The mammalian KIR2.x inward rectifier ion channel family: Expression pattern and pathophysiology

Acta Physiologica

Volumn 199, Issue 3, 2010, Pages 243-256

  De Boer, T P ^a   Houtman, M J C ^a   Compier, M ^a   Van Der Heyden, M A G ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

Andersen Tawil syndrome; Barium; Expression pattern; Inward rectifier current; KIR2.x; Thyrotoxic periodic paralysis

Indexed keywords

CELASTROL; CHLOROETHYLCLONICINE; CHLOROQUINE; CHLORPROMAZINE; INWARDLY RECTIFYING POTASSIUM CHANNEL; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.1; INWARDLY RECTIFYING POTASSIUM CHANNEL SUBUNIT KIR2.X; PENTAMIDINE; POTASSIUM CHANNEL BLOCKING AGENT; TAMOXIFEN; UNCLASSIFIED DRUG;

BONE TISSUE; CLINICAL FEATURE; DRUG ACTIVITY; DRUG INHIBITION; GENE EXPRESSION; GENE MUTATION; HUMAN; KNOCKOUT MOUSE; MUSCLE TISSUE; NONHUMAN; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVIEW; ANIMAL; BIOSYNTHESIS; DRUG EFFECTS; GENETICS; MOUSE; MUTATION; PHENOTYPE; PHYSIOLOGY;

ANIMALS; HUMANS; MICE; MICE, KNOCKOUT; MUTATION; PHENOTYPE; POTASSIUM CHANNEL BLOCKERS; POTASSIUM CHANNELS, INWARDLY RECTIFYING;

EID: 77953219441     PISSN: 17481708     EISSN: 17481716     Source Type: Journal    
DOI: 10.1111/j.1748-1716.2010.02108.x     Document Type: Review

References (102)

1. Andelfinger, G., Tapper, A.R., Welch, R.C., Vanoye, C.G., George, A.L., Jr. Benson, D.W. 2002. KCNJ2 mutation results in Andersen syndrome with sex-specific cardiac and skeletal muscle phenotypes. Am J Hum Genet 71, 663 668.
2. Anumonwo, J.M.B. 2004. Biophysical properties of inward rectifier potassium channels. In : D. Zipes J. Jalife (eds) Cardiac Electrophysiology: From Cell to Bedside, 4th edn, pp. 112 119. Saunders
3. + channels by chloroethylclonidine. Br J Pharmacol 128, 760 766.
4. Bichet, D., Haass, F.A. Jan, L.Y. 2003. Merging functional studies with structures of inward-rectifier K(+) channels. Nat Rev Neurosci 4, 957 967.
5. Boehm, R. 1875. Ueber die Wirkungen der Barytsalze auf den Thierkörper nebst Bemerkungen über die Wirkung des Wasserschierlings (Cicuta virosa) auf Frösche. Naunyn-Schmiedeberg Arch Pharmacol 3, 216 251.
6. ir2.1 encodes the inward rectifier potassium channel in rat arterial smooth muscle cells. J Physiol 515, 639 651.
7. Bredt, D.S., Wang, T.L., Cohen, N.A., Guggino, W.B. Snyder, S.H. 1995. Cloning and expression of two brain-specific inwardly rectifying potassium channels. Proc Natl Acad Sci USA 92, 6753 6757.
8. Brodie, B.C. 1812. Further experiments and observations on the action of poisons on the animal system. Philos Trans R Soc Lond 102, 205 227.
9. Chen, F., Wetzel, G.T., Friedman, W.F. Klitzner, T.S. 1991. Single-channel recording of inwardly rectifying potassium currents in developmental myocardium. J Mol Cell Cardiol 23, 259 267.
10. + currents regulate the resting membrane potential, proliferation, and contractile responses in ventricular fibroblasts and myofibroblasts. Am J Physiol Heart Circ Physiol 288, H2931 H2939.
11. Chugh, S.S., Blackshear, J.L., Shen, W., Hammill, S.C. Gersh, B.J. 2001. Epidemiology and natural history of atrial fibrillation: clinical implications. J Am Coll Cardiol 37, 371 378.
12. IR2.x-mediated inward rectifier current by entering the cytoplasmic pore region of the channel. Br J Pharmacol 159, 1532 1541.
13. K1) controls cardiac excitability and is involved in arrhythmogenesis. Heart Rhythm 2, 316 324.
14. + current. Circ Res 94, 1332 1339.
15. Dobrev, D., Friedrich, A., Voigt, N., Jost, N., Wettwer, E., Christ, T., Knaut, M. Ravens, U. 2005. The G protein-gated potassium current I(K,ACh) is constitutively active in patients with chronic atrial fibrillation. Circulation 112, 3697 3706.
16. K1 potassium current downregulation. J Mol Cell Cardiol 42, 63 70.
17. Donaldson, M.R., Yoon, G., Fu, Y.H. Ptá̌ek, L.J. 2004. Andersen-Tawil syndrome: a model of clinical variability, pleiotropy, and genetic heterogeneity. Ann Med 36 (Suppl. 1 92 97.
18. Falk, T., Meyerhof, W., Corrette, B.J., Schafer, J., Bauer, C.K., Schwarz, J.R. Richter, D. 1995. Cloning, functional expression and mRNA distribution of an inwardly rectifying potassium channel protein. FEBS Lett 367, 127 131.
19. ir2.2. Am J Physiol Cell Physiol 289, C1134 C1144.
20. ir2.1 channels. J Cell Biol 153, 677 685.
21. Fülöp, L., Bányász, T., Szabó, G., Tóth, I.B., Bíro, T., Lôrincz, I., Balogh, Á., Petô, K., Mikó, I. Nánási, P.P. 2006. Effects of sex hormones on ECG parameters and expression of cardiac ion channels in dogs. Acta Physiol 188, 163 171.
22. Gaborit, N., Le Bouter, S., Szuts, V., Varro, A., Escande, D., Nattel, S. Demolombe, S. 2007. Regional and tissue specific transcript signatures of ion channel genes in the non-diseased human heart. J Physiol 582, 675 693.
23. Garny, A., Noble, D., Hunter, P.J. Kohl, P. 2009. Cellular Open Resource (COR): current status and future directions. Philos Trans R Soc Lond A 367, 1885 1906.
24. K1 up-regulation in human atrial fibrillation. Heart Rhythm 6, 1802 1809.
25. Grandy, S.A., Trépanier-Boulay, V. Fiset, C. 2007. Postnatal development has a marked effect on ventricular repolarization in mice. Am J Physiol Heart Circ Physiol 293, H2168 H2177.
26. Harrell, M.D., Harbi, S., Hoffman, J.F., Zavadil, J. Coetzee, W.A. 2007. Large-scale analysis of ion channel gene expression in the mouse heart during perinatal development. Physiol Genomics 28, 273 283.
27. Ho, K., Nichols, C.G., Lederer, W.J., Lytton, J., Vassilev, P.M., Kanazirska, M.V. Hebert, S.C. 1993. Cloning and expression of an inwardly rectifying ATP-regulated potassium channel. Nature 362, 31 38.
28. Horio, Y., Morishige, K., Takahashi, N. Kurachi, Y. 1996. Differential distribution of classical inwardly rectifying potassium channel mRNAs in the brain: comparison of IRK2 with IRK1 and IRK3. FEBS Lett 379, 239 243.
29. + spatial buffering. J Comp Neurol 506, 877 893.
30. ir2.4, a pH-sensitive inwardly rectifying K(+) channel. Am J Physiol Cell Physiol 279, C771 C784.
31. Jacobs, I.A., Taddeo, J., Kelly, K. Valenziano, C. 2002. Poisoning as a result of barium styphnate explosion. Am J Ind Med 41, 285 288.
32. Jantzi, M.C., Brett, S.E., Jackson, W.F., Corteling, R., Vigmond, E.J. Welsh, D.G. 2006. Inward rectifying potassium channels facilitate cell-to-cell communication in hamster retractor muscle feed arteries. Am J Physiol Heart Circ Physiol 291, H1319 H1328.
33. Johnson, C.H. VanTassell, V.J. 1991. Acute barium poisoning with respiratory failure and rhabdomyolysis. Ann Emerg Med 20, 1138 1142.
34. ir2.1 channels in astrocytes under pathophysiological conditions. Mol Cells 25, 124 130.
35. Karkanis, T., Li, S., Pickering, J.G. Sims, S.M. 2003. Plasticity of KIR channels in human smooth muscle cells from internal thoracic artery. Am J Physiol Heart Circ Physiol 284, H2325 H2334.
36. Karschin, C. Karschin, A. 1997. Ontogeny of gene expression of Kir channel subunits in the rat. Mol Cell Neurosci 10, 131 148.
37. + channel mRNAs are differentially expressed in the adult rat brain. J Neurosci 16, 3559 3570.
38. Katz, B. 1949. Les constantes electriques de la membrane du muscle. Archs Sci Physiol 3, 285 299.
39. IR currents to extracellular pH-dependent changes of contractility in rat superior mesenteric artery. Am J Physiol Heart Circ Physiol 289, H792 H800.
40. + channel Kir2.3. PLoS ONE 4, e6311.
41. ir potassium channel subunit expression in retinal glial cells: implications for spatial potassium buffering. Glia 39, 292 303.
42. + channels by chlorpromazine in rat ventricular myocytes. J Pharmacol Exp Ther 271, 632 637.
43. Kubo, Y., Baldwin, T.J., Jan, Y.N. Jan, L.Y. 1993. Primary structure and functional expression of a mouse inward rectifier potassium channel. Nature 362, 127 133. (Pubitemid 23085250)
44. Kung, A.W.C. 2006. Clinical review: thyrotoxic periodic paralysis: a diagnostic challenge. J Clin Endocrinol Metab 91, 2490 2495.
45. K1 in a dominant-negative fashion. Cardiovasc Res 59, 321 327.
46. Lehnart, S.E., Ackerman, M.J., Benson, D.W., Brugada, R., Clancy, C.E., Donahue, J.K., George, A.L., Jr., Grant, A.O., Groft, S.C., January, C.T. et al. 2007. Inherited arrhythmias: a National Heart, Lung, and Blood Institute and Office of Rare Diseases Workshop consensus report about the diagnosis, phenotyping, molecular mechanisms, and therapeutic approaches for primary cardiomyopathies of gene mutations affecting ion channel function. Circulation 116, 2325 2345.
47. Leichtle, A., Rauch, U., Albinus, M., Benöhr, P., Kalbacher, H., Mack, A.F., Veh, R.W., Quast, U. Russ, U. 2004. Electrophysiological and molecular characterization of the inward rectifier in juxtaglomerular cells from rat kidney. J Physiol 560, 365 376.
48. K1 in the mouse heart leads to multiple abnormalities of cardiac excitability. Am J Physiol Heart Circ Physiol 287, H2790 H2802.
49. + channels from guinea-pig cardiomyocytes. J Physiol 532, 115 126.
50. Lopatin, A.N. Nichols, C.G. 2001. Inward rectifiers in the heart: an update on I(K1). J Mol Cell Cardiol 33, 625 638.
51. Masuda, H. Sperelakis, N. 1993. Inward rectifying potassium current in fetal and neonatal ventricular cardiomyocytes. Am J Physiol Heart Circ Physiol 265, H1107 H1111.
52. Melnyk, P., Ehrlich, J.R., Pourrier, M., Villeneuve, L., Cha, T.J. Nattel, S. 2005. Comparison of ion channel distribution and expression in cardiomyocytes of canine pulmonary veins versus left atrium. Cardiovasc Res 65, 104 116.
53. Miyashita, T. Kubo, Y. 1997. Localization and developmental changes of the expression of two inward rectifying K(+)-channel proteins in the rat brain. Brain Res 750, 251 263.
54. Mongiat, L.A., Espósito, M.S., Lombardi, G. Schinder, A.F. 2009. Reliable activation of immature neurons in the adult hippocampus. PLoS ONE 4, e5320.
55. Muñoz, V., Vaidyanathan, R., Tolkacheva, E.G., Dhamoon, A.S., Taffet, S.M. Anumonwo, J.M.B. 2007. Kir2.3 isoform confers pH sensitivity to heteromeric Kir2.1/Kir2.3 channels in HEK293 cells. Heart Rhythm 4, 487 496.
56. Mylona, P., Clarson, L.H., Greenwood, S.L. Sibley, C.P. 1998. Expression of the Kir2.1 (inwardly rectifying potassium channel) gene in the human placenta and in cultured cytotrophoblast cells at different stages of differentiation. Mol Hum Reprod 4, 195 200.
57. ir2.1 mRNA. Am J Physiol Heart Circ Physiol 274, H892 H900.
58. + current in human bronchial smooth muscle cells. Am J Cell Mol Biol 26, 371 379.
59. ir2.2 in hypercapnic ventilatory response during postnatal development of mouse. Respir Physiol Neurobiol 145, 143 151.
60. K1 in the mouse heart. Am J Physiol Heart Circ Physiol 293, H3558 H3567.
61. Plaster, N.M., Tawil, R., Tristani-Firouzi, M., Canún, S., Bendahhou, S., Tsunoda, A., Donaldson, M.R., Iannaccone, S.T., Brunt, E., Barohn, R. et al. 2001. Mutations in Kir2.1 cause the developmental and episodic electrical phenotypes of Andersen's syndrome. Cell 105, 511 519.
62. + 2.x family of inward rectifier channels by interfering with phosphatidylinositol 4,5-bisphosphate-channel interactions. J Pharmacol Exp Ther 331, 563 573.
63. Preisig-Müller, R., Schlichthörl, G., George, T., Heinen, S., Brüggemann, A., Rajan, S., Derst, C., Veh, R.W. Daut, J. 2002. Heteromerization of Kir2.x potassium channels contributes to the phenotype of Andersen's syndrome. Proc Natl Acad Sci USA 99, 7774 7779.
64. Priori, S.G., Pandit, S.V., Rivolta, I., Berenfeld, O., Ronchetti, E., Dhamoon, A., Napolitano, C., Anumonwo, J., Di Barletta, M.R., Gudapakkam, S., Bosi, G., Stramba-Badiale, M. Jalife, J. 2005. A novel form of Short QT syndrome (SQT3) is caused by a mutation in the KCNJ2 gene. Circ Res 96, 800 807.
65. ir2 family) in rat brain. Brain Res Mol Brain Res 139, 63 79.
66. ir channel subunit mRNA expressed by retinal glial cells of the guinea-pig. NeuroReport 13, 1037 1040.
67. Ravens, U. Cerbai, E. 2008. Role of potassium currents in cardiac arrhythmias. Europace 10, 1133 1137.
68. Ridgway, L.P. Karnofsky, D.A. 1952. The effects of metals on the chick embryo: toxicity and production of abnormalities in development. Ann N Y Acad Sci 55, 203 215.
69. Rinne, A., Littwitz, C., Kienitz, M.C., Gmerek, A., Bösche, L.I., Pott, L. Bender, K. 2006. Gene silencing in adult rat cardiac myocytes in vitro by adenovirus-mediated RNA interference. J Muscle Cell Motil 27, 413 421.
70. Rodríguez-Menchaca, A.A., Navarro-Polanco, R.A., Ferrer-Villada, T., Rupp, J., Sachse, F.B., Tristani-Firouzi, M. Sánchez-Chapula, J.A. 2008. The molecular basis of chloroquine block of the inward rectifier Kir2.1 channel. Proc Natl Acad Sci USA 105, 1364 1368.
71. Roza, O. Berman, L.B. 1971. The pathophysiology of barium: hypolalemic and cardiovascular effects. J Pharmacol Exp Ther 177, 433 439.
72. + channel, in spiral ganglion and cochlear hair cells of mouse inner ear. Dev Neurosci 30, 374 388.
73. Ryan, D.P., Dias da Silva, M.R., Soong, T.W., Fontaine, B., Donaldson, M.R., Kung, A.W.C., Jongjaroenprasert, W., Liang, M.C., Khoo, D.H.C., Cheah, J.S., Ho, S.C., Bernstein, H.S., Maciel, R.M.B., Brown, R.H., Jr. Ptá̌ek, L.J. 2010. Mutations in potassium channel Kir2.6 cause susceptibility to thyrotoxic hypolalemic periodic paralysis. Cell 140, 88 98.
74. Sansone, V. Tawil, R. 2007. Management and treatment of Andersen-Tawil syndrome (ATS). Neurotherapeutics 4, 233 237.
75. 3-adrenoceptors is mediated via different signalling pathways with a predominant role of PKC for Kir2.1 and of PKA for Kir2.2. Naunyn Schmiedebergs Arch Pharmacol 375, 311 322.
76. + channel subunits co-assemble: a potential new contributor to inward rectifier current heterogeneity. J Physiol 544, 337 349.
77. Schram, G., Pourrier, M., Wang, Z., White, M. Nattel, S. 2003. Barium block of Kir2 and human cardiac inward rectifier currents: evidence for subunit-heteromeric contribution to native currents. Cardiovasc Res 59, 328 338.
78. Smith, P.K., Winkler, A.W. Hoff, H.E. 1940. Cardiovascular changes following the intravenous administration of barium chloride. J Pharmacol Exp Ther 68, 113 122.
79. IR channels function as electrical amplifiers in rat vascular smooth muscle. J Physiol 586, 1147 1160.
80. ir2.0 proteins in the rat cerebellum and hippocampus by polyclonal antibodies. Histochem Cell Biol 112, 457 465.
81. Sun, H., Liu, X., Xiong, Q., Shikano, S. Li, M. 2006. Chronic inhibition of cardiac Kir2.1 and hERG potassium channels by Celastrol with dual effects on both ion conductivity and protein trafficking. J Biol Chem 281, 5877 5884.
82. Takahashi, N., Morishige, K., Jahangir, A., Yamada, M., Findlay, I., Koyama, H. Kurachi, Y. 1994. Molecular cloning and functional expression of cDNA encoding a second class of inward rectifier potassium channels in the mouse brain. J Biol Chem 269, 23274 23279.
83. Tawil, R., Ptá̌ek, L.J., Pavlakis, S.G., DeVivo, D.C., Penn, A.S., Øzdemir, C. Griggs, R.C. 1994. Andersen's syndrome: potassium-sensitive periodic paralysis, ventricular ectopy, and dysmorphic features. Ann Neurol 35, 326 330.
84. Ten Tusscher, K.H., Noble, D., Noble, P.J. Panfilov, A.V. 2004. A model for human ventricular tissue. Am J Physiol Heart Circ Physiol 286, 1573 1589.
85. Tenenbein, M. 1985. Severe cardiac dysrhythmia from barium acetate ingestion. Pediatr Emerg Care 1, 34 36.
86. ir2.4 subunits. J Membr Biol 213, 19 29.
87. Tian, M., Chen, L., Xie, J.X., Yang, X.L. Zhao, J.W. 2003. Expression patterns of inwardly rectifying potassium channel subunits in rat retina. Neurosci Lett 345, 9 12.
88. + inward rectifier channel associated with motoneurons of cranial nerve nuclei. J Neurosci 18, 4096 4105.
89. Vega, A.L., Tester, D.J., Ackerman, M.J. Makielski, J.C. 2009. Protein kinase A-dependent biophysical phenotype for V227F-KCNJ2 mutation in catecholaminergic polymorphic ventricular tachycardia. Circ Arrhythm Electrophysiol 2, 540 547.
90. Wahler, G.M. 1992. Developmental increases in the inwardly rectifying potassium current of rat ventricular myocytes. Am J Physiol Cell Physiol 262, 1266 1272.
91. Watt, J. 1790. On the effects produced by different combinations of the Terra Ponderosa given to animals. Memoirs of the Literary and Philosophical Society of Manchester 3, 609 618.
92. Withering, W. 1784. Experiments and observations on the Terra Ponderosa, etc. Philos Trans R Soc Lond 74, 293 311.
93. Wulfsen, I., Hauber, H.P., Schiemann, D., Bauer, C.K. Schwarz, J.R. 2000. Expression of mRNA for voltage-dependent and inward-rectifying K channels in GH3/B6 cells and rat pituitary. J Neuroendocrinol 12, 263 272.
94. Xia, M., Jin, Q., Bendahhou, S., He, Y., Larroque, M.M., Chen, Y., Zhou, Q., Yang, Y., Liu, Y., Liu, B. et al. 2005. A Kir2.1 gain-of-function mutation underlies familial atrial fibrillation. Biochem Biophys Res Commun 332, 1012 1019.
95. + channel Kir2.1 in native bovine corneal endothelial cells. Invest Ophthalmol Vis Sci 44, 3511 3519. (Pubitemid 36909789)
96. Yang, B., Lin, H., Xiao, J., Lu, Y., Luo, X., Li, B., Zhang, Y., Xu, C., Bai, Y., Wang, H., Chen, G. Wang, Z. 2007. The muscle-specific microRNA miR-1 regulates cardiac arrhythmogenic potential by targeting GJA1 and KCNJ2. Nat Med 13, 486 491.
97. Yang, D., Zhang, X. Hughes, B.A. 2008. Expression of inwardly rectifying potassium channel subunits in native human retinal pigment epithelium. Exp Eye Res 87, 176 183.
98. Yoon, G., Quitania, L., Kramer, J.H., Fu, Y.H., Miller, B.L. Ptá̌ek, L.J. 2006. Andersen-Tawil syndrome: definition of a neurocognitive phenotype. Neurology 66, 1703 1710.
99. +-mediated vasodilation. Circ Res 87, 160 166.
100. ir2.2 genes. J Physiol 533, 697 710.
101. K1 in action potential shortening associated with atrial fibrillation in humans. Cardiovasc Res 66, 493 502.
102. ir2.2. J Physiol 550, 365 372.