Genetic predisposition to Parkinson's disease: CYP2D6 and HFE in the Faroe Islands

Pharmacogenetics and Genomics

Volumn 18, Issue 3, 2008, Pages 209-212

  Halling, Jónrit ^a,c   Petersen, Maria Skaalum ^a   Grandjean, Philippe ^a   Weihe, Pál ^b   Brosen, Kim ^a  

^a UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^b FAROESE HOSPITAL SYSTEM   (Faroe Islands)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

Author keywords

CYP2D6 polymorphism; Faroe Islands; HFE; Parkinson's disease; Risk factors

Indexed keywords

CYTOCHROME P450 2D6; FLUROTHYL;

ARTICLE; BLOOD SAMPLING; CONFIDENCE INTERVAL; CONTROLLED STUDY; FAROE ISLANDS; GENE FREQUENCY; GENE MUTATION; GENE SEQUENCE; GENETIC PREDISPOSITION; GENETIC VARIABILITY; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PARKINSON DISEASE; PREVALENCE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

AGED; AGED, 80 AND OVER; ALLELES; BASE SEQUENCE; CASE-CONTROL STUDIES; CYTOCHROME P-450 CYP2D6; DENMARK; DNA PRIMERS; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HISTOCOMPATIBILITY ANTIGENS CLASS I; HUMANS; MALE; MEMBRANE PROTEINS; MIDDLE AGED; PARKINSON DISEASE; PHARMACOGENETICS;

EID: 40049083541     PISSN: 17446872     EISSN: 17446880     Source Type: Journal    
DOI: 10.1097/FPC.0b013e3282f5106e     Document Type: Article

References (29)

1. Samii A, Nutt JG, Ransom BR. Parkinson's disease. Lancet 2004; 363:1783-1793.
2. Di Monte DA, Lavasani M, Manning-Bog AB. Environmental factors in Parkinson's disease. Neurotoxicology 2002; 23:487-502.
3. Coppede F, Mancuso M, Siciliano G, Migliore L, Murri L. Genes and the environment in neurodegeneration. Biosci Rep 2006; 26:341-367.
4. Wermuth L, Bech S, Petersen MS, Joensen P, Weihe P, Grandjean P. Prevalence and incidence of Parkinson's Disease in the Faroe Islands. Acta Neurol Scand July 2007. (Submitted).
5. Wermuth L, Joensen P, Bunger N, Jeune B. High prevalence of Parkinson's disease in the Faroe Islands. Neurology 1997; 49:426-432.
6. Wermuth L, von Weitzel-Mudersbach P, Jeune B. A two-fold difference in the age-adjusted prevalences of Parkinson's disease between the island of Als and the Faroe Islands. Eur J Neurol 2000; 7:655-660.
7. Halling J, Petersen MS, Damkier P, Nielsen F, Grandjean P, Weihe P, et al. Polymorphism of CYP2D6, CYP2C19, CYP2C9 and CYP2C8 in the Faroese population. Eur J Clin Pharmacol 2005; 61:491-497.
8. Milman N, Steig T, Koefoed P, Pedersen P, Fenger K, Nielsen FC. Frequency of the hemochromatosis HFE mutations C282Y, H63D, and S65C in blood donors in the Faroe Islands. Ann Hematol 2005; 84:146-149.
9. Koefoed P, Dalhoff K, Dissing J, Kramer I, Milman N, Pedersen P, et al. HFE mutations and hemochromatosis in Danish patients admitted for HFE genotyping. Scand J Clin Lab Invest 2002; 62:527-535.
10. McCann SJ, Pond SM, James KM, Le Couteur DG. The association between polymorphisms in the cytochrome P-450 2D6 gene and Parkinson's disease: a case-control study and meta-analysis. J Neurol Sci 1997; 153:50-53.
11. Christensen PM, Gotzsche PC, Brosen K. The sparteine/debrisoquine (CYP2D6) oxidation polymorphism and the risk of Parkinson's disease: a meta-analysis. Pharmacogenetics 1998; 6:473-479.
12. Joost O, Taylor CA, Thomas CA, Cupples LA, Saint-Hilaire MH, Feldman RG, et al. Absence of effect of seven functional mutations in the CYP2D6 gene in Parkinson's disease. Mov Disord 1999; 14:590-595.
13. Barbeau A, Cloutier T, Roy M, Plasse L, Paris S, Poirier J. Ecogenetics of Parkinson's disease: 4-hydroxylation of debrisoquine. Lancet 1985; 2:1213-1216.
14. Mellick GD. CYP450, genetics and Parkinson's disease: gene x environment interactions hold the key. J Neural Transm Suppl 2006; 70:159-165.
15. Elbaz A, Levecque C, Clavel J, Vidal JS, Richard F, Amouyel P, et al. CYP2D6 polymorphism, pesticide exposure, and Parkinson's disease. Ann Neurol 2004; 55:430-434.
16. Chan DK, Woo J, Ho SC, Pang CP, Law LK, Ng PW, et al. Genetic and environmental risk factors for Parkinson's disease in a Chinese population. J Neurol Neurosurg Psychiatry 1998; 65:781-784.
17. Priyadarshi A, Khuder SA, Schaub EA, Shrivastava S. A meta-analysis of Parkinson's disease and exposure to pesticides. Neurotoxicology 2000; 21:435-440.
18. Miksys S, Tyndale RF. Nicotine induces brain CYP enzymes: relevance to Parkinson's disease. J Neural Transm Suppl 2006; 70:177-180.
19. LeCouteur DG, MsLean AJ, Taylor MC, Woodham BL, Board PG. Pesticides and Parkinson's disease. Biomed Pharmacother 1999; 53:122-130.
20. Allam MF, Campbell MJ, Campbell A, Hofman AS, Del Castillo R, Fernandez-Crehuet N. Smoking and Parkinson's disease: systematic review of prospective studies. Mov Disord 2004; 19:614-621.
21. Thacker EL, O'Reilly EJ, Weisskopf MG, Chen H, Schwarzschild MA, McCullough ML, et al. Temporal relationship between cigarette smoking and risk of Parkinson disease. Neurology 2007; 68:764-768.
22. Dekker MC, Giesbergen PC, Njajou OT, van Swieten JC, Hofman A, Breteler MM, van Duijn CM. Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism. Neurosci Lett 2003; 348:117-119.
23. Borie C, Gasparini F, Verpillat P, Bonnet AM, Agid Y, Hetet G, et al. Association study between iron-related genes polymorphisms and Parkinson's disease. J Neurol 2002; 249:801-804.
24. Buchanan DD, Silburn PA, Chalk JB, Le Couteur DG, Mellick GD. The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients. Neurosci Lett 2002; 327:91-94.
25. Aamodt AH, Stovner LJ, Thorstensen K, Lydersen S, White LR, Aasly JO. Prevalence of haemochromatosis (HFE) gene mutations in Parkinson's disease. J Neurol Neurosurg Psychiatry 2007; 78:315-317.
26. Guerreiro RJ, Bras JM, Santana I, Januario C, Santiago B, Morgadinho AS, et al. Association of HFE common mutations with Parkinson's disease, Alzheimer's disease and mild cognitive impairment in a Portuguese cohort. BMC Neurol 2006; 6:24.
27. Costello DJ, Walsh SL, Harrington HJ, Walsh CH. Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease: a case report series. J Neurol Neurosurg Psychiatry 2004; 75:631-633.
28. Akbas N, Hochstrasser H, Deplazes J, Tomiuk J, Bauer P, Walter U, et al. Screening for mutations of the HFE gene in Parkinson's disease patients with hyperechogenicity of the substantia nigra. Neurosci Lett 2006; 407:16-19.
29. Petersen MS, Halling J, Bech S, Wermuth L, Nielsen F, Jørgensen PJ, et al. Impact of dietary exposure to food contaminants on the risk of Parkinson's disease. Submitted to Neurotoxicology July 2007.