Is there a genetic susceptibility locus for Parkinson's disease on chromosome 22q13?

Annals of Neurology

Volumn 41, Issue 6, 1997, Pages 813-817

  Wilhelmsen, K ^a   Mirel, D ^a   Marder, K ^b,c   Bernstein, M ^a   Naini, A ^c   Leal, S M ^e   Cote, L J ^c   Tang, M X ^b,c   Freyer, G ^d   Graziano, J ^c,d   Mayeux, R ^b,c,d  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b Taub Institute for Research on Alzheimer's Disease and the Aging Brain and the Gertrude H Sergievsky Center   (United States)

^c Columbia University ^*  (United States)

^d Och Spine at New York Presbyterian Hospitals   (United States)

^e ROCKEFELLER UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOCHROME P450; UNSPECIFIC MONOOXYGENASE;

ADULT; AGED; ARTICLE; CHROMOSOME 22Q; CONTROLLED STUDY; DINUCLEOTIDE REPEAT; DNA POLYMORPHISM; FEMALE; GENE EXPRESSION; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR CLINICAL STUDY; MALE; PARKINSON DISEASE; PRIORITY JOURNAL;

ADULT; AGED; AGED, 80 AND OVER; ALLELES; CASE-CONTROL STUDIES; CHROMOSOME MAPPING; CHROMOSOMES, HUMAN, PAIR 22; CYTOCHROME P-450 ENZYME SYSTEM; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; MICROSATELLITE REPEATS; MIDDLE AGED; PARKINSON DISEASE; POLYMORPHISM, GENETIC;

EID: 15644367326     PISSN: 03645134     EISSN: None     Source Type: Journal    
DOI: 10.1002/ana.410410619     Document Type: Article

References (24)

1. Barbeau A, Cloutier T, Roy M, et al. Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine. Lancet 1985;2: 1213-1216
2. Armstrong M, Daly AK, Cholerton S, et al. Mutant debrisoquine hydroxylation genes in Parkinson's disease. Lancet 1992; 339:1017-1018
3. Smith CA, Gough AC, Leigh PN, et al. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease. Lancet 1992;339:1375-1377
4. Kondo I, Kanazawa I. Association of Xba I allele (Xba I 44kb) of the human cytochrome P-450dbl(CYP2D6) gene in Japanese patients with idiopathic Parkinson's disease. In: Nagatsu T, Narabayashi H, Yoshida M, eds. Parkinson's disease: from clinical aspects to molecular basis. New York: Springer-Verlag, 1991:111-117
5. Kurth MC, Kurth JH. Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease. Am J Med Genet 1993; 48:166-168
6. Tsuneoka Y, Matsuo Y, Iwahashi K, et al. A novel cytochrome P-450IID6 mutant gene associated with Parkinson's disease. J Biochem 1993;114:263-266
7. Daily AK, Armstrong M, Monkman SC, et al. Genetic and metabolic criteria for the assignment of debrisoquine 4-hydroxylation (cytochrome P4502D6) phenotypes. Pharmacogenetics 1991;1:33-41
8. Gough AC, Miles JS, Spurr NK, et al. Identification of the primary defect at the cytochrome P450 CYP2D locus. Nature 1990;347:773-776
9. Heim M, Meyer UA. Genotyping of poor metabolizers of debrisoquine by allele-specific PCR amplification. Lancet 1990; 336:529-532
10. Agundez JAG, Jimenez-Jimenez FJ, Luengo A, et al. Association between the oxidative polymorphism and early onset Parkinson's disease. Clin Pharmacol Ther 1995;57:291-298
11. Johansson I, Lundqvist E, Bertilsson L, et al. Inherited amplification of an active gene in the cytochrome P450 CYP2D loeus as a cause of ultra-rapid metabolism of debrisoquine. Proc Natl Acad Sci USA 1993;90:11825-11829
12. Sandy MS, Armstrong M, Tanner CM, et al. CYP2D6 allelic frequencies in young-onset Parkinson's disease. Neurology 1996;47:225-230
13. Logroscino G, Marder K, Cote L, et al. Dietary lipids and antioxidants in Parkinson's disease: a population-based, case-control study. Ann Neurol 1996;39:89-94
14. Mayeux R, Marder K, Cote LJ, et al. The frequency of idiopathic Parkinson's disease by age, ethnic group, and sex in northern Manhattan, 1988-1993. Am J Epidemiol 1995;142: 820-827
15. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-184
16. Hughes AJ, Ben-Shlomo Y, Kilford L, Lees AJ. What features improve the accuracy of clinical diagnosis in Parkinson's disease: a clinicopathologic study. Neurology 1992;42:1142-1146
17. Lasser DM, Wilhelmsen KC, Nygaard TG, Tantravahi U. Characterization of microsatellite polymorphisms DXS691 and DXS692: genetic mapping to Xq26.2-Xq27 and Xq25-Xq26.2. Genomics 1993;16:785-786
18. Matise T, Perlin M, Chakravarti A. Automated construction of genetic linkage maps using an expert system (Multimap): a human genome linkage map. Nature Genet 1994;6:384-390
19. Boehnke M, Lange K, Cox DR. Statistical methods for multipoint radiation hybrid mapping. Am J Hum Genet 1991;49: 1174-1188
20. Diederich N, Hilger C, Goetz CG, et al. Genetic variability of the CYP 2D6 gene is not a risk factor for sporadic Parkinson's disease. Ann Neurol 1996;40:463-465
21. Platé-Bordeneuve V, Davis MB, Maraganore DM, et al. Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease. J Neurol Neurosurg Psychiatry 1994;57:911-913
22. Ott J. Analysis of human genetic linkage. Baltimore: Johns Hopkins University Press, 1991:241-242
23. Thompson G. Identifying complex disease genes: progress and paradigms. Nature Genet 1994;8:108-110
24. Kim UJ, Shizuya H, Kang HL, et al. A bacterial artificial chromosome-based framework contig map of human chromosome 22q. Proc Natl Acad Sci USA 1996;93:6297-6301