메뉴 건너뛰기




Volumn 72, Issue 2, 2013, Pages 287-303

CYP2D6 polymorphisms influence tamoxifen treatment outcomes in breast cancer patients: A meta-analysis

Author keywords

Breast cancer; Cytochrome P450 2D6; Meta analysis; Pharmacogenomics; Tamoxifen

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOCHROME P450 2D6; TAMOXIFEN;

EID: 84880920061     PISSN: 03445704     EISSN: 14320843     Source Type: Journal    
DOI: 10.1007/s00280-013-2195-9     Document Type: Review
Times cited : (28)

References (61)
  • 2
  • 3
    • 0019786905 scopus 로고
    • Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: Correlation with blood levels in patients with metastatic breast cancer
    • Fabian C, Tilzer L, Sternson L (1981) Comparative binding affinities of tamoxifen, 4-hydroxytamoxifen, and desmethyltamoxifen for estrogen receptors isolated from human breast carcinoma: correlation with blood levels in patients with metastatic breast cancer. Biopharm Drug Dispos 2(4):381-390 (Pubitemid 12223758)
    • (1981) Biopharmaceutics and Drug Disposition , vol.2 , Issue.4 , pp. 381-390
    • Fabian, C.1    Tilzer, L.2    Sternson, L.3
  • 4
    • 84866016004 scopus 로고    scopus 로고
    • Physiologically based pharmacokinetic modeling of tamoxifen and its metabolites in women of different CYP2D6 phenotypes provides new insight into the tamoxifen mass balance
    • 22661948 10.3389/fphar.2012.00092 1:CAS:528:DC%2BC38XptVersLY%3D
    • Dickschen K, Willmann S, Thelen K et al (2012) Physiologically based pharmacokinetic modeling of tamoxifen and its metabolites in women of different CYP2D6 phenotypes provides new insight into the tamoxifen mass balance. Front Pharmacol 3:92
    • (2012) Front Pharmacol , vol.3 , pp. 92
    • Dickschen, K.1    Willmann, S.2    Thelen, K.3
  • 5
    • 80053153296 scopus 로고    scopus 로고
    • The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: A systematic review
    • Fleeman N, Martin Saborido C, Payne K et al (2011) The clinical effectiveness and cost-effectiveness of genotyping for CYP2D6 for the management of women with breast cancer treated with tamoxifen: a systematic review. Health Technol Assess 15(33):1-102
    • (2011) Health Technol Assess , vol.15 , Issue.33 , pp. 1-102
    • Fleeman, N.1    Martin Saborido, C.2    Payne, K.3
  • 6
    • 36148976077 scopus 로고    scopus 로고
    • Influence of cytochrome P450 polymorphisms on drug therapies: Pharmacogenetic, pharmacoepigenetic and clinical aspects
    • DOI 10.1016/j.pharmthera.2007.09.004, PII S016372580700201X
    • Ingelman-Sundberg M, Sim SC, Gomez A et al (2007) Influence of cytochrome P450 polymorphisms on drug therapies: pharmacogenetic, pharmacoepigenetic and clinical aspects. Pharmacol Ther 116(3):496-526 (Pubitemid 350116943)
    • (2007) Pharmacology and Therapeutics , vol.116 , Issue.3 , pp. 496-526
    • Ingelman-Sundberg, M.1    Sim, S.C.2    Gomez, A.3    Rodriguez-Antona, C.4
  • 7
    • 19344364880 scopus 로고    scopus 로고
    • Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: An overview of the randomised trials
    • DOI 10.1016/S0140-6736(05)66544-0, PII S0140673605665440
    • (EBCTCG) EBCTCG (2005) Effects of chemotherapy and hormonal therapy for early breast cancer on recurrence and 15-year survival: an overview of the randomised trials. Lancet 365(9472):1687-1717 (Pubitemid 40719106)
    • (2005) Lancet , vol.365 , Issue.9472 , pp. 1687-1717
  • 9
    • 47749105202 scopus 로고    scopus 로고
    • Association between CYP2D610 genotype and survival of breast cancer patients receiving tamoxifen treatment
    • 18407954 10.1093/annonc/mdn155 1:STN:280:DC%2BD1cvotVKmsA%3D%3D
    • Xu Y, Sun Y, Yao L et al (2008) Association between CYP2D610 genotype and survival of breast cancer patients receiving tamoxifen treatment. Ann Oncol 19(8):1423-1429
    • (2008) Ann Oncol , vol.19 , Issue.8 , pp. 1423-1429
    • Xu, Y.1    Sun, Y.2    Yao, L.3
  • 10
    • 70349910091 scopus 로고    scopus 로고
    • The CYP2D64 polymorphism affects breast cancer survival in tamoxifen users
    • 19189212 10.1007/s10549-008-0272-2 1:CAS:528:DC%2BD1MXht1GmtbbI
    • Bijl MJ, van Schaik RH, Lammers LA et al (2009) The CYP2D64 polymorphism affects breast cancer survival in tamoxifen users. Breast Cancer Res Treat 118(1):125-130
    • (2009) Breast Cancer Res Treat , vol.118 , Issue.1 , pp. 125-130
    • Bijl, M.J.1    Van Schaik, R.H.2    Lammers, L.A.3
  • 11
    • 70349929431 scopus 로고    scopus 로고
    • Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen
    • 19809024 10.1001/jama.2009.1420 1:CAS:528:DC%2BD1MXht1CksrjO
    • Schroth W, Goetz MP, Hamann U et al (2009) Association between CYP2D6 polymorphisms and outcomes among women with early stage breast cancer treated with tamoxifen. JAMA 302(13):1429-1436
    • (2009) JAMA , vol.302 , Issue.13 , pp. 1429-1436
    • Schroth, W.1    Goetz, M.P.2    Hamann, U.3
  • 12
    • 77950502100 scopus 로고    scopus 로고
    • Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients
    • 20124171 10.1200/JCO.2009.25.7246 1:CAS:528:DC%2BC3cXksFSqtb0%3D
    • Kiyotani K, Mushiroda T, Imamura CK et al (2010) Significant effect of polymorphisms in CYP2D6 and ABCC2 on clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients. J Clin Oncol 28(8):1287-1293
    • (2010) J Clin Oncol , vol.28 , Issue.8 , pp. 1287-1293
    • Kiyotani, K.1    Mushiroda, T.2    Imamura, C.K.3
  • 13
    • 84863443426 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2D6 increase the risk for recurrence of breast cancer in patients receiving tamoxifen as an adjuvant therapy
    • 22623212 10.1007/s00280-012-1891-1 1:CAS:528:DC%2BC38XpsFajt7g%3D
    • Damodaran SE, Pradhan SC, Umamaheswaran G et al (2012) Genetic polymorphisms of CYP2D6 increase the risk for recurrence of breast cancer in patients receiving tamoxifen as an adjuvant therapy. Cancer Chemother Pharmacol 70(1):75-81
    • (2012) Cancer Chemother Pharmacol , vol.70 , Issue.1 , pp. 75-81
    • Damodaran, S.E.1    Pradhan, S.C.2    Umamaheswaran, G.3
  • 14
    • 84874017348 scopus 로고    scopus 로고
    • Impact of CYP2D6 polymorphisms on tamoxifen responses of women with breast cancer: A microarray-based study in Thailand
    • 23167378 10.7314/APJCP.2012.13.9.4549
    • Sukasem C, Sirachainan E, Chamnanphon M et al (2012) Impact of CYP2D6 polymorphisms on tamoxifen responses of women with breast cancer: a microarray-based study in Thailand. Asian Pac J Cancer Prev 13(9):4549-4553
    • (2012) Asian Pac J Cancer Prev , vol.13 , Issue.9 , pp. 4549-4553
    • Sukasem, C.1    Sirachainan, E.2    Chamnanphon, M.3
  • 15
    • 84857627005 scopus 로고    scopus 로고
    • The risk of recurrence in breast cancer patients treated with tamoxifen: Polymorphisms of CYP2D6 and ABCB1
    • 22183189 10.1208/s12248-011-9313-6 1:CAS:528:DC%2BC38XjtVGhu7k%3D
    • Teh LK, Mohamed NI, Salleh MZ et al (2012) The risk of recurrence in breast cancer patients treated with tamoxifen: polymorphisms of CYP2D6 and ABCB1. AAPS J 14(1):52-59
    • (2012) AAPS J , vol.14 , Issue.1 , pp. 52-59
    • Teh, L.K.1    Mohamed, N.I.2    Salleh, M.Z.3
  • 16
    • 84872580456 scopus 로고    scopus 로고
    • CYP2D6 metabolism and patient outcome in the austrian breast and colorectal cancer study group trial (ABCSG) 8
    • 23213055 10.1158/1078-0432.CCR-12-2153 1:CAS:528:DC%2BC3sXht1Cnsr0%3D
    • Goetz MP, Suman VJ, Hoskin TL et al (2013) CYP2D6 metabolism and patient outcome in the austrian breast and colorectal cancer study group trial (ABCSG) 8. Clin Cancer Res 19(2):500-507
    • (2013) Clin Cancer Res , vol.19 , Issue.2 , pp. 500-507
    • Goetz, M.P.1    Suman, V.J.2    Hoskin, T.L.3
  • 17
    • 77958115704 scopus 로고    scopus 로고
    • Impact of CYP2D64 genotype on progression free survival in tamoxifen breast cancer treatment
    • 20849243 10.1185/03007995.2010.518304 1:CAS:528:DC%2BC3cXhtlWmur7E
    • Stingl JC, Parmar S, Huber-Wechselberger A et al (2010) Impact of CYP2D64 genotype on progression free survival in tamoxifen breast cancer treatment. Curr Med Res Opin 26(11):2535-2542
    • (2010) Curr Med Res Opin , vol.26 , Issue.11 , pp. 2535-2542
    • Stingl, J.C.1    Parmar, S.2    Huber-Wechselberger, A.3
  • 18
    • 33644639136 scopus 로고    scopus 로고
    • Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes
    • 16361630 10.1200/JCO.2005.03.3266 1:CAS:528:DC%2BD28Xnt1ynuw%3D%3D
    • Goetz MP, Rae JM, Suman VJ et al (2005) Pharmacogenetics of tamoxifen biotransformation is associated with clinical outcomes of efficacy and hot flashes. J Clin Oncol 23(36):9312-9318
    • (2005) J Clin Oncol , vol.23 , Issue.36 , pp. 9312-9318
    • Goetz, M.P.1    Rae, J.M.2    Suman, V.J.3
  • 22
    • 34248208754 scopus 로고    scopus 로고
    • Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer
    • DOI 10.1186/bcr1640
    • Wegman P, Elingarami S, Carstensen J et al (2007) Genetic variants of CYP3A5, CYP2D6, SULT1A1, UGT2B15 and tamoxifen response in postmenopausal patients with breast cancer. Breast Cancer Res 9(1):R7 (Pubitemid 350215154)
    • (2007) Breast Cancer Research , vol.9 , Issue.1
    • Wegman, P.1    Elingarami, S.2    Carstensen, J.3    Stal, O.4    Nordenskjold, B.5    Wingren, S.6
  • 23
    • 53249086540 scopus 로고    scopus 로고
    • Impaired tamoxifen metabolism reduces survival in familial breast cancer patients
    • 18794105 10.1158/1078-0432.CCR-07-5235 1:CAS:528:DC%2BD1cXhtFaitrjF
    • Newman WG, Hadfield KD, Latif A et al (2008) Impaired tamoxifen metabolism reduces survival in familial breast cancer patients. Clin Cancer Res 14(18):5913-5918
    • (2008) Clin Cancer Res , vol.14 , Issue.18 , pp. 5913-5918
    • Newman, W.G.1    Hadfield, K.D.2    Latif, A.3
  • 24
    • 61449171134 scopus 로고    scopus 로고
    • Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen
    • 19156902 10.1002/cncr.24111 1:CAS:528:DC%2BD1MXjs1Kjur0%3D
    • Okishiro M, Taguchi T, Jin Kim S et al (2009) Genetic polymorphisms of CYP2D6 10 and CYP2C19 2, 3 are not associated with prognosis, endometrial thickness, or bone mineral density in Japanese breast cancer patients treated with adjuvant tamoxifen. Cancer 115(5):952-961
    • (2009) Cancer , vol.115 , Issue.5 , pp. 952-961
    • Okishiro, M.1    Taguchi, T.2    Jin Kim, S.3
  • 25
    • 78650890739 scopus 로고    scopus 로고
    • CYP2D6 gene variants: Association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen
    • 20731819 10.1186/bcr2629
    • Abraham JE, Maranian MJ, Driver KE et al (2010) CYP2D6 gene variants: association with breast cancer specific survival in a cohort of breast cancer patients from the United Kingdom treated with adjuvant tamoxifen. Breast Cancer Res 12(4):R64
    • (2010) Breast Cancer Res , vol.12 , Issue.4 , pp. 64
    • Abraham, J.E.1    Maranian, M.J.2    Driver, K.E.3
  • 26
    • 80052665548 scopus 로고    scopus 로고
    • Association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment
    • 21860550 10.3346/jkms.2011.26.8.1007
    • Park HS, Choi JY, Lee MJ et al (2011) Association between genetic polymorphisms of CYP2D6 and outcomes in breast cancer patients with tamoxifen treatment. J Korean Med Sci 26(8):1007-1013
    • (2011) J Korean Med Sci , vol.26 , Issue.8 , pp. 1007-1013
    • Park, H.S.1    Choi, J.Y.2    Lee, M.J.3
  • 27
    • 79952838781 scopus 로고    scopus 로고
    • CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark
    • 21325141 10.1093/jnci/djr010 1:CAS:528:DC%2BC3MXjsF2isbk%3D
    • Lash TL, Cronin-Fenton D, Ahern TP et al (2011) CYP2D6 inhibition and breast cancer recurrence in a population-based study in Denmark. J Natl Cancer Inst 103(6):489-500
    • (2011) J Natl Cancer Inst , vol.103 , Issue.6 , pp. 489-500
    • Lash, T.L.1    Cronin-Fenton, D.2    Ahern, T.P.3
  • 28
    • 78651076124 scopus 로고    scopus 로고
    • Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy
    • 20809362 10.1007/s10549-010-1139-x 1:CAS:528:DC%2BC3cXhsFWgtLvF
    • Thompson AM, Johnson A, Quinlan P et al (2011) Comprehensive CYP2D6 genotype and adherence affect outcome in breast cancer patients treated with tamoxifen monotherapy. Breast Cancer Res Treat 125(1):279-287
    • (2011) Breast Cancer Res Treat , vol.125 , Issue.1 , pp. 279-287
    • Thompson, A.M.1    Johnson, A.2    Quinlan, P.3
  • 29
    • 84856227640 scopus 로고    scopus 로고
    • Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment
    • 21437611 10.1007/s10549-011-1425-2 1:CAS:528:DC%2BC38XktFartA%3D%3D
    • Park IH, Ro J, Park S et al (2012) Lack of any association between functionally significant CYP2D6 polymorphisms and clinical outcomes in early breast cancer patients receiving adjuvant tamoxifen treatment. Breast Cancer Res Treat 131(2):455-461
    • (2012) Breast Cancer Res Treat , vol.131 , Issue.2 , pp. 455-461
    • Park, I.H.1    Ro, J.2    Park, S.3
  • 30
    • 84859093970 scopus 로고    scopus 로고
    • CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: The breast international group 1-98 trial
    • 22395644 10.1093/jnci/djs125 1:CAS:528:DC%2BC38Xksl2rsbo%3D
    • Regan MM, Leyland-Jones B, Bouzyk M et al (2012) CYP2D6 genotype and tamoxifen response in postmenopausal women with endocrine-responsive breast cancer: the breast international group 1-98 trial. J Natl Cancer Inst 104(6):441-451
    • (2012) J Natl Cancer Inst , vol.104 , Issue.6 , pp. 441-451
    • Regan, M.M.1    Leyland-Jones, B.2    Bouzyk, M.3
  • 31
    • 84859054082 scopus 로고    scopus 로고
    • CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients
    • 22395643 10.1093/jnci/djs126 1:CAS:528:DC%2BC38Xksl2rsb8%3D
    • Rae JM, Drury S, Hayes DF et al (2012) CYP2D6 and UGT2B7 genotype and risk of recurrence in tamoxifen-treated breast cancer patients. J Natl Cancer Inst 104(6):452-460
    • (2012) J Natl Cancer Inst , vol.104 , Issue.6 , pp. 452-460
    • Rae, J.M.1    Drury, S.2    Hayes, D.F.3
  • 32
    • 77955556907 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: Results of a meta-analysis
    • 20454926 10.1007/s10549-010-0902-3 1:CAS:528:DC%2BC3cXoslehsbc%3D
    • Seruga B, Amir E (2010) Cytochrome P450 2D6 and outcomes of adjuvant tamoxifen therapy: results of a meta-analysis. Breast Cancer Res Treat 122(3):609-617
    • (2010) Breast Cancer Res Treat , vol.122 , Issue.3 , pp. 609-617
    • Seruga, B.1    Amir, E.2
  • 33
    • 85031896203 scopus 로고    scopus 로고
    • Genetic variation, classification and 'race'
    • 15508000 10.1038/ng1435 1:CAS:528:DC%2BD2cXovFamtbw%3D
    • Jorde LB, Wooding SP (2004) Genetic variation, classification and 'race'. Nat Genet 36(11 Suppl):S28-S33
    • (2004) Nat Genet , vol.36 , Issue.11 SUPPL.
    • Jorde, L.B.1    Wooding, S.P.2
  • 34
    • 79952005028 scopus 로고    scopus 로고
    • Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias
    • 21145753 10.1016/j.jcms.2010.11.001
    • Knobloch K, Yoon U, Vogt PM (2011) Preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement and publication bias. J Craniomaxillofac Surg 39(2):91-92
    • (2011) J Craniomaxillofac Surg , vol.39 , Issue.2 , pp. 91-92
    • Knobloch, K.1    Yoon, U.2    Vogt, P.M.3
  • 36
    • 0037098199 scopus 로고    scopus 로고
    • Quantifying heterogeneity in a meta-analysis
    • DOI 10.1002/sim.1186
    • Higgins JP, Thompson SG (2002) Quantifying heterogeneity in a meta-analysis. Stat Med 21(11):1539-1558 (Pubitemid 34746062)
    • (2002) Statistics in Medicine , vol.21 , Issue.11 , pp. 1539-1558
    • Higgins, J.P.T.1    Thompson, S.G.2
  • 38
    • 0022992740 scopus 로고
    • Meta-analysis in clinical trials
    • DOI 10.1016/0197-2456(86)90046-2
    • DerSimonian R, Laird N (1986) Meta-analysis in clinical trials. Control Clin Trials 7(3):177-188 (Pubitemid 17189972)
    • (1986) Controlled Clinical Trials , vol.7 , Issue.3 , pp. 177-188
    • DerSimonian, R.1    Laird, N.2
  • 39
    • 84959801619 scopus 로고
    • Statistical aspects of the analysis of data from retrospective studies of disease
    • 13655060 1:STN:280:DyaG1M%2FosVOhtQ%3D%3D
    • Mantel N, Haenszel W (1959) Statistical aspects of the analysis of data from retrospective studies of disease. J Natl Cancer Inst 22(4):719-748
    • (1959) J Natl Cancer Inst , vol.22 , Issue.4 , pp. 719-748
    • Mantel, N.1    Haenszel, W.2
  • 40
    • 0030922816 scopus 로고    scopus 로고
    • Bias in meta-analysis detected by a simple, graphical test
    • Egger M, Davey Smith G, Schneider M et al (1997) Bias in meta-analysis detected by a simple, graphical test. BMJ 315(7109):629-634 (Pubitemid 27387172)
    • (1997) British Medical Journal , vol.315 , Issue.7109 , pp. 629-634
    • Egger, M.1    Smith, G.D.2    Schneider, M.3    Minder, C.4
  • 41
    • 0000976601 scopus 로고    scopus 로고
    • Meta-analysis, funnel plots and sensitivity analysis
    • DOI 10.1093/biostatistics/1.3.247
    • Copas J, Shi JQ (2000) Meta-analysis, funnel plots and sensitivity analysis. Biostatistics 1(3):247-262 (Pubitemid 33213534)
    • (2000) Biostatistics Oxford , vol.1 , Issue.3 , pp. 247-262
    • Copas, J.1    Shi, J.Q.2
  • 42
    • 70349899258 scopus 로고    scopus 로고
    • No association between CYP2D610 genotype and survival of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen treatment
    • 19596663 10.1093/jjco/hyp076
    • Toyama T, Yamashita H, Sugiura H et al (2009) No association between CYP2D610 genotype and survival of node-negative Japanese breast cancer patients receiving adjuvant tamoxifen treatment. Jpn J Clin Oncol 39(10):651-656
    • (2009) Jpn J Clin Oncol , vol.39 , Issue.10 , pp. 651-656
    • Toyama, T.1    Yamashita, H.2    Sugiura, H.3
  • 43
    • 72449150287 scopus 로고    scopus 로고
    • Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment
    • 10.1007/s10549-009-0328-y
    • y Cajal TR, Altes A, Pare L et al (2010) Impact of CYP2D6 polymorphisms in tamoxifen adjuvant breast cancer treatment. Breast Cancer Res Treat 119(1):33-38
    • (2010) Breast Cancer Res Treat , vol.119 , Issue.1 , pp. 33-38
    • Cajal T R, Y.1    Altes, A.2    Pare, L.3
  • 44
    • 77950893913 scopus 로고    scopus 로고
    • Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen
    • 20156115 10.3109/02841860903575273 1:CAS:528:DC%2BC3cXkvVagu7k%3D
    • Lash TL, Cronin-Fenton D, Ahern TP et al (2010) Breast cancer recurrence risk related to concurrent use of SSRI antidepressants and tamoxifen. Acta Oncol 49(3):305-312
    • (2010) Acta Oncol , vol.49 , Issue.3 , pp. 305-312
    • Lash, T.L.1    Cronin-Fenton, D.2    Ahern, T.P.3
  • 45
    • 84868143866 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients
    • 23226070 1:CAS:528:DC%2BC38Xhs1GmsbfN
    • Sirachainan E, Jaruhathai S, Trachu N et al (2012) CYP2D6 polymorphisms influence the efficacy of adjuvant tamoxifen in Thai breast cancer patients. Pharmgenomics Pers Med 5:149-153
    • (2012) Pharmgenomics Pers Med , vol.5 , pp. 149-153
    • Sirachainan, E.1    Jaruhathai, S.2    Trachu, N.3
  • 46
    • 70449554041 scopus 로고    scopus 로고
    • Prevalent breast cancer patients with a homozygous mutant status for CYP2D64: Response and biomarkers in tamoxifen users
    • 19597703 10.1007/s10549-009-0463-5 1:CAS:528:DC%2BD1MXhtlyls7%2FL
    • Dieudonne AS, Lambrechts D, Claes B et al (2009) Prevalent breast cancer patients with a homozygous mutant status for CYP2D64: response and biomarkers in tamoxifen users. Breast Cancer Res Treat 118(3):531-538
    • (2009) Breast Cancer Res Treat , vol.118 , Issue.3 , pp. 531-538
    • Dieudonne, A.S.1    Lambrechts, D.2    Claes, B.3
  • 47
    • 67849116739 scopus 로고    scopus 로고
    • Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients
    • 19421167 10.1038/tpj.2009.14 1:CAS:528:DC%2BD1MXlsVKksbw%3D
    • Rae JM, Sikora MJ, Henry NL et al (2009) Cytochrome P450 2D6 activity predicts discontinuation of tamoxifen therapy in breast cancer patients. Pharmacogenomics J 9(4):258-264
    • (2009) Pharmacogenomics J , vol.9 , Issue.4 , pp. 258-264
    • Rae, J.M.1    Sikora, M.J.2    Henry, N.L.3
  • 48
    • 84863833145 scopus 로고    scopus 로고
    • Endoxifen levels and its association with CYP2D6 genotype and phenotype: Evaluation of a southern Brazilian population under tamoxifen pharmacotherapy
    • 22777153 1:CAS:528:DC%2BC38XhtVams7bE
    • Antunes MV, Linden R, Santos TV et al (2012) Endoxifen levels and its association with CYP2D6 genotype and phenotype: evaluation of a southern Brazilian population under tamoxifen pharmacotherapy. Ther Drug Monit 34(4):422-431
    • (2012) Ther Drug Monit , vol.34 , Issue.4 , pp. 422-431
    • Antunes, M.V.1    Linden, R.2    Santos, T.V.3
  • 49
    • 29144491089 scopus 로고    scopus 로고
    • Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients
    • 15987423 10.1186/bcr993 1:CAS:528:DC%2BD2MXitF2qtr0%3D
    • Wegman P, Vainikka L, Stal O et al (2005) Genotype of metabolic enzymes and the benefit of tamoxifen in postmenopausal breast cancer patients. Breast Cancer Res 7(3):R284-R290
    • (2005) Breast Cancer Res , vol.7 , Issue.3
    • Wegman, P.1    Vainikka, L.2    Stal, O.3
  • 50
    • 78449231785 scopus 로고    scopus 로고
    • Novel pathway analysis of genomic polymorphism-cancer risk interaction in the Breast cancer prevention trial
    • 21152245 1:CAS:528:DC%2BC3cXht1WksrjK
    • Dunn BK, Greene MH, Kelley JM et al (2010) Novel pathway analysis of genomic polymorphism-cancer risk interaction in the Breast cancer prevention trial. Int J Mol Epidemiol Genet 1(4):332-349
    • (2010) Int J Mol Epidemiol Genet , vol.1 , Issue.4 , pp. 332-349
    • Dunn, B.K.1    Greene, M.H.2    Kelley, J.M.3
  • 51
    • 80455168584 scopus 로고    scopus 로고
    • Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: Results from the NSABP P1 and P2 clinical trials
    • 21880792 10.1158/1078-0432.CCR-11-0860 1:CAS:528:DC%2BC3MXhsVWlsr3O
    • Goetz MP, Schaid DJ, Wickerham DL et al (2011) Evaluation of CYP2D6 and efficacy of tamoxifen and raloxifene in women treated for breast cancer chemoprevention: results from the NSABP P1 and P2 clinical trials. Clin Cancer Res 17(21):6944-6951
    • (2011) Clin Cancer Res , vol.17 , Issue.21 , pp. 6944-6951
    • Goetz, M.P.1    Schaid, D.J.2    Wickerham, D.L.3
  • 52
    • 77957559661 scopus 로고    scopus 로고
    • Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian tamoxifen prevention trial
    • 20309015 10.1038/tpj.2010.17 1:CAS:528:DC%2BC3cXjslWgurs%3D
    • Serrano D, Lazzeroni M, Zambon CF et al (2011) Efficacy of tamoxifen based on cytochrome P450 2D6, CYP2C19 and SULT1A1 genotype in the Italian tamoxifen prevention trial. Pharmacogenomics J 11(2):100-107
    • (2011) Pharmacogenomics J , vol.11 , Issue.2 , pp. 100-107
    • Serrano, D.1    Lazzeroni, M.2    Zambon, C.F.3
  • 53
    • 84874118766 scopus 로고    scopus 로고
    • CYP2D6 phenotype indicative for optimized antiestrogen efficacy associates with outcome in early breast cancer patients
    • Trojan A, Vergopoulos A, Breitenstein U et al (2013) CYP2D6 phenotype indicative for optimized antiestrogen efficacy associates with outcome in early breast cancer patients. Cancer Chemother Pharmacol 71(2):301-306
    • (2013) Cancer Chemother Pharmacol , vol.71 , Issue.2 , pp. 301-306
    • Trojan, A.1    Vergopoulos, A.2    Breitenstein, U.3
  • 54
    • 78650996411 scopus 로고    scopus 로고
    • Potent CYP2D6 Inhibiting drugs do not increase relapse rate in early breast cancer patients treated with adjuvant tamoxifen
    • 20593233 10.1007/s10549-010-1008-7 1:CAS:528:DC%2BC3cXhsFCqt7zE
    • Siegelmann-Danieli N, Kurnik D, Lomnicky Y et al (2011) Potent CYP2D6 Inhibiting drugs do not increase relapse rate in early breast cancer patients treated with adjuvant tamoxifen. Breast Cancer Res Treat 125(2):505-510
    • (2011) Breast Cancer Res Treat , vol.125 , Issue.2 , pp. 505-510
    • Siegelmann-Danieli, N.1    Kurnik, D.2    Lomnicky, Y.3
  • 55
    • 77956242845 scopus 로고    scopus 로고
    • CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: Expanded polymorphism coverage improves risk stratification
    • 20515869 10.1158/1078-0432.CCR-10-0478 1:CAS:528:DC%2BC3cXhtV2rt7fO
    • Schroth W, Hamann U, Fasching PA et al (2010) CYP2D6 polymorphisms as predictors of outcome in breast cancer patients treated with tamoxifen: expanded polymorphism coverage improves risk stratification. Clin Cancer Res 16(17):4468-4477
    • (2010) Clin Cancer Res , vol.16 , Issue.17 , pp. 4468-4477
    • Schroth, W.1    Hamann, U.2    Fasching, P.A.3
  • 57
    • 77955924464 scopus 로고    scopus 로고
    • Lessons for pharmacogenomics studies: Association study between CYP2D6 genotype and tamoxifen response
    • 20574415 10.1097/FPC.0b013e32833af231 1:CAS:528:DC%2BC3cXpvFemtbc%3D
    • Kiyotani K, Mushiroda T, Hosono N et al (2010) Lessons for pharmacogenomics studies: association study between CYP2D6 genotype and tamoxifen response. Pharmacogenet Genomics 20(9):565-568
    • (2010) Pharmacogenet Genomics , vol.20 , Issue.9 , pp. 565-568
    • Kiyotani, K.1    Mushiroda, T.2    Hosono, N.3
  • 58
    • 84858204909 scopus 로고    scopus 로고
    • A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese
    • 22180457 10.1093/hmg/ddr597 1:CAS:528:DC%2BC38Xjs1SrtLo%3D
    • Kiyotani K, Mushiroda T, Tsunoda T et al (2012) A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese. Hum Mol Genet 21(7):1665-1672
    • (2012) Hum Mol Genet , vol.21 , Issue.7 , pp. 1665-1672
    • Kiyotani, K.1    Mushiroda, T.2    Tsunoda, T.3
  • 59
    • 61549105328 scopus 로고    scopus 로고
    • Early and locally advanced breast cancer: Diagnosis and treatment National Institute for Health and Clinical Excellence guideline 2009
    • 10.1016/j.clon.2008.12.008 1:STN:280:DC%2BD1M3gtlGquw%3D%3D
    • Yarnold J (2009) Early and locally advanced breast cancer: diagnosis and treatment National Institute for Health and Clinical Excellence guideline 2009. Clin Oncol 21(3):159-160
    • (2009) Clin Oncol , vol.21 , Issue.3 , pp. 159-160
    • Yarnold, J.1
  • 60
    • 79951901358 scopus 로고    scopus 로고
    • Avoidance of CYP2D6 inhibitors in patients receiving tamoxifen
    • 20823421 10.1200/JCO.2010.30.1887 author reply e586
    • Ferraldeschi R, Howell SJ, Thompson AM et al (2010) Avoidance of CYP2D6 inhibitors in patients receiving tamoxifen. J Clin Oncol 28(29):e584-e585 author reply e586
    • (2010) J Clin Oncol , vol.28 , Issue.29
    • Ferraldeschi, R.1    Howell, S.J.2    Thompson, A.M.3
  • 61
    • 75749092296 scopus 로고    scopus 로고
    • Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen
    • 19949017 10.1200/JCO.2009.23.1274 1:CAS:528:DC%2BC3cXivFartbk%3D
    • Dowsett M, Cuzick J, Ingle J et al (2010) Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol 28(3):509-518
    • (2010) J Clin Oncol , vol.28 , Issue.3 , pp. 509-518
    • Dowsett, M.1    Cuzick, J.2    Ingle, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.