Andrographolide downregulates the v-Src and Bcr-Abl oncoproteins and induces Hsp90 cleavage in the ROS-dependent suppression of cancer malignancy

Biochemical Pharmacology

Volumn 87, Issue 2, 2014, Pages 229-242

  Liu, Sheng Hung ^a,b   Lin, Chao Hsiung ^a,b   Liang, Fong Ping ^a   Chen, Pei Fen ^a   Kuo, Cheng Deng ^c   Alam, Mohd Mujahid ^d   Maiti, Barnali ^d   Hung, Shih Kai ^e   Chi, Chin Wen ^a,b   Sun, Chung Ming ^d   Fu, Shu Ling ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b ACADEMIA SINICA   (Taiwan)

^c TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^d NATIONAL CHIAO TUNG UNIVERSITY   (Taiwan)

^e BUDDHIST TZU CHI GENERAL HOSPITAL   (Taiwan)

Author keywords

Andrographolide; Apoptosis; Bcr Abl; Hsp90; ROS; Src

Indexed keywords

ACETYLCYSTEINE; ANDROGRAPHOLIDE; BCR ABL PROTEIN; HEAT SHOCK PROTEIN 90; PROTEIN KINASE P60; REACTIVE OXYGEN METABOLITE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CANCER INHIBITION; CONTROLLED STUDY; DRUG EFFECT; ENZYME DEGRADATION; HUMAN; HUMAN CELL; NEOPLASM; PRIORITY JOURNAL; PROTEIN CLEAVAGE; RECEPTOR DOWN REGULATION;

ANDROGRAPHOLIDE; APOPTOSIS; BCR-ABL; HSP90; ROS; SRC;

AMINO ACID SEQUENCE; ANTI-INFLAMMATORY AGENTS; ANTINEOPLASTIC AGENTS, PHYTOGENIC; DITERPENES; DOWN-REGULATION; GENES, ABL; GENES, SRC; HSP90 HEAT-SHOCK PROTEINS; HUMANS; K562 CELLS; LEUKEMIA, MYELOGENOUS, CHRONIC, BCR-ABL POSITIVE; MOLECULAR SEQUENCE DATA; REACTIVE OXYGEN SPECIES;

EID: 84892373230     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.10.014     Document Type: Article

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