J Med , vol.363 , pp. 24-35
    • Ang, K.K.1    Harris, J.2    Wheeler, R.3
  • 3
    • 10044248559 scopus 로고    scopus 로고
    • Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity
    • Gillison M.L. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Semin Oncol 2004, 31:744-754.
    • (2004) Semin Oncol , vol.31 , pp. 744-754
    • Gillison, M.L.1
  • 4
    • 77954339808 scopus 로고    scopus 로고
    • Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical practice guidelines for diagnosis, treatment and follow-up
    • Grégoire V., Lefebvre J.-L., Licitra L., Felip E. Squamous cell carcinoma of the head and neck: EHNS-ESMO-ESTRO Clinical practice guidelines for diagnosis, treatment and follow-up. Ann Oncol 2010, 21(Suppl. 5):v184-v186.
    • (2010) Ann Oncol , vol.21 , Issue.SUPPL. 5
    • Grégoire, V.1    Lefebvre, J.-L.2    Licitra, L.3    Felip, E.4
  • 5
    • 36549072385 scopus 로고    scopus 로고
    • Validation of HB-EGF and amphiregulin as target for human cancer therapy
    • Yotsumoto F., Yagi H., Suzuki S.O., et al. Validation of HB-EGF and amphiregulin as target for human cancer therapy. Biochem Biophys Res Commun 2008, 365:555-561.
    • (2008) Biochem Biophys Res Commun , vol.365 , pp. 555-561
    • Yotsumoto, F.1    Yagi, H.2    Suzuki, S.O.3
  • 6
    • 33748188459 scopus 로고    scopus 로고
    • Epidermal growth factor biology in head and neck cancer
    • Kalyankrishna S., Grandis J.R. Epidermal growth factor biology in head and neck cancer. J Clin Oncol 2006, 24:2666-2672.
    • (2006) J Clin Oncol , vol.24 , pp. 2666-2672
    • Kalyankrishna, S.1    Grandis, J.R.2
  • 7
    • 0037115674 scopus 로고    scopus 로고
    • Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma
    • Ang K.K., Berkey B.A., Tu X., et al. Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 2002, 62:7350-7356.
    • (2002) Cancer Res , vol.62 , pp. 7350-7356
    • Ang, K.K.1    Berkey, B.A.2    Tu, X.3
  • 8
    • 84859872673 scopus 로고    scopus 로고
    • Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma
    • Wheeler S., Siwak D.R., Chai R., et al. Tumor epidermal growth factor receptor and EGFR PY1068 are independent prognostic indicators for head and neck squamous cell carcinoma. Clin Cancer Res 2012, 18:2278-2289.
    • (2012) Clin Cancer Res , vol.18 , pp. 2278-2289
    • Wheeler, S.1    Siwak, D.R.2    Chai, R.3
  • 9
    • 0032478998 scopus 로고    scopus 로고
    • Levels of TGFA and EGFR protein in head and neck squamous cell carcinoma and patient survival
    • Rubin Grandis J.R., Melhem M.F., Gooding W.E., et al. Levels of TGFA and EGFR protein in head and neck squamous cell carcinoma and patient survival. J Natl Cancer Inst 1998, 90:824-832.
    • (1998) J Natl Cancer Inst , vol.90 , pp. 824-832
    • Rubin Grandis, J.R.1    Melhem, M.F.2    Gooding, W.E.3
  • 10
    • 84871939282 scopus 로고    scopus 로고
    • EGFR status and EGFR ligand expression influence the treatment response of head and neck cancer cell lines
    • Jedlinski A., Ansell A., Johansson A.C., Roberg K.J. EGFR status and EGFR ligand expression influence the treatment response of head and neck cancer cell lines. Oral Pathol Med 2013, 42:26-36.
    • (2013) Oral Pathol Med , vol.42 , pp. 26-36
    • Jedlinski, A.1    Ansell, A.2    Johansson, A.C.3    Roberg, K.J.4
  • 11
    • 24944479590 scopus 로고    scopus 로고
    • Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial
    • Bentzen S.M., Atasoy B.M., Daley F.M., et al. Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial. J Clin Oncol 2005, 23:5560-5567.
    • (2005) J Clin Oncol , vol.23 , pp. 5560-5567
    • Bentzen, S.M.1    Atasoy, B.M.2    Daley, F.M.3
  • 12
    • 24744449739 scopus 로고    scopus 로고
    • Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase
    • Dittmann K., Mayer C., Fehrenbacher B., et al. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem 2005, 280:31182-31189.
    • (2005) J Biol Chem , vol.280 , pp. 31182-31189
    • Dittmann, K.1    Mayer, C.2    Fehrenbacher, B.3
  • 13
    • 37049038610 scopus 로고    scopus 로고
    • Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA repair: a COX-2 independent mechanism
    • Dittmann K., Mayer C., Ohneseit P.A., et al. Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA repair: a COX-2 independent mechanism. Int J Radiat Oncol Biol Phys 2008, 70:203-212.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 203-212
    • Dittmann, K.1    Mayer, C.2    Ohneseit, P.A.3
  • 14
    • 28444453967 scopus 로고    scopus 로고
    • Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity
    • Dittmann K., Mayer C., Rodemann H.P. Inhibition of radiation-induced EGFR nuclear import by C225 (Cetuximab) suppresses DNA-PK activity. Radiother Oncol 2005, 76:157-161.
    • (2005) Radiother Oncol , vol.76 , pp. 157-161
    • Dittmann, K.1    Mayer, C.2    Rodemann, H.P.3
  • 15
    • 33846565885 scopus 로고    scopus 로고
    • Identification of a novel EGF-sensitive cell cycle checkpoint
    • Walker F., Zhang H.H., Burgess A.W. Identification of a novel EGF-sensitive cell cycle checkpoint. Exp Cell Res 2007, 313:511-526.
    • (2007) Exp Cell Res , vol.313 , pp. 511-526
    • Walker, F.1    Zhang, H.H.2    Burgess, A.W.3
  • 16
    • 79551510855 scopus 로고    scopus 로고
    • EGFR Nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment
    • Liccardi G., Hartley J.A., Hochhauser D. EGFR Nuclear translocation modulates DNA repair following cisplatin and ionizing radiation treatment. Cancer Res 2011, 71:1103-1114.
    • (2011) Cancer Res , vol.71 , pp. 1103-1114
    • Liccardi, G.1    Hartley, J.A.2    Hochhauser, D.3
  • 17
    • 84871298461 scopus 로고    scopus 로고
    • Nuclear epidermal growth factor receptor and p16 expression in head and neck squamous cell carcinoma
    • Husain H., Psyrri A., Markovic A., et al. Nuclear epidermal growth factor receptor and p16 expression in head and neck squamous cell carcinoma. Laryngoscope 2012, 122:2762-2768.
    • (2012) Laryngoscope , vol.122 , pp. 2762-2768
    • Husain, H.1    Psyrri, A.2    Markovic, A.3
  • 18
    • 23844442173 scopus 로고    scopus 로고
    • Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis
    • Psyrri A., Yu Z., Weinberger P.M., et al. Quantitative determination of nuclear and cytoplasmic epidermal growth factor receptor expression in oropharyngeal squamous cell cancer by using automated quantitative analysis. Clin Cancer Res 2005, 11:5856-5862.
    • (2005) Clin Cancer Res , vol.11 , pp. 5856-5862
    • Psyrri, A.1    Yu, Z.2    Weinberger, P.M.3
  • 19
    • 34250155320 scopus 로고    scopus 로고
    • Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer
    • Temam S., Kawaguchi H., El-Naggar A.K., et al. Epidermal growth factor receptor copy number alterations correlate with poor clinical outcome in patients with head and neck squamous cancer. J Clin Oncol 2007, 25:2164-2170.
    • (2007) J Clin Oncol , vol.25 , pp. 2164-2170
    • Temam, S.1    Kawaguchi, H.2    El-Naggar, A.K.3
  • 20
    • 23044482678 scopus 로고    scopus 로고
    • Epidermal growth factor receptor-its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinoma
    • Mrhalova M., Plzak J., Betka J., Kodet R. Epidermal growth factor receptor-its expression and copy numbers of EGFR gene in patients with head and neck squamous cell carcinoma. Neoplasma 2005, 52:338-343.
    • (2005) Neoplasma , vol.52 , pp. 338-343
    • Mrhalova, M.1    Plzak, J.2    Betka, J.3    Kodet, R.4
  • 21
    • 33748653109 scopus 로고    scopus 로고
    • Increased epidermal growth factor receptor gene copy number is associated with poor progonis in head and neck squamous cell carcinomas
    • Chung C.H., Ely K., McGavran L., et al. Increased epidermal growth factor receptor gene copy number is associated with poor progonis in head and neck squamous cell carcinomas. J Clin Oncol 2006, 24:4170-4176.
    • (2006) J Clin Oncol , vol.24 , pp. 4170-4176
    • Chung, C.H.1    Ely, K.2    McGavran, L.3
  • 22
    • 39149095593 scopus 로고    scopus 로고
    • Association of epidermal growth factor receptor (EGFR) gene copy number amplification with neck lymph node metastasis in areca-associated oral carcinoma
    • Chiang W.F., Liu S.Y., Yen C.Y., et al. Association of epidermal growth factor receptor (EGFR) gene copy number amplification with neck lymph node metastasis in areca-associated oral carcinoma. Oral Oncol 2008, 44:270-276.
    • (2008) Oral Oncol , vol.44 , pp. 270-276
    • Chiang, W.F.1    Liu, S.Y.2    Yen, C.Y.3
  • 23
    • 13944263935 scopus 로고    scopus 로고
    • Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review
    • Kreimer A.R., Clifford G.M., Boyle P., Franceschi S. Human papillomavirus types in head and neck squamous cell carcinomas worldwide: a systematic review. Cancer Epidemiol Biomarkers Prev 2005, 14:467-475.
    • (2005) Cancer Epidemiol Biomarkers Prev , vol.14 , pp. 467-475
    • Kreimer, A.R.1    Clifford, G.M.2    Boyle, P.3    Franceschi, S.4
  • 24
    • 41449085148 scopus 로고    scopus 로고
    • Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers
    • Gillison M.L., D'Souza G., Westra W., et al. Distinct risk factor profiles for human papillomavirus type 16-positive and human papillomavirus type 16-negative head and neck cancers. J Natl Cancer Inst 2008, 100:407-420.
    • (2008) J Natl Cancer Inst , vol.100 , pp. 407-420
    • Gillison, M.L.1    D'Souza, G.2    Westra, W.3
  • 25
    • 34548152357 scopus 로고    scopus 로고
    • Basic mechanisms of high risk human papillomavirus-induced carcinogenesis: Roles of E6 and E7 proteins
    • Narisawa-Saito M., Kiyono T. Basic mechanisms of high risk human papillomavirus-induced carcinogenesis: Roles of E6 and E7 proteins. Cancer Sci 2007, 98:1505-1511.
    • (2007) Cancer Sci , vol.98 , pp. 1505-1511
    • Narisawa-Saito, M.1    Kiyono, T.2
  • 26
    • 32944464047 scopus 로고    scopus 로고
    • Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma
    • Slebos R.J., Yi Y., Ely K., et al. Gene expression differences associated with human papillomavirus status in head and neck squamous cell carcinoma. Clin Cancer Res 2006, 12:701-709.
    • (2006) Clin Cancer Res , vol.12 , pp. 701-709
    • Slebos, R.J.1    Yi, Y.2    Ely, K.3
  • 27
    • 84892821722 scopus 로고    scopus 로고
    • A pilot study comparing HPV-positive and HPV-negative head and neck squamous cell carcinomas by whole exome sequencing
    • Nichols A.C., Chan-Seng-Yue M., Yoo J., et al. A pilot study comparing HPV-positive and HPV-negative head and neck squamous cell carcinomas by whole exome sequencing. ISRN Oncol 2012, 2012:809370.
    • (2012) ISRN Oncol , vol.2012 , pp. 809370
    • Nichols, A.C.1    Chan-Seng-Yue, M.2    Yoo, J.3
  • 28
    • 68949212920 scopus 로고    scopus 로고
    • Defining molecular phenotypes of human papillomavirus-associated oropharyngeal squamous cell carcinoma: validation of three-class hypothesis
    • Weinberger P.M., Yu Z., Kountourakis P., et al. Defining molecular phenotypes of human papillomavirus-associated oropharyngeal squamous cell carcinoma: validation of three-class hypothesis. Otolaryngol Head Neck Surg 2009, 141:382-389.
    • (2009) Otolaryngol Head Neck Surg , vol.141 , pp. 382-389
    • Weinberger, P.M.1    Yu, Z.2    Kountourakis, P.3
  • 29
    • 77949450418 scopus 로고    scopus 로고
    • Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer
    • Smith E.M., Rubenstein L.M., Hoffman H., Haugen T.H., Turek L.P. Human papillomavirus, p16 and p53 expression associated with survival of head and neck cancer. Infect Agent Cancer 2010, 5:4.
    • (2010) Infect Agent Cancer , vol.5 , pp. 4
    • Smith, E.M.1    Rubenstein, L.M.2    Hoffman, H.3    Haugen, T.H.4    Turek, L.P.5
  • 30
    • 70350656518 scopus 로고    scopus 로고
    • Radiation therapy oncology group. survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129
    • (abstr 6003)
    • Gillison M.L., Harris J., Westra W., et al. Radiation therapy oncology group. survival outcomes by tumor human papillomavirus (HPV) status in stage III-IV oropharyngeal cancer (OPC) in RTOG 0129. J Clin Oncol 2009, 27:15s. (abstr 6003).
    • (2009) J Clin Oncol , vol.27
    • Gillison, M.L.1    Harris, J.2    Westra, W.3
  • 31
    • 84875196919 scopus 로고    scopus 로고
    • Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer
    • Morrow M.P., Yan J., Sardesai N.Y. Human papillomavirus therapeutic vaccines: targeting viral antigens as immunotherapy for precancerous disease and cancer. Expert Rev Vaccines 2013, 12:271-283.
    • (2013) Expert Rev Vaccines , vol.12 , pp. 271-283
    • Morrow, M.P.1    Yan, J.2    Sardesai, N.Y.3
  • 32
    • 2342471392 scopus 로고    scopus 로고
    • Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib
    • Lynch T.J., Bell D.W., Sordella R., et al. Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 2004, 350:2129-2139.
    • (2004) N Engl J Med , vol.350 , pp. 2129-2139
    • Lynch, T.J.1    Bell, D.W.2    Sordella, R.3
  • 33
    • 70349436013 scopus 로고    scopus 로고
    • Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma
    • Hama T., Yuza Y., Saito Y., et al. Prognostic significance of epidermal growth factor receptor phosphorylation and mutation in head and neck squamous cell carcinoma. Oncologist 2009, 14:900-908.
    • (2009) Oncologist , vol.14 , pp. 900-908
    • Hama, T.1    Yuza, Y.2    Saito, Y.3
  • 34
    • 29144520704 scopus 로고    scopus 로고
    • Low incidence of mutations in EGFR kinase domain in caucasian patients with head and neck squamous cell carcinoma
    • Loeffler-Ragg J., Witsch-Baumgartner M., Tzankov A., Hilbe W., Schwentner I., Sprinzl G.M. Low incidence of mutations in EGFR kinase domain in caucasian patients with head and neck squamous cell carcinoma. Eur J Cancer 2006, 42:109-111.
    • (2006) Eur J Cancer , vol.42 , pp. 109-111
    • Loeffler-Ragg, J.1    Witsch-Baumgartner, M.2    Tzankov, A.3    Hilbe, W.4    Schwentner, I.5    Sprinzl, G.M.6
  • 35
    • 50249148896 scopus 로고    scopus 로고
    • Identification of the rare EGFR mutation p.G796S as somatic and germline mutation in white patients with squamous cell carcinoma of the head and neck
    • Schwentner I., Witsch-Baumgartner M., Sprinzl G.M. Identification of the rare EGFR mutation p.G796S as somatic and germline mutation in white patients with squamous cell carcinoma of the head and neck. Head Neck 2008, 30:1040-1044.
    • (2008) Head Neck , vol.30 , pp. 1040-1044
    • Schwentner, I.1    Witsch-Baumgartner, M.2    Sprinzl, G.M.3
  • 36
    • 0025686126 scopus 로고
    • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts
    • Bigner S.H., Humphrey P.A., Wong A.J., et al. Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. Cancer Res 1990, 50:8017-8022.
    • (1990) Cancer Res , vol.50 , pp. 8017-8022
    • Bigner, S.H.1    Humphrey, P.A.2    Wong, A.J.3
  • 37
    • 33749035470 scopus 로고    scopus 로고
    • Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting
    • Sok J.C., Coppelli F.M., Thomas S.M., et al. Mutant epidermal growth factor receptor (EGFRvIII) contributes to head and neck cancer growth and resistance to EGFR targeting. Clin Cancer Res 2006, 12:5064-5073.
    • (2006) Clin Cancer Res , vol.12 , pp. 5064-5073
    • Sok, J.C.1    Coppelli, F.M.2    Thomas, S.M.3
  • 38
    • 79951952444 scopus 로고    scopus 로고
    • The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    • Chau N.G., Perez-Ordonez B., Zhang K., et al. The association between EGFR variant III, HPV, p16, c-MET, EGFR gene copy number and response to EGFR inhibitors in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Head Neck Oncol 2011, 3:11.
    • (2011) Head Neck Oncol , vol.3 , pp. 11
    • Chau, N.G.1    Perez-Ordonez, B.2    Zhang, K.3
  • 39
    • 0031961980 scopus 로고    scopus 로고
    • Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor
    • Moscatello D.K., Holgado-Madruga M., Emlet D.R., Montgomery R.B., Wong A.J. Constitutive activation of phosphatidylinositol 3-kinase by a naturally occurring mutant epidermal growth factor receptor. J Biol Chem 1998, 273:200-206.
    • (1998) J Biol Chem , vol.273 , pp. 200-206
    • Moscatello, D.K.1    Holgado-Madruga, M.2    Emlet, D.R.3    Montgomery, R.B.4    Wong, A.J.5
  • 40
    • 77956941983 scopus 로고    scopus 로고
    • Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation
    • Wheeler S.E., Suzuki S., Thomas S.M., et al. Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation. Oncogene 2010, 29:5135-5145.
    • (2010) Oncogene , vol.29 , pp. 5135-5145
    • Wheeler, S.E.1    Suzuki, S.2    Thomas, S.M.3
  • 41
    • 79961000118 scopus 로고    scopus 로고
    • Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment
    • Tinhofer I., Klinghammer K., Weichert W., et al. Expression of amphiregulin and EGFRvIII affect outcome of patients with squamous cell carcinoma of the head and neck receiving cetuximab-docetaxel treatment. Clin Cancer Res 2011, 17:5197-5204.
    • (2011) Clin Cancer Res , vol.17 , pp. 5197-5204
    • Tinhofer, I.1    Klinghammer, K.2    Weichert, W.3
  • 42
    • 80052177544 scopus 로고    scopus 로고
    • Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
    • Agrawal N., Frederick M.J., Pickering C.R., et al. Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 2011, 333:1154-1157.
    • (2011) Science , vol.333 , pp. 1154-1157
    • Agrawal, N.1    Frederick, M.J.2    Pickering, C.R.3
  • 44
    • 80052158097 scopus 로고    scopus 로고
    • The mutational landscape of head and neck squamous cell carcinoma
    • Stransky N., Egloff A.M., Tward A.D., et al. The mutational landscape of head and neck squamous cell carcinoma. Science 2011, 333:1157-1160.
    • (2011) Science , vol.333 , pp. 1157-1160
    • Stransky, N.1    Egloff, A.M.2    Tward, A.D.3
  • 45
    • 10044248559 scopus 로고    scopus 로고
    • Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity
    • Gillison M.L. Human papillomavirus-associated head and neck cancer is a distinct epidemiologic, clinical, and molecular entity. Semin Oncol 2004, 31:744-754.
    • (2004) Semin Oncol , vol.31 , pp. 744-754
    • Gillison, M.L.1
  • 46
    • 17444403242 scopus 로고    scopus 로고
    • Structural basis for inhibition of the epidermal growth factor receptor by cetuximab
    • Li S., Schmitz K.R., Jeffrey P.D., et al. Structural basis for inhibition of the epidermal growth factor receptor by cetuximab. Cancer Cell 2005, 7:301-311.
    • (2005) Cancer Cell , vol.7 , pp. 301-311
    • Li, S.1    Schmitz, K.R.2    Jeffrey, P.D.3
  • 47
    • 69049115069 scopus 로고    scopus 로고
    • Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells
    • Lopez-Albaitero A., Lee S.C., Morgan S., et al. Role of polymorphic Fc gamma receptor IIIa and EGFR expression level in cetuximab mediated, NK cell dependent in vitro cytotoxicity of head and neck squamous cell carcinoma cells. Cancer Immunol Immunother 2009, 58:1853-1864.
    • (2009) Cancer Immunol Immunother , vol.58 , pp. 1853-1864
    • Lopez-Albaitero, A.1    Lee, S.C.2    Morgan, S.3
  • 48
    • 0033561522 scopus 로고    scopus 로고
    • Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck
    • Huang S.M., Bock J.M., Harari P.M. Epidermal growth factor receptor blockade with C225 modulates proliferation, apoptosis, and radiosensitivity in squamous cell carcinomas of the head and neck. Cancer Res 1999, 59:1935-1940.
    • (1999) Cancer Res , vol.59 , pp. 1935-1940
    • Huang, S.M.1    Bock, J.M.2    Harari, P.M.3
  • 49
    • 36749008023 scopus 로고    scopus 로고
    • The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage
    • Chen D.J., Nirodi C.S. The epidermal growth factor receptor: a role in repair of radiation-induced DNA damage. Clin Cancer Res 2007, 13:6555-6560.
    • (2007) Clin Cancer Res , vol.13 , pp. 6555-6560
    • Chen, D.J.1    Nirodi, C.S.2
  • 50
    • 0033966576 scopus 로고    scopus 로고
    • In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody
    • Milas L., Mason K., Hunter N. In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody. Clin Cancer Res 2000, 6:701-708.
    • (2000) Clin Cancer Res , vol.6 , pp. 701-708
    • Milas, L.1    Mason, K.2    Hunter, N.3
  • 51
    • 32144433159 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous cell carcinoma of the head and neck
    • Bonner J.A., Harari P.M., Girald J., et al. Radiotherapy plus cetuximab for squamous cell carcinoma of the head and neck. N Engl J Med 2006, 354:567-578.
    • (2006) N Engl J Med , vol.354 , pp. 567-578
    • Bonner, J.A.1    Harari, P.M.2    Girald, J.3
  • 52
    • 73249143536 scopus 로고    scopus 로고
    • Radiotherapy plus cetuximab for squamous cell carcinoma of the head and neck: 5-year survival data from a phase 3 randomized trial, and relation between cetuximab-induced rash and survival
    • Bonner J.A., Harari P.M., Giralt J., et al. Radiotherapy plus cetuximab for squamous cell carcinoma of the head and neck: 5-year survival data from a phase 3 randomized trial, and relation between cetuximab-induced rash and survival. Lancet Oncol 2010, 11:21-28.
    • (2010) Lancet Oncol , vol.11 , pp. 21-28
    • Bonner, J.A.1    Harari, P.M.2    Giralt, J.3
  • 53
    • 0034681783 scopus 로고    scopus 로고
    • Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC collaborative group. Meta-analysis of chemotherapy on head and neck cancer
    • Pignon J.P., Bourhis J., Domenge C., Designé L. Chemotherapy added to locoregional treatment for head and neck squamous-cell carcinoma: three meta-analyses of updated individual data. MACH-NC collaborative group. Meta-analysis of chemotherapy on head and neck cancer. Lancet 2000, 355:949-955.
    • (2000) Lancet , vol.355 , pp. 949-955
    • Pignon, J.P.1    Bourhis, J.2    Domenge, C.3    Designé, L.4
  • 54
    • 80053368876 scopus 로고    scopus 로고
    • A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC)
    • (abst 5500)
    • Ang K.K., Zhang Q., Rosenthal D.I., et al. A randomized phase III trial (RTOG 0522) of concurrent accelerated radiation plus cisplatin with or without cetuximab for stage III-IV head and neck squamous cell carcinomas (HNC). J Clin Oncol 2011, 29:15s. (abst 5500).
    • (2011) J Clin Oncol , vol.29
    • Ang, K.K.1    Zhang, Q.2    Rosenthal, D.I.3
  • 55
    • 84875711689 scopus 로고    scopus 로고
    • Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study
    • Lefebvre J.L., Pointreau Y., Rolland F., et al. Induction chemotherapy followed by either chemoradiotherapy or bioradiotherapy for larynx preservation: the TREMPLIN randomized phase II study. J Clin Oncol 2013, 31:853-859.
    • (2013) J Clin Oncol , vol.31 , pp. 853-859
    • Lefebvre, J.L.1    Pointreau, Y.2    Rolland, F.3
  • 56
    • 84888051359 scopus 로고    scopus 로고
    • A phase II-III study comparing concomitant chemoradiotherapy (CRT) versus cetuximab/RT (CET/RT) with or without induction docetaxel/cisplatin/5-fluorouracil (TPF) in locally advanced head and neck squamous cell carcinoma (LASCCHN): efficacy results (NCT01086826)
    • (suppl; abstr 6003)
    • Ghi M.G., Paccagnella A., Ferrari D., et al. A phase II-III study comparing concomitant chemoradiotherapy (CRT) versus cetuximab/RT (CET/RT) with or without induction docetaxel/cisplatin/5-fluorouracil (TPF) in locally advanced head and neck squamous cell carcinoma (LASCCHN): efficacy results (NCT01086826). J Clin Oncol 2013, 31. (suppl; abstr 6003).
    • (2013) J Clin Oncol , vol.31
    • Ghi, M.G.1    Paccagnella, A.2    Ferrari, D.3
  • 57
    • 23844523253 scopus 로고    scopus 로고
    • Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck
    • Baselga J., Trigo J.M., Bourhis J., et al. Phase II multicenter study of the antiepidermal growth factor receptor monoclonal antibody cetuximab in combination with platinum-based chemotherapy in patients with platinum-refractory metastatic and/or recurrent squamous cell carcinoma of the head and neck. J Clin Oncol 2005, 23:5568-5577.
    • (2005) J Clin Oncol , vol.23 , pp. 5568-5577
    • Baselga, J.1    Trigo, J.M.2    Bourhis, J.3
  • 58
    • 24944490558 scopus 로고    scopus 로고
    • Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck
    • Herbst R.S., Arquette M., Shin D.M., et al. Phase II multicenter study of the epidermal growth factor receptor antibody cetuximab and cisplatin for recurrent and refractory squamous cell carcinoma of the head and neck. J Clin Oncol 2005, 23:5578-5587.
    • (2005) J Clin Oncol , vol.23 , pp. 5578-5587
    • Herbst, R.S.1    Arquette, M.2    Shin, D.M.3
  • 59
    • 34250180582 scopus 로고    scopus 로고
    • Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy
    • Vermorken J.B., Trigo J., Hitt R., et al. Open-label, uncontrolled, multicenter phase II study to evaluate the efficacy and toxicity of cetuximab as a single agent in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck who failed to respond to platinum-based therapy. J Clin Oncol 2007, 25:2171-2177.
    • (2007) J Clin Oncol , vol.25 , pp. 2171-2177
    • Vermorken, J.B.1    Trigo, J.2    Hitt, R.3
  • 60
    • 46049084643 scopus 로고    scopus 로고
    • Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies
    • Vermorken J.B., Herbst R.S., Leon X., Amellal N., Baselga J. Overview of the efficacy of cetuximab in recurrent and/or metastatic squamous cell carcinoma of the head and neck in patients who previously failed platinum-based therapies. Cancer 2008, 112:2710-2719.
    • (2008) Cancer , vol.112 , pp. 2710-2719
    • Vermorken, J.B.1    Herbst, R.S.2    Leon, X.3    Amellal, N.4    Baselga, J.5
  • 61
    • 23744495620 scopus 로고    scopus 로고
    • A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy
    • León X., Hitt R., Constenla M., et al. A retrospective analysis of the outcome of patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck refractory to a platinum-based chemotherapy. Clin Oncol 2005, 17:418-424.
    • (2005) Clin Oncol , vol.17 , pp. 418-424
    • León, X.1    Hitt, R.2    Constenla, M.3
  • 62
    • 84892886646 scopus 로고    scopus 로고
    • http://www.fda.gov.
  • 63
    • 33144461661 scopus 로고    scopus 로고
    • Eastern cooperative oncology groupe. Phase IIIrandomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern cooperative oncology group study
    • Burtness B., Goldwasser M.A., Flood W., Mattar B., Mattar A.A. Eastern cooperative oncology groupe. Phase IIIrandomized trial of cisplatin plus placebo compared with cisplatin plus cetuximab in metastatic/recurrent head and neck cancer: an Eastern cooperative oncology group study. J Clin Oncol 2005, 23:8646-8654.
    • (2005) J Clin Oncol , vol.23 , pp. 8646-8654
    • Burtness, B.1    Goldwasser, M.A.2    Flood, W.3    Mattar, B.4    Mattar, A.A.5
  • 64
    • 51649085865 scopus 로고    scopus 로고
    • Platinum-based chemotherapy plus cetuximab in head and neck cancer
    • Vermorken J.B., Mesia R., Rivera F., et al. Platinum-based chemotherapy plus cetuximab in head and neck cancer. N Engl J Med 2008, 359:1116-1127.
    • (2008) N Engl J Med , vol.359 , pp. 1116-1127
    • Vermorken, J.B.1    Mesia, R.2    Rivera, F.3
  • 65
    • 84892854637 scopus 로고    scopus 로고
    • Safety and efficacy of cisplatin plus 5-FU and cetuximab in HPV-positive and HPV-negative recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): analysis of the phase III EXTREME trial
    • Psyrri A., Licitra L., DeBlas B., Celik I., Vermorken J.B. Safety and efficacy of cisplatin plus 5-FU and cetuximab in HPV-positive and HPV-negative recurrent and/or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): analysis of the phase III EXTREME trial. Ann Oncol 2012, 23(Suppl. 9):ix334-ix347.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Psyrri, A.1    Licitra, L.2    DeBlas, B.3    Celik, I.4    Vermorken, J.B.5
  • 66
    • 79953183347 scopus 로고    scopus 로고
    • Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: an open-label, randomised phase 3 trial
    • Machiels J.P., Subramanian S., Ruzsa A., et al. Zalutumumab plus best supportive care versus best supportive care alone in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck after failure of platinum-based chemotherapy: an open-label, randomised phase 3 trial. Lancet Oncol 2011, 12:333-343.
    • (2011) Lancet Oncol , vol.12 , pp. 333-343
    • Machiels, J.P.1    Subramanian, S.2    Ruzsa, A.3
  • 67
    • 84879785532 scopus 로고    scopus 로고
    • Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial
    • Vermorken J.B., Stöhlmacher-Williams J., Davidenko I., et al. Cisplatin and fluorouracil with or without panitumumab in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck (SPECTRUM): an open-label phase 3 randomised trial. Lancet Oncol 2013, 14:697-710.
    • (2013) Lancet Oncol , vol.14 , pp. 697-710
    • Vermorken, J.B.1    Stöhlmacher-Williams, J.2    Davidenko, I.3
  • 68
    • 84868351429 scopus 로고    scopus 로고
    • Safety and efficacy of panitumumab (pmab) in HPV-positive (+) and HPV-negative (-) recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): analysis of the global phase III SPECTRUM trial
    • (abstr 5504)
    • Stoehlmacher-Williams J., Villanueva C., Foa P., et al. Safety and efficacy of panitumumab (pmab) in HPV-positive (+) and HPV-negative (-) recurrent/metastatic squamous cell carcinoma of the head and neck (R/M SCCHN): analysis of the global phase III SPECTRUM trial. J Clin Oncol 2012, 20:15s. (abstr 5504).
    • (2012) J Clin Oncol , vol.20
    • Stoehlmacher-Williams, J.1    Villanueva, C.2    Foa, P.3
  • 69
    • 84868345415 scopus 로고    scopus 로고
    • A phase II, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab (pmab) in patients (pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN)
    • (abstr 2000)
    • Giralt J., Fortin A., Mesia R., et al. A phase II, randomized trial (CONCERT-1) of chemoradiotherapy (CRT) with or without panitumumab (pmab) in patients (pts) with unresected, locally advanced squamous cell carcinoma of the head and neck (LASCCHN). J Clin Oncol 2012, 30:15. (abstr 2000).
    • (2012) J Clin Oncol , vol.30 , pp. 15
    • Giralt, J.1    Fortin, A.2    Mesia, R.3
  • 70
    • 84888645853 scopus 로고    scopus 로고
    • Phase 2, randomized trial (Concert-2) of panitumumab (Pmab) plus radiotherapy (PRT) compared with chemotherapy (CRT) in patients (pts) with unresected locally advanced squamous cell carcinoma of the head and neck (LASCCHN). Abstract 10160
    • Giralt J., Trigo J.M., Nuyts S., et al. Phase 2, randomized trial (Concert-2) of panitumumab (Pmab) plus radiotherapy (PRT) compared with chemotherapy (CRT) in patients (pts) with unresected locally advanced squamous cell carcinoma of the head and neck (LASCCHN). Abstract 10160. Ann Oncol 2012, 23(Suppl. 9):ix334-ix347.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Giralt, J.1    Trigo, J.M.2    Nuyts, S.3
  • 71
    • 84888064205 scopus 로고    scopus 로고
    • PARTNER: A randomized phase II study of docetaxel/cisplatin (doc/cis) chemotherapy with or without panitumumab (pmab) as first-line treatment (tx) for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN)
    • (abstr 6029)
    • Wirth L.J., Dakhil S.R., Kornek G., et al. PARTNER: A randomized phase II study of docetaxel/cisplatin (doc/cis) chemotherapy with or without panitumumab (pmab) as first-line treatment (tx) for recurrent or metastatic squamous cell carcinoma of the head and neck (R/M SCCHN). J Clin Oncol 2013, 31. (abstr 6029).
    • (2013) J Clin Oncol , vol.31
    • Wirth, L.J.1    Dakhil, S.R.2    Kornek, G.3
  • 72
    • 77953694219 scopus 로고    scopus 로고
    • Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck
    • Rodríguez M.O., Rivero T.C., Del Castillo Bahi R. et al. Nimotuzumab plus radiotherapy for unresectable squamous-cell carcinoma of the head and neck. Cancer Biol Ther 2010, 9:343-349.
    • (2010) Cancer Biol Ther , vol.9 , pp. 343-349
    • Rodríguez, M.O.1    Rivero, T.C.2    Del Castillo Bahi, R.3
  • 73
    • 79251477943 scopus 로고    scopus 로고
    • An open-label, randomized, study of h-R3mAb (nimotuzumab) in patients with advanced (stage III or IVa) squamous cell carcinoma of head and neck (SCCHN): four-year survival results from a phase IIb study
    • (abst 5530)
    • Babu K.G., Viswanath L., Reddy B.K., et al. An open-label, randomized, study of h-R3mAb (nimotuzumab) in patients with advanced (stage III or IVa) squamous cell carcinoma of head and neck (SCCHN): four-year survival results from a phase IIb study. J Clin Oncol 2010, 28:15. (abst 5530).
    • (2010) J Clin Oncol , vol.28 , pp. 15
    • Babu, K.G.1    Viswanath, L.2    Reddy, B.K.3
  • 74
    • 84892845993 scopus 로고    scopus 로고
    • A phase 1 study of ABT-806, a 40humanized recombinant anti-EGFR monoclonal antibody, in patients with advanced solid tumors
    • (Abstract 2506)
    • Cleary J.M., Yee K.-C.L., Azad N., et al. A phase 1 study of ABT-806, a 40humanized recombinant anti-EGFR monoclonal antibody, in patients with advanced solid tumors. Cancer Res 2012, 72:s1. (Abstract 2506).
    • (2012) Cancer Res , vol.72
    • Cleary, J.M.1    Yee, K.-C.L.2    Azad, N.3
  • 75
    • 84892846194 scopus 로고    scopus 로고
    • A phase I and biodistribution study of ABT-806i, an [111] indium-labeled conjugate of the tumor-specific anti-EGFR antibody ABT-806
    • (abst 2520)
    • Gan H.K., Burge M.E., Solomon B.J., et al. A phase I and biodistribution study of ABT-806i, an [111] indium-labeled conjugate of the tumor-specific anti-EGFR antibody ABT-806. J Clin Oncol 2013, 31:15S. (abst 2520).
    • (2013) J Clin Oncol , vol.31
    • Gan, H.K.1    Burge, M.E.2    Solomon, B.J.3
  • 76
    • 62449303549 scopus 로고    scopus 로고
    • Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms
    • Lai S.Y., Koppikar P., Thomas S.M., et al. Intratumoral epidermal growth factor receptor antisense DNA therapy in head and neck cancer: first human application and potential antitumor mechanisms. J Clin Oncol 2009, 10(27):1235-1242.
    • (2009) J Clin Oncol , vol.10 , Issue.27 , pp. 1235-1242
    • Lai, S.Y.1    Koppikar, P.2    Thomas, S.M.3
  • 77
    • 1842772526 scopus 로고    scopus 로고
    • Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck
    • Soulieres D., Senzer N.N., Vokes E.E., Hidalgo M., Agarwala S.S., Siu L.L. Multicenter phase II study of erlotinib, an oral epidermal growth factor receptor tyrosine kinase inhibitor, in patients with recurrent or metastatic squamous cell cancer of the head and neck. J Clin Oncol 2004, 22:77-85.
    • (2004) J Clin Oncol , vol.22 , pp. 77-85
    • Soulieres, D.1    Senzer, N.N.2    Vokes, E.E.3    Hidalgo, M.4    Agarwala, S.S.5    Siu, L.L.6
  • 78
    • 0037674062 scopus 로고    scopus 로고
    • Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen E.E., Rosen F., Stadler W.M., et al. Phase II trial of ZD1839 in recurrent or metastatic squamous cell carcinoma of the head and neck. J Clin Oncol 2003, 15(21):1980-1987.
    • (2003) J Clin Oncol , vol.15 , Issue.21 , pp. 1980-1987
    • Cohen, E.E.1    Rosen, F.2    Stadler, W.M.3
  • 79
    • 64649097892 scopus 로고    scopus 로고
    • Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck
    • Stewart J.S., Cohen E.E., Licitra L., et al. Phase III study of gefitinib compared with intravenous methotrexate for recurrent squamous cell carcinoma of the head and neck. J Clin Oncol 2009, 27:1864-1871.
    • (2009) J Clin Oncol , vol.27 , pp. 1864-1871
    • Stewart, J.S.1    Cohen, E.E.2    Licitra, L.3
  • 80
    • 84876073132 scopus 로고    scopus 로고
    • A phase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: an eastern cooperative oncology group trial
    • Argiris A., Ghebremichael M., Gilbert J., Burtness B., Forastiere A. A phase III randomized, placebo-controlled trial of docetaxel with or without gefitinib in recurrent or metastatic head and neck cancer: an eastern cooperative oncology group trial. J Clin Oncol 2013 Apr 10, 31(11):1405-1414.
    • (2013) J Clin Oncol , vol.31 , Issue.11 , pp. 1405-1414
    • Argiris, A.1    Ghebremichael, M.2    Gilbert, J.3    Burtness, B.4    Forastiere, A.5
  • 81
    • 84876079071 scopus 로고    scopus 로고
    • Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial
    • Martins R.G., Parvathaneni U., Bauman J.E., et al. Cisplatin and radiotherapy with or without erlotinib in locally advanced squamous cell carcinoma of the head and neck: a randomized phase II trial. J Clin Oncol 2013, 31:1415-1421.
    • (2013) J Clin Oncol , vol.31 , pp. 1415-1421
    • Martins, R.G.1    Parvathaneni, U.2    Bauman, J.E.3
  • 82
    • 80051781911 scopus 로고    scopus 로고
    • Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: a phase II, randomized, double-blind, placebo-controlled study
    • Gregoire V., Hamoir M., Chen C., et al. Gefitinib plus cisplatin and radiotherapy in previously untreated head and neck squamous cell carcinoma: a phase II, randomized, double-blind, placebo-controlled study. Radiother Oncol 2011, 100:62-69.
    • (2011) Radiother Oncol , vol.100 , pp. 62-69
    • Gregoire, V.1    Hamoir, M.2    Chen, C.3
  • 83
    • 84892836611 scopus 로고    scopus 로고
    • Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease
    • Harrington K., Berrier A., Robinson M., et al. Randomised Phase II study of oral lapatinib combined with chemoradiotherapy in patients with advanced squamous cell carcinoma of the head and neck: rationale for future randomised trials in human papilloma virus-negative disease. Eur J Cancer 2012, 19:9.
    • (2012) Eur J Cancer , vol.19 , pp. 9
    • Harrington, K.1    Berrier, A.2    Robinson, M.3
  • 84
    • 80052029219 scopus 로고    scopus 로고
    • Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck
    • Del Campo J.M., Hitt R., Sebastian P., et al. Effects of lapatinib monotherapy: results of a randomised phase II study in therapy-naive patients with locally advanced squamous cell carcinoma of the head and neck. Br J Cancer 2011, 105:618-627.
    • (2011) Br J Cancer , vol.105 , pp. 618-627
    • Del Campo, J.M.1    Hitt, R.2    Sebastian, P.3
  • 85
    • 84859873106 scopus 로고    scopus 로고
    • A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck
    • De Souza J.A., Davis D.W., Zhang Y., et al. A phase II study of lapatinib in recurrent/metastatic squamous cell carcinoma of the head and neck. Clin Cancer Res 2012, 18:2336-2343.
    • (2012) Clin Cancer Res , vol.18 , pp. 2336-2343
    • De Souza, J.A.1    Davis, D.W.2    Zhang, Y.3
  • 86
    • 84871330978 scopus 로고    scopus 로고
    • EORTC 24051: unexpected side effects in a phase I study of TPF induction chemotherapy followed by chemoradiation with lapatinib, a dual EGFR/ErbB2 inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinoma
    • Lalami Y., Specenier P.M., Awada A., et al. EORTC 24051: unexpected side effects in a phase I study of TPF induction chemotherapy followed by chemoradiation with lapatinib, a dual EGFR/ErbB2 inhibitor, in patients with locally advanced resectable larynx and hypopharynx squamous cell carcinoma. Radiother Oncol 2012, 105(2):238-240.
    • (2012) Radiother Oncol , vol.105 , Issue.2 , pp. 238-240
    • Lalami, Y.1    Specenier, P.M.2    Awada, A.3
  • 87
    • 84879716636 scopus 로고    scopus 로고
    • A randomized, open-label, phase II study of Afatinib versus Cetuximab in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC)
    • Seiwert T.Y., Fayette J., Cupissol D., et al. A randomized, open-label, phase II study of Afatinib versus Cetuximab in recurrent/metastatic head and neck squamous cell carcinoma (HNSCC). Ann Oncol 2012, 23:xi35-xi36.
    • (2012) Ann Oncol , vol.23
    • Seiwert, T.Y.1    Fayette, J.2    Cupissol, D.3
  • 88
    • 84888043119 scopus 로고    scopus 로고
    • A randomized, open-label, phase II study of afatinib versus cetuximab in patients (pts) with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): analysis of stage 2 (S2) following crossover
    • (abstr 6001)
    • Cupissol D., Seiwert T.Y., Fayette J., et al. A randomized, open-label, phase II study of afatinib versus cetuximab in patients (pts) with recurrent or metastatic (R/M) head and neck squamous cell carcinoma (HNSCC): analysis of stage 2 (S2) following crossover. J Clin Oncol 2013, 31. (abstr 6001).
    • (2013) J Clin Oncol , vol.31
    • Cupissol, D.1    Seiwert, T.Y.2    Fayette, J.3
  • 89
    • 84874569165 scopus 로고    scopus 로고
    • A phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck
    • Abdul Razak A.R., Soulières D., Laurie S.A., et al. A phase II trial of dacomitinib, an oral pan-human EGF receptor (HER) inhibitor, as first-line treatment in recurrent and/or metastatic squamous-cell carcinoma of the head and neck. Ann Oncol 2013, 24:761-769.
    • (2013) Ann Oncol , vol.24 , pp. 761-769
    • Abdul Razak, A.R.1    Soulières, D.2    Laurie, S.A.3
  • 90
    • 80052591747 scopus 로고    scopus 로고
    • Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab
    • [99ra86]
    • Yonesaka K., Zejnullahu K., Okamoto I., et al. Activation of ERBB2 signaling causes resistance to the EGFR-directed therapeutic antibody cetuximab. Sci Transl Med 2011, 3. [99ra86].
    • (2011) Sci Transl Med , vol.3
    • Yonesaka, K.1    Zejnullahu, K.2    Okamoto, I.3
  • 91
    • 67649472398 scopus 로고    scopus 로고
    • Novel anticancer targets: revisiting ERBB2 and discovering ERBB3
    • Baselga J., Swain S.M. Novel anticancer targets: revisiting ERBB2 and discovering ERBB3. Nat Rev Cancer 2009, 9(7):463-475.
    • (2009) Nat Rev Cancer , vol.9 , Issue.7 , pp. 463-475
    • Baselga, J.1    Swain, S.M.2
  • 92
    • 80051578430 scopus 로고    scopus 로고
    • Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers
    • Wilson T.R., Lee D.Y., Berry L., Shames D.S., Settleman J. Neuregulin-1-mediated autocrine signaling underlies sensitivity to HER2 kinase inhibitors in a subset of human cancers. Cancer Cell 2011, 20:158-172.
    • (2011) Cancer Cell , vol.20 , pp. 158-172
    • Wilson, T.R.1    Lee, D.Y.2    Berry, L.3    Shames, D.S.4    Settleman, J.5
  • 93
    • 80054765331 scopus 로고    scopus 로고
    • A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies
    • Schaefer G., Haber L., Crocker L.M., et al. A two-in-one antibody against HER3 and EGFR has superior inhibitory activity compared with monospecific antibodies. Cancer Cell 2011, 20:472-486.
    • (2011) Cancer Cell , vol.20 , pp. 472-486
    • Schaefer, G.1    Haber, L.2    Crocker, L.M.3
  • 94
    • 84892874977 scopus 로고    scopus 로고
    • A phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual-action antibody, in patients (pts) with refractory/recurrent epithelial tumors: expansion cohorts
    • (abstr 2565)
    • Cervantes-Ruiperez A., Juric D., Hidalgo M., et al. A phase I study of MEHD7945A (MEHD), a first-in-class HER3/EGFR dual-action antibody, in patients (pts) with refractory/recurrent epithelial tumors: expansion cohorts. J Clin Oncol 2009, 27:15s. (abstr 2565).
    • (2009) J Clin Oncol , vol.27
    • Cervantes-Ruiperez, A.1    Juric, D.2    Hidalgo, M.3
  • 95
    • 84856034032 scopus 로고    scopus 로고
    • Trifunctional antibodies induce efficient antitumour activity with immune cells from head and neck squamous cell
    • Schroeder P., Lindemann C., Dettmar K., et al. Trifunctional antibodies induce efficient antitumour activity with immune cells from head and neck squamous cell. Clin Transl Oncol 2011, 13:889-898.
    • (2011) Clin Transl Oncol , vol.13 , pp. 889-898
    • Schroeder, P.1    Lindemann, C.2    Dettmar, K.3
  • 96
    • 76549085643 scopus 로고    scopus 로고
    • Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy
    • Pedersen M.W., Jacobsen H.J., Koefoed K., et al. Sym004: a novel synergistic anti-epidermal growth factor receptor antibody mixture with superior anticancer efficacy. Cancer Res 2010, 70:588-597.
    • (2010) Cancer Res , vol.70 , pp. 588-597
    • Pedersen, M.W.1    Jacobsen, H.J.2    Koefoed, K.3
  • 97
    • 84884306879 scopus 로고    scopus 로고
    • Sym004, a novel strategy to target EGFR with an antibody mixture, in patients with advanced SCCHN progressing after monoclonal antibody: a proof of concept study
    • (abstr 6002)
    • Machiels J.P., Specenier P.M., Krauss J., et al. Sym004, a novel strategy to target EGFR with an antibody mixture, in patients with advanced SCCHN progressing after monoclonal antibody: a proof of concept study. J Clin Oncol 2013, 31. (abstr 6002).
    • (2013) J Clin Oncol , vol.31
    • Machiels, J.P.1    Specenier, P.M.2    Krauss, J.3
  • 98
    • 78649420006 scopus 로고    scopus 로고
    • MET signalling: principles and functions in development, organ regeneration and cancer
    • Trusolino L., Bertotti A., Comoglio P.M. MET signalling: principles and functions in development, organ regeneration and cancer. Nat Rev Mol Cell Biol 2010, 11:834-848.
    • (2010) Nat Rev Mol Cell Biol , vol.11 , pp. 834-848
    • Trusolino, L.1    Bertotti, A.2    Comoglio, P.M.3
  • 99
    • 37549061078 scopus 로고    scopus 로고
    • PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib
    • Engelman J.A., Zejnullahu K., Gale C.M., et al. PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. Cancer Res 2007, 67:11924-11932.
    • (2007) Cancer Res , vol.67 , pp. 11924-11932
    • Engelman, J.A.1    Zejnullahu, K.2    Gale, C.M.3
  • 100
    • 73649102105 scopus 로고    scopus 로고
    • Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC
    • Turke A.B., Zejnullahu K., Wu Y.L., et al. Preexistence and clonal selection of MET amplification in EGFR mutant NSCLC. Cancer Cell 2010, 17:77-88.
    • (2010) Cancer Cell , vol.17 , pp. 77-88
    • Turke, A.B.1    Zejnullahu, K.2    Wu, Y.L.3
  • 101
    • 77954586493 scopus 로고    scopus 로고
    • Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis
    • Benedettini E., Sholl L.M., Peyton M., et al. Met activation in non-small cell lung cancer is associated with de novo resistance to EGFR inhibitors and the development of brain metastasis. Am J Pathol 2010, 177:415-423.
    • (2010) Am J Pathol , vol.177 , pp. 415-423
    • Benedettini, E.1    Sholl, L.M.2    Peyton, M.3
  • 102
    • 62549161686 scopus 로고    scopus 로고
    • Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells
    • Agarwal S., Zerillo C., Kolmakova J., et al. Association of constitutively activated hepatocyte growth factor receptor (Met) with resistance to a dual EGFR/Her2 inhibitor in non-small-cell lung cancer cells. Br J Cancer 2009, 100:941-949.
    • (2009) Br J Cancer , vol.100 , pp. 941-949
    • Agarwal, S.1    Zerillo, C.2    Kolmakova, J.3
  • 103
    • 66149135285 scopus 로고    scopus 로고
    • The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma
    • Seiwert T.Y., Jagadeeswaran R., Faoro L., et al. The MET receptor tyrosine kinase is a potential novel therapeutic target for head and neck squamous cell carcinoma. Cancer Res 2009, 69:3021-3031.
    • (2009) Cancer Res , vol.69 , pp. 3021-3031
    • Seiwert, T.Y.1    Jagadeeswaran, R.2    Faoro, L.3
  • 104
    • 78649672549 scopus 로고    scopus 로고
    • C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma
    • Kim C.H., Koh Y.W., Han J.H. C-Met expression as an indicator of survival outcome in patients with oral tongue carcinoma. Head Neck 2010, 32:1655-1664.
    • (2010) Head Neck , vol.32 , pp. 1655-1664
    • Kim, C.H.1    Koh, Y.W.2    Han, J.H.3
  • 105
    • 71849099890 scopus 로고    scopus 로고
    • MET Y1253D-activating point mutation and development of distant metastasis in advanced head and neck cancers
    • Ghadjar P., Blank-Liss W., Simcock M. MET Y1253D-activating point mutation and development of distant metastasis in advanced head and neck cancers. Clin Exp Metastasis 2009, 26:809-815.
    • (2009) Clin Exp Metastasis , vol.26 , pp. 809-815
    • Ghadjar, P.1    Blank-Liss, W.2    Simcock, M.3
  • 106
    • 79960300164 scopus 로고    scopus 로고
    • Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells
    • Xu H., Stabile L.P., Gubish C.T., et al. Dual blockade of EGFR and c-Met abrogates redundant signaling and proliferation in head and neck carcinoma cells. Clin Cancer Res 2011, 17:4425-4438.
    • (2011) Clin Cancer Res , vol.17 , pp. 4425-4438
    • Xu, H.1    Stabile, L.P.2    Gubish, C.T.3
  • 107
    • 66649131963 scopus 로고    scopus 로고
    • HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer
    • Knowles L.M., Stabile L.P., Egloff A.M., et al. HGF and c-Met participate in paracrine tumorigenic pathways in head and neck squamous cell cancer. Clin Cancer Res 2009, 15:3740-3750.
    • (2009) Clin Cancer Res , vol.15 , pp. 3740-3750
    • Knowles, L.M.1    Stabile, L.P.2    Egloff, A.M.3
  • 108
    • 84879554465 scopus 로고    scopus 로고
    • Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    • Seiwert T., Sarantopoulos J., Kallender H., McCallum S., Keer H.N., Blumenschein G. Phase II trial of single-agent foretinib (GSK1363089) in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Invest New Drugs 2012, 31:417-424.
    • (2012) Invest New Drugs , vol.31 , pp. 417-424
    • Seiwert, T.1    Sarantopoulos, J.2    Kallender, H.3    McCallum, S.4    Keer, H.N.5    Blumenschein, G.6
  • 109
    • 79953885749 scopus 로고    scopus 로고
    • Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies
    • Yap T.A., Olmos D., Brunetto A.T., et al. Phase I trial of a selective c-MET inhibitor ARQ 197 incorporating proof of mechanism pharmacodynamic studies. J Clin Oncol 2011, 29:1271-1279.
    • (2011) J Clin Oncol , vol.29 , pp. 1271-1279
    • Yap, T.A.1    Olmos, D.2    Brunetto, A.T.3
  • 110
    • 0034515459 scopus 로고    scopus 로고
    • Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway
    • Kurihara S., Hakuno F., Takahashi S. Insulin-like growth factor-I-dependent signal transduction pathways leading to the induction of cell growth and differentiation of human neuroblastoma cell line SH-SY5Y: the roles of MAP kinase pathway and PI 3-kinase pathway. Endocr J 2000, 47:739-751.
    • (2000) Endocr J , vol.47 , pp. 739-751
    • Kurihara, S.1    Hakuno, F.2    Takahashi, S.3
  • 111
    • 0037444268 scopus 로고    scopus 로고
    • Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor
    • Tang Y., Zhang D., Fallavollita L., Brodt P. Vascular endothelial growth factor C expression and lymph node metastasis are regulated by the type I insulin-like growth factor receptor. Cancer Res 2003, 63:1166-1171.
    • (2003) Cancer Res , vol.63 , pp. 1166-1171
    • Tang, Y.1    Zhang, D.2    Fallavollita, L.3    Brodt, P.4
  • 112
    • 0029027521 scopus 로고
    • The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo
    • Resnicoff M., Abraham D., Yutanawiboonchai W., Rotman H.L., et al. The insulin-like growth factor I receptor protects tumor cells from apoptosis in vivo. Cancer Res 1995, 55:2463-2469.
    • (1995) Cancer Res , vol.55 , pp. 2463-2469
    • Resnicoff, M.1    Abraham, D.2    Yutanawiboonchai, W.3    Rotman, H.L.4
  • 113
    • 23644446486 scopus 로고    scopus 로고
    • The insulin-like growth factor-I receptor as a target for cancer therapy
    • Baserga R. The insulin-like growth factor-I receptor as a target for cancer therapy. Expert Opin Ther Targets 2005, 9:753-768.
    • (2005) Expert Opin Ther Targets , vol.9 , pp. 753-768
    • Baserga, R.1
  • 114
    • 34547107855 scopus 로고    scopus 로고
    • Insulin-like growth factor receptor as a therapeutic target in head and neck cancer
    • Barnes C.J., Ohshiro K., Rayala S.K., El-Naggar A.K., Kumar R. Insulin-like growth factor receptor as a therapeutic target in head and neck cancer. Clin Cancer Res 2007, 13:4291-4299.
    • (2007) Clin Cancer Res , vol.13 , pp. 4291-4299
    • Barnes, C.J.1    Ohshiro, K.2    Rayala, S.K.3    El-Naggar, A.K.4    Kumar, R.5
  • 115
    • 79955015087 scopus 로고    scopus 로고
    • Clinical significance of type 1 insulin-like growth factor receptor and insulin-like growth factor binding protein-3 expression in squamous cell carcinoma of head and neck
    • (abstr 6036)
    • Jun H., Chang M., Ko Y., et al. Clinical significance of type 1 insulin-like growth factor receptor and insulin-like growth factor binding protein-3 expression in squamous cell carcinoma of head and neck. J Clin Oncol 2009, 27:15s. (abstr 6036).
    • (2009) J Clin Oncol , vol.27
    • Jun, H.1    Chang, M.2    Ko, Y.3
  • 116
    • 84857656268 scopus 로고    scopus 로고
    • Phase II study of figitumumab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: clinical activity and molecular response (GORTEC 2008-02)
    • Schmitz S., Kaminsky-Forrett M.C., Henry S., et al. Phase II study of figitumumab in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck: clinical activity and molecular response (GORTEC 2008-02). Ann Oncol 2012, 23:2153-2161.
    • (2012) Ann Oncol , vol.23 , pp. 2153-2161
    • Schmitz, S.1    Kaminsky-Forrett, M.C.2    Henry, S.3
  • 117
    • 84880709088 scopus 로고    scopus 로고
    • Randomized phase II trial of cixutumumab (CIX) alone or with cetuximab (CET) for refractory recurrent/metastatic squamous cancer of head and neck (R/M-SCCHN)
    • (abstr 6030)
    • Glisson B.S., Tseng J., Marur S., et al. Randomized phase II trial of cixutumumab (CIX) alone or with cetuximab (CET) for refractory recurrent/metastatic squamous cancer of head and neck (R/M-SCCHN). J Clin Oncol 2013, 31. (abstr 6030).
    • (2013) J Clin Oncol , vol.31
    • Glisson, B.S.1    Tseng, J.2    Marur, S.3
  • 118
    • 33645504221 scopus 로고    scopus 로고
    • Hypoxic induction of an HIF-1a-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells
    • Calvani M., Rapsiarda A., Uranchimeg B., Shoemaker R.H., Melillo G. Hypoxic induction of an HIF-1a-dependent bFGF autocrine loop drives angiogenesis in human endothelial cells. Blood 2006, 107:2705-2712.
    • (2006) Blood , vol.107 , pp. 2705-2712
    • Calvani, M.1    Rapsiarda, A.2    Uranchimeg, B.3    Shoemaker, R.H.4    Melillo, G.5
  • 119
    • 34548545297 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2
    • Lewis C.E., Hughes R. Inflammation and breast cancer. Microenvironmental factors regulating macrophage function in breast tumours: hypoxia and angiopoietin-2. Breast Cancer Res 2007, 9:209.
    • (2007) Breast Cancer Res , vol.9 , pp. 209
    • Lewis, C.E.1    Hughes, R.2
  • 120
    • 33846326878 scopus 로고    scopus 로고
    • Hypoxia induces transforming growth factor b1 gene expression in the pulmonary artery of rats with hypoxia-inductible factor-1a
    • Jiang Y., Dai A., Li Q., Hu R. Hypoxia induces transforming growth factor b1 gene expression in the pulmonary artery of rats with hypoxia-inductible factor-1a. Acta Biochim Biophys Sin 2007, 39:73-80.
    • (2007) Acta Biochim Biophys Sin , vol.39 , pp. 73-80
    • Jiang, Y.1    Dai, A.2    Li, Q.3    Hu, R.4
  • 121
    • 14644411058 scopus 로고    scopus 로고
    • Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis
    • Kyzas P.A., Cunha I.W., Ioannidis J.P. Prognostic significance of vascular endothelial growth factor immunohistochemical expression in head and neck squamous cell carcinoma: a meta-analysis. Clin Cancer Res 2005, 11:1434-1440.
    • (2005) Clin Cancer Res , vol.11 , pp. 1434-1440
    • Kyzas, P.A.1    Cunha, I.W.2    Ioannidis, J.P.3
  • 122
    • 33846857321 scopus 로고    scopus 로고
    • VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites
    • Hirakawa S., Brown L.F., Kodama S., Paavonen K., Alitalo K., Detmar M. VEGF-C-induced lymphangiogenesis in sentinel lymph nodes promotes tumor metastasis to distant sites. Blood 2007, 109(3):1010-1017.
    • (2007) Blood , vol.109 , Issue.3 , pp. 1010-1017
    • Hirakawa, S.1    Brown, L.F.2    Kodama, S.3    Paavonen, K.4    Alitalo, K.5    Detmar, M.6
  • 123
    • 84865597654 scopus 로고    scopus 로고
    • Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer
    • Kudo Y., Iizuka S., Yoshida M., et al. Periostin directly and indirectly promotes tumor lymphangiogenesis of head and neck cancer. PLOS One 2012, 7:e44488.
    • (2012) PLOS One , vol.7
    • Kudo, Y.1    Iizuka, S.2    Yoshida, M.3
  • 124
    • 0031834239 scopus 로고    scopus 로고
    • A plasticity window for blood vessel remodeling is defined by pericyte coverage of the performed endothelial network and is regulated by BDGF-B and VEGF
    • Benjamin L.E., Hemo I., Keshet E. A plasticity window for blood vessel remodeling is defined by pericyte coverage of the performed endothelial network and is regulated by BDGF-B and VEGF. Development 1998, 125:1591-1598.
    • (1998) Development , vol.125 , pp. 1591-1598
    • Benjamin, L.E.1    Hemo, I.2    Keshet, E.3
  • 125
    • 1442290142 scopus 로고    scopus 로고
    • Combined inhibition of VEGF-and PDGF-signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms
    • Erber R., Thurnher A., Katsen A., et al. Combined inhibition of VEGF-and PDGF-signaling enforces tumor vessel regression by interfering with pericyte-mediated endothelial cell survival mechanisms. FASEB J 2004, 18:338-340.
    • (2004) FASEB J , vol.18 , pp. 338-340
    • Erber, R.1    Thurnher, A.2    Katsen, A.3
  • 126
    • 0038476608 scopus 로고    scopus 로고
    • Benefits of targeted both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors
    • Bergers G., Song S., Meyer-Morse N., Bergsland E., Hanahan D. Benefits of targeted both pericytes and endothelial cells in the tumor vasculature with kinase inhibitors. J Clin Invest 2003, 111:1287-1295.
    • (2003) J Clin Invest , vol.111 , pp. 1287-1295
    • Bergers, G.1    Song, S.2    Meyer-Morse, N.3    Bergsland, E.4    Hanahan, D.5
  • 127
    • 79952741923 scopus 로고    scopus 로고
    • Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer
    • Argiris A., Karamouzis M.V., Gooding W.E., et al. Phase II trial of pemetrexed and bevacizumab in patients with recurrent or metastatic head and neck cancer. J Clin Oncol 2011, 29:1140-1145.
    • (2011) J Clin Oncol , vol.29 , pp. 1140-1145
    • Argiris, A.1    Karamouzis, M.V.2    Gooding, W.E.3
  • 128
    • 62349097073 scopus 로고    scopus 로고
    • A phase II study of erlotinib and bevacizumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck
    • Cohen E., Davis D., Karrison T., et al. A phase II study of erlotinib and bevacizumab in patients with recurrent or metastatic squamous cell carcinoma of the head and neck. Lancet Oncol 2009, 10:247-257.
    • (2009) Lancet Oncol , vol.10 , pp. 247-257
    • Cohen, E.1    Davis, D.2    Karrison, T.3
  • 129
    • 43249128897 scopus 로고    scopus 로고
    • Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer
    • Seiwert T.Y., Haraf D.J., Cohen E.E., et al. Phase I study of bevacizumab added to fluorouracil- and hydroxyurea-based concomitant chemoradiotherapy for poor-prognosis head and neck cancer. J Clin Oncol 2008, 26:1732-1741.
    • (2008) J Clin Oncol , vol.26 , pp. 1732-1741
    • Seiwert, T.Y.1    Haraf, D.J.2    Cohen, E.E.3
  • 130
    • 80053144167 scopus 로고    scopus 로고
    • A randomized phase II study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and T4N0-1 head and neck cancers
    • Salama J.K., Haraf D.J., Stenson K.M., et al. A randomized phase II study of 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy compared with bevacizumab plus 5-fluorouracil, hydroxyurea, and twice-daily radiotherapy for intermediate-stage and T4N0-1 head and neck cancers. Ann Oncol 2011, 22:2304-2309.
    • (2011) Ann Oncol , vol.22 , pp. 2304-2309
    • Salama, J.K.1    Haraf, D.J.2    Stenson, K.M.3
  • 131
    • 84866375175 scopus 로고    scopus 로고
    • Phase I trial of bevacizumab combined with concurrent chemoradiation for squamous cell carcinoma of the head and neck: preliminary outcome results
    • (abstract 5518)
    • Harari P.M., Khuntia D., Traynor A.M., et al. Phase I trial of bevacizumab combined with concurrent chemoradiation for squamous cell carcinoma of the head and neck: preliminary outcome results. J Clin Oncol 2011, 29:15s. (abstract 5518).
    • (2011) J Clin Oncol , vol.29
    • Harari, P.M.1    Khuntia, D.2    Traynor, A.M.3
  • 132
    • 84867334724 scopus 로고    scopus 로고
    • A phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer
    • Fury M.G., Lee N.Y., Sherman E., et al. A phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer. Cancer 2012, 118:5008-5014.
    • (2012) Cancer , vol.118 , pp. 5008-5014
    • Fury, M.G.1    Lee, N.Y.2    Sherman, E.3
  • 133
    • 84871554687 scopus 로고    scopus 로고
    • Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck
    • Argiris A., Kotsakis A.P., Hoang T., et al. Cetuximab and bevacizumab: preclinical data and phase II trial in recurrent or metastatic squamous cell carcinoma of the head and neck. Ann Oncol 2013, 24:220-225.
    • (2013) Ann Oncol , vol.24 , pp. 220-225
    • Argiris, A.1    Kotsakis, A.P.2    Hoang, T.3
  • 134
    • 68049094591 scopus 로고    scopus 로고
    • Antitumor activity of cediranib in patients with metastatic or recurrent head and neck cancer (HNC) or recurrent non-small cell lung cancer (NSCLC): an open-label exploratory study
    • (abst 6023)
    • Saura C., Baselga J., Herbst R., et al. Antitumor activity of cediranib in patients with metastatic or recurrent head and neck cancer (HNC) or recurrent non-small cell lung cancer (NSCLC): an open-label exploratory study. J Clin Oncol 2009, 27:15S. (abst 6023).
    • (2009) J Clin Oncol , vol.27
    • Saura, C.1    Baselga, J.2    Herbst, R.3
  • 135
    • 73949143686 scopus 로고    scopus 로고
    • Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01
    • Machiels J.P., Henry S., Zanetta S., et al. Phase II study of sunitinib in recurrent or metastatic squamous cell carcinoma of the head and neck: GORTEC 2006-01. J Clin Oncol 2010, 28:21-28.
    • (2010) J Clin Oncol , vol.28 , pp. 21-28
    • Machiels, J.P.1    Henry, S.2    Zanetta, S.3
  • 136
    • 75749105462 scopus 로고    scopus 로고
    • A phase II study of sunitinib in patients with recurrent and/or metastatic non-nasopharyngeal head and neck cancer
    • Fountzilas G., Fragkoulidi A., Kalogera-Fountzila A., et al. A phase II study of sunitinib in patients with recurrent and/or metastatic non-nasopharyngeal head and neck cancer. Cancer Chemother Pharmacol 2010, 65:649-660.
    • (2010) Cancer Chemother Pharmacol , vol.65 , pp. 649-660
    • Fountzilas, G.1    Fragkoulidi, A.2    Kalogera-Fountzila, A.3
  • 137
    • 77956056104 scopus 로고    scopus 로고
    • Phase II study of sunitinib malate in head and neck squamous cell carcinoma
    • Choong N.W., Kozloff M., Taber D., et al. Phase II study of sunitinib malate in head and neck squamous cell carcinoma. Invest New Drugs 2010, 28:677-683.
    • (2010) Invest New Drugs , vol.28 , pp. 677-683
    • Choong, N.W.1    Kozloff, M.2    Taber, D.3
  • 138
    • 77954754601 scopus 로고    scopus 로고
    • Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: southwest oncology group study S0420
    • Williamson S.K., Moon J., Huang C.H., et al. Phase II evaluation of sorafenib in advanced and metastatic squamous cell carcinoma of the head and neck: southwest oncology group study S0420. J Clin Oncol 2010, 28:3330-3335.
    • (2010) J Clin Oncol , vol.28 , pp. 3330-3335
    • Williamson, S.K.1    Moon, J.2    Huang, C.H.3
  • 139
    • 84877135784 scopus 로고    scopus 로고
    • Final results of a phase II study of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic or recurrent squamous cell cancer of the head and neck (SCCHN)
    • (abst 5592)
    • Blumenschein G.R., Glisson B.S., Lu C., et al. Final results of a phase II study of sorafenib in combination with carboplatin and paclitaxel in patients with metastatic or recurrent squamous cell cancer of the head and neck (SCCHN). Journal of Clinical Oncology 2012, 30:15S. (abst 5592).
    • (2012) Journal of Clinical Oncology , vol.30
    • Blumenschein, G.R.1    Glisson, B.S.2    Lu, C.3
  • 140
    • 79953314675 scopus 로고    scopus 로고
    • Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro
    • Sano D., Matsumoto F., Valdecanas D.R., et al. Vandetanib restores head and neck squamous cell carcinoma cells' sensitivity to cisplatin and radiation in vivo and in vitro. Clin Cancer Res 2011, 17:1815-1827.
    • (2011) Clin Cancer Res , vol.17 , pp. 1815-1827
    • Sano, D.1    Matsumoto, F.2    Valdecanas, D.R.3
  • 141
    • 33947732141 scopus 로고    scopus 로고
    • Antitumor effects of ZD6474 on head and neck squamous cell carcinoma
    • Sano D., Kawakami M., Fujita K., et al. Antitumor effects of ZD6474 on head and neck squamous cell carcinoma. Oncol Rep 2007, 17:289-295.
    • (2007) Oncol Rep , vol.17 , pp. 289-295
    • Sano, D.1    Kawakami, M.2    Fujita, K.3
  • 142
    • 34548820978 scopus 로고    scopus 로고
    • Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative
    • Molinolo A.A., Hewitt S.M., Amornphimoltham P., et al. Dissecting the Akt/mammalian target of rapamycin signaling network: emerging results from the head and neck cancer tissue array initiative. Clin Cancer Res 2007, 13:4964-4973.
    • (2007) Clin Cancer Res , vol.13 , pp. 4964-4973
    • Molinolo, A.A.1    Hewitt, S.M.2    Amornphimoltham, P.3
  • 143
    • 0036304685 scopus 로고    scopus 로고
    • Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction
    • Gupta A.K., McKenna W.G., Weber C.N., et al. Local recurrence in head and neck cancer: relationship to radiation resistance and signal transduction. Clin Cancer Res 2002, 8:885-892.
    • (2002) Clin Cancer Res , vol.8 , pp. 885-892
    • Gupta, A.K.1    McKenna, W.G.2    Weber, C.N.3
  • 144
    • 79952690921 scopus 로고    scopus 로고
    • PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors
    • Janku F., Tsimberidou A.M., Garrido-Laguna I., et al. PIK3CA mutations in patients with advanced cancers treated with PI3K/AKT/mTOR axis inhibitors. Mol Cancer Ther 2011, 10:558-565.
    • (2011) Mol Cancer Ther , vol.10 , pp. 558-565
    • Janku, F.1    Tsimberidou, A.M.2    Garrido-Laguna, I.3
  • 145
    • 79955758721 scopus 로고    scopus 로고
    • Et al Phosphatase and tensin homologue (PTEN) loss and response to phase I trials targeting PI3K/AKT/mTOR pathway in patients with advanced cancer
    • (e13018)
    • Garrido-Laguna I., Janku F., Tsimberidou A. Et al Phosphatase and tensin homologue (PTEN) loss and response to phase I trials targeting PI3K/AKT/mTOR pathway in patients with advanced cancer. J Clin Oncol 2010, 28:15S. (e13018).
    • (2010) J Clin Oncol , vol.28
    • Garrido-Laguna, I.1    Janku, F.2    Tsimberidou, A.3
  • 146
    • 33751184394 scopus 로고    scopus 로고
    • A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer
    • Argiris A., Cohen E., Karrison T., et al. A phase II trial of perifosine, an oral alkylphospholipid, in recurrent or metastatic head and neck cancer. Cancer Biol Ther 2006, 5:766-770.
    • (2006) Cancer Biol Ther , vol.5 , pp. 766-770
    • Argiris, A.1    Cohen, E.2    Karrison, T.3
  • 147
    • 84869152615 scopus 로고    scopus 로고
    • Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models
    • Cassell A., Freilino M.L., Lee J., et al. Targeting TORC1/2 enhances sensitivity to EGFR inhibitors in head and neck cancer preclinical models. Neoplasia 2012, 14:1005-1014.
    • (2012) Neoplasia , vol.14 , pp. 1005-1014
    • Cassell, A.1    Freilino, M.L.2    Lee, J.3
  • 148
    • 79956198835 scopus 로고    scopus 로고
    • The mTOR-targeting drug temsirolimus enhances the growth-inhibiting effects of the cetuximab-bevacizumab-irradiation combination on head and neck cancer xenografts
    • Bozec A., Etienne-Grimaldi M.C., Fischel J.L., et al. The mTOR-targeting drug temsirolimus enhances the growth-inhibiting effects of the cetuximab-bevacizumab-irradiation combination on head and neck cancer xenografts. Oral Oncol 2011, 47:340-344.
    • (2011) Oral Oncol , vol.47 , pp. 340-344
    • Bozec, A.1    Etienne-Grimaldi, M.C.2    Fischel, J.L.3
  • 149
    • 43749116022 scopus 로고    scopus 로고
    • Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines
    • Aissat N., Le Tourneau C., Ghoul A., et al. Antiproliferative effects of rapamycin as a single agent and in combination with carboplatin and paclitaxel in head and neck cancer cell lines. Cancer Chemother Pharmacol 2008, 62(2):305-313.
    • (2008) Cancer Chemother Pharmacol , vol.62 , Issue.2 , pp. 305-313
    • Aissat, N.1    Le Tourneau, C.2    Ghoul, A.3
  • 150
    • 84944270674 scopus 로고    scopus 로고
    • Phase II study of temsirolimus and erlotinib in patients (pts) with recurrent/metastatic (R/M), platinum-refractory head and neck squamous cell carcinoma (HNSCC)
    • (abstr 5549)
    • Bauman J.E., Arias-Pulido H., Lee S.-J., et al. Phase II study of temsirolimus and erlotinib in patients (pts) with recurrent/metastatic (R/M), platinum-refractory head and neck squamous cell carcinoma (HNSCC). J Clin Oncol 2012, 30:15s. (abstr 5549).
    • (2012) J Clin Oncol , vol.30
    • Bauman, J.E.1    Arias-Pulido, H.2    Lee, S.-J.3
  • 151
    • 84892864943 scopus 로고    scopus 로고
    • CAPRA: Safety, efficacy, and translational biomarkers of weekly everolimus, carboplatin, and paclitaxel as induction therapy for locally advanced head and neck squamous cell carcinoma (HNSCC)
    • (abstr 6036)
    • Raymond E., LeTourneau C., Gatineau M., et al. CAPRA: Safety, efficacy, and translational biomarkers of weekly everolimus, carboplatin, and paclitaxel as induction therapy for locally advanced head and neck squamous cell carcinoma (HNSCC). J Clin Oncol 2013, 31. (abstr 6036).
    • (2013) J Clin Oncol , vol.31
    • Raymond, E.1    LeTourneau, C.2    Gatineau, M.3
  • 152
    • 79960347232 scopus 로고    scopus 로고
    • Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma
    • Bonner J.A., Yang E.S., Trummell H.Q., et al. Inhibition of STAT-3 results in greater cetuximab sensitivity in head and neck squamous cell carcinoma. Radiother Oncol 2011, 99:339-343.
    • (2011) Radiother Oncol , vol.99 , pp. 339-343
    • Bonner, J.A.1    Yang, E.S.2    Trummell, H.Q.3
  • 153
    • 84866431328 scopus 로고    scopus 로고
    • Targeting Stat3 abrogates EGFR inhibitor resistance in cancer
    • Sen M., Joyce S., Panahandeh M., et al. Targeting Stat3 abrogates EGFR inhibitor resistance in cancer. Clin Cancer Res 2012, 18:4986-4996.
    • (2012) Clin Cancer Res , vol.18 , pp. 4986-4996
    • Sen, M.1    Joyce, S.2    Panahandeh, M.3
  • 154
    • 84871300677 scopus 로고    scopus 로고
    • Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways
    • Raju U., Riesterer O., Wang Z.Q., et al. Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways. Radiother Oncol 2012, 105:241-249.
    • (2012) Radiother Oncol , vol.105 , pp. 241-249
    • Raju, U.1    Riesterer, O.2    Wang, Z.Q.3
  • 155
    • 79955487784 scopus 로고    scopus 로고
    • Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma
    • Brooks H.D., Glisson B.S., Bekele B.N., et al. Phase 2 study of dasatinib in the treatment of head and neck squamous cell carcinoma. Cancer 2011, 117:2112-2119.
    • (2011) Cancer , vol.117 , pp. 2112-2119
    • Brooks, H.D.1    Glisson, B.S.2    Bekele, B.N.3
  • 156
    • 79851495693 scopus 로고    scopus 로고
    • Phase II study of saracatinib (AZD0530) for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC)
    • Fury M.G., Baxi S., Shen R., et al. Phase II study of saracatinib (AZD0530) for patients with recurrent or metastatic head and neck squamous cell carcinoma (HNSCC). Anticancer Res 2011, 31:249-253.
    • (2011) Anticancer Res , vol.31 , pp. 249-253
    • Fury, M.G.1    Baxi, S.2    Shen, R.3
  • 157
    • 84865649644 scopus 로고    scopus 로고
    • Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells
    • Lin Y.C., Wu M.H., Wei T.T., et al. Degradation of epidermal growth factor receptor mediates dasatinib-induced apoptosis in head and neck squamous cell carcinoma cells. Neoplasia 2012, 14:463-475.
    • (2012) Neoplasia , vol.14 , pp. 463-475
    • Lin, Y.C.1    Wu, M.H.2    Wei, T.T.3
  • 158
    • 2642551603 scopus 로고    scopus 로고
    • Development of the proteasome inhibitor Velcade (bortezomib)
    • Adams J., Kauffman M. Development of the proteasome inhibitor Velcade (bortezomib). Cancer Invest 2004, 22:304-311.
    • (2004) Cancer Invest , vol.22 , pp. 304-311
    • Adams, J.1    Kauffman, M.2
  • 159
    • 0034902354 scopus 로고    scopus 로고
    • Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma
    • Sunwoo J.B., Chen Z., Dong G., et al. Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res 2001, 7:1419-1428.
    • (2001) Clin Cancer Res , vol.7 , pp. 1419-1428
    • Sunwoo, J.B.1    Chen, Z.2    Dong, G.3
  • 160
    • 77951964186 scopus 로고    scopus 로고
    • Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma
    • Chung C.H., Aulino J., Muldowney N.J., et al. Nuclear factor-kappa B pathway and response in a phase II trial of bortezomib and docetaxel in patients with recurrent and/or metastatic head and neck squamous cell carcinoma. Ann Oncol 2010, 21:864-870.
    • (2010) Ann Oncol , vol.21 , pp. 864-870
    • Chung, C.H.1    Aulino, J.2    Muldowney, N.J.3
  • 161
    • 80052428483 scopus 로고    scopus 로고
    • Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer
    • Argiris A., Duffy A.G., Kummar S., et al. Early tumor progression associated with enhanced EGFR signaling with bortezomib, cetuximab, and radiotherapy for head and neck cancer. Clin Cancer Res 2011, 17:5755-5764.
    • (2011) Clin Cancer Res , vol.17 , pp. 5755-5764
    • Argiris, A.1    Duffy, A.G.2    Kummar, S.3
  • 162
    • 84892880191 scopus 로고    scopus 로고
    • Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoma of the head and neck (E1304): a trial of the eastern cooperative oncology group
    • Gilbert J., Lee J.W., Argiris A., et al. Phase II 2-arm trial of the proteasome inhibitor, PS-341 (bortezomib) in combination with irinotecan or PS-341 alone followed by the addition of irinotecan at time of progression in patients with locally recurrent or metastatic squamous cell carcinoma of the head and neck (E1304): a trial of the eastern cooperative oncology group. Head Neck 2012, 13.
    • (2012) Head Neck , vol.13
    • Gilbert, J.1    Lee, J.W.2    Argiris, A.3
  • 163
    • 0031861993 scopus 로고    scopus 로고
    • Impaired regulation of nuclear factor-kappaB results in apoptosis induced by gamma radiation
    • Jung M., Zhang Y., Dimtchev A., Dritschilo A. Impaired regulation of nuclear factor-kappaB results in apoptosis induced by gamma radiation. Radiat Res 1998, 149:596-601.
    • (1998) Radiat Res , vol.149 , pp. 596-601
    • Jung, M.1    Zhang, Y.2    Dimtchev, A.3    Dritschilo, A.4
  • 164
    • 34447315913 scopus 로고    scopus 로고
    • Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid
    • Rikiishi H., Shinohara F., Sato T., Sato Y., Suzuki M., Echigo S. Chemosensitization of oral squamous cell carcinoma cells to cisplatin by histone deacetylase inhibitor, suberoylanilide hydroxamic acid. Int J Oncol 2007, 30:1181-1188.
    • (2007) Int J Oncol , vol.30 , pp. 1181-1188
    • Rikiishi, H.1    Shinohara, F.2    Sato, T.3    Sato, Y.4    Suzuki, M.5    Echigo, S.6
  • 165
    • 84869497592 scopus 로고    scopus 로고
    • Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer
    • Haigentz M., Kim M., Sarta C., et al. Phase II trial of the histone deacetylase inhibitor romidepsin in patients with recurrent/metastatic head and neck cancer. Oral Oncol 2012, 48:1281-1288.
    • (2012) Oral Oncol , vol.48 , pp. 1281-1288
    • Haigentz, M.1    Kim, M.2    Sarta, C.3
  • 166
    • 79956150123 scopus 로고    scopus 로고
    • Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma
    • Okui T., Shimo T., Hassan N.M., et al. Antitumor effect of novel HSP90 inhibitor NVP-AUY922 against oral squamous cell carcinoma. Anticancer Res 2011, 31:1197-1204.
    • (2011) Anticancer Res , vol.31 , pp. 1197-1204
    • Okui, T.1    Shimo, T.2    Hassan, N.M.3
  • 167
    • 84859857989 scopus 로고    scopus 로고
    • The HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damage
    • Zaidi S., McLaughlin M., Bhide S.A., et al. The HSP90 inhibitor NVP-AUY922 radiosensitizes by abrogation of homologous recombination resulting in mitotic entry with unresolved DNA damage. PLoS One 2012, 7:e35436.
    • (2012) PLoS One , vol.7
    • Zaidi, S.1    McLaughlin, M.2    Bhide, S.A.3
  • 168
    • 84865263433 scopus 로고    scopus 로고
    • Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors
    • Ahsan A., Ramanand S.G., Whitehead C., et al. Wild-type EGFR is stabilized by direct interaction with HSP90 in cancer cells and tumors. Neoplasia 2012, 14:670-677.
    • (2012) Neoplasia , vol.14 , pp. 670-677
    • Ahsan, A.1    Ramanand, S.G.2    Whitehead, C.3
  • 169
    • 84856101707 scopus 로고    scopus 로고
    • Fine-tuning of the intracellular canonical notch signaling pathway
    • Borggrefe T., Liefke R. Fine-tuning of the intracellular canonical notch signaling pathway. Cell Cycle 2012, 11(2):264-276.
    • (2012) Cell Cycle , vol.11 , Issue.2 , pp. 264-276
    • Borggrefe, T.1    Liefke, R.2
  • 170
    • 78049473992 scopus 로고    scopus 로고
    • Association of high levels of jagged-1 and notch-1 expression with poor prognosis in head and neck cancer
    • Lin J.T., Chen M.K., Yeh K.T., et al. Association of high levels of jagged-1 and notch-1 expression with poor prognosis in head and neck cancer. Ann Surg Oncol 2010, 17:2976-2983.
    • (2010) Ann Surg Oncol , vol.17 , pp. 2976-2983
    • Lin, J.T.1    Chen, M.K.2    Yeh, K.T.3
  • 171
    • 77349109465 scopus 로고    scopus 로고
    • Expression of stat3 and notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma
    • Gu F., Ma Y., Zhang Z., et al. Expression of stat3 and notch1 is associated with cisplatin resistance in head and neck squamous cell carcinoma. Oncol Rep 2010, 23:671-676.
    • (2010) Oncol Rep , vol.23 , pp. 671-676
    • Gu, F.1    Ma, Y.2    Zhang, Z.3
  • 172
    • 77749333021 scopus 로고    scopus 로고
    • Upregulation of notch pathway molecules in oral squamous cell carcinoma
    • Hijioka H., Setoguchi T., Miyawaki A., et al. Upregulation of notch pathway molecules in oral squamous cell carcinoma. Int J Oncol 2010, 36:817-822.
    • (2010) Int J Oncol , vol.36 , pp. 817-822
    • Hijioka, H.1    Setoguchi, T.2    Miyawaki, A.3
  • 173
    • 84892852952 scopus 로고    scopus 로고
    • The importance of window opportunity studies
    • Machiels J.P., Schmitz S. The importance of window opportunity studies. Ann Oncol 2012, 23(Suppl. 9):ix42-ix43.
    • (2012) Ann Oncol , vol.23 , Issue.SUPPL. 9
    • Machiels, J.P.1    Schmitz, S.2
  • 174
    • 33645098237 scopus 로고    scopus 로고
    • Changes from 1992 to 2002 in the pretreatment delay for patients with squamous cell carcinoma of larynx or pharynx: a Danish nationwide survey from DAHANCA
    • Primdahl H., Nielsen A.L., Larsen S., et al. Changes from 1992 to 2002 in the pretreatment delay for patients with squamous cell carcinoma of larynx or pharynx: a Danish nationwide survey from DAHANCA. Acta Oncol 2006, 45:156-161.
    • (2006) Acta Oncol , vol.45 , pp. 156-161
    • Primdahl, H.1    Nielsen, A.L.2    Larsen, S.3
  • 175
    • 19244386786 scopus 로고    scopus 로고
    • The role of professional diagnostic delays in the prognosis of upper aerodigestive tract carcinoma
    • Allison P., Franco E., Black M., Feine J. The role of professional diagnostic delays in the prognosis of upper aerodigestive tract carcinoma. Oral Oncol 1998, 34:147-153.
    • (1998) Oral Oncol , vol.34 , pp. 147-153
    • Allison, P.1    Franco, E.2    Black, M.3    Feine, J.4
  • 176
    • 34447105686 scopus 로고    scopus 로고
    • Tumor progression in waiting time for radiotherapy in head and neck cancer
    • Jensen A.R., Nellemann H.M., Overgaard J. Tumor progression in waiting time for radiotherapy in head and neck cancer. Radiother Oncol 2007, 84:5-10.
    • (2007) Radiother Oncol , vol.84 , pp. 5-10
    • Jensen, A.R.1    Nellemann, H.M.2    Overgaard, J.3
  • 177
    • 37249081478 scopus 로고    scopus 로고
    • Pilot study of neoadjuvant treatment with erlotinib in nonmetastatic head and neck squamous cell carcinoma
    • Thomas F., Rochaix P., Benlyazid A., et al. Pilot study of neoadjuvant treatment with erlotinib in nonmetastatic head and neck squamous cell carcinoma. Clin Cancer Res 2007, 13:7086-7092.
    • (2007) Clin Cancer Res , vol.13 , pp. 7086-7092
    • Thomas, F.1    Rochaix, P.2    Benlyazid, A.3
  • 178
    • 84878018022 scopus 로고    scopus 로고
    • Gene expression profiling on pre- and post-erlotinib tumors from patients with head and neck squamous cell carcinoma
    • Thomas F., Delmar P., Vergez S., et al. Gene expression profiling on pre- and post-erlotinib tumors from patients with head and neck squamous cell carcinoma. Head Neck 2013, 35:809-818.
    • (2013) Head Neck , vol.35 , pp. 809-818
    • Thomas, F.1    Delmar, P.2    Vergez, S.3
  • 179
    • 84883367731 scopus 로고    scopus 로고
    • Tumour response and safety of cetuximab in a window pre-operative study in patients with squamous cell carcinoma of the head and neck
    • Schmitz S., Hamoir M., Reychler H., et al. Tumour response and safety of cetuximab in a window pre-operative study in patients with squamous cell carcinoma of the head and neck. Ann Oncol 2013, 24(9):2261-2266.
    • (2013) Ann Oncol , vol.24 , Issue.9 , pp. 2261-2266
    • Schmitz, S.1    Hamoir, M.2    Reychler, H.3
  • 180
    • 84892859062 scopus 로고    scopus 로고
    • Surgical immunotherapy. Ferris RL, oral communication at ASCO meeting Chicago.
    • Ferris, R. Surgical immunotherapy. Ferris RL, oral communication at ASCO meeting 2012, Chicago.
    • (2012)
    • Ferris, R.1
  • 181
    • 84855490786 scopus 로고    scopus 로고
    • Era of personalized medicine may herald end of soaring cancer costs
    • Keogh B. Era of personalized medicine may herald end of soaring cancer costs. J Natl Cancer Inst 2012, 104:12-17.
    • (2012) J Natl Cancer Inst , vol.104 , pp. 12-17
    • Keogh, B.1
  • 182
    • 61649124065 scopus 로고    scopus 로고
    • Biotherapy development association. market and patient access to new oncology products in Europe: a current, multidisciplinary perspective
    • McCabe C., Bergmann L., Bosanquet N., et al. Biotherapy development association. market and patient access to new oncology products in Europe: a current, multidisciplinary perspective. Ann Oncol 2009, 20:403-412.
    • (2009) Ann Oncol , vol.20 , pp. 403-412
    • McCabe, C.1    Bergmann, L.2    Bosanquet, N.3
  • 183
    • 84858297956 scopus 로고    scopus 로고
    • The cost-effectiveness of screening lung cancer patients for targeted drug sensitivity markers
    • Atherly A.J., Camidge D.R. The cost-effectiveness of screening lung cancer patients for targeted drug sensitivity markers. Br J Cancer 2012, 106:1100-1106.
    • (2012) Br J Cancer , vol.106 , pp. 1100-1106
    • Atherly, A.J.1    Camidge, D.R.2
  • 184
    • 79961006282 scopus 로고    scopus 로고
    • The national institute for health and clinical excellence and its role in assessing the value of new cancer treatments in England and Wales
    • Trowman R., Chung H., Longson C., Littlejohns P., Clark P. The national institute for health and clinical excellence and its role in assessing the value of new cancer treatments in England and Wales. Clin Cancer Res 2011, 17:4930-4935.
    • (2011) Clin Cancer Res , vol.17 , pp. 4930-4935
    • Trowman, R.1    Chung, H.2    Longson, C.3    Littlejohns, P.4    Clark, P.5
  • 185
    • 48149086257 scopus 로고    scopus 로고
    • Economic evaluations of medical care interventions for cancer patients: how, why, and what does it mean?
    • Shih Y.-C.T., Halpern M.T. Economic evaluations of medical care interventions for cancer patients: how, why, and what does it mean?. CA Cancer J Clin 2008, 58:231-244.
    • (2008) CA Cancer J Clin , vol.58 , pp. 231-244
    • Shih, Y.-C.T.1    Halpern, M.T.2
  • 186
    • 84861757517 scopus 로고    scopus 로고
    • Financial relationships in economic analyses of targeted therapies in oncology
    • Valachis A., Polyzos N.P., Nearchou A., Lind P., Mauri D. Financial relationships in economic analyses of targeted therapies in oncology. J Clin Oncol 2012, 30:1316-1320.
    • (2012) J Clin Oncol , vol.30 , pp. 1316-1320
    • Valachis, A.1    Polyzos, N.P.2    Nearchou, A.3    Lind, P.4    Mauri, D.5


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