Hypoconnectivity and hyperfrontality in retired american football players

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Hampshire, Adam ^a,b   MacDonald, Alex ^b   Owen, Adrian M ^b  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

^b UNIVERSITY OF WESTERN ONTARIO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

ADULT; ARTICLE; ATHLETE; BRAIN INJURY; BRAIN MAPPING; CONNECTOME; FEMALE; FOOTBALL; FRONTAL LOBE; HUMAN; INJURY; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TEST; NUCLEAR MAGNETIC RESONANCE IMAGING; PATHOPHYSIOLOGY; SUPPORT VECTOR MACHINE; YOUNG ADULT;

ADULT; ATHLETES; BRAIN INJURY, CHRONIC; BRAIN MAPPING; CONNECTOME; FEMALE; FOOTBALL; FRONTAL LOBE; HUMANS; MAGNETIC RESONANCE IMAGING; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; SUPPORT VECTOR MACHINES; YOUNG ADULT;

EID: 84889577876     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02972     Document Type: Article

References (32)

1. Russo, M. B. & Crutchfield, K. E. Ethical perspectives in neurology: sportsacquired traumatic brain injury. Continuum (Minneap Minn) 16, 161-165, doi:10.1212/01.CON.0000391462.98911.26 (2010).
2. Langlois, J. A., Rutland-Brown, W. &Wald, M. M. The epidemiology and impact of traumatic brain injury: a brief overview. J Head Trauma Rehabil 21, 375-378 (2006). (Pubitemid 44413110)
3. Crisco, J. J. et al. Frequency and location of head impact exposures in individual collegiate football players. J Athl Train 45, 549-559, doi:10.4085/1062-6050-45.6.549 (2010).
4. Crisco, J. J. et al.Head impact exposure in collegiate football players. J Biomech 44, 2673-2678, doi:10.1016/j.jbiomech.2011.08.003 (2011).
5. Greenwald, R. M., Gwin, J. T., Chu, J. J. & Crisco, J. J. Head impact severity measures for evaluating mild traumatic brain injury risk exposure. Neurosurgery 62, 789-798; discussion 798, doi:10.1227/01.neu.0000318162.67472.ad (2008).
6. Marchi, N. et al. Consequences of repeated blood-brain barrier disruption in football players. PLoS One 8, e56805, doi:10.1371/journal.pone.0056805 (2013).
7. Pellman, E. J., Lovell, M. R., Viano, D. C. & Casson, I. R. Concussion in professional football: recovery of NFL and high school athletes assessed by computerized neuropsychological testing-Part 12. Neurosurgery 58, 263-274; discussion 263-274, doi:10.1227/01.NEU.0000200272.56192.62 (2006). (Pubitemid 43212780)
8. Pellman, E. J., Lovell, M. R., Viano, D. C., Casson, I. R. & Tucker, A. M. Concussion in professional football: neuropsychological testing-part 6. Neurosurgery 55, 1290-1303; discussion 1303-1295 (2004). (Pubitemid 39612871)
9. Guskiewicz, K. M. et al. Association between recurrent concussion and late-life cognitive impairment in retired professional football players. Neurosurgery 57, 719-726; discussion 719-726 (2005).
10. Lehman, E. J., Hein, M. J., Baron, S. L.&Gersic, C. M. Neurodegenerative causes of death among retired National Football League players. Neurology 79, 1970-1974, doi:10.1212/WNL.0b013e31826daf50 (2012).
11. Weir, D. R., Jackson, J. S. & Sonnega, A. National Football League Player Care Foundation: Study of retired NFL players. (Institute for Social Research University of Michigan, Ann Arbor, MI, 2009).
12. Omalu, B. I. et al. Chronic traumatic encephalopathy in a National Football League player. Neurosurgery 57, 128-134; discussion 128-134 (2005).
13. McKee, A. C. et al. Chronic traumatic encephalopathy in athletes: progressive tauopathy after repetitive head injury. J Neuropathol Exp Neurol 68, 709-735, doi:10.1097/NEN.0b013e3181a9d503 (2009).
14. McKee, A. C. et al. The spectrum of disease in chronic traumatic encephalopathy. Brain 136, 43-64, doi:10.1093/brain/aws307 (2013).
15. Amen, D. G. et al. Impact of playing American professional football on long-term brain function. J Neuropsychiatry Clin Neurosci 23, 98-106, doi:10.1176/appi.neuropsych.23.1.98 (2011).
16. McMillan, T.M., Teasdale, G. M.,Weir, C. J. & Stewart, E. Death after head injury: the 13 year outcome of a case control study. Journal of neurology, neurosurgery, and psychiatry 82, 931-935, doi:10.1136/jnnp.2010.222232 (2011).
17. Hanna-Pladdy, B. Dysexecutive syndromes in neurologic disease. J Neurol Phys Ther 31, 119-127, doi:10.1097/NPT.0b013e31814a63c2 (2007).
18. Wood, R. L.&Liossi, C. The ecological validity of executive tests in a severely brain injured sample. Arch Clin Neuropsychol 21, 429-437, doi:10.1016/j.acn.2005.06.014 (2006). (Pubitemid 44247521)
19. Williams-Gray, C. H.,Hampshire, A., Robbins, T. W., Owen, A. M.&Barker, R. A. Catechol O-methyltransferase Val158Met genotype influences frontoparietal activity during planning in patients with Parkinson's disease. J Neurosci 27, 4832-4838 (2007). (Pubitemid 46699066)
20. Shallice, T. Specific impairments of planning. Philos Trans R Soc Lond B Biol Sci 298, 199-209 (1982).
21. Belanger, H. G., Spiegel, E. & Vanderploeg, R. D. Neuropsychological performance following a history of multiple self-reported concussions: a metaanalysis. J Int Neuropsychol Soc 16, 262-267, doi:10.1017/S1355617709991287 (2010).
22. Bressler, S. L. & Seth, A. K. Wiener-Granger causality: a well established methodology. Neuroimage 58, 323-329, doi:10.1016/j.neuroimage.2010. 02.059 (2011).
23. Seth, A. K. A MATLAB toolbox for Granger causal connectivity analysis. J Neurosci Methods 186, 262-273, doi:10.1016/j.jneumeth.2009.11.020 (2010).
24. Chen, J. K. et al. Functional abnormalities in symptomatic concussed athletes: an fMRI study. Neuroimage 22, 68-82, doi:10.1016/j.neuroimage.2003.12. 032 (2004). (Pubitemid 38515814)
25. Jantzen, K. J., Anderson, B., Steinberg, F. L. & Kelso, J. A. A prospective functional MR imaging study of mild traumatic brain injury in college football players. AJNR Am J Neuroradiol 25, 738-745 (2004). (Pubitemid 38657654)
26. Pardini, J. E. et al. Postconcussive symptoms are associated with compensatory cortical recruitment during a workingmemory task. Neurosurgery 67, 1020-1027; discussion 1027-1028, doi:10.1227/NEU.0b013e3181ee33e2 (2010).
27. Slobounov, S. M. et al. Functional abnormalities in normally appearing athletes following mild traumatic brain injury: a functional MRI study. Exp Brain Res 202, 341-354, doi:10.1007/s00221-009-2141-6 (2010).
28. Grant, J. E. et al. A Proof of Concept Study of Tolcapone for Pathological Gambling: Relationships with COMT Genotype and Brain Activation. European Neuropsychopharmacology (2013).
29. Brett, M., Anton, J., Valabregue, R. & Poline, J. in 8th International Conference on Functional Mapping of the Human Brain.
30. Bullmore, E. T. et al. Global, voxel, and cluster tests, by theory and permutation, for a difference between two groups of structural MR images of the brain. IEEE Trans Med Imaging 18, 32-42 (1999).
31. Hayasaka, S. & Nichols, T. E. Validating cluster size inference: random field and permutation methods. Neuroimage 20, 2343-2356 (2003). (Pubitemid 37543644)
32. Hampshire, A.,Highfield, R. R., Parkin, B. L. & Owen, A. M. Fractionating human intelligence. Neuron 76, 1225-1237, doi:10.1016/j.neuron. 2012.06.022 (2012).