ESCRT regulates surface expression of the Kir2.1 potassium channel

Molecular Biology of the Cell

Volumn 25, Issue 2, 2014, Pages 276-289

  Kolb, Alexander R ^a   Needham, Patrick G ^a   Rothenberg, Cari ^b   Guerriero, Christopher J ^a   Welling, Paul A ^b   Brodsky, Jeffrey L ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

^b UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ESCRT PROTEIN; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; SYNTHETIC DNA;

APS1 GENE; ARL1 GENE; ARL3 GENE; ARTICLE; BGL2 GENE; BIOGENESIS; BSD2 GENE; CCR4 GENE; CELL MEMBRANE; COG5 GENE; COG6 GENE; COG7 GENE; COG8 GENE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CULTURE MEDIUM; DID2 GENE; ECM30 GENE; ENDOPLASMIC RETICULUM ASSOCIATED DEGRADATION; FUNGUS GROWTH; FUNGUS MUTATION; GDH3 GENE; GENE; GENE DELETION; GIM4 GENE; GOS1 GENE; GTR2 GENE; GYP7 GENE; HOMEOSTASIS; HUMAN; HUMAN CELL; IRS4 GENE; MAK10 GENE; MULTIGENE FAMILY; MVB12 GENE; NONHUMAN; OPI8 GENE; PKR1 GENE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN TARGETING; RAV1 GENE; RAV2 GENE; RGD2 GENE; SAP155 GENE; SCS7 GENE; TCA17 GENE; TRE1 GENE; TRS85 GENE; VAB2 GENE; VAM10 GENE; VPS13 GENE; VPS17 GENE; VPS2 GENE; VPS22 GENE; VPS23 GENE; VPS26 GENE; VPS27 GENE; VPS29 GENE; VPS30 GENE; VPS35 GENE; VPS36 GENE; VPS37 GENE; VPS38 GENE; VPS5 GENE; VPS52 GENE; VPS54 GENE; VTA1 GENE; YJL118W GENE; YJL132W GENE; YJL163C GENE; YPT6 GENE;

CELL MEMBRANE; ENDOPLASMIC RETICULUM-ASSOCIATED DEGRADATION; ENDOSOMAL SORTING COMPLEXES REQUIRED FOR TRANSPORT; ENDOSOMES; GENE EXPRESSION REGULATION; HUMANS; POTASSIUM CHANNELS, INWARDLY RECTIFYING; PROTEIN TRANSPORT; SURFACE PROPERTIES;

EID: 84892555605     PISSN: 10591524     EISSN: 19394586     Source Type: Journal    
DOI: 10.1091/mbc.E13-07-0394     Document Type: Article

References (123)

1. Adams A, Gottschling DE, Kaiser CA, Stearns T (1998). Methods in Yeast Genetics: A Cold Spring Harbor Laboratory Course Manual, Plainview, NY: Cold Spring Harbor Laboratory Press.
2. Aebi M, Bernasconi R, Clerc S, Molinari M (2010). N-glycan structures: recognition and processing in the ER. Trends Biochem Sci 35, 74-82.
3. Ahner A, Nakatsukasa K, Zhang H, Frizzell RA, Brodsky JL (2007). Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation. Mol Biol Cell 18, 806-814. (Pubitemid 46399487)
4. Alesutan I, Munoz C, Sopjani M, Dermaku-Sopjani M, Michael D, Fraser S, Kemp BE, Seebohm G, Foller M, Lang F (2011). Inhibition of Kir2.1 (KCNJ2) by the AMP-activated protein kinase. Biochem Biophys Res Commun 408, 505-510.
5. Apaja PM, Xu H, Lukacs GL (2010). Quality control for unfolded proteins at the plasma membrane. J Cell Biol 191, 553-570.
6. Armstrong J, Patel S, Riddle P (1990). Lysosomal sorting mutants of coronavirus E1 protein, a Golgi membrane protein. J Cell Sci 95 (Pt 2), 191-197.
7. Arvan P, Zhao X, Ramos-Castaneda J, Chang A (2002). Secretory pathway quality control operating in Golgi, plasmalemmal, and endosomal systems. Traffic 3, 771-780. (Pubitemid 35277003)
8. Ashok A, Hegde RS (2009). Selective processing and metabolism of disease-causing mutant prion proteins. PLoS Pathog 5, e1000479.
9. Azmi IF, Davies BA, Xiao J, Babst M, Xu Z, Katzmann DJ (2008). ESCRT-III family members stimulate Vps4 ATPase activity directly or via Vta1. Dev Cell 14, 50-61.
10. Babst M, Odorizzi G, Estepa EJ, Emr SD (2000). Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 1, 248-258.
11. Babst M, Wendland B, Estepa EJ, Emr SD (1998). The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J 17, 2982-2993. (Pubitemid 28254371)
12. Balut CM, Hamilton KL, Devor DC (2012). Trafficking of intermediate (KCa3.1) and small (KCa2.x) conductance, Ca(2+)-activated K(+) channels: a novel target for medicinal chemistry efforts. Chem Med Chem 7, 1741-1755.
13. Barreto L et al. (2011). A genomewide screen for tolerance to cationic drugs reveals genes important for potassium homeostasis in Saccharomyces cerevisiae. Eukaryot Cell 10, 1241-1250.
14. Behnia R, Panic B, Whyte JR, Munro S (2004). Targeting of the Arf-like GTPase Arl3p to the Golgi requires N-terminal acetylation and the membrane protein Sys1p. Nat Cell Biol 6, 405-413. (Pubitemid 38607500)
15. Bilodeau PS, Urbanowski JL, Winistorfer SC, Piper RC (2002). The Vps27p Hse1p complex binds ubiquitin and mediates endosomal protein sorting. Nat Cell Biol 4, 534-539. (Pubitemid 34752441)
16. Bonangelino CJ, Chavez EM, Bonifacino JS (2002). Genomic screen for vacuolar protein sorting genes in Saccharomyces cerevisiae. Mol Biol Cell 13, 2486-2501. (Pubitemid 34831350)
17. Brachmann CB, Davies A, Cost GJ, Caputo E, Li J, Hieter P, Boeke JD (1998). Designer deletion strains derived from Saccharomyces cerevisiae S288C: a useful set of strains and plasmids for PCR-mediated gene disruption and other applications. Yeast 14, 115-132. (Pubitemid 28062863)
18. Brodsky JL, Schekman R (1993). A Sec63p-BiP complex from yeast is required for protein translocation in a reconstituted proteoliposome. J Cell Biol 123, 1355-1363. (Pubitemid 24012016)
19. Brodsky JL, Werner ED, Dubas ME, Goeckeler JL, Kruse KB, McCracken AA (1999). The requirement for molecular chaperones during endoplasmic reticulum-associated protein degradation demonstrates that protein export and import are mechanistically distinct. J Biol Chem 274, 3453-3460. (Pubitemid 29077185)
20. Buck TM, Kolb AR, Boyd CR, Kleyman TR, Brodsky JL (2010). The endoplasmic reticulum-associated degradation of the epithelial sodium channel requires a unique complement of molecular chaperones. Mol Biol Cell 21, 1047-1058.
21. Burda P, Padilla SM, Sarkar S, Emr SD (2002). Retromer function in endosome-to-Golgi retrograde transport is regulated by the yeast Vps34 PtdIns 3-kinase. J Cell Sci 115, 3889-3900. (Pubitemid 35256490)
22. Carvalho P, Goder V, Rapoport TA (2006). Distinct ubiquitin-ligase complexes define convergent pathways for the degradation of ER proteins. Cell 126, 361-373. (Pubitemid 44092963)
23. Chang A, Fink GR (1995). Targeting of the yeast plasma membrane [H+]ATPase: a novel gene AST1 prevents mislocalization of mutant ATPase to the vacuole. J Cell Biol 128, 39-49.
24. Claessen JH, Kundrat L, Ploegh HL (2012). Protein quality control in the ER: balancing the ubiquitin checkbook. Trends Cell Biol 22, 22-32.
25. Conibear E, Stevens TH (2000). Vps52p, Vps53p, and Vps54p form a novel multisubunit complex required for protein sorting at the yeast late Golgi. Mol Biol Cell 11, 305-323. (Pubitemid 30075525)
26. Coughlan CM, Walker JL, Cochran JC, Wittrup KD, Brodsky JL (2004). Degradation of mutated bovine pancreatic trypsin inhibitor in the yeast vacuole suggests post-endoplasmic reticulum protein quality control. J Biol Chem 279, 15289-15297. (Pubitemid 38618926)
27. Dang H, Klokk TI, Schaheen B, McLaughlin BM, Thomas AJ, Durns TA, Bitler BG, Sandvig K, Fares H (2011). Derlin-dependent retrograde transport from endosomes to the Golgi apparatus. Traffic 12, 1417-1431.
28. de Boer TP, Houtman MJ, Compier M, van der Heyden MA (2010). The mammalian K(IR)2.x inward rectifier ion channel family: expression pattern and pathophysiology. Acta Physiol (Oxf) 199, 243-256.
29. Denic V, Quan EM, Weissman JS (2006). A luminal surveillance complex that selects misfolded glycoproteins for ER-associated degradation. Cell 126, 349-359. (Pubitemid 44092967)
30. Dupre S, Urban-Grimal D, Haguenauer-Tsapis R (2004). Ubiquitin and endocytic internalization in yeast and animal cells. Biochim Biophys Acta 1695, 89-111. (Pubitemid 39574969)
31. Escola JM, Kleijmeer MJ, Stoorvogel W, Griffith JM, Yoshie O, Geuze HJ (1998). Selective enrichment of tetraspan proteins on the internal vesicles of multivesicular endosomes and on exosomes secreted by human B-lymphocytes. J Biol Chem 273, 20121-20127. (Pubitemid 28377568)
32. Fisher EA, Khanna NA, McLeod RS (2011). Ubiquitination regulates the assembly of VLDL in HepG2 cells and is the committing step of the apoB-100 ERAD pathway. J Lipid Res 52, 1170-1180.
33. Gestwicki JE, Garza D (2012). Protein quality control in neurodegenerative disease. Prog Mol Biol Transl Sci 107, 327-353.
34. Gill DJ, Teo H, Sun J, Perisic O, Veprintsev DB, Emr SD, Williams RL (2007). Structural insight into the ESCRT-I/-II link and its role in MVB trafficking. EMBO J 26, 600-612. (Pubitemid 46160959)
35. Grove DE, Rosser MF, Ren HY, Naren AP, Cyr DM (2009). Mechanisms for rescue of correctable folding defects in CFTRDelta F508. Mol Biol Cell 20, 4059-4069.
36. Guerriero CJ, Brodsky JL (2012). The delicate balance between secreted protein folding and endoplasmic reticulum-associated degradation in human physiology. Physiol Rev 92, 537-576.
37. Haass FA, Jonikas M, Walter P, Weissman JS, Jan YN, Jan LY, Schuldiner M (2007). Identification of yeast proteins necessary for cell-surface function of a potassium channel. Proc Natl Acad Sci USA 104, 18079-18084. (Pubitemid 350210823)
38. Halaban R, Cheng E, Zhang Y, Moellmann G, Hanlon D, Michalak M, Setaluri V, Hebert DN (1997). Aberrant retention of tyrosinase in the endoplasmic reticulum mediates accelerated degradation of the enzyme and contributes to the dedifferentiated phenotype of amelanotic melanoma cells. Proc Natl Acad Sci USA 94, 6210-6215. (Pubitemid 27270663)
39. Han S, Liu Y, Chang A (2007). Cytoplasmic Hsp70 promotes ubiquitination for endoplasmic reticulum-associated degradation of a misfolded mutant of the yeast plasma membrane ATPase, PMA1. J Biol Chem 282, 26140-26149. (Pubitemid 47443767)
40. Haynes CM, Caldwell S, Cooper AA (2002). An HRD/DER-independent ER quality control mechanism involves Rsp5p-dependent ubiquitination and ER-Golgi transport. J Cell Biol 158, 91-101.
41. Hebert DN, Molinari M (2012). Flagging and docking: dual roles for N-glycans in protein quality control and cellular proteostasis. Trends Biochem Sci 37, 404-410.
42. Helliwell SB, Losko S, Kaiser CA (2001). Components of a ubiquitin ligase complex specify polyubiquitination and intracellular trafficking of the general amino acid permease. J Cell Biol 153, 649-662. (Pubitemid 34286099)
43. Hettema EH, Valdez-Taubas J, Pelham HR (2004). Bsd2 binds the ubiquitin ligase Rsp5 and mediates the ubiquitination of transmembrane proteins. EMBO J 23, 1279-1288. (Pubitemid 38525000)
44. Hibino H, Inanobe A, Furutani K, Murakami S, Findlay I, Kurachi Y (2010). Inwardly rectifying potassium channels: their structure, function, and physiological roles. Physiol Rev 90, 291-366.
45. Hicke L, Dunn R (2003). Regulation of membrane protein transport by ubiquitin and ubiquitin-binding proteins. Annu Rev Cell Dev Biol 19, 141-172. (Pubitemid 37487346)
46. Hill K, Cooper AA (2000). Degradation of unassembled Vph1p reveals novel aspects of the yeast ER quality control system. EMBO J 19, 550-561. (Pubitemid 30093728)
47. Hong E, Davidson AR, Kaiser CA (1996). A pathway for targeting soluble misfolded proteins to the yeast vacuole. J Cell Biol 135, 623-633. (Pubitemid 26372920)
48. Huang CL, Feng S, Hilgemann DW (1998). Direct activation of inward rectifier potassium channels by PIP2 and its stabilization by Gbetagamma. Nature 391, 803-806. (Pubitemid 28099680)
49. Huotari J, Helenius A (2011). Endosome maturation. EMBO J 30, 3481-3500.
50. Hurtley SM, Helenius A (1989). Protein oligomerization in the endoplasmic reticulum. Annu Rev Cell Biol 5, 277-307. (Pubitemid 19286686)
51. Jansen JA, de Boer TP, Wolswinkel R, van Veen TA, Vos MA, van Rijen HV, van der Heyden MA (2008). Lysosome mediated Kir2.1 breakdown directly influences inward rectifier current density. Biochem Biophys Res Commun 367, 687-692.
52. Jenness DD, Li Y, Tipper C, Spatrick P (1997). Elimination of defective alpha-factor pheromone receptors. Mol Cell Biol 17, 6236-6245. (Pubitemid 27451167)
53. Katzmann DJ, Sarkar S, Chu T, Audhya A, Emr SD (2004). Multivesicular body sorting: ubiquitin ligase Rsp5 is required for the modification and sorting of carboxypeptidase S. Mol Biol Cell 15, 468-480. (Pubitemid 38146466)
54. Keener JM, Babst M (2013). Quality control and substrate-dependent downregulation of the nutrient transporter Fur4. Traffic 14, 412-427.
55. Kihara A, Noda T, Ishihara N, Ohsumi Y (2001). Two distinct Vps34 phosphatidylinositol 3-kinase complexes function in autophagy and carboxypeptidase Y sorting in Saccharomyces cerevisiae. J Cell Biol 152, 519-530. (Pubitemid 34280235)
56. Kim Y, Deng Y, Philpott CC (2007). GGA2- and ubiquitin-dependent trafficking of Arn1, the ferrichrome transporter of Saccharomyces cerevisiae. Mol Biol Cell 18, 1790-1802. (Pubitemid 46717560)
57. Kincaid MM, Cooper AA (2007). Misfolded proteins traffic from the endoplasmic reticulum (ER) due to ER export signals. Mol Biol Cell 18, 455-463. (Pubitemid 46213215)
58. Komada M, Masaki R, Yamamoto A, Kitamura N (1997). Hrs, a tyrosine kinase substrate with a conserved double zinc finger domain, is localized to the cytoplasmic surface of early endosomes. J Biol Chem 272, 20538-20544. (Pubitemid 27355611)
59. Korolchuk VI, Schutz MM, Gomez-Llorente C, Rocha J, Lansu NR, Collins SM, Wairkar YP, Robinson IM, O'Kane CJ (2007). Drosophila Vps35 function is necessary for normal endocytic trafficking and actin cytoskeleton organisation. J Cell Sci 120, 4367-4376.
60. Kostelansky MS, Schluter C, Tam YY, Lee S, Ghirlando R, Beach B, Conibear E, Hurley JH (2007). Molecular architecture and functional model of the complete yeast ESCRT-I heterotetramer. Cell 129, 485-498. (Pubitemid 46671555)
61. Li B, Warner JR (1996). Mutation of the Rab6 homologue of Saccharomyces cerevisiae, YPT6, inhibits both early Golgi function and ribosome biosynthesis. J Biol Chem 271, 16813-16819. (Pubitemid 26239048)
62. Li Y, Kane T, Tipper C, Spatrick P, Jenness DD (1999). Yeast mutants affecting possible quality control of plasma membrane proteins. Mol Cell Biol 19, 3588-3599. (Pubitemid 29193818)
63. Li Z et al. (2011). Systematic exploration of essential yeast gene function with temperature-sensitive mutants. Nat Biotechnol 29, 361-367.
64. Lu C, Jiang C, Pribanic S, Rotin D (2007). CFTR stabilizes ENaC at the plasma membrane. J Cyst Fibros 6, 419-422. (Pubitemid 350028701)
65. Luo W, Chang A (1997). Novel genes involved in endosomal traffic in yeast revealed by suppression of a targeting-defective plasma membrane ATPase mutant. J Cell Biol 138, 731-746. (Pubitemid 27365038)
66. Ma D, Taneja TK, Hagen BM, Kim BY, Ortega B, Lederer WJ, Welling PA (2011). Golgi export of the Kir2.1 channel is driven by a trafficking signal located within its tertiary structure. Cell 145, 1102-1115.
67. Ma D, Zerangue N, Lin YF, Collins A, Yu M, Jan YN, Jan LY (2001). Role of ER export signals in controlling surface potassium channel numbers. Science 291, 316-319. (Pubitemid 32096319)
68. Makuc J, Cappellaro C, Boles E (2004). Co-expression of a mammalian accessory trafficking protein enables functional expression of the rat MCT1 monocarboxylate transporter in Saccharomyces cerevisiae. FEMS Yeast Res 4, 795-801. (Pubitemid 39140649)
69. Mayers JR, Fyfe I, Schuh AL, Chapman ER, Edwardson JM, Audhya A (2011). ESCRT-0 assembles as a heterotetrameric complex on membranes and binds multiple ubiquitinylated cargoes simultaneously. J Biol Chem 286, 9636-9645.
70. McCullough J, Row PE, Lorenzo O, Doherty M, Beynon R, Clague MJ, Urbe S (2006). Activation of the endosome-associated ubiquitin isopeptidase AMSH by STAM, a component of the multivesicular body-sorting machinery. Curr Biol 16, 160-165. (Pubitemid 43117430)
71. Mehnert M, Sommer T, Jarosch E (2010). ERAD ubiquitin ligases: multifunctional tools for protein quality control and waste disposal in the endoplasmic reticulum. Bioessays 32, 905-913.
72. Minor DL Jr, Masseling SJ, Jan YN, Jan LY (1999). Transmembrane structure of an inwardly rectifying potassium channel. Cell 96, 879-891. (Pubitemid 29165090)
73. Mitchell DM, Zhou M, Pariyarath R, Wang H, Aitchison JD, Ginsberg HN, Fisher EA (1998). Apoprotein B100 has a prolonged interaction with the translocon during which its lipidation and translocation change from dependence on the microsomal triglyceride transfer protein to independence. Proc Natl Acad Sci USA 95, 14733-14738. (Pubitemid 29003699)
74. Montpetit B, Conibear E (2009). Identification of the novel TRAPP associated protein Tca17. Traffic 10, 713-723.
75. Mumberg D, Muller R, Funk M (1994). Regulatable promoters of Saccharomyces cerevisiae: comparison of transcriptional activity and their use for heterologous expression. Nucleic Acids Res 22, 5767-5768.
76. Mumberg D, Muller R, Funk M (1995). Yeast vectors for the controlled expression of heterologous proteins in different genetic backgrounds. Gene 156, 119-122.
77. Nakamura RL, Gaber RF (1998). Studying ion channels using yeast genetics. Methods Enzymol 293, 89-104. (Pubitemid 29342483)
78. Nakatsukasa K, Huyer G, Michaelis S, Brodsky JL (2008). Dissecting the ER-associated degradation of a misfolded polytopic membrane protein. Cell 132, 101-112.
79. Nalos L, de Boer TP, Houtman MJ, Rook MB, Vos MA, van der Heyden MA (2011). Inhibition of lysosomal degradation rescues pentamidine-mediated decreases of K(IR)2.1 ion channel expression but not that of K(v)11.1. Eur J Pharmacol 652, 96-103.
80. Obara K, Sekito T, Ohsumi Y (2006). Assortment of phosphatidylinositol 3-kinase complexes-Atg14p directs association of complex I to the pre-autophagosomal structure in Saccharomyces cerevisiae. Mol Biol Cell 17, 1527-1539. (Pubitemid 44011573)
81. Okiyoneda T, Barriere H, Bagdany M, Rabeh WM, Du K, Hohfeld J, Young JC, Lukacs GL (2010). Peripheral protein quality control removes unfolded CFTR from the plasma membrane. Science 329, 805-810.
82. Pizzirusso M, Chang A (2004). Ubiquitin-mediated targeting of a mutant plasma membrane ATPase, Pma1-7, to the endosomal/vacuolar system in yeast. Mol Biol Cell 15, 2401-2409. (Pubitemid 38580655)
83. Plaster NM et al. (2001). Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell 105, 511-519. (Pubitemid 32520856)
84. Plemper RK, Bohmler S, Bordallo J, Sommer T, Wolf DH (1997). Mutant analysis links the translocon and BiP to retrograde protein transport for ER degradation. Nature 388, 891-895. (Pubitemid 27377063)
85. Portnoy ME, Liu XF, Culotta VC (2000). Saccharomyces cerevisiae expresses three functionally distinct homologues of the nramp family of metal transporters. Mol Cell Biol 20, 7893-7902.
86. Priori SG et al. (2005). A novel form of short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ Res 96, 800-807. (Pubitemid 40559520)
87. Qu D, Teckman JH, Omura S, Perlmutter DH (1996). Degradation of a mutant secretory protein, alpha1-antitrypsin Z, in the endoplasmic reticulum requires proteasome activity. J Biol Chem 271, 22791-22795. (Pubitemid 26304726)
88. Ram RJ, Li B, Kaiser CA (2002). Identification of Sec36p, Sec37p, and Sec38p: components of yeast complex that contains Sec34p and Sec35p. Mol Biol Cell 13, 1484-1500. (Pubitemid 34522633)
89. Reggiori F, Pelham HR (2002). A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Nat Cell Biol 4, 117-123. (Pubitemid 34141477)
90. Roberg KJ, Rowley N, Kaiser CA (1997). Physiological regulation of membrane protein sorting late in the secretory pathway of Saccharomyces cerevisiae. J Cell Biol 137, 1469-1482. (Pubitemid 27282230)
91. Robinson JS, Klionsky DJ, Banta LM, Emr SD (1988). Protein sorting in Saccharomyces cerevisiae: isolation of mutants defective in the delivery and processing of multiple vacuolar hydrolases. Mol Cell Biol 8, 4936-4948. (Pubitemid 18261566)
92. Romanenko VG, Fang Y, Byfield F, Travis AJ, Vandenberg CA, Rothblat GH, Levitan I (2004). Cholesterol sensitivity and lipid raft targeting of Kir2.1 channels. Biophys J 87, 3850-3861. (Pubitemid 39602891)
93. Rothman JH, Stevens TH (1986). Protein sorting in yeast: mutants defective in vacuole biogenesis mislocalize vacuolar proteins into the late secretory pathway. Cell 47, 1041-1051. (Pubitemid 17005076)
94. Sacher M, Barrowman J, Schieltz D, Yates JR 3rd, Ferro-Novick S (2000). Identification and characterization of five new subunits of TRAPP. Eur J Cell Biol 79, 71-80. (Pubitemid 30119574)
95. Sato BK, Schulz D, Do PH, Hampton RY (2009). Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Mol Cell 34, 212-222.
96. Schubert U, Anton LC, Bacik I, Cox JH, Bour S, Bennink JR, Orlowski M, Strebel K, Yewdell JW (1998). CD4 glycoprotein degradation induced by human immunodeficiency virus type 1 Vpu protein requires the function of proteasomes and the ubiquitin-conjugating pathway. J Virol 72, 2280-2288. (Pubitemid 28100787)
97. Schwalbe RA, Rudin A, Xia SL, Wingo CS (2002). Site-directed glycosylation tagging of functional Kir2.1 reveals that the putative pore-forming segment is extracellular. J Biol Chem 277, 24382-24389. (Pubitemid 34951960)
98. Seaman MN, McCaffery JM, Emr SD (1998). A membrane coat complex essential for endosome-to-Golgi retrograde transport in yeast. J Cell Biol 142, 665-681. (Pubitemid 28381486)
99. Siniossoglou S, Pelham HR (2002). Vps51p links the VFT complex to the SNARE Tlg1p. J Biol Chem 277, 48318-48324. (Pubitemid 35470786)
100. Smith MH, Ploegh HL, Weissman JS (2011). Road to ruin: targeting proteins for degradation in the endoplasmic reticulum. Science 334, 1086-1090.
101. Spear ED, Ng DT (2003). Stress tolerance of misfolded carboxypeptidase Y requires maintenance of protein trafficking and degradative pathways. Mol Biol Cell 14, 2756-2767. (Pubitemid 36871519)
102. Stimpson HE, Lewis MJ, Pelham HR (2006). Transferrin receptor-like proteins control the degradation of a yeast metal transporter. EMBO J 25, 662-672. (Pubitemid 43292429)
103. Sullivan ML, Youker RT, Watkins SC, Brodsky JL (2003). Localization of the BiP molecular chaperone with respect to endoplasmic reticulum foci containing the cystic fibrosis transmembrane conductance regulator in yeast. J Histochem Cytochem 51, 545-548. (Pubitemid 36418051)
104. Tang W, Ruknudin A, Yang WP, Shaw SY, Knickerbocker A, Kurtz S (1995). Functional expression of a vertebrate inwardly rectifying K+ channel in yeast. Mol Biol Cell 6, 1231-1240.
105. Taxis C, Vogel F, Wolf DH (2002). ER-Golgi traffic is a prerequisite for efficient ER degradation. Mol Biol Cell 13, 1806-1818. (Pubitemid 34651473)
106. Teo H, Gill DJ, Sun J, Perisic O, Veprintsev DB, Vallis Y, Emr SD, Williams RL (2006). ESCRT-I core and ESCRT-II GLUE domain structures reveal role for GLUE in linking to ESCRT-I and membranes. Cell 125, 99-111.
107. Teo H, Perisic O, Gonzalez B, Williams RL (2004). ESCRT-II, an endosome-associated complex required for protein sorting: crystal structure and interactions with ESCRT-III and membranes. Dev Cell 7, 559-569. (Pubitemid 39341841)
108. Tinker A, Jan YN, Jan LY (1996). Regions responsible for the assembly of inwardly rectifying potassium channels. Cell 87, 857-868. (Pubitemid 26404285)
109. Tong AH, Boone C (2006). Synthetic genetic array analysis in Saccharomyces cerevisiae. Methods Mol Biol 313, 171-192.
110. Trzcinska-Daneluti AM, Ly D, Huynh L, Jiang C, Fladd C, Rotin D (2009). High-content functional screen to identify proteins that correct F508del-CFTR function. Mol Cell Proteomics 8, 780-790.
111. Ungar D, Oka T, Brittle EE, Vasile E, Lupashin VV, Chatterton JE, Heuser JE, Krieger M, Waters MG (2002). Characterization of a mammalian Golgi-localized protein complex, COG, that is required for normal Golgi morphology and function. J Cell Biol 157, 405-415. (Pubitemid 34839805)
112. Vallejo AN, Pogulis RJ, Pease LR (1994). In vitro synthesis of novel genes: mutagenesis and recombination by PCR. PCR Methods Appl 4, S123-130.
113. Vashist S, Kim W, Belden WJ, Spear ED, Barlowe C, Ng DT (2001). Distinct retrieval and retention mechanisms are required for the quality control of endoplasmic reticulum protein folding. J Cell Biol 155, 355-368.
114. Vashist S, Ng DT (2004). Misfolded proteins are sorted by a sequential checkpoint mechanism of ER quality control. J Cell Biol 165, 41-52. (Pubitemid 38649175)
115. Vij N, Fang S, Zeitlin PL (2006). Selective inhibition of endoplasmic reticulum-associated degradation rescues DeltaF508-cystic fibrosis transmembrane regulator and suppresses interleukin-8 levels: therapeutic implications. J Biol Chem 281, 17369-17378.
116. Wang S, Ng DT (2010). Evasion of endoplasmic reticulum surveillance makes Wsc1p an obligate substrate of Golgi quality control. Mol Biol Cell 21, 1153-1165.
117. Wang S, Thibault G, Ng DT (2011). Routing misfolded proteins through the multivesicular body (MVB) pathway protects against proteotoxicity. J Biol Chem 286, 29376-29387.
118. Wolf DH, Stolz A (2012). The Cdc48 machine in endoplasmic reticulum associated protein degradation. Biochim Biophys Acta 1823, 117-124.
119. Wollert T, Hurley JH (2010). Molecular mechanism of multivesicular body biogenesis by ESCRT complexes. Nature 464, 864-869.
120. Wollert T, Wunder C, Lippincott-Schwartz J, Hurley JH (2009). Membrane scission by the ESCRT-III complex. Nature 458, 172-177.
121. Xia WF, Tang FL, Xiong L, Xiong S, Jung JU, Lee DH, Li XS, Feng X, Mei L, Xiong WC (2013). Vps35 loss promotes hyperresorptive osteoclastogenesis and osteoporosis via sustained RANKL signaling. J Cell Biol 200, 821-837.
122. Zhang Y, Nijbroek G, Sullivan ML, McCracken AA, Watkins SC, Michaelis S, Brodsky JL (2001). Hsp70 molecular chaperone facilitates endoplasmic reticulum-associated protein degradation of cystic fibrosis transmembrane conductance regulator in yeast. Mol Biol Cell 12, 1303-1314. (Pubitemid 33044412)
123. Zhao Y, Macgurn JA, Liu M, Emr S (2013). The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress. Elife 2, e00459.