Investigation of process temperature and screw speed on properties of a pharmaceutical solid dispersion using corotating and counter-rotating twin-screw extruders

Journal of Pharmacy and Pharmacology

Volumn 66, Issue 2, 2014, Pages 204-217

  Keen, Justin M ^a,b   Martin, Charlie ^c   MacHado, Augie ^c   Sandhu, Harpreet ^d   McGinity, James W ^a   Dinunzio, James C ^d  

^a UNIVERSITY OF TEXAS AT AUSTIN   (United States)

^b DisperSol Technologies LLC   (United States)

^c American Leistritz Extruder Corp   (United States)

^d HOFFMANN LA ROCHE INC   (United States)

Author keywords

amorphous; dissolution; solid dispersion; thermal processing; twin screw melt extrusion

Indexed keywords

GRISEOFULVIN; POLYMER;

ANALYTIC METHOD; ARTICLE; DISPERSION; DRUG PURITY; DRUG SOLUBILITY; DRUG STABILITY; FLOW KINETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HOT MELT EXTRUSION; LOW TEMPERATURE; MELTING POINT; PELLET EXTRUSION; SOLID STATE; TEMPERATURE; THERMAL ANALYSIS; THERMAL EXPOSURE; THERMODYNAMICS; X RAY POWDER DIFFRACTION;

AMORPHOUS; DISSOLUTION; SOLID DISPERSION; THERMAL PROCESSING; TWIN-SCREW MELT EXTRUSION;

CHEMISTRY, PHARMACEUTICAL; DRUG CARRIERS; DRUG COMPOUNDING; DRUG STABILITY; FELODIPINE; FREEZING; HOT TEMPERATURE; HUMANS; MOLECULAR STRUCTURE; POLYMERS; SOLUBILITY; SOLUTIONS; TEMPERATURE; THERMODYNAMICS;

EID: 84892772878     PISSN: 00223573     EISSN: 20427158     Source Type: Journal    
DOI: 10.1111/jphp.12106     Document Type: Article

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