Enriched rehabilitative training promotes improved forelimb motor function and enhanced dendritic growth after focal ischemic injury

Journal of Neuroscience

Volumn 21, Issue 14, 2001, Pages 5272-5280

  Biernaskie, J ^a   Corbett, D ^a  

^a MEMORIAL UNIVERSITY OF NEWFOUNDLAND   (Canada)

Author keywords

Dendritic arborization; Enrichment; Forelimb; Functional recovery; Motor cortex; Rehabilitation; Stroke

Indexed keywords

ENDOTHELIN 1;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CONVALESCENCE; FORELIMB; ISCHEMIA; LATENT PERIOD; MALE; MOTOR ACTIVITY; MOTOR CORTEX; MOTOR PERFORMANCE; NERVE CELL PLASTICITY; NERVE GROWTH; NERVE INJURY; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT; SKILL; STROKE; TASK PERFORMANCE; TRAINING; WEIGHT BEARING;

EID: 0035879070     PISSN: 02706474     EISSN: None     Source Type: Journal    
DOI: 10.1523/jneurosci.21-14-05272.2001     Document Type: Article

References (49)

1. Differential gene expression associated with axonal sprouting after focal cortical lesions
2. Limb preference after lesions of the cerebral hemisphere in adult and neonatal rats
3. Differential spine loss and regrowth of striatal neurons following multiple forms of deafferentation: A Golgi study
4. Ultrastructural evidence for cortical axon sprouting in the deafferented striatum of adult rat
5. Environmental effects on cortical dendritic fields. I. Rearing in the dark
6. A functional MRI study of subjects recovered from hemiparetic stroke
7. Bihemispheric contribution to motor recovery after stroke: A longitudinal study with transcranial Doppler ultrasonography
8. Environmental enrichment alters nerve growth factor-induced gene A and glucocorticoid receptor messenger RNA expression after middle cerebral artery occlusion in rats
9. Unilateral lesions of the forelimb area of rat motor cortex: Lack of evidence for use-dependent neural growth in the undamaged hemisphere
10. A method for vibratome sectioning of Golgi-Cox stained whole rat brain
11. Analysis of thick brain sections by obverse-reverse computer microscopy: Application of a new, high clarity Golgi-Nissl stain
12. Paw-reaching, sensorimotor, and rotational behavior after brain infarction in rats
13. Effects of unilateral and bilateral training in a reaching task on dendritic branching of neurons in the rat motor-sensory forelimb cortex
14. Environment, social interaction, and physical activity as determinants of functional outcome after cerebral infarction in the rat
15. Overgrowth and pruning of dendrites in adult rats recovering from neocortical damage
16. Use-dependent growth of pyramidal neurons after neocortical damage
17. Motor skills training enhances lesion-induced structural plasticity in the motor cortex of adult rats
18. Intracisternal basic fibroblast growth factor enhances functional recovery and up-regulates the expression of a molecular marker of neuronal sprouting following cerebral infarction
19. Synaptogenesis and Fos expression in the motor cortex of the adult rat after motor skill learning
20. Environmental enrichment and cortical injury: Behavioral and anatomical consequences of frontal cortex lesions in rats
21. Dissociation of the contributions of the prefrontal, motor, and parietal cortex to the control of movement in the rat: An experimental review
22. Age, experience, and the changing brain
23. Plasticity in the motor system related to therapy-induced improvement of movement after stroke
24. Use-dependent exaggeration of neuronal injury after unilateral sensorimotor cortex lesions
25. Constraint-induced movement therapy for motor recovery in chronic stroke patients
26. Mechanisms underlying functional recovery following stroke
27. Treatment-induced cortical reorganization after stroke in humans
28. The "staircase test": A measure of independent forelimb reaching and grasping abilities in rats
29. The organization of the rat motor cortex: A microstimulation mapping study
30. Periinfarct and remote excitability changes after transient middle cerebral artery occlusion
31. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct
32. Environment influences functional outcome of cerebral infarction in rats
33. Motor functions of the striatum in the rat: Critical role of the lateral region in tongue and forelimb reaching
34. Morphology of identified corticospinal cells in the rat following motor cortex injury: Absence of use-dependent change
35. Early training may exacerbate brain damage after focal brain ischemia in the rat
36. Effects of environmental complexity and training on brain chemistry and anatomy: A replication and extension
37. Blockade of basic fibroblast growth factor retards recovery from motor cortex injury in rats
38. Characterisation of an experimental model of stroke produced by intracerebral microinjection of endothelin-1 adjacent to the rat middle cerebral artery
39. Perivascular microapplication of endothelin-1: A new model of focal ischemia in the rat
40. Neocortical neural sprouting, synaptogenesis, and behavioral recovery following neocortical infarction in rats
41. Technique to improve chronic motor deficit after stroke
42. A ventral uncrossed corticospinal tract in the rat
43. Loss of innate cortical engram for action patterns used in skilled reaching and the development of behavioral compensation following motor cortex lesions in the rat
44. The contributions of the motor cortex, nigrostriatal dopamine, and caudate-putamen to skilled forelimb use in the rat
45. The impairments in reaching and the movements of compensation in rats with motor cortex lesions: An endpoint, videorecording, and movement notation analysis
46. Environmental influence on brain-derived neurotrophic factor messenger RNA expression after middle cerebral artery occlusion in spontaneously hypertensive rats
47. Cortex: Areal and laminar structure