The neuropathology of sport

Acta Neuropathologica

Volumn 127, Issue 1, 2014, Pages 29-51

  McKee, Ann C ^a,b   Daneshvar, Daniel H ^b   Alvarez, Victor E ^b   Stein, Thor D ^a,b  

^a VA BOSTON HEALTHCARE SYSTEM   (United States)

^b BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACADEMIC ACHIEVEMENT; AEROBIC EXERCISE; ANGIOGENESIS; ATHLETE; AXONAL INJURY; BASEBALL; BEHAVIOR CHANGE; BODY IMAGE; BOXING; BRAIN CONCUSSION; BRAIN SIZE; BRAIN STEM; CELL SURVIVAL; CLINICAL STUDY; COGNITIVE DEFECT; COMPUTER ASSISTED TOMOGRAPHY; CROSS-SECTIONAL STUDY; DEGENERATIVE DISEASE; DIFFUSION TENSOR IMAGING; ELECTROENCEPHALOGRAM; ENDURANCE TRAINING; EXECUTIVE FUNCTION; FITNESS; FOOTBALL; FRONTOTEMPORAL DEMENTIA; FUNCTIONAL MAGNETIC RESONANCE IMAGING; HEALTH; HIGH SCHOOL STUDENT; HOPELESSNESS; HUMAN; ICE HOCKEY; IMMUNOHISTOCHEMISTRY; INCIDENCE; LIFE SATISFACTION; MORTALITY; MOTOR NEURON DISEASE; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; NERVE DEGENERATION; NERVOUS SYSTEM DEVELOPMENT; NEUROPATHOLOGY; NEUROPROTECTION; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PHOSPHORYLATION; PHYSICAL ACTIVITY; PREVALENCE; PRIORITY JOURNAL; PSYCHOLOGICAL WELL BEING; RESTING HEART RATE; REVIEW; RISK REDUCTION; RUGBY; SECOND IMPACT SYNDROME; SELF ESTEEM; SINGLE PHOTON EMISSION COMPUTER TOMOGRAPHY; SOCCER; SOCIAL ACCEPTANCE; SOCIAL ISOLATION; SPATIAL MEMORY; SPORT; SUDDEN DEATH; SYNAPTOGENESIS; SYSTEMATIC REVIEW (TOPIC); TASK PERFORMANCE; TDP 43 PROTEINOPATHY; TEAM SPORT; TEMPORAL LOBE; TRAUMATIC BRAIN INJURY; TREADMILL EXERCISE; WEIGHT CONTROL; WHITE MATTER; WORKING MEMORY; WRESTLING;

ANIMALS; ATHLETIC INJURIES; BRAIN; BRAIN INJURIES; COGNITION; HUMANS; SPORTS;

EID: 84892672872     PISSN: 00016322     EISSN: 14320533     Source Type: Journal    
DOI: 10.1007/s00401-013-1230-6     Document Type: Review

References (201)

1. JE Ahlskog 2011 Does vigorous exercise have a neuroprotective effect in Parkinson disease? Neurology 77 3 288 294 10.1212/WNL.0b013e318225ab66
2. ET Ang GS Dawe PT Wong S Moochhala YK Ng 2006 Alterations in spatial learning and memory after forced exercise Brain Res 1113 1 186 193 10.1016/j.brainres.2006.07.023
3. ET Ang F Gomez-Pinilla 2007 Potential therapeutic effects of exercise to the brain Curr Med Chem 14 24 2564 2571
4. IC Anthony KE Norrby T Dingwall FW Carnie T Millar JC Arango R Robertson JE Bell 2010 Predisposition to accelerated Alzheimer-related changes in the brains of human immunodeficiency virus negative opiate abusers Brain 133 Pt 12 3685 3698 10.1093/brain/awq263
5. Y Aoki R Inokuchi M Gunshin N Yahagi H Suwa 2012 Diffusion tensor imaging studies of mild traumatic brain injury: a meta-analysis J Neurol Neurosurg Psychiatry 83 9 870 876 10.1136/jnnp-2012-302742
6. R Au S Seshadri K Knox A Beiser JJ Himali HJ Cabral S Auerbach RC Green PA Wolf AC McKee 2012 The Framingham Brain Donation Program: neuropathology along the cognitive continuum Curr Alzheimer Res 9 6 673 686
7. BK Barber LD Erickson 2001 Adolescent social initiative: antecedents in the ecology of social connections J Adolesc Res 16 326 354
8. DE Barnes T Blackwell KL Stone SE Goldman T Hillier K Yaffe 2008 Cognition in older women: the importance of daytime movement J Am Geriatr Soc 56 9 1658 1664 10.1111/j.1532-5415.2008.01841.x
9. Bartholomew J, Ciccolo JT (2008) Exercise, depression, and cognition. In: Spirduso W, Poon L, Chodzko-Zajko W (eds) Exercise and its mediating effects on cognition. Human Kinetics, Champaign
10. L Bherer KI Erickson T Liu-Ambrose 2013 A review of the effects of physical activity and exercise on cognitive and brain functions in older adults J Aging Res 2013 657508 10.1155/2013/657508
11. K Blennow J Hardy H Zetterberg 2012 The neuropathology and neurobiology of traumatic brain injury Neuron 76 5 886 899 10.1016/j.neuron.2012.11.021
12. PC Blumbergs G Scott J Manavis H Wainwright DA Simpson AJ McLean 1994 Staining of amyloid precursor protein to study axonal damage in mild head injury Lancet 344 8929 1055 1056
13. E Boone B Leadbeater 2006 Game on: diminishing risks for depressive symptoms in early adolescence through positive involvement in team sports J Res Adolesc 16 1 79 90
14. PA Boyle AS Buchman RS Wilson SE Leurgans DA Bennett 2010 Physical frailty is associated with incident mild cognitive impairment in community-based older persons J Am Geriatr Soc 58 2 248 255 10.1111/j.1532-5415.2009.02671.x
15. H Braak K Del Tredici 2011 The pathological process underlying Alzheimer's disease in individuals under thirty Acta Neuropathol (Berl) 121 2 171 181 10.1007/s00401-010-0789-4
16. EL Breedlove M Robinson TM Talavage KE Morigaki U Yoruk K O'Keefe J King LJ Leverenz JW Gilger EA Nauman 2012 Biomechanical correlates of symptomatic and asymptomatic neurophysiological impairment in high school football J Biomech 45 7 1265 1272 10.1016/j.jbiomech.2012.01.034
17. AS Buchman PA Boyle L Yu RC Shah RS Wilson DA Bennett 2012 Total daily physical activity and the risk of AD and cognitive decline in older adults Neurology 78 17 1323 1329 10.1212/WNL.0b013e3182535d35
18. JM Burns BB Cronk HS Anderson JE Donnelly GP Thomas A Harsha WM Brooks RH Swerdlow 2008 Cardiorespiratory fitness and brain atrophy in early Alzheimer disease Neurology 71 3 210 216 10.1212/01.wnl.0000317094.86209.cb
19. Cantu R, Gean A (2010) Second impact syndrome in a small SDH: an uncommon catastrophic result of repetitive head injury with a characteristic imaging appearance. J Neurotrauma. doi: 10.1089/neu.2010.1334
20. RC Cantu 1998 Second-impact syndrome Clin Sports Med 17 1 37 44
21. RC Cantu K Guskiewicz JK Register-Mihalik 2010 A retrospective clinical analysis of moderate to severe athletic concussions PM R 2 12 1088 1093 10.1016/j.pmrj.2010.07.483
22. Cantu RC, Herring SA, Putukian M (2007) Concussion. N Engl J Med 356 (17):1787; author reply 1789. doi: 10.1056/NEJMc070289
23. RC Cantu FO Mueller 2009 The prevention of catastrophic head and spine injuries in high school and college sports Br J Sports Med 43 13 981 986 10.1136/bjsm.2009.067728
24. H Chen M Richard DP Sandler DM Umbach F Kamel 2007 Head injury and amyotrophic lateral sclerosis Am J Epidemiol 166 7 810 816 10.1093/aje/kwm153
25. HI Chen LC Lin L Yu YF Liu YM Kuo AM Huang JI Chuang FS Wu PC Liao CJ Jen 2008 Treadmill exercise enhances passive avoidance learning in rats: the role of down-regulated serotonin system in the limbic system Neurobiol Learn Mem 89 4 489 496 10.1016/j.nlm.2007.08.004
26. JK Chen KM Johnston M Petrides A Ptito 2008 Recovery from mild head injury in sports: evidence from serial functional magnetic resonance imaging studies in male athletes Clin J Sport Med 18 3 241 247 10.1097/JSM. 0b013e318170b59d
27. MF Chen TY Huang YM Kuo L Yu HI Chen CJ Jen 2013 Early postinjury exercise reverses memory deficits and retards the progression of closed-head injury in mice J Physiol 591 Pt 4 985 1000 10.1113/jphysiol.2012.241125
28. XH Chen R Siman A Iwata DF Meaney JQ Trojanowski DH Smith 2004 Long-term accumulation of amyloid-beta, beta-secretase, presenilin-1, and caspase-3 in damaged axons following brain trauma Am J Pathol 165 2 357 371
29. DT Chien S Bahri AK Szardenings JC Walsh F Mu MY Su WR Shankle A Elizarov HC Kolb 2013 Early clinical PET imaging results with the novel PHF-tau radioligand [F-18]-T807 J Alzheimers Dis 34 2 457 468 10.3233/JAD-122059
30. A Chio G Benzi M Dossena R Mutani G Mora 2005 Severely increased risk of amyotrophic lateral sclerosis among Italian professional football players Brain 128 Pt 3 472 476 10.1093/brain/awh373
31. A Chio A Calvo M Dossena P Ghiglione R Mutani G Mora 2009 ALS in Italian professional soccer players: the risk is still present and could be soccer-specific Amyotroph Lateral Scler 10 4 205 209 10.1080/17482960902721634
32. GL Clifton MG Ziegler RG Grossman 1981 Circulating catecholamines and sympathetic activity after head injury Neurosurgery 8 1 10 14
33. RJ Cloots HM Gervaise JA van Dommelen MG Geers 2008 Biomechanics of traumatic brain injury: influences of the morphologic heterogeneities of the cerebral cortex Ann Biomed Eng 36 7 1203 1215 10.1007/s10439-008-9510-3
34. SJ Colcombe KI Erickson PE Scalf JS Kim R Prakash E McAuley S Elavsky DX Marquez L Hu AF Kramer 2006 Aerobic exercise training increases brain volume in aging humans J Gerontol A Biol Sci Med Sci 61 11 1166 1170
35. SJ Colcombe AF Kramer KI Erickson P Scalf E McAuley NJ Cohen A Webb GJ Jerome DX Marquez S Elavsky 2004 Cardiovascular fitness, cortical plasticity, and aging Proc Natl Acad Sci USA 101 9 3316 3321 10.1073/pnas.0400266101
36. Collins M, Lovell MR, Iverson GL, Ide T, Maroon J (2006) Examining concussion rates and return to play in high school football players wearing newer helmet technology: a three-year prospective cohort study. Neurosurgery 58(2):275-286; discussion 275-286. doi: 10.1227/01.NEU.0000200441.92742.46
37. Concussion (mild traumatic brain injury) and the team physician: a consensus statement (2006). Med Sci Sports Exerc 38 (2):395-399. doi: 10.1249/01.mss.0000202025.48774.31
38. JA Corsellis CJ Bruton D Freeman-Browne 1973 The aftermath of boxing Psychol Med 3 3 270 303
39. CW Cotman NC Berchtold LA Christie 2007 Exercise builds brain health: key roles of growth factor cascades and inflammation Trends Neurosci 30 9 464 472 10.1016/j.tins.2007.06.011
40. T Covassin CB Swanik ML Sachs 2003 Epidemiological considerations of concussions among intercollegiate athletes Appl Neuropsychol 10 1 12 22
41. JJ Crisco R Fiore JG Beckwith JJ Chu PG Brolinson S Duma TW McAllister AC Duhaime RM Greenwald 2010 Frequency and location of head impact exposures in individual collegiate football players J Athl Train 45 6 549 559 10.4085/1062-6050-45.6.549
42. JJ Crisco BJ Wilcox JG Beckwith JJ Chu AC Duhaime S Rowson SM Duma AC Maerlender TW McAllister RM Greenwald 2011 Head impact exposure in collegiate football players J Biomech 44 15 2673 2678 10.1016/j.jbiomech.2011.08.003
43. Critchley M (1949) Punch-drunk syndromes: the chronic traumatic encephalopathy of boxers. In: Hommage a Clovis Vincent (ed). Maloine, Paris
44. M Critchley 1957 Medical aspects of boxing, particularly from a neurological standpoint Br Med J 1 5015 357 362
45. VA Cubon M Putukian C Boyer A Dettwiler 2011 A diffusion tensor imaging study on the white matter skeleton in individuals with sports-related concussion J Neurotrauma 28 2 189 201 10.1089/neu2010.1430
46. Dal Bello-Haas V, Florence JM (2013) Therapeutic exercise for people with amyotrophic lateral sclerosis or motor neuron disease. The Cochrane Database Syst Rev 5:CD005229. doi: 10.1002/14651858.CD005229.pub3
47. Daneshvar DH, Nowinski CJ, McKee AC, Cantu RC (2011) The epidemiology of sport-related concussion. Clin Sports Med 30(1):1-17, vii. doi: 10.1016/j.csm.2010.08.006
48. Daneshvar DH, Riley DO, Nowinski CJ, McKee AC, Stern RA, Cantu RC (2011) Long-term consequences: effects on normal development profile after concussion. Phys Med Rehabil Clin N Am 22 (4):683-700, ix. doi: 10.1016/j.pmr.2011.08.009
49. MH De Moor AL Beem JH Stubbe DI Boomsma EJ De Geus 2006 Regular exercise, anxiety, depression and personality: a population-based study Prev Med 42 4 273 279 10.1016/j.ypmed.2005.12.002
50. MH De Moor JH Stubbe DI Boomsma EJ De Geus 2007 Exercise participation and self-rated health: do common genes explain the association? Eur J Epidemiol 22 1 27 32 10.1007/s10654-006-9088-8
51. PJ Dean A Sterr 2013 Long-term effects of mild traumatic brain injury on cognitive performance Frontiers Hum Neurosci 7 30 10.3389/fnhum.2013.00030
52. N Didehbani C Munro Cullum S Mansinghani H Conover J Hart Jr 2013 Depressive symptoms and concussions in aging retired NFL players Arch Clin Neuropsychol 28 5 418 424 10.1093/arclin/act028
53. Q Ding S Vaynman M Akhavan Z Ying F Gomez-Pinilla 2006 Insulin-like growth factor I interfaces with brain-derived neurotrophic factor-mediated synaptic plasticity to modulate aspects of exercise-induced cognitive function Neuroscience 140 3 823 833 10.1016/j.neuroscience.2006.02.084
54. BD Eadie VA Redila BR Christie 2005 Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density J Comp Neurol 486 1 39 47 10.1002/cne.20493
55. RM Eime JA Young JT Harvey MJ Charity WR Payne 2013 A systematic review of the psychological and social benefits of participation in sport for children and adolescents: informing development of a conceptual model of health through sport Int J Behav Nutr Phys Activity 10 98 10.1186/1479-5868-10-98
56. KI Erickson DL Miller KA Roecklein 2012 The aging hippocampus: interactions between exercise, depression, and BDNF Neurosci Rev J Bringing Neurobiol Neurol Psychiatry 18 1 82 97 10.1177/1073858410397054
57. KI Erickson MW Voss RS Prakash C Basak A Szabo L Chaddock JS Kim S Heo H Alves SM White TR Wojcicki E Mailey VJ Vieira SA Martin BD Pence JA Woods E McAuley AF Kramer 2011 Exercise training increases size of hippocampus and improves memory Proc Natl Acad Sci USA 108 7 3017 3022 10.1073/pnas.1015950108
58. KI Erickson AM Weinstein OL Lopez 2012 Physical activity, brain plasticity, and Alzheimer's disease Arch Med Res 43 8 615 621 10.1016/j.arcmed.2012.09.008
59. J Farmer X Zhao H van Praag K Wodtke FH Gage BR Christie 2004 Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo Neuroscience 124 1 71 79 10.1016/j.neuroscience.2003.09.029
60. C Ferron F Narring M Cauderay PA Michaud 1999 Sport activity in adolescence: associations with health perceptions and experimental behaviours Health Educ Res 14 2 225 233
61. M Field MW Collins MR Lovell J Maroon 2003 Does age play a role in recovery from sports-related concussion? A comparison of high school and collegiate athletes J Pediatr 142 5 546 553 10.1067/mpd.2003.190
62. D Fogelman R Zafonte 2012 Exercise to enhance neurocognitive function after traumatic brain injury PM R 4 11 908 913 10.1016/j.pmrj.2012.09.028
63. Ford JH, Giovanello KS, Guskiewicz KM (2013) Episodic memory in former professional football players with a history of concussion: an event-related functional neuroimaging study. J Neurotrauma. doi: 10.1089/neu.2012.2535
64. YE Geda RO Roberts DS Knopman TJ Christianson VS Pankratz RJ Ivnik BF Boeve EG Tangalos RC Petersen WA Rocca 2010 Physical exercise, aging, and mild cognitive impairment: a population-based study Arch Neurol 67 1 80 86 10.1001/archneurol.2009.297
65. JF Geddes GH Vowles JA Nicoll T Revesz 1999 Neuronal cytoskeletal changes are an early consequence of repetitive head injury Acta Neuropathol (Berl) 98 2 171 178
66. JF Geddes GH Vowles SF Robinson JC Sutcliffe 1996 Neurofibrillary tangles, but not Alzheimer-type pathology, in a young boxer Neuropathol Appl Neurobiol 22 1 12 16
67. RP Gelber H Petrovitch KH Masaki RD Abbott GW Ross LJ Launer LR White 2012 Lifestyle and the risk of dementia in Japanese-American men J Am Geriatr Soc 60 1 118 123 10.1111/j.1532-5415.2011.03768.x
68. LM Gessel SK Fields CL Collins RW Dick RD Comstock 2007 Concussions among United States high school and collegiate athletes J Athl Train 42 4 495 503
69. JN Giedd J Blumenthal NO Jeffries FX Castellanos H Liu A Zijdenbos T Paus AC Evans JL Rapoport 1999 Brain development during childhood and adolescence: a longitudinal MRI study Nat Neurosci 2 10 861 863 10.1038/13158
70. CC Giza GS Griesbach DA Hovda 2005 Experience-dependent behavioral plasticity is disturbed following traumatic injury to the immature brain Behav Brain Res 157 1 11 22 10.1016/j.bbr.2004.06.003
71. CC Giza DA Hovda 2001 The neurometabolic cascade of concussion J Athl Train 36 3 228 235
72. Goldstein LE, Fisher AM, Tagge CA, Zhang XL, Velisek L, Sullivan JA, Upreti C, Kracht JM, Ericsson M, Wojnarowicz MW, Goletiani CJ, Maglakelidze GM, Casey N, Moncaster JA, Minaeva O, Moir RD, Nowinski CJ, Stern RA, Cantu RC, Geiling J, Blusztajn JK, Wolozin BL, Ikezu T, Stein TD, Budson AE, Kowall NW, Chargin D, Sharon A, Saman S, Hall GF, Moss WC, Cleveland RO, Tanzi RE, Stanton PK, McKee AC (2012) Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model. Sci Transl Med 4(134):134ra60. doi: 10.1126/scitranslmed.3003716
73. S Gore F Farrell J Gordon 2001 Sports involvement as protection against depressed mood J Res Adolesc 11 119 130
74. N Gosselin C Bottari JK Chen M Petrides S Tinawi E de Guise A Ptito 2011 Electrophysiology and functional MRI in post-acute mild traumatic brain injury J Neurotrauma 28 3 329 341 10.1089/neu2010.1493
75. KN Green LM Billings B Roozendaal JL McGaugh FM LaFerla 2006 Glucocorticoids increase amyloid-beta and tau pathology in a mouse model of Alzheimer's disease J Neurosci 26 35 9047 9056 10.1523/JNEUROSCI.2797-06.2006
76. SM Grieve MS Korgaonkar CR Clark LM Williams 2011 Regional heterogeneity in limbic maturational changes: evidence from integrating cortical thickness, volumetric and diffusion tensor imaging measures Neuroimage 55 3 868 879 10.1016/j.neuroimage.2010.12.087
77. Guskiewicz KM, Marshall SW, Bailes J, McCrea M, Cantu RC, Randolph C, Jordan BD (2005) Association between recurrent concussion and late-life cognitive impairment in retired professional football players. Neurosurgery 57(4):719-726; discussion 719-726
78. KM Guskiewicz SW Marshall J Bailes M McCrea HP Harding Jr A Matthews JR Mihalik RC Cantu 2007 Recurrent concussion and risk of depression in retired professional football players Med Sci Sports Exerc 39 6 903 909 10.1249/mss.0b013e3180383da500005768-200706000-00002
79. Guskiewicz KM, Mihalik JP, Shankar V, Marshall SW, Crowell DH, Oliaro SM, Ciocca MF, Hooker DN (2007) Measurement of head impacts in collegiate football players: relationship between head impact biomechanics and acute clinical outcome after concussion. Neurosurgery 61(6):1244-1252; discussion 1252-1243. doi: 10.1227/01.neu.0000306103.68635.1a
80. Guskiewicz KM, Valovich McLeod TC (2011) Pediatric sports-related concussion. PM R 3 (4):353-364; quiz 364. doi: 10.1016/j.pmrj.2010.12.006
81. SM Gysland JP Mihalik JK Register-Mihalik SC Trulock EW Shields KM Guskiewicz 2012 The relationship between subconcussive impacts and concussion history on clinical measures of neurologic function in collegiate football players Ann Biomed Eng 40 1 14 22 10.1007/s10439-011-0421-3
82. B Hagel W Meeuwisse 2004 Risk compensation: a "side effect" of sport injury prevention? Clin J Sport Med 14 4 193 196 00042752-200407000-00001
83. M Hamer Y Chida 2009 Physical activity and risk of neurodegenerative disease: a systematic review of prospective evidence Psychol Med 39 1 3 11 10.1017/S0033291708003681
84. A Hampshire A Macdonald AM Owen 2013 Hypoconnectivity and hyperfrontality in retired American football players Sci Rep 3 2972 10.1038/srep02972
85. EM Hanlon CA Bir 2012 Real-time head acceleration measurement in girls' youth soccer Med Sci Sports Exerc 44 6 1102 1108 10.1249/MSS.0b013e3182444d7d
86. KG Harmon JA Drezner M Gammons KM Guskiewicz M Halstead SA Herring JS Kutcher A Pana M Putukian WO Roberts 2013 American Medical Society for Sports Medicine position statement: concussion in sport Br J Sports Med 47 1 15 26 10.1136/bjsports-2012-091941
87. J Hart Jr MA Kraut KB Womack J Strain N Didehbani E Bartz H Conover S Mansinghani H Lu CM Cullum 2013 Neuroimaging of cognitive dysfunction and depression in aging retired National Football League players: a cross-sectional study JAMA Neurol 70 3 326 335 10.1001/2013.jamaneurol.340
88. LN Hazrati MC Tartaglia P Diamandis KD Davis RE Green R Wennberg JC Wong L Ezerins CH Tator 2013 Absence of chronic traumatic encephalopathy in retired football players with multiple concussions and neurological symptomatology Frontiers Hum Neurosci 7 222 10.3389/fnhum.2013.00222
89. P Heyn BC Abreu KJ Ottenbacher 2004 The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis Arch Phys Med Rehabil 85 10 1694 1704
90. CH Hillman KI Erickson AF Kramer 2008 Be smart, exercise your heart: exercise effects on brain and cognition Nat Rev Neurosci 9 1 58 65 10.1038/nrn2298
91. PR Hof C Bouras L Buee A Delacourte DP Perl JH Morrison 1992 Differential distribution of neurofibrillary tangles in the cerebral cortex of dementia pugilistica and Alzheimer's disease cases Acta Neuropathol (Berl) 85 1 23 30
92. PR Hof R Knabe P Bovier C Bouras 1991 Neuropathological observations in a case of autism presenting with self-injury behavior Acta Neuropathol (Berl) 82 4 321 326
93. SJ Hollis MR Stevenson AS McIntosh EA Shores MW Collins CB Taylor 2009 Incidence, risk, and protective factors of mild traumatic brain injury in a cohort of Australian nonprofessional male rugby players Am J Sports Med 37 12 2328 2333 10.1177/0363546509341032
94. Hong YT, Veenith T, Dewar D, Outtrim JG, Mani V, Williams C, Pimlott S, Hutchinson PJ, Tavares A, Canales R, Mathis CA, Klunk WE, Aigbirhio FI, Coles JP, Baron JC, Pickard JD, Fryer TD, Stewart W, Menon DK (2013) Amyloid Imaging With Carbon 11-Labeled Pittsburgh Compound B for Traumatic Brain Injury. JAMA Neurol. doi: 10.1001/jamaneurol.2013.4847
95. JM Hootman R Dick J Agel 2007 Epidemiology of collegiate injuries for 15 sports: summary and recommendations for injury prevention initiatives J Athl Train 42 2 311 319
96. S Hu Z Ying F Gomez-Pinilla SA Frautschy 2009 Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus Brain Res 1249 191 201 10.1016/j.brainres.2008.10.054
97. AM Huang CJ Jen HF Chen L Yu YM Kuo HI Chen 2006 Compulsive exercise acutely upregulates rat hippocampal brain-derived neurotrophic factor J Neural Transm 113 7 803 811 10.1007/s00702-005-0359-4
98. MD Ikonomovic K Uryu EE Abrahamson JR Ciallella JQ Trojanowski VM Lee RS Clark DW Marion SR Wisniewski ST DeKosky 2004 Alzheimer's pathology in human temporal cortex surgically excised after severe brain injury Exp Neurol 190 1 192 203 10.1016/j.expneurol.2004.06.011
99. KR Isaacs BJ Anderson AA Alcantara JE Black WT Greenough 1992 Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning J Cereb Blood Flow Metab 12 1 110 119 10.1038/jcbfm.1992.14
100. BD Jordan AB Kanik MS Horwich D Sweeney NR Relkin CK Petito S Gandy 1995 Apolipoprotein E epsilon 4 and fatal cerebral amyloid angiopathy associated with dementia pugilistica Ann Neurol 38 4 698 699 10.1002/ana.410380429
101. EE Kors GM Terwindt FL Vermeulen RB Fitzsimons PE Jardine P Heywood S Love AM van den Maagdenberg J Haan RR Frants MD Ferrari 2001 Delayed cerebral edema and fatal coma after minor head trauma: role of the CACNA1A calcium channel subunit gene and relationship with familial hemiplegic migraine Ann Neurol 49 6 753 760
102. Kunz M (2007) Big count: 265 million playing football. Fifa Mag 7:10-15
103. G Lace PG Ince C Brayne GM Savva FE Matthews R de Silva JE Simpson SB Wharton 2012 Mesial temporal astrocyte tau pathology in the MRC-CFAS ageing brain cohort Dement Geriatr Cogn Disord 34 1 15 24 10.1159/000341581
104. TA Lakka DE Laaksonen 2007 Physical activity in prevention and treatment of the metabolic syndrome. Applied physiology, nutrition, and metabolism Physiologie appliquee, nutrition et metabolisme 32 1 76 88 10.1139/h06-113
105. JM Lam JN Hsiang WS Poon 1997 Monitoring of autoregulation using laser Doppler flowmetry in patients with head injury J Neurosurg 86 3 438 445 10.3171/jns.1997.86.3.0438
106. W Langburt B Cohen N Akhthar K O'Neill JC Lee 2001 Incidence of concussion in high school football players of Ohio and Pennsylvania J Child Neurol 16 2 83 85
107. EB Larson L Wang JD Bowen WC McCormick L Teri P Crane W Kukull 2006 Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older Ann Intern Med 144 2 73 81
108. NT Lautenschlager KL Cox L Flicker JK Foster FM van Bockxmeer J Xiao KR Greenop OP Almeida 2008 Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial JAMA 300 9 1027 1037 10.1001/jama.300.9.1027
109. EJ Lehman MJ Hein SL Baron CM Gersic 2012 Neurodegenerative causes of death among retired National Football League players Neurology 79 19 1970 1974 10.1212/WNL.0b013e31826daf50
110. FP Leung LM Yung I Laher X Yao ZY Chen Y Huang 2008 Exercise, vascular wall and cardiovascular diseases: an update (Part 1) Sports Med 38 12 1009 1024 10.2165/00007256-200838120-00005
111. ML Lipton N Kim ME Zimmerman M Kim WF Stewart CA Branch RB Lipton 2013 Soccer heading is associated with white matter microstructural and cognitive abnormalities Radiology 268 3 850 857 10.1148/radiol.13130545
112. YF Liu HI Chen L Yu YM Kuo FS Wu JI Chuang PC Liao CJ Jen 2008 Upregulation of hippocampal TrkB and synaptotagmin is involved in treadmill exercise-enhanced aversive memory in mice Neurobiol Learn Mem 90 1 81 89 10.1016/j.nlm.2008.02.005
113. SM Logan GW Bell JC Leonard 2001 Acute subdural hematoma in a high school football player after 2 unreported episodes of head trauma: a case report J Athl Train 36 4 433 436
114. I Lopez-Gonzalez M Carmona R Blanco J Luna-Munoz A Martinez-Mandonado R Mena I Ferrer 2013 Characterization of thorn-shaped astrocytes in white matter of temporal lobe in Alzheimer's disease brains Brain Pathol 23 2 144 153 10.1111/j.1750-3639.2012.00627.x
115. Lovell MR, Pardini JE, Welling J, Collins MW, Bakal J, Lazar N, Roush R, Eddy WF, Becker JT (2007) Functional brain abnormalities are related to clinical recovery and time to return-to-play in athletes. Neurosurgery 61(2):352-359; discussion 359-360. doi: 10.1227/01.NEU.0000279985.94168.7F
116. M Marar NM McIlvain SK Fields RD Comstock 2012 Epidemiology of concussions among United States high school athletes in 20 sports Am J Sports Med 40 4 747 755 10.1177/0363546511435626
117. BJ Maron 2003 Sudden death in young athletes N Engl J Med 349 11 1064 1075 10.1056/NEJMra022783
118. HS Martland 1928 Punch drunk JAMA 91 15 1103 1107
119. M Maruyama H Shimada T Suhara H Shinotoh B Ji J Maeda MR Zhang JQ Trojanowski VM Lee M Ono K Masamoto H Takano N Sahara N Iwata N Okamura S Furumoto Y Kudo Q Chang TC Saido A Takashima J Lewis MK Jang I Aoki H Ito M Higuchi 2013 Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls Neuron 79 6 1094 1108 10.1016/j.neuron.2013.07.037
120. AR Mayer MV Mannell J Ling C Gasparovic RA Yeo 2011 Functional connectivity in mild traumatic brain injury Hum Brain Mapp 32 11 1825 1835 10.1002/hbm.21151
121. TW McAllister LA Flashman A Maerlender RM Greenwald JG Beckwith TD Tosteson JJ Crisco PG Brolinson SM Duma AC Duhaime MR Grove JH Turco 2012 Cognitive effects of one season of head impacts in a cohort of collegiate contact sport athletes Neurology 78 22 1777 1784 10.1212/WNL.0b013e3182582fe7
122. TW McAllister AJ Saykin LA Flashman MB Sparling SC Johnson SJ Guerin AC Mamourian JB Weaver N Yanofsky 1999 Brain activation during working memory 1 month after mild traumatic brain injury: a functional MRI study Neurology 53 6 1300 1308
123. P McCrory 2001 Does second impact syndrome exist? Clin J Sport Med 11 3 144 149
124. McCrory P, Meeuwisse W, Johnston K, Dvorak J, Aubry M, Molloy M, Cantu R (2009) Consensus statement on concussion in sport-the 3rd International Conference on concussion in sport, held in Zurich, November 2008. J Clin Neurosci 16(6):755-763. doi: 10.1016/j.jocn.2009.02.002
125. McCrory P, Meeuwisse WH, Aubry M, Cantu B, Dvorak J, Echemendia RJ, Engebretsen L, Johnston K, Kutcher JS, Raftery M, Sills A, Benson BW, Davis GA, Ellenbogen RG, Guskiewicz K, Herring SA, Iverson GL, Jordan BD, Kissick J, McCrea M, McIntosh AS, Maddocks D, Makdissi M, Purcell L, Putukian M, Schneider K, Tator CH, Turner M (2013) Consensus statement on concussion in sport: the 4th International Conference on Concussion in Sport held in Zurich, November 2012. Br J Sports Med 47 (5):250-258. doi: 10.1136/bjsports-2013-092313
126. AC McKee RC Cantu CJ Nowinski ET Hedley-Whyte BE Gavett AE Budson VE Santini HS Lee CA Kubilus RA Stern 2009 Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury J Neuropathol Exp Neurol 68 7 709 735 10.1097/NEN.0b013e3181a9d503
127. McKee AC, Gavett BE, Stern RA, Nowinski CJ, Cantu RC, Kowall NW, Perl DP, Hedley-Whyte ET, Price B, Sullivan C, Morin P, Lee HS, Kubilus CA, Daneshvar DH, Wulff M, Budson AE (2010) TDP-43 proteinopathy and motor neuron disease in chronic traumatic encephalopathy. J Neuropathol Exp Neurol. doi: 10.1097/NEN.0b013e3181ee7d85
128. AC McKee TD Stein CJ Nowinski RA Stern DH Daneshvar VE Alvarez HS Lee G Hall SM Wojtowicz CM Baugh DO Riley CA Kubilus KA Cormier MA Jacobs BR Martin CR Abraham T Ikezu RR Reichard BL Wolozin AE Budson LE Goldstein NW Kowall RC Cantu 2013 The spectrum of disease in chronic traumatic encephalopathy Brain 136 Pt 1 43 64 10.1093/brain/aws307
129. JB McQuillen EN McQuillen P Morrow 1988 Trauma, sport, and malignant cerebral edema Am J Forensic Med Pathol 9 1 12 15
130. DF Meaney DH Smith DI Shreiber AC Bain RT Miller DT Ross TA Gennarelli 1995 Biomechanical analysis of experimental diffuse axonal injury J Neurotrauma 12 4 689 694
131. WP Meehan 3rd RG Bachur 2009 Sport-related concussion Pediatrics 123 1 114 123 10.1542/peds.2008-0309
132. LE Middleton DE Barnes LY Lui K Yaffe 2010 Physical activity over the life course and its association with cognitive performance and impairment in old age J Am Geriatr Soc 58 7 1322 1326 10.1111/j.1532-5415.2010.02903.x
133. VJ Miele L Carson A Carr JE Bailes 2004 Acute on chronic subdural hematoma in a female boxer: a case report Med Sci Sports Exerc 36 11 1852 1855
134. K Moisse J Mepham K Volkening I Welch T Hill MJ Strong 2009 Cytosolic TDP-43 expression following axotomy is associated with caspase 3 activation in NFL-/- mice: support for a role for TDP-43 in the physiological response to neuronal injury Brain Res 1296 176 186 10.1016/j.brainres.2009.07.023
135. K Moisse K Volkening C Leystra-Lantz I Welch T Hill MJ Strong 2009 Divergent patterns of cytosolic TDP-43 and neuronal progranulin expression following axotomy: implications for TDP-43 in the physiological response to neuronal injury Brain Res 1249 202 211 10.1016/j.brainres.2008.10.021
136. R Morales KM Green C Soto 2009 Cross currents in protein misfolding disorders: interactions and therapy CNS Neurol Disord: Drug Targets 8 5 363 371
137. T Mori Y Katayama T Kawamata 2006 Acute hemispheric swelling associated with thin subdural hematomas: pathophysiology of repetitive head injury in sports Acta Neurochirurgica Supplement 96 40 43
138. Morris S (2002) Heading the ball killed striker. The Guardian, November 11. Retrieved from http://www.theguardian.com/uk/2002/nov/12/football. stevenmorris
139. Mueller FO, Cantu RC (2009) Catastrophic football injuries annual report. National Center for Catastrophic Injury Research
140. Mueller FO, Cantu RC (Spring 2003) Catastrophic sport injury research 26th annual report: fall 1982-Spring 2003. National Center for Catastrophic Injury Research
141. MG Murer Q Yan R Raisman-Vozari 2001 Brain-derived neurotrophic factor in the control human brain, and in Alzheimer's disease and Parkinson's disease Prog Neurobiol 63 1 71 124
142. RS Naunheim J Standeven C Richter LM Lewis 2000 Comparison of impact data in hockey, football, and soccer J Trauma 48 5 938 941
143. J Niebauer JP Cooke 1996 Cardiovascular effects of exercise: role of endothelial shear stress J Am Coll Cardiol 28 7 1652 1660 10.1016/S0735-1097(96) 00393-2
144. Y Okawa K Ishiguro SC Fujita 2003 Stress-induced hyperphosphorylation of tau in the mouse brain FEBS Lett 535 1-3 183 189
145. A Olsson L Csajbok M Ost K Hoglund K Nylen L Rosengren B Nellgard K Blennow 2004 Marked increase of beta-amyloid(1-42) and amyloid precursor protein in ventricular cerebrospinal fluid after severe traumatic brain injury J Neurol 251 7 870 876 10.1007/s00415-004-0451-y
146. Omalu B, Bailes J, Hamilton RL, Kamboh MI, Hammers J, Case M, Fitzsimmons R (2011) Emerging histomorphologic phenotypes of chronic traumatic encephalopathy in American athletes. Neurosurgery 69(1):173-183; discussion 183. doi: 10.1227/NEU.0b013e318212bc7b
147. Omalu BI, DeKosky ST, Hamilton RL, Minster RL, Kamboh MI, Shakir AM, Wecht CH (2006) Chronic traumatic encephalopathy in a national football league player: part II. Neurosurgery 59(5):1086-1092; discussion 1092-1083. doi: 10.1227/01.NEU.0000245601.69451.27
148. Omalu BI, DeKosky ST, Minster RL, Kamboh MI, Hamilton RL, Wecht CH (2005) Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 57(1):128-134; discussion 128-134
149. MB Oni EA Wilde ED Bigler SR McCauley TC Wu R Yallampalli Z Chu X Li JV
150. DR Oppenheimer 1968 Microscopic lesions in the brain following head injury J Neurol Neurosurg Psychiatry 31 4 299 306
151. S Pedersen E Seidman 2004 Team sports achievement and self-esteem development among urban adolescent girls Psychol Women Q 28 4 412 422 10.1111/j.1471-6402.2004.00158.x
152. Petersen AM, Pedersen BK (2005) The anti-inflammatory effect of exercise. J Appl Physiol (1985) 98(4):1154-1162. doi: 10.1152/japplphysiol.00164.2004
153. GM Petzinger BE Fisher S McEwen JA Beeler JP Walsh MW Jakowec 2013 Exercise-enhanced neuroplasticity targeting motor and cognitive circuitry in Parkinson's disease Lancet Neurol 12 7 716 726 10.1016/S1474-4422(13)70123-6
154. Physical activity guidelines advisory committee report (2008). Available from http://www.health.gov/paguidelines/report/
155. JT Povlishock 1992 Traumatically induced axonal injury: pathogenesis and pathobiological implications Brain Pathol 2 1 1 12
156. JT Povlishock DP Becker CL Cheng GW Vaughan 1983 Axonal change in minor head injury J Neuropathol Exp Neurol 42 3 225 242
157. C Randolph S Karantzoulis K Guskiewicz 2013 Prevalence and characterization of mild cognitive impairment in retired national football league players J Int Neuropsychol Soc 19 8 873 880 10.1017/S1355617713000805
158. TM Reeves LL Phillips JT Povlishock 2005 Myelinated and unmyelinated axons of the corpus callosum differ in vulnerability and functional recovery following traumatic brain injury Exp Neurol 196 1 126 137 10.1016/j.expneurol. 2005.07.014
159. GW Roberts SM Gentleman A Lynch DI Graham 1991 Beta A4 amyloid protein deposition in brain after head trauma Lancet 338 1422 1433
160. SM Rothman KJ Griffioen R Wan MP Mattson 2012 Brain-derived neurotrophic factor as a regulator of systemic and brain energy metabolism and cardiovascular health Ann N Y Acad Sci 1264 1 49 63 10.1111/j.1749-6632.2012.06525.x
161. MJ Sa 2013 Exercise therapy and multiple sclerosis: a systematic review J Neurol 10.1007/s00415-013-7183-9
162. T Sato S Takeuchi A Saito W Ding H Bamba H Matsuura Y Hisa I Tooyama M Urushitani 2009 Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons Neuroscience 164 4 1565 1578 10.1016/j.neuroscience. 2009.09.050
163. C Sattler KI Erickson P Toro J Schroder 2011 Physical fitness as a protective factor for cognitive impairment in a prospective population-based study in Germany J Alzheimers Dis 26 4 709 718 10.3233/JAD-2011-110548
164. RL Saunders RE Harbaugh 1984 The second impact in catastrophic contact-sports head trauma JAMA 252 4 538 539
165. ML Schmidt V Zhukareva KL Newell VM Lee JQ Trojanowski 2001 Tau isoform profile and phosphorylation state in dementia pugilistica recapitulate Alzheimer's disease Acta Neuropathol (Berl) 101 5 518 524
166. S Schmidt LC Kwee KD Allen EZ Oddone 2010 Association of ALS with head injury, cigarette smoking and APOE genotypes J Neurol Sci 291 1-2 22 29 10.1016/j.jns.2010.01.011
167. CF Sephton B Cenik BK Cenik J Herz G Yu 2012 TDP-43 in central nervous system development and function: clues to TDP-43-associated neurodegeneration Biol Chem 393 7 589 594 10.1515/hsz-2012-0115
168. SM Slobounov K Zhang D Pennell W Ray B Johnson W Sebastianelli 2010 Functional abnormalities in normally appearing athletes following mild traumatic brain injury: a functional MRI study Exp Brain Res 202 2 341 354 10.1007/s00221-009-2141-6
169. DH Smith XH Chen A Iwata DI Graham 2003 Amyloid beta accumulation in axons after traumatic brain injury in humans J Neurosurg 98 5 1072 1077 10.3171/jns.2003.98.5.1072
170. PJ Smith JA Blumenthal BM Hoffman H Cooper TA Strauman K Welsh-Bohmer JN Browndyke A Sherwood 2010 Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials Psychosom Med 72 3 239 252 10.1097/PSY.0b013e3181d14633
171. M Smits DW Dippel GC Houston PA Wielopolski PJ Koudstaal MG Hunink A van der Lugt 2009 Postconcussion syndrome after minor head injury: brain activation of working memory and attention Hum Brain Mapp 30 9 2789 2803
172. AR Snyder JC Martinez RC Bay JT Parsons EL Sauers TC Valovich McLeod 2010 Health-related quality of life differs between adolescent athletes and adolescent nonathletes J Sport Rehabil 19 3 237 248
173. I Sotiropoulos C Catania T Riedemann JP Fry KC Breen TM Michaelidis OF Almeida 2008 Glucocorticoids trigger Alzheimer disease-like pathobiochemistry in rat neuronal cells expressing human tau J Neurochem 107 2 385 397 10.1111/j.1471-4159.2008.05613.x
174. H Soya T Nakamura CC Deocaris A Kimpara M Iimura T Fujikawa H Chang BS McEwen T Nishijima 2007 BDNF induction with mild exercise in the rat hippocampus Biochem Biophys Res Commun 358 4 961 967 10.1016/j.bbrc.2007.04.173
175. Stern RA, Daneshvar DH, Baugh CM, Seichepine DR, Montenigro PH, Riley DO, Fritts NG, Stamm JM, Robbins CA, McHale L, I. S, Stein TD, V. A, Goldstein LE, Budson AE, Kowall NW, Nowinski CJ, Cantu RC, McKee AC (2013) Clinical presentation of neuropathologically-confirmed chronic traumatic encephalopathy in athletes. Neurology (in Press)
176. J Strain N Didehbani CM Cullum S Mansinghani H Conover MA Kraut J Hart Jr KB Womack 2013 Depressive symptoms and white matter dysfunction in retired NFL players with concussion history Neurology 81 1 25 32 10.1212/WNL. 0b013e318299ccf8
177. MJ Strong W Yang 2011 The frontotemporal syndromes of ALS. Clinicopathological correlates J Mol Neurosci 45 3 648 655 10.1007/s12031-011- 9609-0
178. DL Swift CJ Lavie NM Johannsen R Arena CP Earnest JH O'Keefe RV Milani SN Blair TS Church 2013 Physical activity, cardiorespiratory fitness, and exercise training in primary and secondary coronary prevention Circ J Off J Jpn Circ Soc 77 2 281 292
179. N Tajiri T Yasuhara T Shingo A Kondo W Yuan T Kadota F Wang T Baba JT Tayra T Morimoto M Jing Y Kikuchi S Kuramoto T Agari Y Miyoshi H Fujino F Obata I Takeda T Furuta I Date 2010 Exercise exerts neuroprotective effects on Parkinson's disease model of rats Brain Res 1310 200 207 10.1016/j.brainres. 2009.10.075
180. TM Talavage EA Nauman EL Breedlove U Yoruk AE Dye KE Morigaki H Feuer LJ Leverenz 2013 Functionally-detected cognitive impairment in high school football players without clinically-diagnosed concussion J Neurotrauma 10.1089/neu.2010.1512
181. M Thomas TS Haas JJ Doerer JS Hodges BO Aicher RF Garberich FO Mueller RC Cantu BJ Maron 2011 Epidemiology of sudden death in young, competitive athletes due to blunt trauma Pediatrics 128 1 e1 e8
182. AT Tysvaer OV Storli 1989 Soccer injuries to the brain. A neurologic and electroencephalographic study of active football players Am J Sports Med 17 4 573 578
183. A Uematsu M Matsui C Tanaka T Takahashi K Noguchi M Suzuki H Nishijo 2012 Developmental trajectories of amygdala and hippocampus from infancy to early adulthood in healthy individuals PLoS ONE 7 10 e46970 10.1371/journal.pone. 0046970PONE-D-12-12929
184. R Vagnozzi S Signoretti L Cristofori F Alessandrini R Floris E Isgro A Ria S Marziale G Zoccatelli B Tavazzi F Del Bolgia R Sorge SP Broglio TK McIntosh G Lazzarino 2010 Assessment of metabolic brain damage and recovery following mild traumatic brain injury: a multicentre, proton magnetic resonance spectroscopic study in concussed patients Brain 133 11 3232 3242 10.1093/brain/awq200
185. RF Valois KJ Zullig ES Huebner JW Drane 2004 Physical activity behaviors and perceived life satisfaction among public high school adolescents J Sch Health 74 2 59 65
186. H van Praag BR Christie TJ Sejnowski FH Gage 1999 Running enhances neurogenesis, learning, and long-term potentiation in mice Proc Natl Acad Sci USA 96 23 13427 13431
187. H van Praag T Shubert C Zhao FH Gage 2005 Exercise enhances learning and hippocampal neurogenesis in aged mice J Neurosci 25 38 8680 8685 10.1523/JNEUROSCI.1731-05.2005
188. S Vaynman F Gomez-Pinilla 2006 Revenge of the "sit": how lifestyle impacts neuronal and cognitive health through molecular systems that interface energy metabolism with neuronal plasticity J Neurosci Res 84 4 699 715 10.1002/jnr.20979
189. C Voelcker-Rehage B Godde UM Staudinger 2010 Physical and motor fitness are both related to cognition in old age Eur J Neurosci 31 1 167 176 10.1111/j.1460-9568.2009.07014.x
190. Voelcker-Rehage C, Niemann C (2013) Structural and functional brain changes related to different types of physical activity across the life span. Neurosci Biobehav Rev 37 (9 Pt B):2268-2295. doi: 10.1016/j.neubiorev.2013.01. 028
191. MW Voss KI Erickson RS Prakash L Chaddock E Malkowski H Alves JS Kim KS Morris SM White TR Wojcicki L Hu A Szabo E Klamm E McAuley AF Kramer 2010 Functional connectivity: a source of variance in the association between cardiorespiratory fitness and cognition? Neuropsychologia 48 5 1394 1406 10.1016/j.neuropsychologia.2010.01.005
192. KR Walker G Tesco 2013 Molecular mechanisms of cognitive dysfunction following traumatic brain injury Frontiers Aging Neurosci 5 29 10.3389/fnagi.2013.00029
193. J Weuve JH Kang JE Manson MM Breteler JH Ware F Grodstein 2004 Physical activity, including walking, and cognitive function in older women JAMA 292 12 1454 1461 10.1001/jama.292.12.1454
194. L White 2009 Brain lesions at autopsy in older Japanese-American men as related to cognitive impairment and dementia in the final years of life: a summary report from the Honolulu-Asia aging study J Alzheimers Dis 18 3 713 725 10.3233/JAD-2009-1178
195. BJ Wilcox JG Beckwith RM Greenwald JJ Chu TW McAllister LA Flashman AC Maerlender AC Duhaime JJ Crisco 2013 Head impact exposure in male and female collegiate ice hockey players J Biomech 10.1016/j.jbiomech.2013.10.004
196. EA Wilde SR McCauley JV Hunter ED Bigler Z Chu ZJ Wang GR Hanten M Troyanskaya R Yallampalli X Li J Chia HS Levin 2008 Diffusion tensor imaging of acute mild traumatic brain injury in adolescents Neurology 70 12 948 955 10.1212/01.wnl.0000305961.68029.54
197. EK Wise JM Hoffman JM Powell CH Bombardier KR Bell 2012 Benefits of exercise maintenance after traumatic brain injury Arch Phys Med Rehabil 93 8 1319 1323 10.1016/j.apmr.2012.05.009
198. CF Xia J Arteaga G Chen U Gangadharmath LF Gomez D Kasi C Lam Q Liang C Liu VP Mocharla F Mu A Sinha H Su AK Szardenings JC Walsh E Wang C Yu W Zhang T Zhao HC Kolb 2013 [(18)F]T807, a novel tau positron emission tomography imaging agent for Alzheimer's disease Alzheimers Dement 10.1016/j.jalz.2012.11.008
199. K Yaffe D Barnes M Nevitt LY Lui K Covinsky 2001 A prospective study of physical activity and cognitive decline in elderly women: women who walk Arch Intern Med 161 14 1703 1708
200. LM Yung I Laher X Yao ZY Chen Y Huang FP Leung 2009 Exercise, vascular wall and cardiovascular diseases: an update (part 2) Sports Med 39 1 45 63 10.2165/00007256-200939010-00004
201. W Zhang J Arteaga DK Cashion G Chen U Gangadharmath LF Gomez D Kasi C Lam Q Liang C Liu VP Mocharla F Mu A Sinha AK Szardenings E Wang JC Walsh C Xia C Yu T Zhao HC Kolb 2012 A highly selective and specific PET tracer for imaging of Tau pathologies J Alzheimers Dis 31 3 601 612 10.3233/JAD-2012-120712