Skin barrier function

Nutrition for Healthy Skin: Strategies for Clinical and Cosmetic Practice

Volumn , Issue , 2011, Pages 35-48

  Elias, Peter M ^a,b   Wakefield, Joan S ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b VETERANS AFFAIRS MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84892224012     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1007/978-3-642-12264-4_4     Document Type: Chapter

References (86)

1. Aberg, K., Radek, K., Choi, E., et al.: Psychological stress downregulates epidermal antimicrobial peptide expression and increases severity of cutaneous infections in mice. J. Clin. Invest. 117, 3339-3349 (2007)
2. Aberg, K. M., Man, M. Q., Gallo, R. L., et al.: Co-regulation and interdependence of the mammalian epidermal permeability and antimicrobial barriers. J. Invest. Dermatol. 128, 917-925 (2008)
3. Altemus, M., Rao, B., Dhabhar, F. S., Ding, W., Granstein, R. D.: Stress-induced changes in skin barrier function in healthy women. J. Invest. Dermatol. 117, 309-317 (2001)
4. Aly, R., Maibach, H. I., Shinefield, H. R.: Microbial flora of atopic dermatitis. Arch. Dermatol. 113, 780-782 (1977)
5. Baker, B. S.: The role of microorganisms in atopic dermatitis. Clin. Exp. Immunol. 144, 1-9 (2006)
6. Behne, M. J., Meyer, J. W., Hanson, K. M., et al.: NHE1 regulates the stratum corneum permeability barrier homeostasis. Microenvironment acidification assessed with fluorescence lifetime imaging. J. Biol. Chem. 277, 47399-47406 (2002)
7. Behne, M. J., Barry, N. P., Hanson, K. M., et al.: Neonatal development of the stratum corneum pH gradient: localization and mechanisms leading to emergence of optimal barrier function. J. Invest. Dermatol. 120, 998-1006 (2003)
8. Bibel, D. J., Aly, R., Shinefield, H. R.: Antimicrobial activity of sphingosines. J. Invest. Dermatol. 98, 269-273 (1992)
9. Braff, M. H., Gallo, R. L.: Antimicrobial peptides: an essential component of the skin defensive barrier. Curr. Top. Microbiol. Immunol. 306, 91-110 (2006)
10. Brattsand, M., Stefansson, K., Lundh, C., Haasum, Y., Egelrud, T.: A proteolytic cascade of kallikreins in the stratum corneum. J. Invest. Dermatol. 124, 198-203 (2005)
11. Chamlin, S. L., Kao, J., Frieden, I. J., et al.: Ceramide-dominant barrier repair lipids alleviate childhood atopic dermatitis: changes in barrier function provide a sensitive indicator of disease activity. J. Am. Acad. Dermatol. 47, 198-208 (2002)
12. Choi, E. H., Man, M. Q., Xu, P., et al.: Stratum corneum acidification is impaired in moderately aged human and murine skin. J. Invest. Dermatol. 127, 2847-2856 (2007)
13. Clarke, S. R., Mohamed, R., Bian, L., et al.: The Staphylococcus aureus surface protein IsdA mediates resistance to innate defenses of human skin. Cell. Host. Microbe. 1, 199-212 (2007)
14. Cork, M. J., Britton, J., Butler, L., et al.: Comparison of parent knowledge, therapy utilization and severity of atopic eczema before and after explanation and demonstration of topical therapies by a specialist dermatology nurse. Br. J. Dermatol. 149, 582-589 (2003)
15. Cork, M. J., Robinson, D. A., Vasilopoulos, Y., et al.: New perspectives on epidermal barrier dysfunction in atopic dermatitis: gene-environment interactions. J. Allergy Clin. Immunol. 118, 3-21 (2006). quiz 22-3
16. Demerjian, M., Hachem, J. P., Tschachler, E., et al.: Acute modulations in permeability barrier function regulate epidermal cornification: role of caspase-14 and the proteaseactivated receptor type 2. Am. J. Pathol. 172, 86-97 (2008)
17. Denda, M., Sato, J., Masuda, Y., et al.: Exposure to a dry environment enhances epidermal permeability barrier function. J. Invest. Dermatol. 111, 858-863 (1998)
18. Denda, M., Sato, J., Tsuchiya, T., Elias, P. M., Feingold, K. R.: Low humidity stimulates epidermal DNA synthesis and amplifies the hyperproliferative response to barrier disruption: implication for seasonal exacerbations of inflammatory dermatoses. J. Invest. Dermatol. 111, 873-878 (1998)
19. Denda, M., Nakatani, M., Ikeyama, K., Tsutsumi, M., Denda, S.: Epidermal keratinocytes as the forefront of the sensory system. Exp. Dermatol. 16, 157-161 (2007)
20. Di Nardo, A., Wertz, P., Giannetti, A., Seidenari, S.: Ceramide and cholesterol composition of the skin of patients with atopic dermatitis. Acta Derm. Venereol. 78, 27-30 (1998)
21. Eberlein-Konig, B., Schafer, T., Huss-Marp, J., et al.: Skin surface pH, stratum corneum hydration, trans-epidermal water loss and skin roughness related to atopic eczema and skin dryness in a population of primary school children. Acta Derm. Venereol. 80, 188-191 (2000)
22. Elias, P.: Epidermal lipids, barrier function, and desquamation. J. Invest. Dermatol. 80(Suppl), 44-49 (1983)
23. Elias, P. M., Menon, G. K.: Structural and lipid biochemical correlates of the epidermal permeability barrier. Adv. Lipid Res. 24, 1-26 (1991)
24. Elias, P. M., Cullander, C., Mauro, T., et al.: The secretory granular cell: the outermost granular cell as a specialized secretory cell. J. Invest. Dermatol. Symp. Proc. 3, 87-100 (1998)
25. Elias, P. M.: The epidermal permeability barrier: from the early days at harvard to emerging concepts. J. Invest. Dermatol. 122, XXXVI-XXXIX (2004)
26. Elias, P. M.: Stratum corneum defensive functions: an integrated view. J. Invest. Dermatol. 125, 183-200 (2005)
27. Elias, P. M., Choi, E. H.: Interactions among stratum corneum defensive functions. Exp. Dermatol. 14, 719-726 (2005)
28. Elias, P. M.: The skin barrier as an innate immune element. Sem. Immunopath. 29, 3-14 (2007)
29. Elias, P. M., Hatano, Y., Williams, M. L.: Basis for the barrier abnormality in atopic dermatitis: outside-inside-outside pathogenic mechanisms. J. Allergy Clin. Immunol. 121, 1337-1343 (2008)
30. Elias, P. M., Steinhoff, M.: "Outside-to-inside" (and now back to "outside") pathogenic mechanisms in atopic dermatitis. J. Invest. Dermatol. 128, 1067-1070 (2008)
31. Feingold, K. R.: The role of epidermal lipids in cutaneous permeability barrier homeostasis. J. Lipid Res. 4812(12), 2531-2546 (2007)
32. Fluhr, J. W., Elias, P. M.: Stratum corneum pH: Formation and function of the "acid mantle". Exog. Dermatol. 1, 163-175 (2002)
33. Fluhr, J. W., Behne, M. J., Brown, B. E., et al.: Stratum corneum acidification in neonatal skin: secretory phospholipase A2 and the sodium/hydrogen antiporter-1 acidify neonatal rat stratum corneum. J. Invest. Dermatol. 122, 320-329 (2004)
34. Fluhr, J. W., Mao-Qiang, M., Brown, B. E., et al.: Functional consequences of a neutral pH in neonatal rat stratum corneum. J. Invest. Dermatol. 123, 140-151 (2004)
35. Garg, A., Chren, M. M., Sands, L. P., et al.: Psychological stress perturbs epidermal permeability barrier homeostasis: implications for the pathogenesis of stress-associated skin disorders. Arch. Dermatol. 137, 53-59 (2001)
36. Gould, H. J., Takhar, P., Harries, H. E., Chevretton, E., Sutton, B. J.: The allergic march from Staphylococcus aureus superantigens to immunoglobulin E. Chem. Immunol. Allergy 93, 106-136 (2007)
37. Gunathilake, R.: pH-regulated mechanisms account for pigment type differences in epidermal barrier function. J. Invest. Dermatol. 129, 1719-1729 (2008)
38. Hachem, J. P., Crumrine, D., Fluhr, J., et al.: pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J. Invest. Dermatol. 121, 345-353 (2003)
39. Hachem, J. P., Behne, M., Aronchik, I., et al.: Extracellular pH Controls NHE1 expression in epidermis and keratinocytes: implications for barrier repair. J. Invest. Dermatol. 125, 790-797 (2005)
40. Hachem, J. P., Man, M. Q., Crumrine, D., et al.: Sustained serine proteases activity by prolonged increase in pH leads to degradation of lipid processing enzymes and profound alterations of barrier function and stratum corneum integrity. J. Invest. Dermatol. 125, 510-520 (2005)
41. Hachem, J. P., Houben, E., Crumrine, D., et al.: Serine protease signaling of epidermal permeability barrier homeostasis. J. Invest. Dermatol. 126, 2074-2086 (2006)
42. Hachem, J. P., Wagberg, F., Schmuth, M., et al.: Serine protease activity and residual LEKTI expression determine phenotype in Netherton syndrome. J. Invest. Dermatol. 126, 1609-1621 (2006)
43. Haratake, A., Uchida, Y., Schmuth, M., et al.: UVB-induced alterations in permeability barrier function: roles for epidermal hyperproliferation and thymocyte-mediated response. J. Invest. Dermatol. 108, 769-775 (1997)
44. Hatano, Y., Terashi, H., Arakawa, S., Katagiri, K.: Interleukin-4 suppresses the enhancement of ceramide synthesis and cutaneous permeability barrier functions induced by tumor necrosis factor-alpha and interferon-gamma in human epidermis. J. Invest. Dermatol. 124, 786-792 (2005)
45. Hatano, Y., Uchida, Y., Man, M., et al.: Maintenance of an acidic stratum corneum prevents emergence of murine atopic dermatitis. JID 129, 1824-1835 (2008)
46. Holleran, W. M., Uchida, Y., Halkier-Sorensen, L., et al.: Structural and biochemical basis for the UVB-induced alterations in epidermal barrier function. Photodermatol. Photoimmunol. Photomed. 13, 117-128 (1997)
47. Holleran, W. M., Takagi, Y., Uchida, Y.: Epidermal sphingolipids: metabolism, function, and roles in skin disorders. FEBS Lett. 580, 5456-5466 (2006)
48. Hong, S. P., Kim, M. J., Jung, M. Y., et al.: Biopositive effects of low-dose uvb on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement. J. Invest. Dermatol. Online publication
49. Howell, M. D., Kim, B. E., Gao, P., et al.: Cytokine modulation of atopic dermatitis filaggrin skin expression. J. Allergy Clin. Immunol. 120, 150-155 (2007)
50. Hudson, T. J.: Skin barrier function and allergic risk. Nat. Genet. 38, 399-400 (2006)
51. Imokawa, G., Abe, A., Jin, K., et al.: Decreased level of ceramides in stratum corneum of atopic dermatitis: an etiologic factor in atopic dry skin? J. Invest. Dermatol. 96, 523-526 (1991)
52. Kim, T. H., Moodycliffe, A. M., Yarosh, D. B., et al.: Viability of the antigen determines whether DNA or urocanic acid act as initiator molecules for UV-induced suppression of delayed-type hypersensitivity. Photochem. Photobiol. 78, 228-234 (2003)
53. Kobayashi, J., Inai, T., Morita, K., et al.: Reciprocal regulation of permeability through a cultured keratinocyte sheet by IFN-gamma and IL-4. Cytokine 28, 186-189 (2004)
54. Komatsu, N., Takata, M., Otsuki, N., et al.: Elevated stratum corneum hydrolytic activity in Netherton syndrome suggests an inhibitory regulation of desquamation by SPINK5-derived peptides. J. Invest. Dermatol. 118, 436-443 (2002)
55. Komatsuzawa, H., Ouhara, K., Yamada, S., et al.: Innate defences against methicillin-resistant Staphylococcus aureus (MRSA) infection. J. Pathol. 208, 249-260 (2006)
56. Korting, H. C., Kober, M., Mueller, M., Braun-Falco, O.: Influence of repeated washings with soap and synthetic detergents on pH and resident flora of the skin of forehead and forearm. Results of a cross-over trial in health probationers. Acta Derm. Venereol. 67, 41-47 (1987)
57. Korting, H. C., Hubner, K., Greiner, K., Hamm, G., Braun-Falco, O.: Differences in the skin surface pH and bacterial microflora due to the long-term application of synthetic detergent preparations of pH 5. 5 and pH 7. 0. Results of a crossover trial in healthy volunteers. Acta Derm. Venereol. 70, 429-431 (1990)
58. Krien, P., Kermici, M.: Evidence for the existence of a self-regulated enzymatic process within human stratum corneuman unexpected role for urocanic acid. J. Invest. Dermatol. 115, 414-420 (2000)
59. Kurahashi, R., Hatano, Y., Katagiri, C.: IL-4 suppresses the recovery of cutaneous permeability barrier functions in vivo. J. Invest. Dermatol. 128, 1329-1331 (2008)
60. Lomholt, H., Andersen, K. E., Kilian, M.: Staphylococcus aureus clonal dynamics and virulence factors in children with atopic dermatitis. J. Invest. Dermatol. 125, 977-982 (2005)
61. Mao-Qiang, M., Feingold, K. R., Jain, M., Elias, P. M.: Extracellular processing of phospholipids is required for permeability barrier homeostasis. J. Lipid Res. 36, 1925-1935 (1995)
62. Mao-Qiang, M., Jain, M., Feingold, K. R., Elias, P. M.: Secretory phospholipase A2 activity is required for permeability barrier homeostasis. J. Invest. Dermatol. 106, 57-63 (1996)
63. Mauro, T., Bench, G., Sidderas-Haddad, E., et al.: Acute barrier perturbation abolishes the Ca2+ and K+ gradients in murine epidermis: quantitative measurement using PIXE. J. Invest. Dermatol. 111, 1198-1201 (1998)
64. Menon, G. K., Elias, P. M., Lee, S. H., Feingold, K. R.: Localization of calcium in murine epidermis following disruption and repair of the permeability barrier. Cell Tissue Res. 270, 503-512 (1992)
65. Menon, G. K., Ghadially, R., Williams, M. L., Elias, P. M.: Lamellar bodies as delivery systems of hydrolytic enzymes: implications for normal and abnormal desquamation. Br. J. Dermatol. 126, 337-345 (1992)
66. Miller, S. J., Aly, R., Shinefeld, H. R., Elias, P. M.: In vitro and in vivo antistaphylococcal activity of human stratum corneum lipids. Arch. Dermatol. 124, 209-215 (1988)
67. Nomura, I., Goleva, E., Howell, M. D., et al.: Cytokine milieu of atopic dermatitis, as compared to psoriasis, skin prevents induction of innate immune response genes. J. Immunol. 171, 3262-3269 (2003)
68. Nylander-Lundqvist, E., Back, O., Egelrud, T.: IL-1 beta activation in human epidermis. J. Immunol. 157, 1699-1704 (1996)
69. Ong, P. Y., Ohtake, T., Brandt, C., et al.: Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N. Engl. J. Med. 347, 1151-1160 (2002)
70. Oren, A., Ganz, T., Liu, L., Meerloo, T.: In human epidermis, beta-defensin 2 is packaged in lamellar bodies. Exp. Mol. Pathol. 74, 180-182 (2003)
71. Palmer, C. N., Irvine, A. D., Terron-Kwiatkowski, A., et al.: Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. Nat. Genet. 38, 441-446 (2006)
72. Potts, R. O., Francoeur, M. L.: Lipid biophysics of water loss through the skin. Proc. Natl. Acad. Sci. USA 87, 3871-3873 (1990)
73. Reed, J. T., Ghadially, R., Elias, P. M.: Skin type, but neither race nor gender, influence epidermal permeability barrier function. Arch. Dermatol. 131, 1134-1138 (1995)
74. Roop, D.: Defects in the barrier. Science 267, 474-475 (1995)
75. Sandilands, A., Smith, F. J., Irvine, A. D., McLean, W. H.: Filaggrin's fuller figure: a glimpse into the genetic architecture of atopic dermatitis. J. Invest. Dermatol. 127, 1282-1284 (2007)
76. Scott, I. R., Harding, C. R.: Filaggrin breakdown to water binding compounds during development of the rat stratum corneum is controlled by the water activity of the environment. Dev. Biol. 115, 84-92 (1986)
77. Seidenari, S., Giusti, G.: Objective assessment of the skin of children affected by atopic dermatitis: a study of pH, capacitance and TEWL in eczematous and clinically uninvolved skin. Acta Derm. Venereol. 75, 429-433 (1995)
78. Sonkoly, E., Muller, A., Lauerma, A. I., et al.: IL-31: a new link between T cells and pruritus in atopic skin inflammation. J. Allergy Clin. Immunol. 117, 411-417 (2006)
79. Steinert, P. M., Marekov, L. N.: The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small prolinerich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope. J. Biol. Chem. 270, 17702-17711 (1995)
80. Sugarman, J., Parish, L.: Efficacy of a lipid-based, barrier repair formulation in moderate-to-severe pediatric atopic dermatitis. J Drugs Dermatol. 8, 1106-1111 (2009)
81. Sugarman, J. L., Fluhr, J. W., Fowler, A. J., et al.: The objective severity assessment of atopic dermatitis score: an objective measure using permeability barrier function and stratum corneum hydration with computer-assisted estimates for extent of disease. Arch. Dermatol. 139, 1417-1422 (2003)
82. Walley, A. J., Chavanas, S., Moffatt, M. F., et al.: Gene polymorphism in Netherton and common atopic disease. Nat. Genet. 29, 175-178 (2001)
83. Warskulat, U., Reinen, A., Grether-Beck, S., Krutmann, J., Haussinger, D.: The osmolyte strategy of normal human keratinocytes in maintaining cell homeostasis. J. Invest. Dermatol. 123, 516-521 (2004)
84. Weidinger, S., Illig, T., Baurecht, H., et al.: Loss-of-function variations within the filaggrin gene predispose for atopic dermatitis with allergic sensitizations. J. Allergy Clin. Immunol. 118, 214-219 (2006)
85. Weidinger, S., Rodriguez, E., Stahl, C., et al.: Filaggrin mutations strongly predispose to early-onset and extrinsic atopic dermatitis. J. Invest. Dermatol. 127, 724-726 (2007)
86. Zaiou, M., Nizet, V., Gallo, R. L.: Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J. Invest. Dermatol. 120, 810-816 (2003)