A randomised controlled trial investigating the effect of nutritional supplementation on visual function in normal, and age-related macular disease affected eyes: Design and methodology [ISRCTN78467674]

Nutrition Journal

Volumn 2, Issue , 2003, Pages 1-7

  Bartlett, Hannah ^a   Eperjesi, Frank ^a  

^a ASTON UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA TOCOPHEROL; ASCORBIC ACID; COPPER; RETINOL; XANTHOPHYLL; ZINC;

ARTICLE; COLOR VISION; CONTRAST SENSITIVITY; EYE PHOTOGRAPHY; GLARE; INFORMATION PROCESSING; NUTRIENT SUPPLY; NUTRITIONAL SUPPORT; OUTCOMES RESEARCH; PARALLEL DESIGN; RETINA MACULA AGE RELATED DEGENERATION; TIME; VISION; VISUAL ACUITY; VISUAL FIELD; VISUAL MASKING;

EID: 3042644268     PISSN: 14752891     EISSN: None     Source Type: Journal    
DOI: 10.1186/1475-2891-2-12     Document Type: Article

References (87)

1. Evans JR: Causes of blindness and partial sight in England and Wales 1990-1991. Studies on medical and population subjects Volume 57. London, HMSO; 1995.
2. Klein R, Klein BEK and Linton KLP: Prevalence of Age-Related Maculopathy - the Beaver Dam Eye Study. Ophthalmology 1992, 99:933-943.
3. Mitchell P, Smith W, Attebo K and Wang JJ: Prevalence of Age-Related Maculopathy in Australia - the Blue Mountains Eye Study. Ophthalmology 1995, 102:1450-1460.
4. United Nations: The world population prospects: the 2002 revision. www.un.org/esa/population/publications/wpp2000/highlights.pdf. 2002.
5. Bird AEC, Bressler NM, Bressler SB, Chisholm IH, Coscas G, Davis MD, Dejong Ptvm, Klaver CCW, Klein BEK, Klein R, Mitchell P, Sarks JP, Sarks SH, Sourbane G, Taylor HR and Vingerling JR: An International Classification and Grading System for Age- Related Maculopathy and Age-Related Macular Degeneration. Survey of Ophthalmology 1995, 39:367-374.
6. Bressler NM, Bressler SB and Fine SL: Age-related macular degeneration. Survey of Ophthalmology 1988, 32:375-413.
7. Bressler NM, Bressler SB and Fine SL: Subfoveal neovascular membranes in senile macular degeneration: relationship between membrane size and visual prognosis. Retina 1983, 3:7-11.
8. Murphy RP: Age-related macular degeneration. Ophthalmology 1986, 93:969-971.
9. Tso MOM: Pathogenic factors of aging macular degeneration. Ophthalmology 1985, 92:628-636.
10. Arnold JJ and Sarks SH: Extracts from "Clinical evidence" - Age related macular degeneration. Br. Med. J. 2000, 321:741-744.
11. Chopdar A, Chakravarthy U and Verma D: Age-related macular degeneration. British Medical Journal 2003, 326:485-488.
12. Kanski JJ: Clinical Ophthalmology. Thirdth edition. Oxford, Butterworth-Heineman; 1994.
13. Holz FG. et. al: Analysis of lipid deposits extracted from human macular and peripheral Bruch's membrane. Archives of Ophthalmology 1994, 112:402-406.
14. Ambati J, Ambati BK, Yoo SH, Ianchulev S and Adamis AP: Age-Related Macular Degeneration: Etiology, Pathogenesis, and Therapeutic Strategies. Survey of Ophthalmology 2003, 48:257-293.
15. Rawes V, Kipling D, Kill IR and Faragher RG: The kinetics of senescence in retinal pigment epithelial cells: a test for the telomere hypothesis of ageing? Biochemistry 1997, 62:1291-1295.
16. Dorey CK, Wu G and Ebenstein D: Cell loss in the aging retina. Relationship to lipofuscin accumulation and macular degeneration. Invest Ophthalmol Vis Sci 1989, 30:1691-1699.
17. Watzke RC, Soldevilla JD and Trune DR: Morphometric analysis of human retinal pigment epithelium: correlation with age and location. Current Eye Research 1993, 12:133-142.
18. Friedman E: A hemodynamic model of the pathogenesis of age-related macular degeneration. American Journal of Ophthalmology 1997, 124:677-682.
19. Friedman E: The role of the atherosclerotic process in the pathogenesis of age-related macular degeneration. American Journal of Ophthalmology 2000, 130:658-663.
20. Grunwald JE, Hariprasad SM and DuPont J: Effect of aging on foveolar choroidal circulation. Archives of Ophthalmology 1998, 116:150-154.
21. Grunwald JE, Hariprasad SM and DuPont J: Foveolar choroidal blood flow in age-related macular degeneration. Investigative Ophthalmological Vision Science 1998, 39:385-390.
22. Hyman LG, Lilienfeld AM, Ferris FL and Fine SL: Senile Macular Degeneration - a Case-Control Study. Am. J. Epidemiol. 1983, 118:213-227.
23. Smith W and Mitchell P: Family history and age-related maculopathy: the Blue Mountains Eye Study. Archives of Ophthalmology 1998, 26:203-206.
24. Bird A: Age-related macular disease. Br. J. Ophthalmol. 1996, 80:2-3.
25. Rose RC, Richer SP and Bode AM: Ocular Oxidants and Antioxidant Protection. Proceedings of the Society for Experimental Biology and Medicine 1998, 217:397-407.
26. Southorn PA and Powis G: Free radicals in medicine I. Chemical nature and biological reactions. Mayo Clinical Procedures 1988, 63:381-389.
27. Halliwell B: Reactive oxygen species in living systems: source, biochemistry and role in human disease. Am J Med 1991, 91 (Supp):14-22.
28. Florence TM: Ther role of free radicals in disease (review). Australian and New Zealand Journal of Ophthalmology 1995, 23:3-7.
29. Sickel W: Retinal metabolism in dark and light. Handbook of sensory physiology Edited by: Fuortes MGF. Berlin, Springer-Verlag; 1972:667-727.
30. Bazan NG: The metabolism of omega-3 polyunsaturated fatty acids in the eye: the possible role of docosahexaenoic acid and docosanoids in retinal physiology and ocular pathology. Progress in Clinical and Biological Research 1989, 312:95-112.
31. Stone WL, Farnsworth CC and Dratz EA: A reinvestigation of the fatty acid content of bovine, rat and frog retinal rod outer segments. Experimental Eye Research 1979, 28:387-397.
32. Delmelle M: Retinal sensitized photodynamic damage to liposomes. Photochemistry and Photobiology 1978, 28:357-360.
33. Gaillard ER, Atherton SJ, Eldred G and Dillon J: Photophysical studies on human retinal lipofuscin. Photochemistry and Photobiology 1995, 61:448-453.
34. Rozanowska M, Jarvis-Evans J and Korytowski W: Blue light-induced reactivity of retinal pigment. In vitro generation of oxygen-reactive species. Journal of Biological Chemistry 1995, 270:18825-18830.
35. Tate DJ Jr, Miceli MV and Newsome DA: Phagocytosis and H202 induce catalase and metallothionein gene expression in human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci 1995, 36:1271-1279.
36. Beatty S, Koh HH, Henson D and Boulton M: The role of oxidative stress in the pathogenesis of age-related macular degeneration. Surv. Ophthalmol. 2000, 45:115-134.
37. Kahn HA and Moorhead HB: Statistics on blindness in the Model Reporting Area 1969-1970. Washington. DC, US DHEW; 1973.
38. Goldberg J, Flowerdew G, Smith E, Brody JA and Tso MOM: Factors Associated with Age-Related Macular Degeneration - an Analysis of Data from the 1st National-Health and Nutrition Examination Survey. Am. J. Epidemiol. 1988, 128:700-710.
39. Hawkins BS, Bird A, Klein R and West SK: Epidemiology of age-related macular degeneration. Mol. Vis. 1999, 5:U7-U10.
40. Klein R: Epidemiology. Age-Related Macular Degeneration Edited by: Berger JW, Fine SL, Maguire MG. Philadelphia, Mosby; 1999:31-55.
41. Smith W, Assink J, Klein R, Mitchell P, Klaver CCW, Klein BEK, Hofman A, Jensen S, Wang JJ and de Jong Ptvm: Risk factors for age related macular degeneration - Pooled findings from three continents. Ophthalmology 2001, 108:697-704.
42. Tamakoshi, Akiko, Yuzawa, Mitsuko, Matsui and Mizuo: Smoking and neovascular form of age-related macular degeneration in late middle aged males: findings from a case-control study in Japan. British Journal of Ophthalmology 1997, 81:901-904.
43. Seddon JM, Willett WC, Speizer FE and Hankinson SE: A prospective study of cigarette smoking and age-related macular degeneration in women. JAMA 1996, 276.
44. Hawkins RL: Smoking, platelets and thrombosis. Nature 1972, 236:450-452.
45. Heiba IM, et. al: Sibling correlations and segregation analysis of age-related maculopathy: the Beaver Dam Eye Study. Genetic Epidemiology 1994, 11:51-67.
46. Klaver CCW, Smith and Smith: Familial aggregation of age-related macular degeneration in the Rotterdam Study (abstract). Investigative Opthalmological Visual Science 1997, 38:S967.
47. Klaver CCW, Wolfs RCW and Assink JJM: Genetic Risk of Age-Related Maculopathy. Population-Based Familial Aggregation Study. Archives of Ophthalmology 1998, 116:1646-1651.
48. Kahn HA, smith and jones.: The Framingon Eye Study. I. Outline and major prevalence findings. American Journal of Epidemiology 1977, 106:17-32.
49. Schachat AP, Hyman L, Leske MC, Connell AMS and Wu SY: Features of Age-Related Macular Degeneration in a Black-Population. Arch. Ophthalmol. 1995, 113:728-735.
50. Friedman DS, Katz J, Bressler NM, Rahmani B and Tielsch JM: Racial differences in the prevalence of age-related macular degeneration - The Baltimore eye survey. Ophthalmology 1999, 06:1049-1055.
51. Jampol LM and Tielsch JM: Race, Macular Degeneration, and the Macular Photocoagulation Study. Archives of Ophthalmology 1992, 10:1699-1700.
52. Cruickshanks KJ, Klein R, Klein BEK and Nondahl DM: Sunlight and the 5-year incidence of early age-related maculopathy - The Beaver Dam Eye Study. Arch. Ophthalmol. 2001, 119:246-250.
53. Delcourt C, Carriere I and Ponton-Sanchez A: Light Exposure and the Risk of Age-Related Macular Degeneration: The POLA Study. Archives of Ophthalmology 2001, 119:1463-1468.
54. Mares-Perlman JA. et. al: Dietary fat and age-related maculopathy. Archives of Ophthalmology 1995, 113:743-748.
55. Yannuzzi LA, Sorenson JA, Sobel RS, Daly JR, Derosa JT, Seddon JM, Gragoudas ES, Puliafito CA, Gelles E, Gonet R, Burton TC, Culver J, Metzger K, Kalbfleisch N, Zarling D, Farber MD, Blair N, Stelmack T, Axelrod A, Waitr SE, Cross A, Rolnick C, Flom T, Haller J, Pusin S, Cassel G, Applegate CA, Seigel D, Sperduto RD, Hiller R, Mowery R, Chew E, Tamboli A, Miller DT, Sowell AL, Gunter EW, Dunn M, Shamban K, Lento D, Alexander JA and Phillips DA: Risk-Factors for Neovascular Age-Related Macular Degeneration. Arch. Ophthalmol. 1992, 110:1701-1708.
56. Hyman L, Smith and Smith: Risk factors for age-related maculopathy. Investigative Ophthalmological Vision Science 1992, 33:801.
57. Smith W, Mitchell P and Leeder SR. et. al: Plasma Fibrinogen Levels, Other Cardiovascular Risk Factors, and Age-Related Maculopathy. Archives of Ophthalmology 1998, 116:583-587.
58. The Age-Related Eye Disease Study Research Group: Risk factors associated with age-related macular degeneration - A case-control study in the Age-Related Eye Disease Study: Age-Related Eye Disease Study report number 3. Ophthalmology 2000, 107:2224-2232.
59. Richer S: Multicenter ophthalmic and nutritional age-related macular degeneration study part 2: antioxidant intervention and conclusions. J Am Optom Assoc 1996, 67:30-49.
60. Bartlett H and Eperjesi F: Age-related macular degeneration and nutritional supplementation: a review of randomised controlled trials. Ophthalmic and Physiological Optics 2003, 23:383-399.
61. Handelman GJ, Dratz EA and Reay CC: Carotenoids in the human macula and the whole retina. Invest Ophthalmol Vis Sci 1988, 29:850-855.
62. Bone RA, Landrum JT, and Tarsis SL: Preliminary identification of the human macular pigment. Vision Res 1985, 25:1531-1535.
63. Khachik F, Bernstein PS and Garland DL: Identification of lutein and zeaxanthin oxidation products in human and monkey retinas. Invest Ophthalmol Vis Sci 1997, 38:1802-1811.
64. Isler O: Carotenoids. Edited by: Basel. Birkhauser-Verlag; 1971.
65. Goodwin TW: Methods in Enzymology Volume 213. Edited by: Packer L. New York, Academic Press; 1992:167-172.
66. Nebeling LC, Forman MR, Graubard BI and Snyder RA: Changes in carotenoid intake in the United States. The 1987 and 1992 National Health Interview Surveys. Journal of the American Dietetic Association 1997, 97:991-996.
67. Nebeling LC, Forman MR, Graubard BI and Snyder RA: The Impact of Lifestyle Characterisitcs on Carotenoid Intake in the United States: The 1987 National Health Interview Survey. American Journal of Public Health 1997, 87:268-271.
68. Bernstein PS, Khachik F, Carvalho LS, Muir GJ, Zhao DY and Katz NB: Identification and quantitation of carotenoids and their metabolites in the tissues of the human eye. Experimental Eye Research 2001, 72:215-223.
69. Rapp LM, Maple SS and Choi JH: Lutein and zeaxanthin concentrations in rod outer segment membranes from perifoveal and peripheral human retina. Investigative Ophthalmology & Visual Science 2000, 41:1200-1209.
70. EDCCS Group: Antioxidant status and neovascular age-related macular degeneration. The Eye Disease Case Control Study Group. Archives of Ophthalmology 1993, 111:104-109.
71. Bone RA, Landrum JT, Mayne ST, Gomez CM, Tibor SE and Twaroska EE: Macular pigment in donor eyes with and without AMD: A case-control study. Invest Ophthalmol Vis Sci 2001, 42:235-240.
72. Beatty S, Murray IJ, Henson DB, Carden D, Koh H and Boulton ME: Macular pigment and risk for age-related macular degeneration in subjects from a Northern European population. Investigative Ophthalmology & Visual Science 2001, 42:439-446.
73. Landrum JT, Bone RA, Joa H, Kilburn MD, Moore LL and Sprague KE: A one year study of the macular pigment: the effect of 140 days of a lutein supplement. Experimental Eye Research 1997, 65:57-62.
74. Hammond BR, Jr, Johnson EJ, Russell RM, Krinsky NI, Yeum KJ, Edwards RB and Snodderly DM: Dietary modification of human macular pigment density. Investigative Ophthalmology & Visual Science 1997, 38:1795-1801.
75. Berendschot Ttjm, Goldbohm RA, Klopping WAA, van de Kraats J, van Norel J and van Norren D: Influence of lutein supplementation on macular pigment, assessed with two objective techniques. Invest. Ophthalmol. Vis. Sci. 2000, 41:3322-3326.
76. Ham WT Jr, Mueller HA and Ruffolo JJ Jr: Basic mechanisms underlying the production of photochemical lesions in the mammalian retina. Curr Eye Res 1984, 3:165-174.
77. Landrum JT and Bone RA: Lutein, zeaxanthin, and the macular pigment. Archives of Biochemistry and Biophysics 2001, 385:28-40.
78. Bierenbaum ML, Noonan FJ and Machlin LJ: The effect of supplemental vitamin E on serum parameters in diabetics, post coronary and normal subjects. Nutr Rep Int 1985, 31:1171-1180.
79. Paolisso G, D'Amore A and Giugliano D: Pharmacologic doses of vitamin E improve insulin action in healthy subjects and non-insulin dependent diabetic patients. Am J Clin Nutr 1993, 57:650-656.
80. Paolisso G, D'Amore A and Galzerano D: Daily vitamin E supplements improve metabolic control but not insulin secretion in elderly type II diabetic patients. Diabetes Care 1993, 16:1433-1437.
81. Tütüncü NB, Bayraktar M and Varli K: Reversal of defective nerve condition with vitamin E supplementation in type 2 diabetes. Diabetes Care 1998, 21:1915-1918.
82. Skrha J, Sindelka G, Kvasnicka J and Hilgertova J: Insulin action and fibrinolysis influenced by vitamin E in obese type 2 diabetes mellitus. Diabetes Res Clin Pract 1999, 44:27-33.
83. Pinto JT: The pharmacokinetic and pharmacodynamic interactions of foods and drugs. Topics in Clinical Nutrition 1991, 6:14-33.
84. Minerals Expert Group on Vitamins and: Safe Upper Limits for Vitamins and Minerals. www.foodstandards.gov.uk/multimedia/pdfs/vitamins2003.pdf, Food Standard Agency; 2003.
85. MacKeben M and Colenbrander A: The assessment of residual vision in patients with maculopathies. Non-invasive assessment of the visual system. Technical Digest 1993, 3:274-277.
86. Brindley GS: Physiology of the retina and visual pathways. Baltimore, Williams and Wilkins; 1970.
87. World Medical Association: Declaration of Helsinki. Journal of the Americal Medical Society 1997, 277:925-926.