Amyloid β accumulation in axons after traumatic brain injury in humans

Journal of Neurosurgery

Volumn 98, Issue 5, 2003, Pages 1072-1077

  Smith, Douglas H ^a   Chen, Xiao Han ^b   Iwata, Akira ^b   Graham, David I ^b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b NONE

Author keywords

Amyloid; Amyloid precursor protein; Axonal injury; Traumatic brain injury

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; ANTIBODY; NEUROFILAMENT PROTEIN; PARAFFIN;

ADOLESCENT; ADULT; AGED; ARTICLE; BRAIN INJURY; BRAIN NERVE CELL; BRAIN TISSUE; CLINICAL ARTICLE; CONTROLLED STUDY; DEATH; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; NERVE FIBER; PRIORITY JOURNAL; PROTEIN LOCALIZATION; STAINING;

EID: 0037404532     PISSN: 00223085     EISSN: None     Source Type: Journal    
DOI: 10.3171/jns.2003.98.5.1072     Document Type: Article

References (29)

1. Adams JH, Graham DI, Gennarelli TA, et al: Diffuse axonal injury in non-missile head injury. J Neurol Neurosurg Psychiatry 54: 481-483, 1991
2. Adle-Biassette H, Duyckaerts C, Wasowicz M, et al: Beta AP deposition and head trauma. Neurobiol Aging 17:415-419, 1996
3. Emmerling MR, Morganti-Kossmann MC, Kossmann T, et al: Traumatic brain injury elevates the Alzheimer's amyloid peptide A beta 42 in human CSF. A possible role for nerve cell injury. Ann NY Acad Sci 903:118-122, 2000
4. Gentleman SM, Nash MJ, Sweeting CJ, et al: Related beta-amyloid precursor protein (beta APP) as a marker for axonal injury after head injury. Neurosci Lett 160:139-144, 1993
5. Gottlieb S: Head injury doubles the risk of Alzheimer's disease. Br Med J 321:1100, 2000
6. Graham DI, Gentleman SM, Lynch A, et al: Distribution of betaamyloid protein in the brain following severe head injury. Neuropathol Appl Neurobiol 21:27-34, 1995
7. Friedman G, Froom P, Sazbon L, et al: Apolipoprotein E-epsilon4 genotype predicts a poor outcome in survivors of traumatic brain injury. Neurology 52:244-248, 1999
8. Horsburgh K, McCarron MO, White F, et al: The role of apolipoprotein E in Alzheimer's disease, acute brain injury and cerebrovascular disease: evidence of common mechanisms and utility of animal models. Neurobiol Aging 21:245-255, 2000
9. Iwata A, Chen XH, McIntosh TK, et al Long-term accumulation of amyloid-β in axons following brain trauma without persistent upregulation of amyloid precursor protein genes. J Neuropathol Exp Neurol 61:1056-1068, 2002
10. Lewen A, Li GL, Nilsson P, et al: Traumatic brain injury in rat produces changes of β-amyloid precursor protein immunoreactivity. Neuroreport 6:357-360, 1995
11. Lye TC, Shores EA: Traumatic brain injury as a risk factor for Alzheimer's disease: a review. Neuropsychol Rev 10:115-129, 2000
12. Mortimer JA, van Duijn CM, Chandra V, et al: Head trauma as a risk factor for Alzheimer's disease: a collaborative re-analysis of case-control studies. EURODEM Risk Factors Research Group. Int J Epidemiol 20 (Suppl 2):S28-S35, 1991
13. Nemetz PN, Leibson C, Naessens JM, et al: Traumatic brain injury and time to onset of Alzheimer's disease: a population-based study. Am J Epidemiol 149:32-40, 1999
14. Nicoll JA, Roberts GW, Graham DI: Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury. Nat Med 1:135-137, 1995
15. Pierce JE, Smith DH, Trojanowski JQ, et al: Enduring cognitive, neurobehavioral and histopathological changes persist for up to one year following severe experimental brain injury in rats. Neuroscience 87:359-369, 1998
16. Pierce JE, Trojanowski JQ, Graham DI, et al: Immunohistochemical characterization of alterations in the distribution of amyloid percursor proteins and β-amyloid peptide after experimental brain injury in the rat. J Neurosci 16:1083-1090, 1996
17. Raby CA, Morganti-Kossmann MC, Kossmann T, et al: Traumatic brain injury increases beta-amyloid peptide 1-42 in cerebrospinal fluid. J Neurochem 71:2505-2509, 1998
18. Rasmusson DX, Brandt J, Martin DB, et al: Head injury as a risk factor in Alzheimer's disease. Brain Inj 9:213-219, 1995
19. Roberts GW, Gentleman SM, Lynch A, et al: beta A4 amyloid protein deposition in brain after head trauma. Lancet 338: 1422-1423, 1991
20. Schmechel DE, Saunders AM, Strittmatter WJ, et al: Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease. Proc Natl Acad Sci USA 90:9649-9653, 1993
21. Schofield PW, Tang M, Marder K, et al: Alzheimer's disease after remote head injury: an incidence study. J Neurol Neurosurg Psychiatry 62:119-124, 1997
22. Sherriff FE, Bridges LR, Sivaloganathan S: Early detection of axonal injury after human head trauma using immunocytochemistry for beta-amyloid precursor protein. Acta Neuropathol 87: 55-62, 1994
23. Smith DH, Chen XH, Nonaka M, et al: Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig. J Neuropathol Exp Neurol 58:982-992, 1999
24. Smith DH, Meaney DF: Axonal damage in traumatic brain injury. Neuroscientist 6:483-495, 2000
25. Smith DH, Nakamura M, McIntosh TK, et al: Brain trauma induces massive hippocampal neuron death linked to a surge in beta-amyloid levels in mice overexpressing mutant amyloid precursor protein. Am J Pathol 153:1005-1010, 1998
26. Smith, DH, Nonaka, M, Miller R, et al: Immediate coma following inertial brain injury in dependent on axonal damage in the brainstem. J Neurosurg 93:315-322, 2000
27. Stone JR, Okonkwo DO, Singleton RH, et al: Caspase-3-mediated cleavage of amyloid precursor protein and formation of amyloid Beta peptide in traumatic axonal injury. J Neurotrauma 19: 601-614, 2002
28. Teasdale GM, Nicoll JA, Murray G, et al: Association of apolipoprotein E polymorphism with outcome after head injury. Lancet 350:1069-1071, 1997
29. Wilkinson AE, Bridges LR, Sivaloganathan S: Correlation of survival time with size of axonal swellings in diffuse axonal injury. Acta Neuropathol 98:197-202, 1999