A review of the effects of physical activity and exercise on cognitive and brain functions in older adults

Journal of Aging Research

Volumn 2013, Issue , 2013, Pages

  Bherer, Louis ^a,b   Erickson, Kirk I ^c   Liu Ambrose, Teresa ^d,e  

^a Gina Cody School of Engineering and Computer Science   (Canada)

^b CENTRE DE RECHERCHE   (Canada)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^e UNIVERSITY OF BRITISH COLUMBIA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

AGING; ANGIOGENESIS; BRAIN FUNCTION; BRAIN REGION; COGNITION; DEGENERATIVE DISEASE; DEMENTIA; EXECUTIVE FUNCTION; EXERCISE; FRAIL ELDERLY; HUMAN; INTERVENTION STUDY; LEISURE; MILD COGNITIVE IMPAIRMENT; NERVOUS SYSTEM DEVELOPMENT; NEUROIMAGING; PHYSICAL ACTIVITY; PHYSICAL CAPACITY; PRIORITY JOURNAL; REVIEW; SENESCENCE; SPATIAL MEMORY; SYNAPTOGENESIS; VOXEL BASED MORPHOMETRY; WORKING MEMORY;

EID: 84884830056     PISSN: 20902204     EISSN: 20902212     Source Type: Journal    
DOI: 10.1155/2013/657508     Document Type: Review

References (86)

1. Wang C. Y., Haskell W. L., Farrell S. W., Lamonte M. J., Blair S. N., Curtin L. R., Hughes J. P., Burt V. L., Cardiorespiratory fitness levels among us adults 20-49 years of age: findings from the 1999-2004 national health and nutrition examination survey. The American Journal of Epidemiology 2010 171 4 426 435 2-s2.0-76649117723 10.1093/aje/kwp412
2. Fratiglioni L., Paillard-Borg S., Winblad B., An active and socially integrated lifestyle in late life might protect against dementia. The Lancet Neurology 2004 3 6 343 353 2-s2.0-2442566380 10.1016/S1474-4422(04)00767-7 (Pubitemid 38648855)
3. Hertzog C., Kramer A. F., Wilson R. S., Lindenberger U., Enrichment effects on adult cognitive development: can the functional capacity of older adults be preserved and enhanced? Psychological Science in the Public Interest 2008 9 1 1 65 2-s2.0-70349179900 10.1111/j.1539-6053.2009.01034.x
4. Kramer A. F., Bherer L., Colcombe S. J., Dong W., Greenough W. T., Environmental influences on cognitive and brain plasticity during aging. Journals of Gerontology A 2004 59 9 940 957 2-s2.0-5644297023 (Pubitemid 39372607)
5. Booth F. W., Gordon S. E., Carlson C. J., Hamilton M. T., Waging war on modern chronic diseases: primary prevention through exercise biology. Journal of Applied Physiology 2000 88 2 774 787 2-s2.0-0033968828 (Pubitemid 30097126)
6. Myers J., Prakash M., Froelicher V., Do D., Partington S., Atwood J. E., Exercise capacity and mortality among men referred for exercise testing. The New England Journal of Medicine 2002 346 11 793 801 2-s2.0-0037076018 10.1056/NEJMoa011858 (Pubitemid 34987553)
7. Larson E. B., Wang L., Bowen J. D., McCormick W. C., Teri L., Crane P., Kukull W., Exercise is associated with reduced risk for incident dementia among persons 65 years of age and older. Annals of Internal Medicine 2006 144 2 73 81 2-s2.0-33644800309 (Pubitemid 46768225)
8. Craik F., Salthouse T., Handbook of Aging and Cognition 2008 3rd New York, NY, USA Psychology Press
9. Reuter-Lorenz P. A., Park D. C., Human neuroscience and the aging mind: a new look at old problems. Journals of Gerontology B 2010 65 4 405 415 2-s2.0-77953628570 10.1093/geronb/gbq035
10. Penke L., Maniega S. M., Murray C., Gow A. J., Valdés Hernández M. C., Clayden J. D., Starr J. M., Wardlaw J. M., Bastin M. E., Deary I. J., A general factor of brain white matter integrity predicts information processing speed in healthy older people. Journal of Neuroscience 2010 30 22 7569 7574 2-s2.0-77953212353 10.1523/JNEUROSCI.1553-10.2010
11. Dennis N. A., Cabeza R., Craik F. I. M., Salthouse T. A., Neuroimaging of healthy cognitive aging. Handbook of Aging and Cognition 2008 3rd New York, NY, USA Psychology Press 1 54
12. Raz N., Cabeza R., Nyberg L., Park D. C., The aging brain observed in vivo: differential changes and there modifiers. Cognitive Neuroscience of Aging 2005 New York, NY, USA Oxford University Press 19 57
13. Raz N., Ghisletta P., Rodrigue K. M., Kennedy K. M., Lindenberger U., Trajectories of brain aging in middle-aged and older adults: regional and individual differences. NeuroImage 2010 51 2 501 511 2-s2.0-77951976368 10.1016/j.neuroimage.2010.03.020
14. Chen J. J., Rosas H. D., Salat D. H., Age-associated reductions in cerebral blood flow are independent from regional atrophy. NeuroImage 2011 55 2 468 478 2-s2.0-79551612703 10.1016/j.neuroimage.2010.12.032
15. Abourezk T., Toole T., Effect of task complexity on the relationship between physical fitness and reaction time in older women. Journal of Aging and Physical Activity 1995 3 251 260
16. Clarkson-Smith L., Hartley A. A., Relationships between physical exercise and cognitive abilities in older adults. Psychology and Aging 1989 4 2 183 189 2-s2.0-0024678793
17. Hillman C. H., Weiss E. P., Hagberg J. M., Hatfield B. D., The relationship of age and cardiovascular fitness to cognitive and motor processes. Psychophysiology 2002 39 3 303 312 2-s2.0-0036250062 10.1017/S0048577201393058 (Pubitemid 34478047)
18. Renaud M., Bherer L., Maquestiaux F., A high level of physical fitness is associated with more efficient response preparation in older adults. Journals of Gerontology B 2010 65 3 317 322 2-s2.0-77951245487 10.1093/geronb/gbq004
19. Spirduso W. W., Reaction and movement time as a function of age and physical activity level. Journals of Gerontology 1975 30 4 435 440 2-s2.0-0016733263
20. Barnes D. E., Yaffe K., Satariano W. A., Tager I. B., A longitudinal study of cardiorespiratory fitness and cognitive function in healthy older adults. Journal of the American Geriatrics Society 2003 51 4 459 465 2-s2.0-0345669746 10.1046/j.1532-5415.2003.51153.x (Pubitemid 36457343)
21. Aichberger M. C., Busch M. A., Reischies F. M., Ströhle A., Heinz A., Rapp M. A., Effect of physical inactivity on cognitive performance after 2.5 years of follow-up: longitudinal results from the survey of health, ageing, and retirement (SHARE). GeroPsych 2010 23 1 7 15 2-s2.0-78649933787 10.1024/1662-9647/a000003
22. Dustman R. E., Ruhling R. O., Russell E. M., Shearer D. E., Bonekat H. W., Shigeoka J. W., Wood J. S., Bradford D. C., Aerobic exercise training and improved neuropsychological function of older individuals. Neurobiology of Aging 1984 5 1 35 42 2-s2.0-0021153521 10.1016/0197-4580(84)90083-6 (Pubitemid 14088822)
23. Rikli R. E., Edwards D. J., Effects of a three-year exercise program on motor function and cognitive processing speed in older women. Research Quarterly for Exercise and Sport 1991 62 1 61 67 2-s2.0-0026130592
24. Hawkins H. L., Kramer A. F., Capaldi D., Aging, exercise, and attention. Psychology and Aging 1992 7 4 643 653 2-s2.0-0027034508 10.1037//0882-7974.7.4. 643
25. Kramer A. F., Hahn S., Cohen N. J., Banich M. T., McAuley E., Harrison C. R., Chason J., Vakil E., Bardell L., Boileau R. A., Colcombe A., Ageing, fitness and neurocognitive function. Nature 1999 400 6743 418 419 2-s2.0-0033614960 10.1038/22682 (Pubitemid 29361788)
26. Albinet C. T., Boucard G., Bouquet C. A., Audiffren M., Increased heart rate variability and executive performance after aerobic training in the elderly. European Journal of Applied Physiology 2010 109 4 617 624 2-s2.0-77954886575 10.1007/s00421-010-1393-y
27. Colcombe S., Kramer A. F., Fitness effects on the cognitive function of older adults: a meta-analytic study. Psychological Science 2003 14 2 125 130 2-s2.0-0038050784 10.1111/1467-9280.t01-1-01430 (Pubitemid 37283096)
28. Etnier J. L., Nowell P. M., Landers D. M., Sibley B. A., A meta-regression to examine the relationship between aerobic fitness and cognitive performance. Brain Research Reviews 2006 52 1 119 130 2-s2.0-33745925273 10.1016/j.brainresrev.2006.01.002 (Pubitemid 44051534)
29. Smiley-Oyen A. L., Lowry K. A., Francois S. J., Kohut M. L., Ekkekakis P., Exercise, fitness, and neurocognitive function in older adults: the "selective improvement" and "cardiovascular fitness" hypotheses. Annals of Behavioral Medicine 2008 36 3 280 291 2-s2.0-57749199936 10.1007/s12160-008-9064-5
30. Renaud M., Maquestiaux F., Joncas S., Kergoat M. J., Bherer L., The effect of three months of aerobic training on response preparation in older adults. Frontiers in Aging Neuroscience 2010 2 article 148
31. Smith P. J., Blumenthal J. A., Hoffman B. M., Cooper H., Strauman T. A., Welsh-Bohmer K., Browndyke J. N., Sherwood A., Aerobic exercise and neurocognitive performance: a meta-analytic review of randomized controlled trials. Psychosomatic Medicine 2010 72 3 239 252 2-s2.0-77951447854 10.1097/PSY.0b013e3181d14633
32. Angevaren M., Aufdemkampe G., Verhaar H. J., Aleman A., Vanhees L., Physical activity and enhanced fitness to improve cognitive function in older people without known cognitive impairment. Cochrane Database of Systematic Reviews 2008 2 CD005381 2-s2.0-44949137396
33. Cassilhas R. C., Viana V. A. R., Grassmann V., Santos R. T., Santos R. F., Tufik S., Mello M. T., The impact of resistance exercise on the cognitive function of the elderly. Medicine and Science in Sports and Exercise 2007 39 8 1401 1407 2-s2.0-34548359428 10.1249/mss.0b013e318060111f (Pubitemid 47344023)
34. Liu-Ambrose T., Donaldson M. G., Ahamed Y., Graf P., Cook W. L., Close J., Lord S. R., Khan K. M., Otago home-based strength and balance retraining improves executive functioning in older fallers: a randomized controlled trial. Journal of the American Geriatrics Society 2008 56 10 1821 1830 2-s2.0-53149089447 10.1111/j.1532-5415.2008.01931.x
35. Fabel K., Kempermann G., Physical activity and the regulation of neurogenesis in the adult and aging brain. NeuroMolecular Medicine 2008 10 2 59 66 2-s2.0-48849109215 10.1007/s12017-008-8031-4
36. Liu-Ambrose T., Nagamatsu L. S., Graf P., Beattie B. L., Ashe M. C., Handy T. C., Resistance training and executive functions: a 12-month randomized controlled trial. Archives of Internal Medicine 2010 170 2 170 178 2-s2.0-75749096280 10.1001/archinternmed.2009.494
37. Rosano C., Newman A. B., Katz R., Hirsch C. H., Kuller L. H., Association between lower digit symbol substitution test score and slower gait and greater risk of mortality and of developing incident disability in well-functioning older adults. Journal of the American Geriatrics Society 2008 56 9 1618 1625 2-s2.0-51249100431 10.1111/j.1532-5415.2008.01856.x
38. Dumurgier J., Elbaz A., Ducimetière P., Tavernier B., Alpérovitch A., Tzourio C., Slow walking speed and cardiovascular death in well functioning older adults: prospective cohort study. The British Medical Journal 2009 339 b4460 2-s2.0-79951605861
39. Hardy S. E., Perera S., Roumani Y. F., Chandler J. M., Studenski S. A., Improvement in usual gait speed predicts better survival in older adults. Journal of the American Geriatrics Society 2007 55 11 1727 1734 2-s2.0-35748937319 10.1111/j.1532-5415.2007.01413.x (Pubitemid 350043779)
40. Voelcker-Rehage C., Nieman C., Structural and functional brain changes related to different types of physical activity across the life span. Neuroscience and Biobehavioral Reviews 2013 10.1016/j.neubiorev.2013.01.028
41. Spirduso W., Francis K., MacRae P., Physical Dimensions of Aging 2005 2nd Champaign, Ill, USA Human Kinetics
42. Lista I., Sorrentino G., Biological mechanisms of physical activity in preventing cognitive decline. Cellular and Molecular Neurobiology 2010 30 4 493 503 2-s2.0-77956263209 10.1007/s10571-009-9488-x
43. Black J. E., Isaacs K. R., Anderson B. J., Alcantara A. A., Greenough W. T., Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proceedings of the National Academy of Sciences of the United States of America 1990 87 14 5568 5572 2-s2.0-0025180876 10.1073/pnas.87.14.5568 (Pubitemid 20260222)
44. Isaacs K. R., Anderson B. J., Alcantara A. A., Black J. E., Greenough W. T., Exercise and the brain: angiogenesis in the adult rat cerebellum after vigorous physical activity and motor skill learning. Journal of Cerebral Blood Flow and Metabolism 1992 12 1 110 119 2-s2.0-0026586247
45. van Praag H., Shubert T., Zhao C., Gage F. H., Exercise enhances learning and hippocampal neurogenesis in aged mice. Journal of Neuroscience 2005 25 38 8680 8685 2-s2.0-25444533023 10.1523/JNEUROSCI.1731-05.2005 (Pubitemid 41362045)
46. Lledo P., Alonso M., Grubb M. S., Adult neurogenesis and functional plasticity in neuronal circuits. Nature Reviews Neuroscience 2006 7 3 179 193 2-s2.0-33644507720 10.1038/nrn1867 (Pubitemid 43292464)
47. Eadie B. D., Redila V. A., Christie B. R., Voluntary exercise alters the cytoarchitecture of the adult dentate gyrus by increasing cellular proliferation, dendritic complexity, and spine density. Journal of Comparative Neurology 2005 486 1 39 47 2-s2.0-17644395604 10.1002/cne.20493 (Pubitemid 40571648)
48. Hu S., Ying Z., Gomez-Pinilla F., Frautschy S. A., Exercise can increase small heat shock proteins (sHSP) and pre- and post-synaptic proteins in the hippocampus. Brain Research 2009 1249 191 201 2-s2.0-58049206654 10.1016/j.brainres.2008.10.054
49. Erickson K. I., Voss M. W., Prakash R. S., Exercise training increases size of hippocampus and improves memory. Proceedings of the National Academy of Sciences of the United States of America 2011 108 7 3017 3022 10.1073/pnas.1015950108
50. Erickson K. I., Kramer A. F., Aerobic exercise effects on cognitive and neural plasticity in older adults. The British Journal of Sports Medicine 2009 43 1 22 24 10.1136/bjsm.2008.052498
51. Hillman C. H., Erickson K. I., Kramer A. F., Be smart, exercise your heart: exercise effects on brain and cognition. Nature Reviews Neuroscience 2008 9 1 58 65 2-s2.0-37349069492 10.1038/nrn2298 (Pubitemid 350295689)
52. Kramer A. F., Erickson K. I., Colcombe S. J., Exercise, cognition, and the aging brain. Journal of Applied Physiology 2006 101 4 1237 1242 2-s2.0-33749330500 10.1152/japplphysiol.00500.2006 (Pubitemid 44497569)
53. Liu-Ambrose T., Nagamatsu L. S., Voss M. W., Khan K. M., Handy T. C., Resistance training and functional plasticity of the aging brain: a 12-month randomized controlled trial. Neurobiology of Aging 2012 33 8 1690 1698 2-s2.0-79959839857 10.1016/j.neurobiolaging.2011.05.010
54. Voelcker-Rehage C., Godde B., Staudinger U. M., Physical and motor fitness are both related to cognition in old age. European Journal of Neuroscience 2010 31 1 167 176 2-s2.0-72949098297 10.1111/j.1460-9568.2009. 07014.x
55. Colcombe S. J., Erickson K. I., Raz N., Webb A. G., Cohen N. J., McAuley E., Kramer A. F., Aerobic fitness reduces brain tissue loss in aging humans. Journals of Gerontology A 2003 58 2 176 180 2-s2.0-0037320180 (Pubitemid 36222821)
56. Erickson K. I., Prakash R. S., Voss M. W., Chaddock L., Hu L., Morris K. S., White S. M., Wójcicki T. R., McAuley E., Kramer A. F., Aerobic fitness is associated with hippocampal volume in elderly humans. Hippocampus 2009 19 10 1030 1039 2-s2.0-66649114067 10.1002/hipo.20547
57. Ruscheweyh R., Willemer C., Krüger K., Duning T., Warnecke T., Sommer J., Völker K., Ho H. V., Mooren F., Knecht S., Flöel A., Physical activity and memory functions: an interventional study. Neurobiology of Aging 2011 32 7 1304 1319 2-s2.0-79955705244 10.1016/j.neurobiolaging.2009.08. 001
58. Colcombe S. J., Kramer A. F., Erickson K. I., Scalf P., McAuley E., Cohen N. J., Webb A., Jerome G. J., Marquez D. X., Elavsky S., Cardiovascular fitness, cortical plasticity, and aging. Proceedings of the National Academy of Sciences of the United States of America 2004 101 9 3316 3321 10.1073/pnas.0400266101 (Pubitemid 38327778)
59. Voss M. W., Prakash R. S., Erickson K. I., Basak C., Chaddock L., Kim J. S., Alves H., Heo S., Szabo A. N., White S. M., Wójcicki T. R., Mailey E. L., Gothe N., Olson E. A., McAuley E., Kramer A. F., Plasticity of brain networks in a randomized intervention trial of exercise training in older adults. Frontiers in Aging Neuroscience 2010 2 article 32 10.3389/fnagi.2010. 00032
60. Spirduso W., Poon L., Chodzo-Zajko W., Spirduso W., Poon L., Chodzo-Zajko W., Using resources and reserves in an exercise-cognition model. Exercise and Its Mediating Effects on Cognition 2008 Champaign, Ill, USA Human Kinetics 3 11
61. Bartholomew J., Ciccolo J., Spirduso W., Poon L., Chodzo-Zajko W., Exercise, depression, and cognition. Exercise and Its Mediating Effects on Cognition 2008 Champaign, Ill, USA Human Kinetics 33 46
62. McAuley E., Elavsky S., Spirduso W., Poon L., Chodzo-Zajko W., Self-efficacy, physical activity, and cognitive function. Exercise and Its Mediating Effects on Cognition 2008 Champaign, Ill, USA Human Kinetics 69 84
63. Joseph J., Spirduso W., Poon L., Chodzo-Zajko W., Diet, motor behavior, and cognition. Exercise and Its Mediating Effects on Cognition 2008 Champaign, Ill, USA Human Kinetics 119 129
64. Lopez M., Spirduso W., Poon L., Chodzo-Zajko W., Exercise and sleep quality. Exercise and Its Mediating Effects on Cognition 2008 Champaign, Ill, USA Human Kinetics 131 146
65. Vitiello M. V., Spirduso W., Poon L., Chodzo-Zajko W., Exercise, sleep, and cognition: interactions in aging. Exercise and Its Mediating Effects on Cognition 2008 Champaign, Ill, USA Human Kinetics 146 165
66. Fried L. P., Tangen C. M., Walston J., Newman A. B., Hirsch C., Gottdiener J., Seeman T., Tracy R., Kop W. J., Burke G., McBurnie M. A., Frailty in older adults: evidence for a phenotype. Journals of Gerontology A 2001 56 3 M146 M156 2-s2.0-2442699834 (Pubitemid 32187141)
67. Rockwood K., Howlett S. E., MacKnight C., Beattie B. L., Bergman H., Hebert R., McDowell I., Prevalence, attributes, and outcomes of fi tness and frailty in community-dwelling older adults: report from the Canadian study of health and aging. Journals of Gerontology A 2004 59 12 1310 1317 (Pubitemid 40209418)
68. Landi F., Abbatecola A. M., Provinciali M., Corsonello A., Bustacchini S., Manigrasso L., Cherubini A., Bernabei R., Lattanzio F., Moving against frailty: does physical activity matter? Biogerontology 2010 11 5 537 545 2-s2.0-78049270285 10.1007/s10522-010-9296-1
69. Peterson M. J., Giuliani C., Morey M. C., Pieper C. F., Evenson K. R., Mercer V., Cohen H. J., Visser M., Brach J. S., Kritchevsky S. B., Goodpaster B. H., Rubin S., Satterfield S., Newman A. B., Simonsick E. M., Physical activity as a preventative factor for frailty: the health, aging, and body composition study. Journals of Gerontology A 2009 64 1 61 68 2-s2.0-64249120400 10.1093/gerona/gln001
70. Helbostad J. L., Sletvold O., Moe-Nilssen R., Home training with and without additional group training in physically frail old people living at home: effect on health-related quality of life and ambulation. Clinical Rehabilitation 2004 18 5 498 508 2-s2.0-4043171300 10.1191/0269215504cr761oa (Pubitemid 39076875)
71. Langlois F., Vu T. T. M., Chassé K., Dupuis G., Kergoat M. J., Bherer L., Benefits of physical exercise training on cognition and quality of life in frail older adults. Journals of Gerontology B 2013 68 3 400 404 10.1093/geronb/gbs069
72. Alzheimer's Association, Alzheimer's disease facts and figures. Alzheimer's & Dementia 2011 7 2
73. Geda Y. E., Roberts R. O., Knopman D. S., Christianson T. J. H., Pankratz V. S., Ivnik R. J., Boeve B. F., Tangalos E. G., Petersen R. C., Rocca W. A., Physical exercise, aging, and mild cognitive impairment a population-based study. Archives of Neurology 2010 67 1 80 86 2-s2.0-74949111301 10.1001/archneurol.2009.297
74. Burns J. M., Cronk B. B., Anderson H. S., Donnelly J. E., Thomas G. P., Harsha A., Brooks W. M., Swerdlow R. H., Cardiorespiratory fitness and brain atrophy in early Alzheimer disease. Neurology 2008 71 3 210 216 2-s2.0-48449106896 10.1212/01.wnl.0000317094.86209.cb
75. Chang M., Jonsson P. V., Snaedal J., Bjornsson S., Saczynski J. S., Aspelund T., Eiriksdottir G., Jonsdottir M. K., Lopez O. L., Harris T. B., Gudnason V., Launer L. J., The effect of midlife physical activity on cognitive function among older adults: AGES-Reykjavik study. Journals of Gerontology A 2010 65 12 1369 1374 10.1093/gerona/glq152
76. Boyle P. A., Buchman A. S., Wilson R. S., Leurgans S. E., Bennett D. A., Physical frailty is associated with incident mild cognitive impairment in community-based older persons. Journal of the American Geriatrics Society 2010 58 2 248 255 2-s2.0-75749155858 10.1111/j.1532-5415.2009.02671.x
77. Sofi F., Valecchi D., Bacci D., Abbate R., Gensini G. F., Casini A., Macchi C., Physical activity and risk of cognitive decline: a meta-analysis of prospective studies. Journal of Internal Medicine 2011 269 1 107 117 2-s2.0-78650213509 10.1111/j.1365-2796.2010.02281.x
78. Heyn P., Abreu B. C., Ottenbacher K. J., The effects of exercise training on elderly persons with cognitive impairment and dementia: a meta-analysis. Archives of Physical Medicine and Rehabilitation 2004 85 10 1694 1704 2-s2.0-5344237365 10.1016/j.apmr.2004.03.019 (Pubitemid 39349417)
79. Lautenschlager N. T., Cox K. L., Flicker L., Foster J. K., van Bockxmeer F. M., Xiao J., Greenop K. R., Almeida O. P., Effect of physical activity on cognitive function in older adults at risk for Alzheimer disease: a randomized trial. The Journal of the American Medical Association 2008 300 9 1027 1037 2-s2.0-50949110086 10.1001/jama.300.9.1027
80. Eggermont L. H. P., Swaab D. F., Hol E. M., Scherder E. J. A., Walking the line: a randomised trial on the effects of a short term walking programme on cognition in dementia. Journal of Neurology, Neurosurgery and Psychiatry 2009 80 7 802 804 2-s2.0-67650470231 10.1136/jnnp.2008.158444
81. Baker L. D., Frank L. L., Foster-Schubert K., Green P. S., Wilkinson C. W., McTiernan A., Plymate S. R., Fishel M. A., Watson G. S., Cholerton B. A., Duncan G. E., Mehta P. D., Craft S., Effects of aerobic exercise on mild cognitive impairment: a controlled trial. Archives of Neurology 2010 67 1 71 79 2-s2.0-74949118967 10.1001/archneurol.2009.307
82. Kemoun G., Thibaud M., Roumagne N., Carette P., Albinet C., Toussaint L., Paccalin M., Dugué B., Effects of a physical training programme on cognitive function and walking efficiency in elderly persons with dementia. Dementia and Geriatric Cognitive Disorders 2010 29 2 109 114 2-s2.0-76149113942 10.1159/000272435
83. Lam L. C. W., Chau R. C. M., Wong B. M. L., Fung A. W. T., Lui V. W. C., Tam C. C. W., Leung G. T. Y., Kwok T. C. Y., Chiu H. F. K., Ng S., Chan W. M., Interim follow-up of a randomized controlled trial comparing Chinese style mind body (Tai Chi) and stretching exercises on cognitive function in subjects at risk of progressive cognitive decline. International Journal of Geriatric Psychiatry 2011 26 7 733 740 2-s2.0-79953889151 10.1002/gps.2602
84. Nagamatsu L. S., Chan A., Davis J. C., Beattie B. L., Graf P., Voss M. W., Sharma D., Liu-Ambrose T., Physical activity improves verbal and spatial memory in older adults with probable mild cognitive impairment: a 6-month randomized controlled trial. Journal of Aging Research 2013 2013 10 861893 10.1155/2013/861893
85. Cyarto E. V., Lautenschlager N. T., Desmond P. M., Ames D., Szoeke C., Salvado O., Sharman M. J., Ellis K. A., Phal P. M., Masters C. L., Rowe C. C., Martins R. N., Cox K. L., Protocol for a randomized controlled trial evaluating the effect of physical activity on delaying the progression of white matter changes on MRI in older adults with memory complaints and mild cognitive impairment: the AIBL active trial. BMC Psychiatry 2012 12 article 167 10.1186/1471-244X-12-167
86. Tyndall A. V., Davenport M. H., Wilson B. J., Burek G. M., Arsenault-Lapierre G., Haley E., Eskes G. A., Friedenreich C. M., Hill M. D., Hogan D. B., Longman R. S., Anderson T. J., Leigh R., Smith E. E., Poulin M. J., The brain-in-motion study: effect of a 6-month aerobic exercise intervention on cerebrovascular regulation and cognitive function in older adults. BMC Geriatrics 2013 13 article 21 10.1186/1471-2318-13