Low-Dose Paclitaxel Ameliorates Pulmonary Fibrosis by Suppressing TGF-β1/Smad3 Pathway via miR-140 Upregulation

PLoS ONE

Volumn 8, Issue 8, 2013, Pages

  Wang, Congjie ^a   Song, Xiaodong ^a   Li, Youjie ^a   Han, Fang ^a   Gao, Shuyan ^a   Wang, Xiaozhi ^b   Xie, Shuyang ^a   Lv, Changjun ^a  

^a BINZHOU MEDICAL UNIVERSITY   (China)

^b Affiliated Hospital of Binzhou Medical University   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; BLEOMYCIN; COLLAGEN; MICRORNA; MICRORNA 140; PACLITAXEL; SMAD3 PROTEIN; SODIUM CHLORIDE; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG; UVOMORULIN; VIMENTIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIFIBROTIC ACTIVITY; ARTICLE; BODY WEIGHT; CONTROLLED STUDY; DRUG ACTIVITY; DRUG EFFICACY; EPITHELIAL MESENCHYMAL TRANSITION; FIBROSING ALVEOLITIS; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LOW DRUG DOSE; LUNG ALVEOLUS EPITHELIUM; LUNG FIBROSIS; LUNG WEIGHT; MALE; NONHUMAN; PHENOTYPE; PROTEIN DEPLETION; PROTEIN METABOLISM; PROTEIN PHOSPHORYLATION; RAT; RISK REDUCTION; SIGNAL TRANSDUCTION; TREATMENT RESPONSE; UPREGULATION;

ANIMALS; BLEOMYCIN; EPITHELIAL-MESENCHYMAL TRANSITION; GENE EXPRESSION REGULATION; MALE; MICRORNAS; PACLITAXEL; PULMONARY FIBROSIS; RATS; SIGNAL TRANSDUCTION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1; TUBULIN MODULATORS; UP-REGULATION;

EID: 84881590424     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0070725     Document Type: Article

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