Mitochondrial-mediated apoptosis in lymphoma cells by the diterpenoid lactone andrographolide, the active component of Andrographis paniculata

Clinical Cancer Research

Volumn 16, Issue 19, 2010, Pages 4755-4768

  Yang, Shuo ^a   Evens, Andrew M ^a   Prachand, Sheila ^a   Singh, Amareshwar T K ^a   Bhalla, Savita ^a   David, Kevin ^a   Gordon, Leo I ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ACETYLCYSTEINE; ANDROGRAPHOLIDE; BUTHIONINE SULFOXIMINE; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; GLUTATHIONE; LIPOCORTIN 5; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROPIDIUM IODIDE; PROTEIN BAK; PROTEIN BAX; REACTIVE OXYGEN METABOLITE;

ANDROGRAPHIS PANICULATA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BURKITT LYMPHOMA; CANCER CELL CULTURE; CELL DEATH; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; FIBROBLAST; FOLLICULAR LYMPHOMA; HUMAN; HUMAN CELL; LARGE CELL LYMPHOMA; LYMPHOMA CELL; MANTLE CELL LYMPHOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN CLEAVAGE;

ANDROGRAPHIS; ANIMALS; ANTINEOPLASTIC AGENTS; APOPTOSIS; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; DITERPENES; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; FIBROBLASTS; HUMANS; LYMPHOMA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, KNOCKOUT; MITOCHONDRIA; REACTIVE OXYGEN SPECIES; TIME FACTORS;

EID: 77957578364     PISSN: 10780432     EISSN: 15573265     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-10-0883     Document Type: Article

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