Localization of the BiP molecular chaperone with respect to endoplasmic reticulum foci containing the cystic fibrosis transmembrane conductance regulator in yeast

Journal of Histochemistry and Cytochemistry

Volumn 51, Issue 4, 2003, Pages 545-548

  Sullivan, Mara L ^a   Youker, Robert T ^a   Watkins, Simon C ^a   Brodsky, Jeffrey L ^a  

^a UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Aggresomes; BiP; CFTR; Chaperone; ER; ERAD; Russell bodies; Yeast

Indexed keywords

CHAPERONE; GLUCOSE REGULATED PROTEIN 78; TRANSMEMBRANE CONDUCTANCE REGULATOR; UNCLASSIFIED DRUG;

ARTICLE; CELL FUNCTION; CELLULAR DISTRIBUTION; ENDOPLASMIC RETICULUM; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN LOCALIZATION; PROTEIN SECRETION; PROTEIN TARGETING; YEAST;

FUNGI;

EID: 0344838393     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1177/002215540305100417     Document Type: Article

References (11)

1. Becherer KA, Rieder SE, Emr SD, Jones EW (1996) Novel syntaxin homologue, Pep12p, required for the sorting of lumenal hydrolases to the lysosome-like vacuole in yeast. Mol Biol Cell 7:579-594
2. Brodsky JL, Hamamoto S, Feldheim D, Schekman R (1993) Reconstitution of protein translocation from solubilized yeast membranes reveals topologically distinct roles for BiP and cytosolic hsc70. J Cell Biol 120:95-102
3. Byers TJ, Kunkel LM, Watkins SC (1991) The subcellular distribution of dystrophin in mouse skeletal, cardiac, and smooth muscle. J Cell Biol 115:411-421
4. Cheng SH, Gregory RJ, Marshall J, Paul S, Souza DW, White GA, O'Riordan CR et al. (1990) Defective intracellular transport and processing of CFTR is the molecular basis of most cystic fibrosis. Cell 63:827-834
5. Fewell SW, Travers KJ, Weissman JS, Brodsky JL (2001) The action of molecular chaperones in the early secretory pathway. Annu Rev Genet 35:149-191
6. Hong E, Davidson AR, Kaiser CA (1996) A pathway for targeting soluble misfolded proteins to the yeast vacuole. J Cell Biol 135:623-633
7. Kopito RR, Sitia R (2000) Aggresomes and Russell bodies. EMBO Rep 1:225-231
8. Nishikawa S, Hirata A, Nakano A (1994) Inhibition of endoplasmic reticulum (ER)-to-Golgi transport induces relocalization of binding protein (BiP) within the ER to form BiP bodies. Mol Biol Cell 5:1129-1143
9. Umebayashi K, Hirata A, Fukuda R, Horiuchi H, Ohta A, Takagi M (1997) Accumulation of misfolded protein aggregates leads to the formation of a Russell body-like dilated endoplasmic reticulum in yeast. Yeast 13:1009-1020
10. Wright R (2000) Transmission electron microscopy of yeast. Microsc Res Techn 51:496-510
11. Zhang Y, Nijbroek G, Sullivan ML, McCracken AA, Watkins SC, Michaelis S, Brodsky JL (2001) The Hsp70 molecular chaperone facilitates the ER associated degradation of the cystic fibrosis transmembrane conductance regulator in yeast. Mol Biol Cell 12:1303-1314