Inactivation of PI3K/Akt signaling mediates proliferation inhibition and G2/M phase arrest induced by andrographolide in human glioblastoma cells

Life Sciences

Volumn 90, Issue 25-26, 2012, Pages 962-967

  Li, Yanchun ^a   Zhang, Pengfei ^a   Qiu, Feng ^a   Chen, Lixia ^a   Miao, Caixia ^a   Li, Jianchun ^a   Xiao, Wei ^b   Ma, Enlong ^a,b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b JIANGSU KANION PHARMACEUTICAL CO   (China)

Author keywords

Andrographolide; Cdk1; G2 M arrest; Glioblastoma; PI3K Akt signaling

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; ANDROGRAPHOLIDE; ANTIINFECTIVE AGENT; CASPASE 3; MAMMALIAN TARGET OF RAPAMYCIN; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; PROTEIN TYROSINE PHOSPHATASE; S6 KINASE; TRYPAN BLUE;

APOPTOSIS; ARTICLE; BLOOD BRAIN BARRIER; CANCER INHIBITION; CELL CYCLE G2 PHASE; CELL CYCLE M PHASE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOTOXICITY; DOWN REGULATION; DRUG EFFICACY; DRUG MECHANISM; ENZYME ACTIVITY; FLOW CYTOMETRY; GLIOBLASTOMA; HUMAN; HUMAN CELL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; WESTERN BLOTTING;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL CYCLE CHECKPOINTS; CELL DIVISION; CELL LINE, TUMOR; CELL PROLIFERATION; DITERPENES; G2 PHASE; GLIOBLASTOMA; GROWTH INHIBITORS; HUMANS; PHOSPHATIDYLINOSITOL 3-KINASES; PROTO-ONCOGENE PROTEINS C-AKT; SIGNAL TRANSDUCTION;

ANDROGRAPHIS PANICULATA; PHOS;

EID: 84863336678     PISSN: 00243205     EISSN: 18790631     Source Type: Journal    
DOI: 10.1016/j.lfs.2012.04.044     Document Type: Article

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