Epidermal growth factor receptor expression in pretreatment biopsies from head and neck squamous cell carcinoma as a predictive factor for a benefit from accelerated radiation therapy in a randomized controlled trial

Journal of Clinical Oncology

Volumn 23, Issue 24, 2005, Pages 5560-5567

  Bentzen, Søren M ^a   Atasoy, Beste M ^a   Daley, Frances M ^a   Dische, Stanley ^a   Richman, Paul I ^a   Saunders, Michele I ^a   Trott, Klaus R ^a   Wilson, George D ^a  

^a Mount Vernon Hospital USA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYCLIN D1; EPIDERMAL GROWTH FACTOR RECEPTOR; MONOCLONAL ANTIBODY KI 67; PROTEIN BCL 2; PROTEIN P53; TUMOR MARKER;

ARTICLE; CANCER RADIOTHERAPY; CELL PROLIFERATION; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; HEAD AND NECK CARCINOMA; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SQUAMOUS CELL CARCINOMA; TUMOR BIOPSY; ADULT; AGED; BIOPSY; ENZYME IMMUNOASSAY; FEMALE; HEAD AND NECK TUMOR; MALE; METABOLISM; METASTASIS; MIDDLE AGED; NONPARAMETRIC TEST; PHASE 3 CLINICAL TRIAL; PROPORTIONAL HAZARDS MODEL; RADIATION DOSE FRACTIONATION; TREATMENT OUTCOME;

ADULT; AGED; AGED, 80 AND OVER; BIOPSY; CARCINOMA, SQUAMOUS CELL; DOSE FRACTIONATION; FEMALE; HEAD AND NECK NEOPLASMS; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MIDDLE AGED; NEOPLASM METASTASIS; PROPORTIONAL HAZARDS MODELS; RECEPTOR, EPIDERMAL GROWTH FACTOR; STATISTICS, NONPARAMETRIC; TREATMENT OUTCOME; TUMOR MARKERS, BIOLOGICAL;

EID: 24944479590     PISSN: 0732183X     EISSN: None     Source Type: Journal    
DOI: 10.1200/JCO.2005.06.411     Document Type: Article

References (37)

1. Withers HR, Taylor JMG, Maciejewski B: The hazard of accelerated tumor clonogen repopulation during radiotherapy. Acta Oncol 27: 131-146, 1988
2. Trott KR: Perspectives of experimental research on repopulation during radiotherapy. Int J Radiat Biol 79:577-580, 2003
3. Bentzen SM: Time-dose relationships for human tumors: Estimation from non-randomized studies, in Beck-Bornholt HP (ed): Current Topics in Clinical Radiobiology of Tumours: Medical Radiology. Berlin, Springer-Verlag, 1993, pp 11-26
4. Maciejewski B, Preuss-Bayer G, Trott KR: The influence of the number of fractions and of overall treatment time on local control and late complication rate in squamous cell carcinoma of the larynx. Int J Radiat Oncol Biol Phys 9:321-328, 1983
5. Bentzen SM: Repopulation in radiation oncology: Perspectives of clinical research. Int J Radiat Biol 79:581-585, 2003
6. Overgaard J, Hansen HS, Specht L, et al: Five compared with six fractions per week of conventional radiotherapy of squamous-cell carcinoma of head and neck: DAHANCA 6 and 7 randomised controlled trial. Lancet 362:933-940, 2003
7. [Erratum: Lancet 362:1588, 2003]
8. Bernier J, Bentzen SM: Altered fractionation and combined radio-chemotherapy approaches: Pioneering new opportunities in head and neck oncology. Eur J Cancer 39:560-571, 2003
9. Saunders MI, Dische S, Barrett A, et al: Continuous hyperfractionated accelerated radiotherapy (CHART) versus conventional radiotherapy in non-small-cell lung cancer: A randomised multicentre trial-CHART Steering Committee. Lancet 350:161-165, 1997
10. El Naggar AK, Kim HW, Clayman GL, et al: Differential expression profiling of head and neck squamous carcinoma: Significance in their phenotypic and biological classification. Oncogene 21:8206-8219, 2002
11. Belbin TJ, Singh B, Barber I, et al: Molecular classification of head and neck squamous cell carcinoma using cDNA microarrays. Cancer Res 62:1184-1190, 2002
12. Chung CH, Parker JS, Karaca G, et al: Molecular classification of head and neck squamous cell carcinomas using patterns of gene expression. Cancer Cell 5:489-500, 2004
13. Buffa FM, Bentzen SM, Daley FM, et al: Molecular marker profiles predict locoregional control of head and neck squamous cell carcinoma in a randomized trial of continuous hyperfractionated accelerated radiotherapy. Clin Cancer Res 10:3745-3754, 2004
14. Carpenter G, King L Jr, Cohen S: Epidermal growth factor stimulates phosphorylation in membrane preparations in vitro. Nature 276:409-410, 1978
15. Yarden Y, Sliwkowski MX: Untangling the ErbB signalling network. Nat Rev Mol Cell Biol 2:127-137, 2001
16. Schmidt-Ullrich RK, Contessa JN, Lammering G, et al: ERBB receptor tyrosine kinases and cellular radiation responses. Oncogene 22:5855-5865, 2003
17. Harari PM, Huang SM: Head and neck cancer as a clinical model for molecular targeting of therapy: Combining EGFR blockade with radiation. Int J Radiat Oncol Biol Phys 49:427-433, 2001
18. Huang SM, Li J, Armstrong EA, et al: Modulation of radiation response and tumor-induced angiogenesis after epidermal growth factor receptor inhibition by ZD1839 (Iressa). Cancer Res 62:4300-4306, 2002
19. Salomon DS, Brandt R, Ciardiello F, et al: Epidermal growth factor-related peptides and their receptors in human malignancies. Crit Rev Oncol Hematol 19:183-232, 1995
20. Herbst RS, Shin DM: Monoclonal antibodies to target epidermal growth factor receptor-positive tumors: A new paradigm for cancer therapy. Cancer 94:1593-1611, 2002
21. Mendelsohn J, Baselga J: Status of epidermal growth factor receptor antagonists in the biology and treatment of cancer. J Clin Oncol 21:2787-2799, 2003
22. Dische S, Saunders MI, Barrett A, et al: A randomised multicentre trial of CHART versus conventional radiotherapy in head and neck cancer. Radiother Oncol 44:123-136, 1997
23. Ataman OU, Bentzen SM, Wilson GD, et al: Molecular biomarkers and site of first recurrence after radiotherapy for head and neck cancer. Eur J Cancer 40:2734-2741, 2004
24. Bennett MH, Wilson GD, Dische S, et al: Tumour proliferation assessed by combined histological and flow cytometric analysis: Implications for therapy in squamous cell carcinoma in the head and neck. Br J Cancer 65:870-878, 1992
25. Wilson GD, Saunders Ml, Dische S, et al: Bcl-2 expression in head and neck cancer: An enigmatic prognostic marker. Int J Radiat Oncol Biol Phys 49:435-441, 2001
26. Kaplan EL, Meier P: Non-parametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958
27. Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50:163-170, 1966
28. Cox DR: Regression models and life-tables (with discussion). J R Stat Soc B 34:178-220, 1972
29. Work E, Nielsen OS, Bentzen SM, et al: Randomized study of initial versus late chest irradiation combined with chemotherapy in limited-stage small-cell lung cancer. Aarhus Lung Cancer Group. J Clin Oncol 15:3030-3037, 1997
30. Hanahan D, Weinberg RA: The hallmarks of cancer. Cell 100:57-70, 2000
31. Bentzen SM, Saunders MI, Dische S, et al: Radiotherapy-related early morbidity in head and neck cancer: Quantitative clinical radiobiology as deduced from the CHART trial. Radiother Oncol 60:123-135, 2001
32. Bentzen SM, Baumann M: The linear-quadratic model in clinical practice, in GG Steel (ed): Basic Clinical Radiobiology. London, United Kingdom, Arnold, 2002, pp 134-146
33. Ang KK, Berkey BA, Tu X, et al: Impact of epidermal growth factor receptor expression on survival and pattern of relapse in patients with advanced head and neck carcinoma. Cancer Res 62:7350-7356, 2002
34. Eriksen JG, Steiniche T, Askaa J, et al: The prognostic value of epidermal growth factor receptor is related to tumor differentiation and the overall treatment time of radiotherapy in squamous cell carcinomas of the head and neck. Int J Radiat Oncol Biol Phys 58:561-566, 2004
35. Chua DT, Nicholls JM, Sham JS, et al: Prognostic value of epidermal growth factor receptor expression in patients with advanced stage nasopharyngeal carcinoma treated with induction chemotherapy and radiotherapy. Int J Radiat Oncol Biol Phys 59:11-20, 2004
36. Fu KK, Pajak TF, Trotti A, et al: A Radiation Therapy Oncology Group (RTOG) phase III randomized study to compare hyperfractionation and two variants of accelerated fractionation to standard fractionation radiotherapy for head and neck squamous cell carcinomas: First report of RTOG 9003. Int J Radiat Oncol Biol Phys 48:7-16, 2000
37. Lukas J, Bartkova J, Bartek J: Convergence of mitogenic signalling cascades from diverse classes of receptors at the cyclin D-cyclin-dependent kinase-pRb-controlled G1 checkpoint. Mol Cell Biol 16:6917-6925, 1996