Saccharomyces cerevisiae expresses three functionally distinct homologues of the Nramp family of metal transporters

Molecular and Cellular Biology

Volumn 20, Issue 21, 2000, Pages 7893-7902

  Portnoy, M E ^a   Xiu Fen Liu, ^a   Culotta, V C ^a  

^a JOHNS HOPKINS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; FUNGAL PROTEIN; GENE PRODUCT; IRON; MANGANESE; METAL; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN; PROTEIN BSD2; PROTEIN SMF1P; PROTEIN SMF2P; PROTEIN SMF3P; UNCLASSIFIED DRUG;

ARTICLE; BIOACCUMULATION; CELL SURFACE; CELL TRANSPORT; CELL VACUOLE; CONTROLLED STUDY; IRON STORAGE; IRON TRANSPORT; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FAMILY; PROTEIN LOCALIZATION; PROTEIN STABILITY; REGULATORY MECHANISM; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY; TRANSCRIPTION REGULATION;

AMINO ACID SEQUENCE; BASE SEQUENCE; BLOTTING, WESTERN; CARRIER PROTEINS; CELL MEMBRANE; COMPARATIVE STUDY; DOWN-REGULATION; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; INTRACELLULAR MEMBRANES; MANGANESE; MEMBRANE PROTEINS; MODELS, BIOLOGICAL; MOLECULAR SEQUENCE DATA; MUTAGENESIS, SITE-DIRECTED; PLASMIDS; PROTEIN ISOFORMS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN STRUCTURE, SECONDARY; SACCHAROMYCES CEREVISIAE; SEQUENCE HOMOLOGY, AMINO ACID; SEQUENCE HOMOLOGY, NUCLEIC ACID; SUPPORT, NON-U.S. GOV'T; SUPPORT, U.S. GOV'T, P.H.S.; TIME FACTORS; VACUOLES;

SACCHAROMYCES CEREVISIAE;

EID: 0033773040     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.20.21.7893-7902.2000     Document Type: Article

References (45)

1. The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake
2. Nramp1 locus encodes a 65 kDa interferon-gamma-inducible protein in murine macrophages
3. Cloning and characterization of the OsNramp family from Oryza sativa, a new family of membrane proteins possibly implicated in the transport of metal ions
4. The AFT1 transcriptional factor is differentially required for expression of high-affinity iron uptake genes in Saccharomyces cerevisiae
5. Resistance to intracellular infections: Comparative genomic analysis of Nramp
6. Nramp defines a family of membrane proteins
7. Yeast SMF1 mediates H(+)-coupled iron uptake with concomitant uncoupled cation currents
8. Structure and functions of the 20S and 26S proteasomes
9. Involvement of NRAMP1 from Arabidopsis thaliana in iron transport
10. Genetic evidence that ferric reductase is required for iron uptake in Saccharomyces cerevisiae
11. The FET3 gene product required for high affinity iron transport in yeast is a cell surface ferroxidase
12. The FET4 gene encodes the low affinity Fe(II) transport protein of Saccharomyces cerevisiae
13. Nramp2 is mutated in the anemic Belgrade (b) rat: Evidence of a role for Nramp2 in endosomal iron transport
14. Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene
15. Macrophage NRAMP1 and its role in resistance to microbial infections
16. The Bcg/Ity/Lsh locus: Genetic transfer of resistance to infections in C57BL/6J mice transgenic for the Nramp1(Gly169) allele
17. Cloning and characterization of a mammalian proton-coupled metal-ion transporter
18. Proteinase yscE, the yeast proteasome/multicatalytic-multifunctional proteinase: Mutants unravel its function in stress induced proteolysis and uncover its necessity for cell survival
19. Three proteolytic systems in the yeast Saccharomyces cerevisiae
20. Resistance to cadmium mediated by ubiquitin-dependent proteolysis
21. Iron metabolism in eukaryotes: Mars and Venus at it again
22. The NRAMP proteins of Salmonella typhimurium and Escherichia coli are selective manganese transporters involved in the response to reactive oxygen
23. The role of the Saccharomyces cerevisiae CCC1 gene in the homeostasis of manganese ions
24. A role for the Saccharomyces cerevisiae ATX1 gene in copper trafficking and iron transport
25. Mutational analysis of Saccharomyces cerevisiae Smf1p, a member of the Nramp family of metal transporters
26. Post-translational control of Nramp metal transport in yeast: Role of metal ions and the BSD2 gene
27. The requirement for yeast superoxide dismutase is bypassed through mutations in BSD2, a novel metal homeostasis gene
28. Negative control of heavy metal uptake by the Saccharomyces cerevisiae BSD2 gene
29. Metal ion transporters and homeostasis
30. Copper-dependent degradation of the Saccharomyces cerevisiae plasma membrane copper transporter Ctr1p in the apparent absence of endocytosis
31. Metal ions suppress the abnormal taste behavior of the Drosophila mutant malvolio
32. Structure-function analyses of the ATX1 metallochaperone
33. Iron storage in Saccharomyces cerevisiae
34. Regulation of iron metabolism in eukaryotes
35. A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
36. A permease-oxidase complex involved in high-affinity iron uptake in yeast
37. A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria
38. Cadmium and iron transport by members of a plant metal transporter family in arabidopsis with homology to Nramp genes
39. Iron-regulatory proteins, iron-responsive elements and ferritin mRNA translation
40. The iron transporter Fth1p forms a complex with the Fet5 iron oxidase and resides on the vacuolar membrane
41. Two related genes encoding extremely hydrophobic proteins suppress a lethal mutation in the yeast mitochondrial processing enhancing protein
42. AFT1: A mediator of iron regulated transcriptional control in Saccharomyces cerevisiae
43. Iron-regulated DNA binding by the AFT1 protein controls the iron regulon in yeast