Inhibitory effects of andrographolide on migration and invasion in human non-small cell lung cancer A549 cells via down-regulation of PI3K/Akt signaling pathway

European Journal of Pharmacology

Volumn 632, Issue 1-3, 2010, Pages 23-32

  Lee, Yi Chieh ^a   Lin, Hui Hsuan ^b   Hsu, Chin Hsun ^a   Wang, Chau Jong ^b   Chiang, Tai An ^a   Chen, Jing Hsien ^a  

^a CHUNG HWA UNIVERSITY OF MEDICAL TECHNOLOGY   (Taiwan)

^b CHUNG SHAN MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Activator protein 1; Andrographolide; Invasion; Metalloproteinase; Migration; PI3K (Phosphatidylinositol 3 kinase) Akt signal

Indexed keywords

ANDROGRAPHOLIDE; COMPLEMENTARY DNA; GELATINASE A; GELATINASE B; MATRILYSIN; MESSENGER RNA; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; TRANSCRIPTION FACTOR AP 1;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CELL INVASION; CELL MIGRATION; CELL MOTILITY; CELL PROLIFERATION; CONTROLLED STUDY; CYTOTOXICITY; DNA BINDING; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG NON SMALL CELL CANCER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; UPREGULATION;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANTINEOPLASTIC AGENTS; CARCINOMA, NON-SMALL-CELL LUNG; CELL LINE, TUMOR; CELL MOVEMENT; DITERPENES; DOWN-REGULATION; HUMANS; LUNG NEOPLASMS; NEOPLASM INVASIVENESS; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

EID: 77349091801     PISSN: 00142999     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejphar.2010.01.009     Document Type: Article

References (48)

1. Aguirre Ghiso J.A., Alonso D.F., Farias E.F., Gomez D.E., and de Kier Joffe E.B. Deregulation of the signaling pathways controlling urokinase production. Its relationship with the invasive phenotype. Eur. J. Biochem. 263 (1999) 295-304
2. Alley M.C., Scudiero D.A., Monks A., Hursey M.L., Czerwinski M.J., Fine D.L., Abbott B.J., Mayo J.G., Shoemaker R.H., and Boyd M.R. Feasibility of drug screening with panels of human tumor cell lines using a microculture tetrazolium assay. Cancer Res. 48 (1988) 589-601
3. Attiga F.A., Fernandez P.M., Weeraratna A.T., Manyak M.J., and Patierno S.R. Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases. Cancer Res. 60 (2000) 4629-4637
4. Barillé S., Bataille R., Rapp M.J., Harousseau J.L., and Amiot M. Production of metalloproteinase-7 (matrilysin) by human myeloma cells and its potential involvement in metalloproteinase-2 activation. J. Immunol. 163 (1999) 5723-5728
5. Bergman M.R., Cheng S., Honbo N., Piacentini L., Karliner J.S., and Lovett D.H. A functional activating protein 1 (AP-1) site regulates matrix metalloproteinase 2 (MMP-2) transcription by cardiac cells through interactions with JunB-Fra1 and JunB-FosB heterodimers. Biochem. J. 369 (2003) 485-496
6. Brodt P., Samani A., and Navab R. Inhibition of the type I insulin-like growth factor receptor expression and signaling: novel strategies for antimetastatic therapy. Biochem. Pharmacol. 60 (2000) 1101-1107
7. Chakraborti S., Mandal M., Das S., Mandal A., and Chakraborti T. Regulation of matrix metalloproteinases: an overview. Mol. Cell. Biochem. 253 (2003) 269-285
8. Chan F.L., Choi H.L., Chen Z.Y., Chan P.S., and Huang Y. Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett. 160 (2000) 219-228
9. Chen J.H., Tseng T.H., Ho Y.C., Lin H.H., Lin W.L., and Wang C.J. Gaseous nitrogen oxides stimulate cell cycle progression by Rb-phosphorylation via activation of cyclins/cdks. Toxicol. Sci. 76 (2003) 83-90
10. Cheung H.Y., Cheung S.H., Li J., Cheung C.S., Lai W.P., Fong W.F., and Leung F.M. Andrographolide isolated from Andrographis paniculata induces cell cycle arrest and mitochondrial-mediated apoptosis in human leukemic HL-60 cells. Planta Med. 71 (2005) 1106-1111
11. Chiu L.C., and Wan J.M. Induction of apoptosis in HL-60 cells by eicosapentaenoic acid (EPA) is associated with downregulation of bcl-2 expression. Cancer Lett. 145 (1999) 17-27
12. Choudhury G.G., Karamitsos C., Hernandez J., Gentilini A., Bardgette J., and Abboud H.E. PI-3-kinase and MAPK regulate mesangial cell proliferation and migration in response to PDGF. Am. J. Physiol. 273 (1997) F931-F938
13. Chu S.C., Chiou H.L., Chen P.N., Yang S.F., and Hsieh Y.S. Silibinin inhibits the invasion of human lung cancer cells via decreased productions of urokinase-plasminogen activator and matrix metalloproteinase-2. Mol. Carcinog. 40 (2004) 143-149
14. Duan C., Bauchat J.R., and Hsieh T. Phosphatidylinositol 3-kinase is required for insulin-like growth factor-I-induced vascular smooth muscle cell proliferation and migration. Circ. Res. 86 (2000) 15-23
15. Fidler I.J. The organ microenvironment and cancer metastasis. Differentiation 70 (2005) 498-505
16. Giehl K. Oncogenic Ras in tumour progression and metastasis. Biol. Chem. 386 (2005) 193-205
17. Ho E., and Ames B.N. Low intracellular zinc induces oxidative DNA damage, disrupts p53, NFkappa B, and AP1 DNA binding, and affects DNA repair in a rat glioma cell line. Proc. Natl. Acad. Sci. U. S. A. 99 (2002) 16770-16775
18. Hou C.H., Hou S.M., and Tang C.H. Ultrasound increased BMP-2 expression via PI3K, Akt, c-Fos/c-Jun, and AP-1 pathways in cultured osteoblasts. J. Cell. Biochem. 106 (2009) 7-15
19. Ito H., Duxbury M., Benoit E., Clancy T.E., Zinner M.J., Ashley S.W., and Whang E.E. Prostaglandin E2 enhances pancreatic cancer invasiveness through an Ets-1-dependent induction of matrix metalloproteinase-2. Cancer Res. 64 (2004) 7439-7446
20. Jada S.R., Subur G.S., Matthews C., Hamzah A.S., Lajis N.H., Saad M.S., Stevens M.F., and Stanslas J. Semisynthesis and in vitro anticancer activities of andrographolide analogues. Phytochemistry 68 (2007) 904-912
21. Keely P.J., Westwick J.K., Whitehead I.P., Der C.J., and Parise L.V. Cdc42 and Rac1 induce integrin-mediated cell motility and invasiveness through PI(3)K. Nature 390 (1997) 632-636
22. Kennedy S.G., Kandel E.S., Cross T.K., and Hay N. Akt/Protein kinase B inhibits cell death by preventing the release of cytochrome c from mitochondria. Mol. Cell. Biol. 19 (1999) 5800-5810
23. Kikuchi J., Kinoshita I., Shimizu Y., Oizumi S., Nishimura M., Birrer M.J., and Dosaka-Akita H. Simultaneous blockade of AP-1 and phosphatidylinositol 3-kinase pathway in non-small cell lung cancer cells. Br. J. Cancer 99 (2008) 2013-2019
24. Kim Y.S., and Milner J.A. Targets for indole-3-carbinol in cancer prevention. J. Nutr. Biochem. 16 (2005) 65-73
25. Kotelevets L., Noë V., Bruyneel E., Myssiakine E., Chastre E., Mareel M., and Gespach C. Inhibition by platelet-activating factor of Src- and hepatocyte growth factor-dependent invasiveness of intestinal and kidney epithelial cells. Phosphatidylinositol 3′-kinase is a critical mediator of tumor invasion. J. Biol. Chem. 273 (1998) 14138-14145
26. Li M., Li W., Kim H.J., Yao Q., Chen C., and Fisher W.E. Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR. J. Surg. Res. 119 (2004) 130-137
27. Lin H.H., Chen J.H., Kuo W.H., and Wang C.J. Chemopreventive properties of Hibiscus sabdariffa L. on human gastric carcinoma cells through apoptosis induction and JNK/p38 MAPK signaling activation. Chem. Biol. Interact 165 (2007) 59-75
28. Parks W.C., and Shapiro S.D. Matrix metalloproteinases in lung biology. Respir. Res. 2 (2001) 10-19
29. Philip S., and Kundu G.C. Osteopontin induces nuclear factor kappa B mediated promatrix metalloproteinase-2 activation through I kappa B alpha/ IKK signaling pathways, and curcumin (diferulolylmethane) down-regulates these pathways. J. Biol. Chem. 278 (2003) 14487-14497
30. Rajagopal S., Ajaya K.R., Devi D.S., Satyanarayana C., and Rajagopalan R. Andrographolide, a potential cancer therapeutic agent isolated from Andrographis paniculata. J. Exp. Ther. Oncol. 3 (2003) 147-158
31. Rao J.S. Molecular mechanisms of glioma invasiveness: the role of proteases. Nat. Rev. Cancer 3 (2003) 489-501
32. Reddy V.L., Reddy S.M., Ravikanth V., Krishnaiah P., Goud T.V., Rao T.P., Ram T.S., Gonnade R.G., Bhadbhade M., and Venkateswarlu Y. A new bis-andrographolide ether from Andrographis paniculata nees and evaluation of anti-HIV activity. Nat. Prod. Res. 19 (2005) 223-230
33. Rudolph-Owen L.A., Chan R., Muller W.J., and Matrisian L.M. The matrix metalloproteinase matrilysin influences early stage mammary tumorigenesis. Cancer Res. 58 (1998) 5500-5506
34. Satyanarayana C., Deevi D.S., Rajagopalan R., Srinivas N., and Rajagopal S. DRF 3188 a novel semi-synthetic analog of andrographolide: cellular response to MCF 7 breast cancer cells. BMC Cancer 4 (2004) 26-33
35. Sheeja K., and Kuttan G. Activation of cytotoxic T lymphocyte responses and attenuation of tumor growth in vivo by Andrographis paniculata extract and andrographolide. Immunopharmacol. Immunotoxicol. 29 (2007) 81-93
36. Shen Y.C., Chen C.F., and Chiou W.F. Andrographolide prevents oxygen radical production by human neutrophils: possible mechanism(s) involved in its anti-inflammatory effect. Br. J. Pharmacol. 135 (2002) 399-406
37. Shi M.D., Lin H.H., Lee Y.C., Chao J.K., Lin R.A., and Chen J.H. Inhibition of cell-cycle progression in human colorectal carcinoma Lovo cells by andrographolide. Chem. Biol. Interact 174 (2008) 201-210
38. Srinivasa R.J., Hamzah A.S., Saad M.S., Lajis N.H., Stevens M.F.G., and Stanslas J. Semisynthesis and cytotoxic activities of andrographolide analogues. J. Enzyme Inhib. Med. Chem. 21 (2006) 145-155
39. Su J.C., Lin K.L., Chien C.M., Lu C.M., Chen Y.L., Chang L.S., and Lin S.R. Novel indoloquinoline derivative, IQDMA, induces G(2)/M phase arrest and apoptosis in A549 cells through JNK/p38 MAPK signaling activation. Life Sci. 85 (2009) 505-516
40. Tanno S., Mitsuuchi Y., Altomare D.A., Xiao G.H., and Testa J.R. AKT activation up-regulates insulin-like growth factor I receptor expression and promotes invasiveness of human pancreatic cancer cells. Cancer Res. 61 (2001) 589-593
41. Tsai H.R., Yang L.M., Tsai W.J., and Chiou W.F. Andrographolide acts through inhibition of ERK1/2 and Akt phosphorylation to suppress chemotactic migration. Eur. J. Pharmacol. 498 (2004) 45-52
42. Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2 (2002) 489-501
43. Westermarck J., and Kahari V.M. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J. 13 (1999) 781-792
44. Wilson C.L., Heppner K.J., Labosky P.A., Hogan B.L.M., and Matrisian L.M. Intestinal tumorigenesis is suppressed in mice lacking the metalloproteinase matrilysin. Proc. Natl Acad. Sci. U.S.A. 94 (1997) 1402-1407
45. Zhang G., Dass C.R., Sumithran E., Di Girolamo N., Sun L.Q., and Khachigian L.M. Effect of deoxyribozymes targeting c-Jun on solid tumor growth and angiogenesis in rodents. J. Natl. Cancer Inst. 96 (2004) 683-696
46. Zhao J., Yang G., Liu H., Wang D., Song X., and Chen Y. Determination of andrographolide, deoxyandrographolide and neoandrographolide in the Chinese herb Andrographis paniculata by micellar electrokinetic capillary chromatography. Phytochem. Anal. 13 (2002) 222-227
47. Zhou J., Zhang S., Ong C.N., and Shen H.M. Critical role of pro-apoptotic Bcl-2 family members in andrographolide-induced apoptosis in human cancer cells. Biochem. Pharmacol. 72 (2006) 132-144
48. Zucker S., and Vacirca J. Role of matrix metalloproteinases (MMPs) in colorectal cancer. Cancer Metastasis Rev. 23 (2004) 101-117