The CYP2D6B allele is not overrepresented in a population of German patients with idiopathic Parkinson's disease

Journal of Neurology Neurosurgery and Psychiatry

Volumn 61, Issue 5, 1996, Pages 518-520

  Gasser, T ^a,i   Muller Myhsok B ^b   Supala, A ^a   Zimmer, E ^c   Wieditz, G ^d   Wszolek, Z K ^e   Vieregge, P ^f   Bonifati, V ^g   Oertel, W H ^h  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b BERNHARD NOCHT INSTITUTE FOR TROPICAL MEDICINE   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^d PARACELSUS ELENA KLINIK   (Germany)

^e UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^f UNIVERSITY OF LÜBECK   (Germany)

^g SAPIENZA UNIVERSITY OF ROME   (Italy)

^h PHILIPPS UNIVERSITY MARBURG   (Germany)

ⁱ Neurologische Klinik   (Germany)

Author keywords

4 hydroxylase; Allelic association; Debrisoquine; Idiopathic Parkinson's disease

Indexed keywords

OXYGENASE;

ADULT; AGED; ALLELE; ALZHEIMER DISEASE; ARTICLE; CONTROLLED STUDY; GENE FREQUENCY; GERMANY; HUMAN; MAJOR CLINICAL STUDY; PARKINSON DISEASE; PRIORITY JOURNAL; SIBLING;

EID: 0029851872     PISSN: 00223050     EISSN: None     Source Type: Journal    
DOI: 10.1136/jnnp.61.5.518     Document Type: Article

References (11)

1. Smith CAD, Gough AC, Leigh PN, et al. Debrisoquine hydroxylase gene polymorphism and susceptibility to Parkinson's disease. Lancet 1992;339:1375-7.
2. Armstrong M, Daly AK, Cholerton S, et al. Mutant debrisoquine hydroxylation genes in Parkinson's disease. Lancet 1992;339:1017-8.
3. Kurth MC, Kurth JH. Variant cytochrome P450 CYP2D6 allelic frequencies in Parkinson's disease. Am J Med Genet 1993;48:166-8.
4. Planté-Bordeneuve V, Davis MB, Maraganore DM, et al. Debrisoquine hydroxylase gene polymorphism in familial Parkinson's disease. J Neurol Neurosurg Psychiatry 1994; 57:911-3.
5. Planté-Bordeneuve V, Bandmann O, Wenning G, et al. CYP2D6-debrisoquine hydroxylase gene polymorphism in multiple system atrophy. Mov Disord 1995;10:277-8.
6. Ward CD, Gibb WRG. Research diagnostic criteria for Parkinson's disease. Adv Neurol 1990;53:245-9.
7. Agundez JA, Jimenez-Jimenez FJ, Luengo A, et al. Association between the oxidative polymorphism and early onset of Parkinson's disease. Clin Pharmacol Ther 1995;57: 291-8.
8. Schaid DJ, Sommer SS. Genotype relative risks: methods for design and analysis of candidate-gene association studies. Am J Hum Genet 1993;53:1114-26.
9. Hochberg Y, Tamhane AC. Multiple comparison procedures. New York: Wiley and sons, 1987.
10. Gasser T, Wszolek ZK, Trofatter J, et al. Linkage studies in autosomal dominant parkinsonism: evaluation of seven candidate genes. Ann Neurol 1994;36:387-96.
11. Kidd KK. Associations of disease with genetic markers: déjà vu all over again. Am J Hum Genet 1993;48:71-3.