메뉴 건너뛰기




Volumn 336, Issue 1-2, 2014, Pages 161-168

CYP2D6 phenotypes and Parkinson's disease risk: A meta-analysis

Author keywords

CYP2D6; Meta analysis; Metabolizer; Parkinson's disease; Phenotypes; Polymorphisms

Indexed keywords

CYTOCHROME P450 2D6;

EID: 84892601053     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2013.10.030     Document Type: Article
Times cited : (31)

References (55)
  • 1
    • 0003100989 scopus 로고
    • The pathology of parkinsonian disorders
    • Academic Press
    • W G The pathology of parkinsonian disorders N. Quinn, P. Jenner, Disorders of movement London 1989 Academic Press 33 57
    • (1989) Disorders of Movement London , pp. 33-57
    • Quinn, N.1    Jenner, P.2
  • 2
    • 0031013848 scopus 로고    scopus 로고
    • Prevalence of parkinsonism and Parkinson's disease in Europe: The EUROPARKINSON Collaborative Study European Community Concerted Action on the Epidemiology of Parkinson's disease
    • M.C. de Rijk et al. Prevalence of parkinsonism and Parkinson's disease in Europe: the EUROPARKINSON Collaborative Study European Community Concerted Action on the Epidemiology of Parkinson's disease J Neurol Neurosurg Psychiatry 62 1 Jan 1997 10 15
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , Issue.1 , pp. 10-15
    • De Rijk, M.C.1
  • 3
    • 0029686092 scopus 로고    scopus 로고
    • Gene-environment interaction in parkinson's disease. The case of CYP2D6 gene polymorphism
    • M.T. Landi, M. Ceroni, E. Martignoni, P.A. Bertazzi, N.E. Caporaso, and G. Nappi Gene-environment interaction in parkinson's disease. The case of CYP2D6 gene polymorphism Adv Neurol 69 1996 61 72
    • (1996) Adv Neurol , vol.69 , pp. 61-72
    • Landi, M.T.1    Ceroni, M.2    Martignoni, E.3    Bertazzi, P.A.4    Caporaso, N.E.5    Nappi, G.6
  • 4
    • 0026608742 scopus 로고
    • Epidemiology of Parkinson's disease
    • C.M. Tanner Epidemiology of Parkinson's disease Neurol Clin 10 2 May 1992 317 329
    • (1992) Neurol Clin , vol.10 , Issue.2 , pp. 317-329
    • Tanner, C.M.1
  • 5
  • 6
    • 0030692086 scopus 로고    scopus 로고
    • Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease
    • O. Bandmann, J. Vaughan, P. Holmans, C.D. Marsden, and N.W. Wood Association of slow acetylator genotype for N-acetyltransferase 2 with familial Parkinson's disease Lancet 350 9085 Oct 18 1997 1136 1139
    • (1997) Lancet , vol.350 , Issue.9085 , pp. 1136-1139
    • Bandmann, O.1    Vaughan, J.2    Holmans, P.3    Marsden, C.D.4    Wood, N.W.5
  • 7
    • 0026747176 scopus 로고
    • Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease
    • C.A. Smith et al. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease Lancet 339 8806 Jun 6 1992 1375 1377
    • (1992) Lancet , vol.339 , Issue.8806 , pp. 1375-1377
    • Smith, C.A.1
  • 8
    • 0026589459 scopus 로고
    • Mutant debrisoquine hydroxylation genes in Parkinson's disease
    • M. Armstrong, A.K. Daly, S. Cholerton, D.N. Bateman, and J.R. Idle Mutant debrisoquine hydroxylation genes in Parkinson's disease Lancet 339 8800 Apr 25 1992 1017 1018
    • (1992) Lancet , vol.339 , Issue.8800 , pp. 1017-1018
    • Armstrong, M.1    Daly, A.K.2    Cholerton, S.3    Bateman, D.N.4    Idle, J.R.5
  • 10
    • 0027330416 scopus 로고
    • Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease
    • M.C. Kurth, and J.H. Kurth Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease Am J Med Genet 48 3 Oct 15 1993 166 168
    • (1993) Am J Med Genet , vol.48 , Issue.3 , pp. 166-168
    • Kurth, M.C.1    Kurth, J.H.2
  • 12
    • 0028964602 scopus 로고
    • Association between the oxidative polymorphism and early onset of Parkinson's disease
    • J.A. Agundez et al. Association between the oxidative polymorphism and early onset of Parkinson's disease Clin Pharmacol Ther 57 3 Mar 1995 291 298
    • (1995) Clin Pharmacol Ther , vol.57 , Issue.3 , pp. 291-298
    • Agundez, J.A.1
  • 13
    • 0029876756 scopus 로고    scopus 로고
    • Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease
    • R. Bordet, F. Broly, A. Destee, C. Libersa, and J.J. Lafitte Lack of relation between genetic polymorphism of cytochrome P-450IID6 and sporadic idiopathic Parkinson's disease Clin Neuropharmacol 19 3 Jun 1996 213 221
    • (1996) Clin Neuropharmacol , vol.19 , Issue.3 , pp. 213-221
    • Bordet, R.1    Broly, F.2    Destee, A.3    Libersa, C.4    Lafitte, J.J.5
  • 14
    • 0030056697 scopus 로고    scopus 로고
    • CYP2D6 allelic frequencies in young-onset Parkinson's disease
    • M.S. Sandy et al. CYP2D6 allelic frequencies in young-onset Parkinson's disease Neurology 47 1 Jul 1996 225 230
    • (1996) Neurology , vol.47 , Issue.1 , pp. 225-230
    • Sandy, M.S.1
  • 15
    • 0029835547 scopus 로고    scopus 로고
    • Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease
    • N. Diederich et al. Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease Ann Neurol 40 3 Sep 1996 463 465
    • (1996) Ann Neurol , vol.40 , Issue.3 , pp. 463-465
    • Diederich, N.1
  • 16
    • 0029846366 scopus 로고    scopus 로고
    • Mutation frequencies of the cytochrome CYP2D6 gene in Parkinson disease patients and in families
    • G. Lucotte, J.C. Turpin, N. Gerard, S. Panserat, and R. Krishnamoorthy Mutation frequencies of the cytochrome CYP2D6 gene in Parkinson disease patients and in families Am J Med Genet 67 4 Jul 26 1996 361 365
    • (1996) Am J Med Genet , vol.67 , Issue.4 , pp. 361-365
    • Lucotte, G.1    Turpin, J.C.2    Gerard, N.3    Panserat, S.4    Krishnamoorthy, R.5
  • 17
    • 0029851872 scopus 로고    scopus 로고
    • The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease
    • T. Gasser et al. The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease J Neurol Neurosurg Psychiatry 61 5 Nov 1996 518 520
    • (1996) J Neurol Neurosurg Psychiatry , vol.61 , Issue.5 , pp. 518-520
    • Gasser, T.1
  • 18
    • 0031472072 scopus 로고    scopus 로고
    • The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: A case-control study and meta-analysis
    • S.J. McCann, S.M. Pond, K.M. James, and D.G. Le Couteur The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis J Neurol Sci 153 1 Dec 9 1997 50 53
    • (1997) J Neurol Sci , vol.153 , Issue.1 , pp. 50-53
    • McCann, S.J.1    Pond, S.M.2    James, K.M.3    Le Couteur, D.G.4
  • 19
    • 15644367326 scopus 로고    scopus 로고
    • Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13?
    • K. Wilhelmsen et al. Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13? Ann Neurol 41 6 Jun 1997 813 817
    • (1997) Ann Neurol , vol.41 , Issue.6 , pp. 813-817
    • Wilhelmsen, K.1
  • 20
    • 0033532119 scopus 로고    scopus 로고
    • Neurogenetic correlates of Parkinson's disease: Apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism
    • M.A. Bon, E.N. Jansen Steur, R.A. de Vos, and I. Vermes Neurogenetic correlates of Parkinson's disease: apolipoprotein-E and cytochrome P450 2D6 genetic polymorphism Neurosci Lett 266 2 May 7 1999 149 151
    • (1999) Neurosci Lett , vol.266 , Issue.2 , pp. 149-151
    • Bon, M.A.1    Jansen Steur, E.N.2    De Vos, R.A.3    Vermes, I.4
  • 21
    • 0033408455 scopus 로고    scopus 로고
    • CYP2D6 polymorphism and Parkinson's disease susceptibility
    • N. Sabbagh et al. CYP2D6 polymorphism and Parkinson's disease susceptibility Mov Disord 14 2 Mar 1999 230 236
    • (1999) Mov Disord , vol.14 , Issue.2 , pp. 230-236
    • Sabbagh, N.1
  • 22
    • 0032918986 scopus 로고    scopus 로고
    • CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease
    • A. Atkinson et al. CYP2D6 is associated with Parkinson's disease but not with dementia with Lewy Bodies or Alzheimer's disease Pharmacogenetics 9 1 Feb 1999 31 35
    • (1999) Pharmacogenetics , vol.9 , Issue.1 , pp. 31-35
    • Atkinson, A.1
  • 23
    • 0033405632 scopus 로고    scopus 로고
    • Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease
    • O. Joost et al. Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease Mov Disord 14 4 Jul 1999 590 595
    • (1999) Mov Disord , vol.14 , Issue.4 , pp. 590-595
    • Joost, O.1
  • 24
    • 0032740464 scopus 로고    scopus 로고
    • A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism
    • D.J. Nicholl et al. A study of five candidate genes in Parkinson's disease and related neurodegenerative disorders. European Study Group on Atypical Parkinsonism Neurology 53 7 Oct 22 1999 1415 1421
    • (1999) Neurology , vol.53 , Issue.7 , pp. 1415-1421
    • Nicholl, D.J.1
  • 26
    • 0033941972 scopus 로고    scopus 로고
    • Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein e gene polymorphisms in Parkinson's disease
    • D.M. Maraganore, M.J. Farrer, J.A. Hardy, S.K. McDonnell, D.J. Schaid, and W.A. Rocca Case-control study of debrisoquine 4-hydroxylase, N-acetyltransferase 2, and apolipoprotein E gene polymorphisms in Parkinson's disease Mov Disord 15 4 Jul 2000 714 719
    • (2000) Mov Disord , vol.15 , Issue.4 , pp. 714-719
    • Maraganore, D.M.1    Farrer, M.J.2    Hardy, J.A.3    McDonnell, S.K.4    Schaid, D.J.5    Rocca, W.A.6
  • 28
    • 0035933142 scopus 로고    scopus 로고
    • Parkinson's disease, CYP2D6 polymorphism, and age
    • H. Payami et al. Parkinson's disease, CYP2D6 polymorphism, and age Neurology 56 10 May 22 2001 1363 1370
    • (2001) Neurology , vol.56 , Issue.10 , pp. 1363-1370
    • Payami, H.1
  • 29
    • 34247173696 scopus 로고    scopus 로고
    • Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease
    • M. Bialecka et al. Polymorphisms of catechol-0-methyltransferase (COMT), monoamine oxidase B (MAOB), N-acetyltransferase 2 (NAT2) and cytochrome P450 2D6 (CYP2D6) gene in patients with early onset of Parkinson's disease Parkinsonism Relat Disord 13 4 May 2007 224 229
    • (2007) Parkinsonism Relat Disord , vol.13 , Issue.4 , pp. 224-229
    • Bialecka, M.1
  • 30
    • 33947512180 scopus 로고    scopus 로고
    • Polymorphisms in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein e (APOE) as risk factors for Parkinson's disease
    • G. Duric, M. Svetel, S.I. Nikolaevic, N. Dragadevic, J. Gavrilovic, and V.S. Kostic Polymorphisms in the genes of cytochrome oxidase P450 2D6 (CYP2D6), paraoxonase 1 (PON1) and apolipoprotein E (APOE) as risk factors for Parkinson's disease Vojnosanit Pregl 64 1 Jan 2007 25 30
    • (2007) Vojnosanit Pregl , vol.64 , Issue.1 , pp. 25-30
    • Duric, G.1    Svetel, M.2    Nikolaevic, S.I.3    Dragadevic, N.4    Gavrilovic, J.5    Kostic, V.S.6
  • 31
    • 34248577222 scopus 로고    scopus 로고
    • CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia
    • M. Golab-Janowska, K. Honczarenko, B. Gawronska-Szklarz, and A. Potemkowski CYP2D6 gene polymorphism as a probable risk factor for Alzheimer's disease and Parkinson's disease with dementia Neurol Neurochir Pol 41 2 Mar-Apr 2007 113 121
    • (2007) Neurol Neurochir Pol , vol.41 , Issue.2 , pp. 113-121
    • Golab-Janowska, M.1    Honczarenko, K.2    Gawronska-Szklarz, B.3    Potemkowski, A.4
  • 32
    • 33846433663 scopus 로고    scopus 로고
    • Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease
    • R. Vilar et al. Association of A313 G polymorphism (GSTP1*B) in the glutathione-S-transferase P1 gene with sporadic Parkinson's disease Eur J Neurol 14 2 Feb 2007 156 161
    • (2007) Eur J Neurol , vol.14 , Issue.2 , pp. 156-161
    • Vilar, R.1
  • 33
    • 40049083541 scopus 로고    scopus 로고
    • Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands
    • J. Halling, M.S. Petersen, P. Grandjean, P. Weihe, and K. Brosen Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands Pharmacogenet Genomics 18 3 Mar 2008 209 212
    • (2008) Pharmacogenet Genomics , vol.18 , Issue.3 , pp. 209-212
    • Halling, J.1    Petersen, M.S.2    Grandjean, P.3    Weihe, P.4    Brosen, K.5
  • 34
    • 84859065441 scopus 로고    scopus 로고
    • The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients
    • A. Mann, S.L. Miksys, A. Gaedigk, S.J. Kish, D.C. Mash, and R.F. Tyndale The neuroprotective enzyme CYP2D6 increases in the brain with age and is lower in Parkinson's disease patients Neurobiol Aging 33 9 Sep 2012 2160 2171
    • (2012) Neurobiol Aging , vol.33 , Issue.9 , pp. 2160-2171
    • Mann, A.1    Miksys, S.L.2    Gaedigk, A.3    Kish, S.J.4    Mash, D.C.5    Tyndale, R.F.6
  • 35
    • 0031038038 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 variants in a Caucasian population: Allele frequencies and phenotypic consequences
    • C. Sachse, J. Brockmoller, S. Bauer, and I. Roots Cytochrome P450 2D6 variants in a Caucasian population: allele frequencies and phenotypic consequences Am J Hum Genet 60 2 Feb 1997 284 295
    • (1997) Am J Hum Genet , vol.60 , Issue.2 , pp. 284-295
    • Sachse, C.1    Brockmoller, J.2    Bauer, S.3    Roots, I.4
  • 36
    • 38349132802 scopus 로고    scopus 로고
    • The CYP2D6 activity score: Translating genotype information into a qualitative measure of phenotype
    • A. Gaedigk, S.D. Simon, R.E. Pearce, L.D. Bradford, M.J. Kennedy, and J.S. Leeder The CYP2D6 activity score: translating genotype information into a qualitative measure of phenotype Clin Pharmacol Ther 83 2 Feb 2008 234 242
    • (2008) Clin Pharmacol Ther , vol.83 , Issue.2 , pp. 234-242
    • Gaedigk, A.1    Simon, S.D.2    Pearce, R.E.3    Bradford, L.D.4    Kennedy, M.J.5    Leeder, J.S.6
  • 37
    • 84880920061 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms influence tamoxifen treatment outcomes in breast cancer patients: A meta-analysis
    • Z. Zeng et al. CYP2D6 polymorphisms influence tamoxifen treatment outcomes in breast cancer patients: a meta-analysis Cancer Chemother Pharmacol 72 2 Aug 2013 287 303
    • (2013) Cancer Chemother Pharmacol , vol.72 , Issue.2 , pp. 287-303
    • Zeng, Z.1
  • 38
    • 0031014344 scopus 로고    scopus 로고
    • Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization
    • D.E. Gilham et al. Metabolism of MPTP by cytochrome P4502D6 and the demonstration of 2D6 mRNA in human foetal and adult brain by in situ hybridization Xenobiotica 27 1 Jan 1997 111 125
    • (1997) Xenobiotica , vol.27 , Issue.1 , pp. 111-125
    • Gilham, D.E.1
  • 39
    • 0032575505 scopus 로고    scopus 로고
    • Dopamine formation from tyramine by CYP2D6
    • T. Hiroi, S. Imaoka, and Y. Funae Dopamine formation from tyramine by CYP2D6 Biochem Biophys Res Commun 249 3 Aug 28 1998 838 843
    • (1998) Biochem Biophys Res Commun , vol.249 , Issue.3 , pp. 838-843
    • Hiroi, T.1    Imaoka, S.2    Funae, Y.3
  • 40
    • 2542513258 scopus 로고    scopus 로고
    • Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease
    • Y. Deng, B. Newman, M.P. Dunne, P.A. Silburn, and G.D. Mellick Further evidence that interactions between CYP2D6 and pesticide exposure increase risk for Parkinson's disease Ann Neurol 55 6 Jun 2004 897
    • (2004) Ann Neurol , vol.55 , Issue.6 , pp. 897
    • Deng, Y.1    Newman, B.2    Dunne, M.P.3    Silburn, P.A.4    Mellick, G.D.5
  • 41
    • 1442329302 scopus 로고    scopus 로고
    • CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease
    • A. Elbaz et al. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease Ann Neurol 55 3 Mar 2004 430 434
    • (2004) Ann Neurol , vol.55 , Issue.3 , pp. 430-434
    • Elbaz, A.1
  • 44
    • 84920227522 scopus 로고
    • Low frequency of slow debrisoquine hydroxylation in a native Chinese population
    • Y.C. Lou, L. Ying, L. Bertilsson, and F. Sjoqvist Low frequency of slow debrisoquine hydroxylation in a native Chinese population Lancet 2 8563 Oct 10 1987 852 853
    • (1987) Lancet , vol.2 , Issue.8563 , pp. 852-853
    • Lou, Y.C.1    Ying, L.2    Bertilsson, L.3    Sjoqvist, F.4
  • 46
    • 0034685429 scopus 로고    scopus 로고
    • Meta-analysis of observational studies in epidemiology: A proposal for reporting. Meta-analysis of Observational Studies in Epidemiology (MOOSE) group
    • D.F. Stroup et al. Meta-analysis of observational studies in epidemiology: a proposal for reporting. Meta-analysis Of Observational Studies in Epidemiology (MOOSE) group JAMA 283 15 Apr 19 2000 2008 2012
    • (2000) JAMA , vol.283 , Issue.15 , pp. 2008-2012
    • Stroup, D.F.1
  • 47
    • 17844365867 scopus 로고    scopus 로고
    • A method for meta-analysis of molecular association studies
    • A. Thakkinstian, P. McElduff, C. D'Este, D. Duffy, and J. Attia A method for meta-analysis of molecular association studies Stat Med 24 9 May 15 2005 1291 1306
    • (2005) Stat Med , vol.24 , Issue.9 , pp. 1291-1306
    • Thakkinstian, A.1    McElduff, P.2    D'Este, C.3    Duffy, D.4    Attia, J.5
  • 48
    • 0023568113 scopus 로고
    • MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation
    • R. Fonne-Pfister, M.J. Bargetzi, and U.A. Meyer MPTP, the neurotoxin inducing Parkinson's disease, is a potent competitive inhibitor of human and rat cytochrome P450 isozymes (P450bufI, P450db1) catalyzing debrisoquine 4-hydroxylation Biochem Biophys Res Commun 148 3 Nov 13 1987 1144 1150
    • (1987) Biochem Biophys Res Commun , vol.148 , Issue.3 , pp. 1144-1150
    • Fonne-Pfister, R.1    Bargetzi, M.J.2    Meyer, U.A.3
  • 49
    • 0025055586 scopus 로고
    • The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: Resolution and identification of two distinct [3H]GBR-12935 binding proteins
    • H.B. Niznik et al. The dopamine transporter and cytochrome P45OIID1 (debrisoquine 4-hydroxylase) in brain: resolution and identification of two distinct [3H]GBR-12935 binding proteins Arch Biochem Biophys 276 2 Feb 1 1990 424 432
    • (1990) Arch Biochem Biophys , vol.276 , Issue.2 , pp. 424-432
    • Niznik, H.B.1
  • 50
    • 70350044889 scopus 로고    scopus 로고
    • New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme
    • B. Wang, L.P. Yang, X.Z. Zhang, S.Q. Huang, M. Bartlam, and S.F. Zhou New insights into the structural characteristics and functional relevance of the human cytochrome P450 2D6 enzyme Drug Metab Rev 41 4 2009 573 643
    • (2009) Drug Metab Rev , vol.41 , Issue.4 , pp. 573-643
    • Wang, B.1    Yang, L.P.2    Zhang, X.Z.3    Huang, S.Q.4    Bartlam, M.5    Zhou, S.F.6
  • 51
    • 77950419280 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4- phenylpyridinium toxicity in SH-SY5Y neuronal cells
    • A. Mann, and R.F. Tyndale Cytochrome P450 2D6 enzyme neuroprotects against 1-methyl-4-phenylpyridinium toxicity in SH-SY5Y neuronal cells Eur J Neurosci 31 7 Apr 2010 1185 1193
    • (2010) Eur J Neurosci , vol.31 , Issue.7 , pp. 1185-1193
    • Mann, A.1    Tyndale, R.F.2
  • 52
    • 67749127877 scopus 로고    scopus 로고
    • Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk
    • N. Bozina, V. Bradamante, and M. Lovric Genetic polymorphism of metabolic enzymes P450 (CYP) as a susceptibility factor for drug response, toxicity, and cancer risk Arh Hig Rada Toksikol 60 2 Jun 2009 217 242
    • (2009) Arh Hig Rada Toksikol , vol.60 , Issue.2 , pp. 217-242
    • Bozina, N.1    Bradamante, V.2    Lovric, M.3
  • 53
    • 0030954171 scopus 로고    scopus 로고
    • Genes and parkinsonism
    • N. Wood Genes and parkinsonism J Neurol Neurosurg Psychiatry 62 4 Apr 1997 305 309
    • (1997) J Neurol Neurosurg Psychiatry , vol.62 , Issue.4 , pp. 305-309
    • Wood, N.1
  • 54
    • 0028334418 scopus 로고
    • Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations
    • J.A. Agundez, C. Martinez, M.C. Ledesma, M.G. Ladona, J.M. Ladero, and J. Benitez Genetic basis for differences in debrisoquin polymorphism between a Spanish and other white populations Clin Pharmacol Ther 55 4 Apr 1994 412 417
    • (1994) Clin Pharmacol Ther , vol.55 , Issue.4 , pp. 412-417
    • Agundez, J.A.1    Martinez, C.2    Ledesma, M.C.3    Ladona, M.G.4    Ladero, J.M.5    Benitez, J.6
  • 55
    • 0031799305 scopus 로고    scopus 로고
    • Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease
    • A. Rostami-Hodjegan, M.S. Lennard, H.F. Woods, and G.T. Tucker Meta-analysis of studies of the CYP2D6 polymorphism in relation to lung cancer and Parkinson's disease Pharmacogenetics 8 3 Jun 1998 227 238
    • (1998) Pharmacogenetics , vol.8 , Issue.3 , pp. 227-238
    • Rostami-Hodjegan, A.1    Lennard, M.S.2    Woods, H.F.3    Tucker, G.T.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.