Understanding upper limb recovery after stroke

Restorative Neurology and Neuroscience

Volumn 31, Issue 6, 2013, Pages 707-722

  Buma, Floor ^a   Kwakkel, Gert ^a,b   Ramsey, Nick ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

^b VU UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

hebbian learning; Neuroplasticity; paresis; recovery; rehabilitation; stroke

Indexed keywords

ARM; BRAIN CORTEX; BRAIN MAPPING; CEREBROVASCULAR ACCIDENT; COMPENSATION; HUMAN; LEARNING; NERVE CELL PLASTICITY; NEUROIMAGING; PRIORITY JOURNAL; REVIEW; SKILL;

HEBBIAN LEARNING; NEUROPLASTICITY; PARESIS; RECOVERY; REHABILITATION; STROKE;

BRAIN MAPPING; CEREBRAL CORTEX; EXERCISE THERAPY; HUMANS; LEARNING; MOTOR SKILLS; NEURONAL PLASTICITY; RECOVERY OF FUNCTION; STROKE; UPPER EXTREMITY;

EID: 84892529436     PISSN: 09226028     EISSN: 18783627     Source Type: Journal    
DOI: 10.3233/RNN-130332     Document Type: Review

References (120)

1. Alibiglou, L., Rymer, W.Z., Harvey, R.L. & Mirbagheri, M.M. (2008). The relation between Ashworth scores and neuromechanical measurements of spasticity following stroke. J Neuroeng Rehabil, 5, 18.
2. Andrews, R. (1991). Transhemispheric diaschisis. A review and comment. Stroke, 22, 943-949.
3. Askim, T., Indredavik, B.&Vangberg, T. (2008). Motor skill relearning after acute ischemic stroke. NeuroRehabilitation, 1, 1-10.
4. Banks, J.L. &Marotta, C.A. (2007). Outcomes validity and reliability of the modified Rankin scale: Implications for stroke clinical trials: A literature review and synthesis. Stroke, 38, 1091-1096.
5. Baron, J. (2005). How healthy is the acutely reperfused ischemic penumbra? Cerebrovasc Dis, 20(suppl 2), 25-31.
6. Biernaskie, J. & Corbett, D. (2001). Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury. Neuroscience, 21(14), 5272-5280
7. Biernaskie, J., Chernenko, G.&Corbett, D. (2004). Efficacy of rehabilitative experience declines with time after focal ischemic brain injury. Neuroscience, 24(5), 1245-1254.
8. Black, J.E., Isaacs, K.R., Anderson, B.J., Alcantara, A.A. & Greenough, W.T. (1990). Learning causes synaptogenesis, whereas motor activity causes angiogenesis, in cerebellar cortex of adult rats. Proc. Nati Acad Sci, 87, 5568-5572.
9. Bradnam, L.V., Stinear, C.M., Barber, P.A. & Byblow,W.D. (2012). Contralesional hemisphere control of the proximal paretic upper limb following stroke. Cereb Cortex, 22(11), 2662-2671.
10. Brouns, R. & Deyn, P.P., De (2009). The complexity of neurobiological processes in acute ischemic stroke. Clin Neurol and Neurosur, 111, 483-495.
11. Brunnstr̈om, S. (1970).Movement therapy in hemiplegia. NewYork: Harper and Row.
12. Buma, F.E., Lindeman, E., Ramsey, N.F. & Kwakkel, G. (2010). Functional neuroimaging studies of early upper limb recovery after stroke: A systematic review of the literature. Neurorehab Neural Re, 24(7), 589-608.
13. Calautti, C. & Baron, J.C. (2003). Functional neuroimaging studies of motor recovery after stroke in adults:Areview. Stroke, 34(6), 1553.
14. Carmichael, S.T. (2005). Rodent models of focal stroke: Size. mechanism, and purpose. NeuroRx, 2(July), 396-409.
15. Carmichael, S.T. (2006). Cellular and Molecular Mechanisms of Neural Repair after Stroke: Making Waves. Ann of Neurol, 59, 735-742.
16. Cheeran, B., Cohen, L., Dobkin, B., Ford, G., Greenwood, R., Howard, D. & Wolf, S. (2009). The future of restorative neurosciences in stroke: Driving the translational research pipeline from basic science to rehabilitation of people after stroke. Neurorehab Neural Re, 23(2), 97-107.
17. Chen, H.-M., Chen, C.C., Hsueh, I.-P., Huang, S.-L. & Hsieh, C.-L. (2009). Test-retest reproducibility and smallest real difference of 5 hand function tests in patients with stroke. Neurorehab Neural Re, 23(5), 435-440.
18. Chopp, M., Zhang, Z.G. & Jiang, Q. (2007). Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke. Stroke, 38(2 Suppl), 827-831.
19. Chu, W.-J. W, Mason, G.F., Pan, J.W., Hetherington, H.P., Pedro, E.C.S. & Mountz, J.M. (2002). Regional cerebral blood flow and magnetic resonance spectroscopic imaging findings in diaschisis from stroke. Stroke, 33(5), 1243-1248.
20. Cirstea, M.C. & Levin, M.F. (2000). Compensatory strategies for reaching in stroke. Brain, 123, 940-953.
21. Clifford, E. (1998). Neural Plasticity: Merzenich, Taub, and Greenough. Harvard Brain, 16-20.
22. Cooke, S.F. & Bliss, T.V.P. (2006). Plasticity in the human central nervous system. Brain, 129, 1659-1673.
23. Dancause, N. (2006). Vicarious function of remote cortex following stroke: Recent evidence from human and animal studies. Neuroscientist, 12, 489.
24. Dancause, N., Barbay, S., Frost, S.B., Plautz, E.J., Chen, D., Zoubina, E. & Nudo, V., R.J. (2005). Extensive cortical rewiring after brain injury. Neuroscience, 25(44), 10167-10179.
25. Dewald, J.P.A., Sheshadri, V., Dawson, M.L. & Beer, R.F. (2001). Upper-limb discoordination in hemiparetic stroke: Implications for neurorehabilitation. Top Stroke Rehab, 8(1), 1-12.
26. Ding, Y., Li, J., Luan, X., Ding, Y.H., Lai, Q., Rafols, J. & Diaz, F.G. (2004). Exercise pre-conditioning reduces brain damage in ischemic rats that may be associated with regional angiogenesis and cellular overexpression of neurotrophin. Neuroscience, 124(3), 583-591.
27. Dobkin, B.H. (2003). Functional MRI: A potential physiologic indicator for stroke rehabilitation interventions. Stroke, 23, 23-28.
28. Dobkin, B.H. (2005). Rehabilitation and functional neuroimaging dose-response trajectories for clinical trials. Neurorehab and Neural Re, 19, 276-283.
29. Dobkin, B.H. (2009). Collaborative models for translational neuroscience and rehabilitation research. Neurorehab and Neural Re, 23(7), 633-640.
30. Dong, Y., Dobkin, B.H., Cen, S.Y., Wu, A.D. & Winstein, C.J. (2006). Motor cortex activation during treatment may predict therapeutic gains in paretic hand function after stroke. Stroke, 1552-1555.
31. Doyle, K.P., Simon, R.P. & Stenzel-poore, M.P. (2008). Mechanisms of ischemic brain damage. Neuropharmacology, 55, 310-318.
32. Duff, M., Chen, Y., Cheng, L., Liu, S.M., Blake, P., Wolf, S.L. & Rikakis, T. (2013). Adaptive mixed reality rehabilitation improves quality of reaching movements more than traditional reaching therapy following stroke. Neurorehab neural re, 27(4), 306-315.
33. Ellis, M.D., Holubar, B.G., Acosta, A.M., Beer, R.F. & Dewald, J.P. (2005). Modifiability of abnormal isometric elbowand shoulder joint torque coupling after stroke. Muscle Nerve, 32(August), 170-178.
34. Endres, M., Gertz, K., Lindauer, U., Katchanov, J., Schultze, J., Schr̈ock, H. & Laufs, U. (2003). Mechanisms of stroke protection by physical activity. Ann Neurol, 54(5), 582-590.
35. Feeney, D.M. & Baron, J.C. (1986). Diaschisis. Stroke, 17(5), 817-830.
36. Font, M.A., Arboix, A. & Krupinski, J. (2010). Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke. Curr Cardiol Rev, 6(3), 238-244.
37. Ge, S., Yang, C., Hsu, K., Ming, G. & Song, H. (2007). A Critical Period for Enhanced Synaptic Plasticity in Newly Generated Neurons of the Adult Brain. Neuron, 559-566.
38. Gold, L. & Lauritzen, M. (2002). Neuronal deactivation explains decreased cerebellar blood flow in response to focal cerebral ischemia or suppressed neocortical function. Proceedings of the National Academy of Sciences of the United States of America, 99(11), 7699-7704.
39. Goodwin, N. & Sunderland, A. (2003). Intensive, time-series measurement of upper limb recovery in the subacute phase following stroke. Clin Rehabil, 17(1), 69-82.
40. Guadagno, J.V., Jones, P.S., Aigbirhio, F.I., Wang, D., Fryer, T.D., Day, D.J. & Baron, J.C. (2008). Selective neuronal loss in rescued penumbra relates to initial hypoperfusion. Brain, 131(Pt 10), 2666-2678.
41. Heuschmann, P., Wiedmann, S., Wellwood, I., Rudd, A., Di Carlo, A., Beyot, Y. & Wolfe, C. (2011). Three-Month stroke outcome: The European Registers of Stroke (EROS) investigators. Neurology, 28(8), 884-892.
42. Hillman, C.H., Erickson, K.I. & Kramer, A.F. (2008). Be smart, exercise your heart: Exercise effects on brain and cognition. Nature, 9, 58-65.
43. Johansen-Berg, H., Dawes, H., Guy, C., Smith, S.M.,Wade, D.T. & Matthews, P.M. (2002). Correlation between motor improvements and altered fMRI activity after rehabilitative therapy. Brain, 125, 2731-2742.
44. Johansen-Berg, H., Rushworth, M.F.S., Bogdanovic, M.D., Kischka, U.,Wimalaratna, S. &Matthews, P.M. (2002). The role of ipsilateral premotor cortex in hand movement after stroke. Stroke, 99(22), 14518-14523.
45. Kelly-Hayes, M., Beiser, A., Kase, C., Scaramucci, A., D'Agostino, R.&Wolf, P. (2003). The influence of gender and age on disability following ischemic stroke: The Framingham study. J Stroke Cerebrovasc, 12(3), 119-126.
46. Kerr, A.L., Cheng, S.-Y. & Jones, T.A. (2011). Experiencedependent neural plasticity in the adult damaged brain. J Commun Disord, 44(5), 538-548.
47. Kim, Y., Jang, S.H., Chang, Y., Byun, W.M., Son, S. & Ahn, S.H. (2003). Bilateral primary sensori-motor cortex activation of post-stroke mirror movements: An fMRI study. Neuroreport, 14(10), 1329-1332.
48. Kitago, T., Liang, J., Huang, V.S., Hayes, S., Simon, P., Tenteromano, L. & Krakauer, J.W. (2012). Improvement After Constraint-Induced Movement Therapy: Recovery of Normal Motor Control or Task-Specific Compensation? Neurorehab Neural Re, 27(2), 99-109.
49. Kleim, J.A., Cooper, N.R. & Vandenberg, P.M. (2002). Exercise induces angiogenesis but does not alter movement representations within rat motor cortex. Brain Res, 934, 1-6.
50. Kollen, B., Van de Port, I., Lindeman, E., Twisk, J. & Kwakkel, G. (2005). Predicting improvement in gait after stroke: A longitudinal prospective study. Stroke, 36(12), 2676-2680.
51. Komaba, Y., Mishina, M., Utsumi, K., Katayama, Y., Kobayashi, S. & Mori, O. (2004). Crossed cerebellar diaschisis in patients with cortical infarction: Logistic regression analysis to control for confounding effects. Stroke, 35(2), 472-476.
52. Krakauer, J.W., Carmichael, S.T., Corbett, D. & Wittenberg, G.F. (2012). Getting neurorehabilitation right: What can be learned from animal models? Neurorehab Neural Re, 26(8), 923-931.
53. Kwakkel, G., Kollen, B. & Lindeman, E. (2004). Understanding the pattern of functional recovery after stroke: Facts and theories. Restor Neurol Neuros, 22, 281-299.
54. Kwakkel, G., Kollen, B. & Twisk, J. (2006). Impact of time on improvement of outcome after stroke. Stroke, 37, 2348-2353.
55. Kwakkel, G., Meskers, C.G.M., Van Wegen, E.E., Lankhorst, G.J., Geurts, A.C.H., Van Kuijk, A.A. & Arendzen, J.H. (2008). Impact of early applied upper limb stimulation: The EXPLICITstroke programme design. BMC Neurol, 8, 49.
56. Kwakkel, G.,Van Peppen, R.,Wagenaar, R.C.,Wood Dauphinee, S., Richards, C., Ashburn, A. & Langhorne, P. (2004). Effects of augmented exercise therapy time after stroke: A meta-analysis. Stroke, 35(11), 2529-2539.
57. Kwakkel, G. & Wagenaar, R.C. (1996). Predicting Disability in Stroke-ACritical Reviewof the Literature. Age Ageing, (25), 479-489.
58. Lang, C.E., Macdonald, J.R., Reisman, D.S., Boyd, L., Jacobson Kimberley, T., Schindler-Ivens, S.M. & Scheets, P.L. (2009). Observation of amounts of movement practice provided during stroke rehabilitation. Arch Physical Med Rehab, 90(10), 1692-1698.
59. Lang, C.E.,Wagner, J.M., Edwards, D.F., Sahrmann, S.A. & Dromerick, A.W. (2006). Recovery of grasp versus reach in people with hemiparesis poststroke. Neurorehab Neural Re, 20(4), 444-454.
60. Langhorne, P., Bernhardt, J. & Kwakkel, G. (2011). Stroke Rehabilitation. Lancet, 377, 1693-1702.
61. Langhorne, P., Coupar, F.&Pollock, A. (2009). Motor recovery after stroke: A systematic review. Lancet Neurol, 8(8), 741-754.
62. Latash, M.L. & Anson, J.G. (1996). What are "normal movements" in atypical populations? Behav Brain Sci, 19(1), 55-106.
63. Latash, M.L., Scholz, J.P. & Scḧoner, G. (2007). Toward a New Theory of Motor Synergies. Motor Control, 11, 276-308.
64. Levin, M.F., Kleim, J.A. & Wolf, S.L. (2009). What Do Motor "Recovery" and "Compensation" Mean in Patients Following Stroke? Neurorehab Neural Re, 23(4), 313.
65. Liepert, J., Bauder, H., Miltner, W.H.R., Taub, E. & Weiller, C. (2000). Treatment-induced cortical reorganization after stroke in humans. Stroke, 31(6), 1210-1216.
66. Lloyd-Jones, D., Adams, R., Carnethon, M., De Simone, G., Ferguson, T.B., Flegal, K. & Hong, Y. (2009). Heart disease and stroke statistics 2009 update. A report from the American Heart Association Statistics Committee and Stroke Statistics Subcommittee. Circulation, 119(3), e21-181.
67. MacLellan, C.L., Keough, M.B., Granter-Button, S., Chernenko, G.A., Butt, S. & Corbett, D. (2011). A critical threshold of rehabilitation involving brain-derived neurotrophic factor is required for poststroke recovery. Neurorehabilitation and neural repair, 25(8), 740-748.
68. Mahony, F.I. & Barthel, D.W. (1965). Functional evaluation: The Barthel Index. Maryland State Med J, 14, 61-65.
69. Maier, M.A., Armand, J., Kirkwood, P.A., Yang, H., Davis, J.N. & Lemon, R.N. (2002). Differences in the Corticospinal Projection from Primary Motor Cortex and Supplementary Motor Area to Macaque Upper Limb Motoneurons: An Anatomical and Electrophysiological Study. Cereb Cortex, 12, 281-296.
70. Metz, G.A., Antonow-Schlorke, I. & Witte, O.W. (2005). Motor improvements after focal cortical ischemia in adult rats are mediated by compensatory mechanisms. Behav Brain Res, 162(1), 71-82.
71. Michaelsen, Stella, M., Jacobs, S. & Levin, A.R.M.F. (2004). Compensation for distal impairments of grasping in adults with hemiparesis. Exp Brain Res, 162-173.
72. Michaelsen, Stella, M., Dannenbaum, R.&Levin,M.F. (2006).Taskspecific training with trunk restraint on arm recovery in stroke: Randomized control trial. Stroke, 37(1), 186-192.
73. Mirbagheri, M.M., Tsao, C. & Rymer,W.Z. (2009). Natural history of neuromuscular properties after stroke: A longitudinal study. J Neurol Neurosur Ps, 80(11), 1212-1217.
74. Mirbagheri, M.M., Tsao, C., Settle, K., Lilaonitkul, T. & Rymer, W.Z. (2008). Time course of changes in neuromuscular properties following stroke. Conf Proc IEEE Eng Med Biol Soc, 1, 5097-5100.
75. Moon, S.K., Alaverdashvili, M., Cross, A.R. & Whishaw, I.Q. (2009). Both compensation and recovery of skilled reaching following small photothrombotic stroke to motor cortex in the rat. Exp Neurol, 218(1), 145-153.
76. Murphy, T.H.T.H. & Corbett, D. (2009). Plasticity during stroke recovery: From synapse to behaviour. Nat Rev Neurosc, 10(12), 861-872.
77. Nelles, G., Jentzen,W., Jueptner, M.,M̈uller, S.&Diener,H. (2001). Arm training induced brain plasticity in stroke studied with serial positron emission tomography. Neuroimage, 13(6), 1146-1154.
78. Newton, J.M., Ward, N.S., Parker, G.J.M., Deichmann, R., Alexander, D.C., Friston, K.J. & Frackowiak, R.S.J. (2006). Non-invasive mapping of corticofugal fibres from multiple motor areas-relevance to stroke recovery. Brain, 129(7), 1844-1858.
79. Ng, Y.S., Stein, J., Ning, M. & Black-Schaffer, R.M. (2007). Comparison of clinical characteristics and functional outcomes of ischemic stroke in different vascular territories. Stroke, 38(8), 2309-2314.
80. Nijland, R.H.M., Wegen, E.E.H., Van, & Wel, B.C.H., Der (2010). presence of finger extension and shoulder abduction within 72 hours after stroke predicts functional recovery early prediction of functional outcome after stroke: The EPOS cohort study. Stroke, 45, 745-750.
81. Nudo, R.J.J. & Milliken, G.W.W. (1996). Reorganization of movement representations in primary motor cortex following focal ischemic infarcts in adult squirrel monkeys. J Neurophysiol, 75(5), 2144-2149.
82. Overman, J.J., Clarkson, A.N., Wanner, I.B., Overman, W.T., Eckstein, I., Maguire, J.L. & Carmichael, S.T. (2012). A role for ephrin-A5 in axonal sprouting, recovery, and activitydependent plasticity after stroke. P Natl Acad Sci USA, 109(33), 1-10.
83. Ploughman, M., Granter-Button, S., Chernenko, G., Tucker, B.A., Mearow, K.M. & Corbett, D. (2005). Endurance exercise regimens induce differential effects on brain-derived neurotrophic factor, synapsin-I and insulin-like growth factor I after focal ischemia. Neuroscience, 136(4), 991-1001.
84. Ploughman, M., Granter-Button, S., Chernenko, G., Attwood, Z., Tucker, B. A, Mearow, K.M. & Corbett, D. (2007). Exercise intensity influences the temporal profile of growth factors involved in neuronal plasticity following focal ischemia. Brain Res, 1150, 207-216.
85. Ploughman, M., Windle, V., MacLellan, C.L., White, N., Dore, J.J. & Corbett, D. (2009). Brain-derived neurotrophic factor contributes to recovery of skilled reaching after focal ischemia in rats. Stroke, 40(4), 1490.
86. Pozo, K. & Goda, Y. (2010). Review Unraveling Mechanisms of Plasticity. Neuron, 66(3), 337-351.
87. Prabhakaran, S., Zarahn, E., Riley, C., Speizer, A., Chong, J.Y., Lazar, R.M. & Krakauer, J.W. (2008). Inter-individual variability in the capacity for motor recovery after ischemic stroke. Neurorehab Neural Re, 22(1), 64-71.
88. Raghavan, P., Santello, M., Gordon, A.M. & Krakauer, J.W. (2010). Compensatory motor control after stroke: An alternative joint strategy for object-dependent shaping of hand posture. Journal of Neurophysiol, 103(6), 3034-3043.
89. Rehme, A.K., Eickhoff, S.B., Rottschy, C., Fink, G.R. & Grefkes, C. (2012). Activation likelihood estimation meta-analysis of motor-related neural activity after stroke. Neuroimage, 59(3), 2771-2782.
90. Remple, M.S., Bruneau, R.M., VandenBerg, P.M., Goertzen, C. & Kleim, J.A. (2001). Sensitivity of cortical movement representations to motor experience: Evidence that skill learning but not strength training induces cortical reorganization. Behav Brain Res, 123(2), 133-141.
91. Rothi, L. & Horner, J. (1983). Restitution and substitution: Two theories of recovery with application to neurobehavioral treatment. J Clin Neuropsychol, 5(1), 73-81.
92. Sawaki, L., Wu, C.W.H., Kaelin-Lang, A. & Cohen, L.G. (2006). Effects of somatosensory stimulation on use-dependent plasticity in chronic stroke. Stroke, 37(1), 246.
93. Scḧabitz, W.-R., Berger, C., Kollmar, R., Seitz, M., Tanay, E., Kiessling, M. & Sommer, C. (2004). Effect of brain-derived neurotrophic factor treatment and forced arm use on functional motor recovery after small cortical ischemia. Stroke, 35(4), 992-997.
94. Schwerin, S., Dewald, J.P.A., Haztl, M., Jovanovich, S., Nickeas, M. & MacKinnon, C. (2010). Ipsilateral versus contralateral cortical motor projections to a shoulder adductor in chronic hemiparetic stroke: Implications for the expression of arm synergies. Exp Brain Res, 185(3), 509-519.
95. Seitz, R.J., Hoflich, P., Binkofski, F., Tellmann, L., Herzog, H. & Freund, H.J. (1998). Role of the Premotor Cortex in Recovery From Middle Cerebral Artery Infarction. Arch Neurol, 55, 1081-1088.
96. Seitz, R.J.J., Azari, N.P.P., Knorr, U., Binkofski, F., Herzog, H. & Freund, H.J.J. (1999). The role of diaschisis in stroke recovery. Stroke, 30(9), 1844-1850.
97. Small, S.L., Hlustik, P., Noll, D.C., Genovese, C. & Solodkin, A. (2002). Cerebellar hemispheric activation ipsilateral to the paretic hand correlates with functional recovery after stroke. Brain, 125, 1544-1557.
98. Stinear, C.M., Barber, P.A., Petoe, M., Anwar, S. & Byblow, W.D. (2012). The PREP algorithm predicts potential for upper limb recovery after stroke. Brain, 135(8), 2527-2535.
99. Sukal, T.M., Ellis, M.D. & Dewald, J.P.A. (2007). Shoulder abduction-induced reductions in reaching work areas following hemiparetic stroke: Neuroscientific implications. Exp Brain Res, 183(2), 215-223.
100. Sunderland, A. & Tuke, A. (2006). Neuroplasticity, learning and recovery after stroke: A critical evaluation of constraintinduced therapy. Neuropsychol Rehabil, 15(2), 81-96.
101. Turrigiano, G.G. (2008). The self-tuning neuron: Synaptic scaling of excitatory synapses. Cell, 135(3), 422-435.
102. Twitchell, T. (1951). The restoration of motor function following hemiplegia in man. Brain, 74, 443-480.
103. van der Zijden, J.P., Van Eijsden, P., De Graaf, R. A, & Dijkhuizen, R.M. (2008). 1H/13C MR spectroscopic imaging of regionally specific metabolic alterations after experimental stroke. Brain, 131(Pt 8), 2209-2219.
104. van Kordelaar, J., vanWegen, E.E., Nijland, R.H., Daffertshofer, A. & Kwakkel, G. (2013) Understanding Adaptive Motor Control of the Paretic Upper Limb Early Poststroke: The EXPLICITstroke Program. Neurorehab Neural Re, 2013 Jul 24.
105. [Epub ahead of print] PubMed PMID: 23884015. Veerbeek, J.M., Van Wegen, E.E.H., Harmeling-Van der Wel, B.C. & Kwakkel, G. (2011). Is accurate prediction of gait in nonambulatory stroke patients possible within 72 hours poststroke? The EPOS study. Neurorehab Neural Re, 25(3), 268-274.
106. Wagner, J.M., Lang, C.E., Sahrmann, S., a, Edwards, D.F. & Dromerick, A.W. (2007). Sensorimotor impairments and reaching performance in subjects with poststroke hemiparesis during the first few months of recovery. Phys Ther, 87(6), 751-765.
107. Ward, N. (2007). Future perspectives in functional neuroimaging in stroke recovery. Eura Medicophys, 43(2), 285-294.
108. Ward, N., Brown, M., Thompson, A. & Frackowiak, R. (2003a). Neural correlates of motor recovery after stroke: A longitudinal fMRI study. Brain, 126(11), 2476-2496.
109. Ward, N., Brown, M., Thompson, A. & Frackowiak, R. (2003b). Neural correlates of outcome after stroke: A cross-sectional fMRI study. Brain, 126(6), 1430-1448.
110. Wardlaw, J.M., Sandercock, P.A.G. & Murray, V. (2009). Should more patients with acute ischaemic stroke receive thrombolytic treatment? BMJ, 339, 1251-1254.
111. Whishaw, I.Q. (2000). Loss of the innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat. Neuropharmacology, 39, 788-805.
112. Whishaw, I.Q., Alaverdashvili, M. & Kolb, B. (2008). The problem of relating plasticity and skilled reaching after motor cortex stroke in the rat. Behav Brain Res, 192, 124-136.
113. Winship, I.R. & Murphy, T.H. (2009). Remapping the somatosensory cortex after stroke: Insight from imaging the synapse to network. Neuroscientist, 15, 507-524.
114. Witte, O.W., Bidmon, H.J., Schiene, K., Redecker, C. & Hagemann, G. (2000). Functional differentiation of multiple perilesional zones after focal cerebral ischemia. J Cerebr Blood F Met, 20, 1149-1165.
115. Wittenberg, G.F., Chen, R., Ishii, K., Bushara, K.O., Taub, E., Gerber, L.H.&Cohen, L.G. (2003). Constraint-Induced Therapy in Stroke: Magnetic-Stimulation Motor Maps and Cerebral Activation. Neurorehab Neural Re, 17(1), 48-57.
116. Wolf, S.L., Butler, A.J., Alberts, J.L. & Kim, M.W. (2005). Contemporary linkages between EMG, kinetics and stroke rehabilitation. J Electromyogr Kines, 15(3), 229-239.
117. Wolf, Steven, L., Winstein, C.J., Miller, J.P. & Morris, D. (2006). Effect of Constraint-Induced Movement Therapy on upper extremity function 3 to 9Months After Stroke. J AmMed Assoc, 296(17), 2095-2104.
118. Zhang, S., Boyd, J., Delaney, K. & Murphy, T.H. (2005). Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. Neuroscience, 25(22), 5333-5338.
119. Zhao, B.-Q., Tejima, E. & Lo, E.H. (2007). Neurovascular proteases in brain injury, hemorrhage and remodeling after stroke. Stroke, 38, 748-752.
120. Zhao, B.-Q.,Wang, S., Kim, H.-Y., Storrie, H., Rosen, B.R., Mooney, D.J. & Lo, E.H. (2006). Role of matrix metalloproteinases in delayed cortical responses after stroke. Nat Med, 12(4), 441-445.