메뉴 건너뛰기




Volumn 8, Issue 12, 2013, Pages

Preventive effect of halofuginone on concanavalin A-induced liver fibrosis

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ALPHA SMOOTH MUSCLE ACTIN; ASPARTATE AMINOTRANSFERASE; COLLAGEN TYPE 1; CONCANAVALIN A; HALOFUGINONE; HYALURONIC ACID; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PROCOLLAGEN; PROCOLLAGEN TYPE 3; SMAD3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

EID: 84892761497     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082232     Document Type: Article
Times cited : (36)

References (51)
  • 1
    • 84878235678 scopus 로고    scopus 로고
    • Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury
    • Perepelyuk M, Terajima M, Wang AY, Georges PC, Janmey PA, et al. (2013) Hepatic stellate cells and portal fibroblasts are the major cellular sources of collagens and lysyl oxidases in normal liver and early after injury. Am J Physiol-gastr L 304: G605-G614
    • (2013) Am J Physiol-gastr L , vol.304
    • Perepelyuk, M.1    Terajima, M.2    Wang, A.Y.3    Georges, P.C.4    Janmey, P.A.5
  • 2
    • 0031018997 scopus 로고    scopus 로고
    • Tissue inhibitors of metalloproteinases in liver fibrosis
    • doi:10.1016/S1357-2725(96)00118-5. PubMed: 9076940
    • Iredale JP (1997) Tissue inhibitors of metalloproteinases in liver fibrosis. Int J Biochem Cell Biol 29: 43-54. doi:10.1016/S1357-2725(96)00118-5. PubMed: 9076940.
    • (1997) Int J Biochem Cell Biol , vol.29 , pp. 43-54
    • Iredale, J.P.1
  • 4
    • 38349048615 scopus 로고    scopus 로고
    • Activities of matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in idiopathic hemotympanum and otitis media with effusion
    • doi: 10.1080/00016480701477610. PubMed: 17851959
    • Moon SK, Linthicum FH Jr, Dong Yang H, Joo Lee S, Park K (2008) Activities of matrix metalloproteinases and tissue inhibitor of metalloproteinase-2 in idiopathic hemotympanum and otitis media with effusion. Acta Oto-Laryngol 128: 144-150. doi: 10.1080/00016480701477610. PubMed: 17851959.
    • (2008) Acta Oto-Laryngol , vol.128 , pp. 144-150
    • Moon, S.K.1    Linthicum Jr., F.H.2    Dong Yang, H.3    Joo Lee, S.4    Park, K.5
  • 5
    • 42949163491 scopus 로고    scopus 로고
    • Mechanisms of hepatic fibrogenesis
    • doi:10.1053/j.gastro.2008.03.003. PubMed: 18471545
    • Friedman SL (2008) Mechanisms of hepatic fibrogenesis. Gastroenterology 134: 1655-1669. doi:10.1053/j.gastro.2008.03.003. PubMed: 18471545.
    • (2008) Gastroenterology , vol.134 , pp. 1655-1669
    • Friedman, S.L.1
  • 6
    • 79960718862 scopus 로고    scopus 로고
    • Novel engineered targeted interferon?Gamma blocks hepatic fibrogenesis in mice
    • doi:10.1016/j.jhep.2010.09.012
    • Bansal R, Prakash J, Post E, Beljaars L, Schuppan D et al. (2011) Novel engineered targeted interferon?gamma blocks hepatic fibrogenesis in mice. Hepatol 54: 586-596. doi:10.1016/j.jhep.2010.09.012.
    • (2011) Hepatol , vol.54 , pp. 586-596
    • Bansal, R.1    Prakash, J.2    Post, E.3    Beljaars, L.4    Schuppan, D.5
  • 7
    • 84860564377 scopus 로고    scopus 로고
    • Natural killer cell recognition and killing of activated hepatic stellate cells
    • doi:10.1136/gutjnl-2011-301968. PubMed: 22466617
    • Clària J (2012) Natural killer cell recognition and killing of activated hepatic stellate cells. Gut 61: 792-793. doi:10.1136/gutjnl-2011- 301968. PubMed: 22466617.
    • (2012) Gut , vol.61 , pp. 792-793
    • Clària, J.1
  • 8
    • 73549111067 scopus 로고    scopus 로고
    • Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation
    • Venugopal SK, Jiang J, Kim T-H, Li Y, Wang S-S, et al. (2010) Liver fibrosis causes downregulation of miRNA-150 and miRNA-194 in hepatic stellate cells, and their overexpression causes decreased stellate cell activation. Am J Physiol-gastr L 298: G101-G106
    • (2010) Am J Physiol-gastr L , vol.298
    • Venugopal, S.K.1    Jiang, J.2    Kim, T.-H.3    Li, Y.4    Wang, S.-S.5
  • 9
    • 78649680029 scopus 로고    scopus 로고
    • Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats
    • doi:10.1038/labinvest.2010.123. PubMed: 20921949
    • Liu C, Tao Q, Sun M, Wu JZ, Yang W et al. (2010) Kupffer cells are associated with apoptosis, inflammation and fibrotic effects in hepatic fibrosis in rats. Lab Invest 90: 1805-1816. doi:10.1038/labinvest.2010.123. PubMed: 20921949.
    • (2010) Lab Invest , vol.90 , pp. 1805-1816
    • Liu, C.1    Tao, Q.2    Sun, M.3    Wu, J.Z.4    Yang, W.5
  • 10
    • 79960714053 scopus 로고    scopus 로고
    • Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis
    • doi:10.1002/hep.24427. PubMed: 21567441
    • Thabut D, Routray C, Lomberk G, Shergill U, Glaser K et al. (2011) Complementary vascular and matrix regulatory pathways underlie the beneficial mechanism of action of sorafenib in liver fibrosis. Hepatology 54: 573-585. doi:10.1002/hep.24427. PubMed: 21567441.
    • (2011) Hepatology , vol.54 , pp. 573-585
    • Thabut, D.1    Routray, C.2    Lomberk, G.3    Shergill, U.4    Glaser, K.5
  • 11
    • 77955686233 scopus 로고    scopus 로고
    • Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver
    • doi:10.1002/hep.23739
    • Jagavelu K, Routray C, Shergill U, O'Hara SP, Faubion W et al. (2010) Endothelial cell toll-like receptor 4 regulates fibrosis-associated angiogenesis in the liver. Hepatol 52: 590-601. doi:10.1002/hep.23739.
    • (2010) Hepatol , vol.52 , pp. 590-601
    • Jagavelu, K.1    Routray, C.2    Shergill, U.3    O'Hara, S.P.4    Faubion, W.5
  • 12
    • 0142104985 scopus 로고    scopus 로고
    • Smad-dependent and Smad-independent pathways in TGF-β family signalling
    • doi:10.1038/nature02006. PubMed: 14534577
    • Derynck R, Zhang YE (2003) Smad-dependent and Smad-independent pathways in TGF-β family signalling. Nature 425: 577-584. doi:10.1038/nature02006. PubMed: 14534577.
    • (2003) Nature , vol.425 , pp. 577-584
    • Derynck, R.1    Zhang, Y.E.2
  • 13
    • 84881590424 scopus 로고    scopus 로고
    • Low-Dose Paclitaxel Ameliorates Pulmonary Fibrosis by Suppressing TGF-β1/Smad3 Pathway via miR-140 Upregulation
    • doi: 10.1371/journal.pone.0070725. PubMed: 23967091
    • Wang C, Song X, Li Y, Han F, Gao S et al. (2013) Low-Dose Paclitaxel Ameliorates Pulmonary Fibrosis by Suppressing TGF-β1/Smad3 Pathway via miR-140 Upregulation. PLOS ONE 8: e70725. doi: 10.1371/journal.pone.0070725. PubMed: 23967091.
    • (2013) PLOS ONE , vol.8
    • Wang, C.1    Song, X.2    Li, Y.3    Han, F.4    Gao, S.5
  • 14
    • 14744291882 scopus 로고    scopus 로고
    • IL-1β and TNF-α upregulate angiotensin II type 1 (AT〈sub〉 1〈/sub〉) receptors on cardiac fibroblasts and are associated with increased AT〈 sub〉 1〈/sub〉 density in the post-MI heart
    • doi:10.1016/j.yjmcc.2004.12.015. PubMed: 15733910
    • Gurantz D, Cowling RT, Varki N, Frikovsky E, Moore CD et al. (2005) IL-1β and TNF-α upregulate angiotensin II type 1 (AT〈sub〉 1〈/sub〉) receptors on cardiac fibroblasts and are associated with increased AT〈 sub〉 1〈/sub〉 density in the post-MI heart. J Mol Cell Cardiol 38: 505-515. doi:10.1016/j.yjmcc.2004.12.015. PubMed: 15733910.
    • (2005) J Mol Cell Cardiol , vol.38 , pp. 505-515
    • Gurantz, D.1    Cowling, R.T.2    Varki, N.3    Frikovsky, E.4    Moore, C.D.5
  • 15
    • 0034705240 scopus 로고    scopus 로고
    • Interleukin-1β and tumor necrosis factor-α decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro
    • doi:10.1161/01.RES.86.12.1259
    • Siwik DA, Chang DL-F, Colucci WS (2000) Interleukin-1β and tumor necrosis factor-α decrease collagen synthesis and increase matrix metalloproteinase activity in cardiac fibroblasts in vitro. Cir Res 86: 1259-1265. doi:10.1161/01.RES.86.12.1259.
    • (2000) Cir Res , vol.86 , pp. 1259-1265
    • Siwik, D.A.1    Chang, D.L.-F.2    Colucci, W.S.3
  • 16
    • 0037184698 scopus 로고    scopus 로고
    • Complex cytokine regulation of tissue fibrosis
    • doi:10.1016/S0024-3205(02)02299-3. PubMed: 12467904
    • Atamas SP (2002) Complex cytokine regulation of tissue fibrosis. Life Sci 72: 631-643. doi:10.1016/S0024-3205(02)02299-3. PubMed: 12467904.
    • (2002) Life Sci , vol.72 , pp. 631-643
    • Atamas, S.P.1
  • 17
    • 0029975447 scopus 로고    scopus 로고
    • Effect of IL-6 on alveolar fibroblast proliferation in interstitial lung diseases
    • doi:10.1006/clin.1996.0075. PubMed: 8635282
    • Shahar I, Fireman E, Topilsky M, Grief J, Kivity S et al. (1996) Effect of IL-6 on alveolar fibroblast proliferation in interstitial lung diseases. Clin Immunol Immunopathol 79: 244-251. doi:10.1006/clin.1996.0075. PubMed: 8635282.
    • (1996) Clin Immunol Immunopathol , vol.79 , pp. 244-251
    • Shahar, I.1    Fireman, E.2    Topilsky, M.3    Grief, J.4    Kivity, S.5
  • 18
    • 38549159026 scopus 로고    scopus 로고
    • Cellular and molecular mechanisms of fibrosis
    • doi:10.1002/path.2277. PubMed: 18161745
    • Wynn TA (2008) Cellular and molecular mechanisms of fibrosis. J Pathol 214: 199-210. doi:10.1002/path.2277. PubMed: 18161745.
    • (2008) J Pathol , vol.214 , pp. 199-210
    • Wynn, T.A.1
  • 19
    • 79651473582 scopus 로고    scopus 로고
    • NF-κB in immunobiology
    • doi:10.1038/cr.2011.13. PubMed: 21243012
    • Hayden MS, Ghosh S (2011) NF-κB in immunobiology. Cell Res 21: 223-244. doi:10.1038/cr.2011.13. PubMed: 21243012.
    • (2011) Cell Res , vol.21 , pp. 223-244
    • Hayden, M.S.1    Ghosh, S.2
  • 20
    • 84868221981 scopus 로고    scopus 로고
    • Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKaγ ubiquitination
    • PubMed: 23102662
    • Ren Z, Cui J, Huo Z, Xue J, Cui H et al. (2012) Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKaγ ubiquitination. Int Immunopharmacol, 14: 698-703. PubMed: 23102662.
    • (2012) Int Immunopharmacol , vol.14 , pp. 698-703
    • Ren, Z.1    Cui, J.2    Huo, Z.3    Xue, J.4    Cui, H.5
  • 21
    • 54249125424 scopus 로고    scopus 로고
    • NF-êB signaling, liver disease and hepatoprotective agents
    • doi:10.1038/onc. 2008.300. PubMed: 18931690
    • Sun B, Karin M (2008) NF-êB signaling, liver disease and hepatoprotective agents. Oncogene 27: 6228-6244. doi:10.1038/onc. 2008.300. PubMed: 18931690.
    • (2008) Oncogene , vol.27 , pp. 6228-6244
    • Sun, B.1    Karin, M.2
  • 22
    • 34548321204 scopus 로고    scopus 로고
    • Nuclear factor-ê2. Elsharkawy AM, Mann DA 200-fibrosis-cancer axis
    • doi:10.1002/hep.21802
    • Elsharkawy AM, Mann DA (2007) Nuclear factor-ê2. Elsharkawy AM, Mann DA (200-fibrosis-cancer axis. Hepatol 46: 590-597. doi:10.1002/hep.21802.
    • (2007) Hepatol , vol.46 , pp. 590-597
    • Elsharkawy, A.M.1    Mann, D.A.2
  • 23
    • 3242700529 scopus 로고    scopus 로고
    • Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: Alcohol disregulation of NF-êB and STAT3 signaling pathways
    • Jaruga B, Hong F, Kim W-H, Sun R, Fan S, et al. (2004) Chronic alcohol consumption accelerates liver injury in T cell-mediated hepatitis: alcohol disregulation of NF-êB and STAT3 signaling pathways. Am J Physiol-gastr L 287: G471-G479
    • (2004) Am J Physiol-gastr L , vol.287
    • Jaruga, B.1    Hong, F.2    Kim, W.-H.3    Sun, R.4    Fan, S.5
  • 24
    • 79751492851 scopus 로고    scopus 로고
    • NF-êB in the liver-linking injury, fibrosis and hepatocellular carcinoma
    • doi:10.1038/nrgastro.2010.213. PubMed: 21293511
    • Luedde T, Schwabe RF (2011) NF-êB in the liver-linking injury, fibrosis and hepatocellular carcinoma. Nat Rev Gastroenterol Hepatol 8: 108-118. doi:10.1038/nrgastro.2010.213. PubMed: 21293511.
    • (2011) Nat Rev Gastroenterol Hepatol , vol.8 , pp. 108-118
    • Luedde, T.1    Schwabe, R.F.2
  • 25
    • 84879822439 scopus 로고    scopus 로고
    • Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2
    • PubMed: 23791612
    • Xia Y, Chen J, Cao Y, Xu C, Li R et al. (2013) Wedelolactone exhibits anti-fibrotic effects on human hepatic stellate cell line LX-2. Eur J Pharmacol, 714: 105-11. PubMed: 23791612.
    • (2013) Eur J Pharmacol , vol.714 , pp. 105-111
    • Xia, Y.1    Chen, J.2    Cao, Y.3    Xu, C.4    Li, R.5
  • 26
    • 33846154628 scopus 로고    scopus 로고
    • Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam
    • doi:10.1016/j.jep.2006.08.011. PubMed: 17010546
    • Nguyen-Pouplin J, Tran H, Tran H, Phan TA, Dolecek C et al. (2007) Antimalarial and cytotoxic activities of ethnopharmacologically selected medicinal plants from South Vietnam. J Ethnopharmacol 109: 417-427. doi:10.1016/j.jep.2006.08.011. PubMed: 17010546.
    • (2007) J Ethnopharmacol , vol.109 , pp. 417-427
    • Nguyen-Pouplin, J.1    Tran, H.2    Tran, H.3    Phan, T.A.4    Dolecek, C.5
  • 28
    • 84868157852 scopus 로고    scopus 로고
    • TGF-β Signaling in Onset and Progression of Hepatocellular Carcinoma
    • doi:10.1159/000341704. PubMed: 23108308
    • Meindl-Beinker NM, Matsuzaki K, Dooley S (2012) TGF-β Signaling in Onset and Progression of Hepatocellular Carcinoma. Dig Dis 30: 514-523. doi:10.1159/000341704. PubMed: 23108308.
    • (2012) Dig Dis , vol.30 , pp. 514-523
    • Meindl-Beinker, N.M.1    Matsuzaki, K.2    Dooley, S.3
  • 29
    • 1442271244 scopus 로고    scopus 로고
    • Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma
    • doi:10.1016/S1083-8791(03)00151-4. PubMed: 12869955
    • Pines M, Snyder D, Yarkoni S, Nagler A (2003) Halofuginone to treat fibrosis in chronic graft-versus-host disease and scleroderma. Biol Blood Marrow Transplant 9: 417-425. doi:10.1016/S1083-8791(03)00151-4. PubMed: 12869955.
    • (2003) Biol Blood Marrow Transplant , vol.9 , pp. 417-425
    • Pines, M.1    Snyder, D.2    Yarkoni, S.3    Nagler, A.4
  • 30
    • 0035142629 scopus 로고    scopus 로고
    • Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats
    • doi:10.1053/jhep.2001.21408
    • Bruck R, Genina O, Aeed H, Alexiev R, Nagler A et al. (2001) Halofuginone to prevent and treat thioacetamide-induced liver fibrosis in rats. Hepatol 33: 379-386. doi:10.1053/jhep.2001.21408.
    • (2001) Hepatol , vol.33 , pp. 379-386
    • Bruck, R.1    Genina, O.2    Aeed, H.3    Alexiev, R.4    Nagler, A.5
  • 31
    • 33846419532 scopus 로고    scopus 로고
    • Halufuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats
    • Benchetrit S, Yarkoni S, Rathaus M, Pines M, Rashid G, et al. (2007) Halufuginone reduces the occurrence of renal fibrosis in 5/6 nephrectomized rats. IMAJ-RAMAT GAN- 9: 30
    • (2007) IMAJ-RAMAT GAN , vol.9 , pp. 30
    • Benchetrit, S.1    Yarkoni, S.2    Rathaus, M.3    Pines, M.4    Rashid, G.5
  • 32
    • 0032054482 scopus 로고    scopus 로고
    • Halofuginone: A novel antifibrotic therapy
    • doi:10.1016/S0306-3623(97)00307-8. PubMed: 9522159
    • Pines M, Nagler A (1998) Halofuginone: a novel antifibrotic therapy. Gen Pharmacol 30: 445-450. doi:10.1016/S0306-3623(97)00307-8. PubMed: 9522159.
    • (1998) Gen Pharmacol , vol.30 , pp. 445-450
    • Pines, M.1    Nagler, A.2
  • 33
    • 84863232768 scopus 로고    scopus 로고
    • Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts
    • PubMed: 22393274
    • Nelson EF, Huang CW, Ewel JM, Chang AA, Yuan C (2012) Halofuginone down-regulates Smad3 expression and inhibits the TGFbeta-induced expression of fibrotic markers in human corneal fibroblasts. Mol Vis 18: 479-487. PubMed: 22393274.
    • (2012) Mol Vis , vol.18 , pp. 479-487
    • Nelson, E.F.1    Huang, C.W.2    Ewel, J.M.3    Chang, A.A.4    Yuan, C.5
  • 34
    • 33748853355 scopus 로고    scopus 로고
    • Halofuginone inhibits NF-κB and p38 MAPK in activated T cells
    • doi:10.1189/jlb.0705409. PubMed: 16769768
    • Leiba M, Cahalon L, Shimoni A, Lider O, Zanin-Zhorov A et al. (2006) Halofuginone inhibits NF-κB and p38 MAPK in activated T cells. J Leukoc Biol 80: 399-406. doi:10.1189/jlb.0705409. PubMed: 16769768.
    • (2006) J Leukoc Biol , vol.80 , pp. 399-406
    • Leiba, M.1    Cahalon, L.2    Shimoni, A.3    Lider, O.4    Zanin-Zhorov, A.5
  • 35
    • 75149196666 scopus 로고    scopus 로고
    • Immune tolerance: What is unique about the liver
    • doi:10.1016/j.jaut.2009.08.008. PubMed: 19717280
    • Tiegs G, Lohse AW (2010) Immune tolerance: what is unique about the liver. J Autoimmun 34: 1-6. doi:10.1016/j.jaut.2009.08.008. PubMed: 19717280.
    • (2010) J Autoimmun , vol.34 , pp. 1-6
    • Tiegs, G.1    Lohse, A.W.2
  • 36
    • 67650713964 scopus 로고    scopus 로고
    • Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injury
    • doi: 10.1248/bpb.32.1215. PubMed: 19571388
    • Itoh A, Isoda K, Kondoh M, Kawase M, Kobayashi M et al. (2009) Hepatoprotective effect of syringic acid and vanillic acid on concanavalin a-induced liver injury. Biol Pharm Bull 32: 1215-1219. doi: 10.1248/bpb.32.1215. PubMed: 19571388.
    • (2009) Biol Pharm Bull , vol.32 , pp. 1215-1219
    • Itoh, A.1    Isoda, K.2    Kondoh, M.3    Kawase, M.4    Kobayashi, M.5
  • 37
    • 0033977426 scopus 로고    scopus 로고
    • Hepatic fibrosis in rheumatoid arthritis patients treated with methotrexate: Application of a new semi-quantitative scoring system
    • doi:10.1093/rheumatology/39.1.50. PubMed: 10662873
    • Richard S, Guerret S, Gerard F, Tebib JG, Vignon E (2000) Hepatic fibrosis in rheumatoid arthritis patients treated with methotrexate: application of a new semi-quantitative scoring system. Rheumatology 39: 50-54. doi:10.1093/rheumatology/39.1.50. PubMed: 10662873.
    • (2000) Rheumatology , vol.39 , pp. 50-54
    • Richard, S.1    Guerret, S.2    Gerard, F.3    Tebib, J.G.4    Vignon, E.5
  • 38
    • 33645799492 scopus 로고    scopus 로고
    • Mechanisms of liver injury. I. TNF-α- induced liver injury: Role of IKK, JNK, and ROS pathways
    • Schwabe RF, Brenner DA (2006) Mechanisms of liver injury. I. TNF-α- induced liver injury: role of IKK, JNK, and ROS pathways. Am J Physiol-gastr L 290: G583-G589
    • (2006) Am J Physiol-gastr L , vol.290
    • Schwabe, R.F.1    Brenner, D.A.2
  • 39
    • 0030759740 scopus 로고    scopus 로고
    • Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine-induced liver cirrhosis
    • doi: 10.1016/S0168-8278(97)80186-9. PubMed: 9288615
    • Pines M, Knopov V, Genina O, Lavelin I, Nagler A (1997) Halofuginone, a specific inhibitor of collagen type I synthesis, prevents dimethylnitrosamine- induced liver cirrhosis. J Hepatol 27: 391-398. doi: 10.1016/S0168-8278(97) 80186-9. PubMed: 9288615.
    • (1997) J Hepatol , vol.27 , pp. 391-398
    • Pines, M.1    Knopov, V.2    Genina, O.3    Lavelin, I.4    Nagler, A.5
  • 40
    • 33746661674 scopus 로고    scopus 로고
    • Protection against D-galactosamine-induced acute liver injury by oral administration of extracts from Lentinus edodes mycelia
    • doi:10.1248/bpb.29.1651. PubMed: 16880621
    • Watanabe A, Kobayashi M, Hayashi S, Kodama D, Isoda K et al. (2006) Protection against D-galactosamine-induced acute liver injury by oral administration of extracts from Lentinus edodes mycelia. Biol Pharm Bull 29: 1651-1654. doi:10.1248/bpb.29.1651. PubMed: 16880621.
    • (2006) Biol Pharm Bull , vol.29 , pp. 1651-1654
    • Watanabe, A.1    Kobayashi, M.2    Hayashi, S.3    Kodama, D.4    Isoda, K.5
  • 41
    • 77953986092 scopus 로고    scopus 로고
    • Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in thioacetamide-induced chronic liver injury
    • doi:10.3346/jkms.2010.25.4.570. PubMed: 20358000
    • Park SY, Shin HW, Lee KB, Lee M-J, Jang J-J (2010) Differential expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in thioacetamide-induced chronic liver injury. J Korean Med Sci 25: 570-576. doi:10.3346/jkms.2010.25.4.570. PubMed: 20358000.
    • (2010) J Korean Med Sci , vol.25 , pp. 570-576
    • Park, S.Y.1    Shin, H.W.2    Lee, K.B.3    Lee, M.-J.4    Jang, J.-J.5
  • 43
    • 0037013742 scopus 로고    scopus 로고
    • Mechanisms of TGF-β signaling in regulation of cell growth and differentiation
    • doi:10.1016/S0165-2478(02)00023-8. PubMed: 12008039
    • Moustakas A, Pardali K, Gaal A, Heldin C-H (2002) Mechanisms of TGF-β signaling in regulation of cell growth and differentiation. Immunol Lett 82: 85-91. doi:10.1016/S0165-2478(02)00023-8. PubMed: 12008039.
    • (2002) Immunol Lett , vol.82 , pp. 85-91
    • Moustakas, A.1    Pardali, K.2    Gaal, A.3    Heldin, C.-H.4
  • 44
    • 62449175839 scopus 로고    scopus 로고
    • Interactions between extracellular matrix and growth factors in wound healing
    • doi:10.1111/j.1524-475X.2009.00466.x. PubMed: 19320882
    • Schultz GS, Wysocki A (2009) Interactions between extracellular matrix and growth factors in wound healing. Wound Repair Regen 17: 153-162. doi:10.1111/j.1524-475X.2009.00466.x. PubMed: 19320882.
    • (2009) Wound Repair Regen , vol.17 , pp. 153-162
    • Schultz, G.S.1    Wysocki, A.2
  • 45
    • 0033854016 scopus 로고    scopus 로고
    • Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine- treated rats
    • doi:10.1053/jhep.2000.9109
    • Nakamura T, Sakata R, Ueno T, Sata M, Ueno H (2000) Inhibition of transforming growth factor β prevents progression of liver fibrosis and enhances hepatocyte regeneration in dimethylnitrosamine-treated rats. Hepatol 32: 247-255. doi:10.1053/jhep.2000.9109.
    • (2000) Hepatol , vol.32 , pp. 247-255
    • Nakamura, T.1    Sakata, R.2    Ueno, T.3    Sata, M.4    Ueno, H.5
  • 46
    • 84892776832 scopus 로고    scopus 로고
    • Effect of chymase inhibitors on dimethylnitrosamine-induced rat liver fibrosis and on chymase and collagen I expression
    • Yin M, Jin S, Cui H (2012) Effect of chymase inhibitors on dimethylnitrosamine-induced rat liver fibrosis and on chymase and collagen I expression. Afr - J Pharm and Pharmaco 6: 2870-2874.
    • (2012) Afr - J Pharm and Pharmaco , vol.6 , pp. 2870-2874
    • Yin, M.1    Jin, S.2    Cui, H.3
  • 47
    • 0036121027 scopus 로고    scopus 로고
    • Halofuginone, an Inhibitor of Type-I Collagen Synthesis and Skin Sclerosis, Blocks Transforming-Growth-Factor-β-Mediated Smad3 Activation in Fibroblasts
    • doi:10.1046/j.0022-202x.2001.01690.x. PubMed: 11874485
    • McGaha TL, Phelps RG, Spiera H, Bona C (2002) Halofuginone, an Inhibitor of Type-I Collagen Synthesis and Skin Sclerosis, Blocks Transforming-Growth- Factor-β-Mediated Smad3 Activation in Fibroblasts. J Invest Dermatol 118: 461-470. doi:10.1046/j.0022-202x.2001.01690.x. PubMed: 11874485.
    • (2002) J Invest Dermatol , vol.118 , pp. 461-470
    • McGaha, T.L.1    Phelps, R.G.2    Spiera, H.3    Bona, C.4
  • 48
    • 2442481893 scopus 로고    scopus 로고
    • Amelioration of radiation-induced fibrosis inhibition of transforming growth factor-β signaling by halofuginone
    • doi:10.1074/jbc.M309798200. PubMed: 14732719
    • Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A et al. (2004) Amelioration of radiation-induced fibrosis inhibition of transforming growth factor-β signaling by halofuginone. J Biol Chem 279: 15167-15176. doi:10.1074/jbc.M309798200. PubMed: 14732719.
    • (2004) J Biol Chem , vol.279 , pp. 15167-15176
    • Xavier, S.1    Piek, E.2    Fujii, M.3    Javelaud, D.4    Mauviel, A.5
  • 49
    • 0031897632 scopus 로고    scopus 로고
    • NF-{kappa} B and Rel proteins: Evolutionarily conserved mediators of immune responses
    • Ghosh S, May MJ, Kopp EB (1998) NF-{kappa} B and Rel proteins: evolutionarily conserved mediators of immune responses. Sci Signal 16: 225.
    • (1998) Sci Signal , vol.16 , pp. 225
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 50
    • 0028167846 scopus 로고
    • Inhibition of NF-kappa B by sodium salicylate and aspirin
    • doi:10.1126/science.8052854. PubMed: 8052854
    • Kopp E, Ghosh S (1994) Inhibition of NF-kappa B by sodium salicylate and aspirin. Science 265: 956-959. doi:10.1126/science.8052854. PubMed: 8052854.
    • (1994) Science , vol.265 , pp. 956-959
    • Kopp, E.1    Ghosh, S.2
  • 51
    • 0028985037 scopus 로고
    • NF-κB and rel proteins in innate immunity
    • doi:10.1016/S0065-2776(08)60618-5. PubMed: 7741027
    • Kopp EB, Ghosh S (1995) NF-κB and rel proteins in innate immunity. Adv Immunol 58: 1-27. doi:10.1016/S0065-2776(08)60618-5. PubMed: 7741027.
    • (1995) Adv Immunol , vol.58 , pp. 1-27
    • Kopp, E.B.1    Ghosh, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.