A proteolytic cascade of kallikreins in the stratum corneum

Journal of Investigative Dermatology

Volumn 124, Issue 1, 2005, Pages 198-203

  Brattsand, Maria ^a   Stefansson, Kristina ^a   Lundh, Christine ^a   Haasum, Ylva ^a   Egelrud, Torbjörn ^a  

^a UMEÅ UNIVERSITY   (Sweden)

Author keywords

KLK; Protease; SCCE; SCTE; Substrate specificity

Indexed keywords

ENZYME PRECURSOR; KALLIKREIN; PROTEINASE; RECOMBINANT ENZYME; SERINE PROTEINASE; TRYPTASE;

ALKALINITY; ARTICLE; DESQUAMATION; ENZYME ACTIVE SITE; ENZYME REGULATION; ENZYME SPECIFICITY; ENZYME SUBSTRATE COMPLEX; HUMAN; HUMAN CELL; PH; PRIORITY JOURNAL; PROTEIN DEGRADATION; STRATUM CORNEUM;

EID: 11944270052     PISSN: 0022202X     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.0022-202X.2004.23547.x     Document Type: Article

References (25)

1. Brattsand M, Egelrud T: Purification, molecular cloning, and expression of a human stratum corneum trypsin-like serine protease with possible function in desquamation. J Biol Chem 274:30033-30040, 1999
2. Britton HTS, Welford GJ: J Chem Soc 1848-1852, 1937
3. Caubet C, Jonca N, Brattsand M, et al: Degradation of corneodesmosome proteins by two serine proteases of the kallikrein family, SCTE/KLK5/hK5 and SCCE/KLK7/hK7. J Invest Dermatol 122:1235-1244, 2004
4. Clements J, Hooper J, Dong Y, Harvey T: The expanded human kallikrein (KLK) gene family: Genomic organisation, tissue-specific expression and potential functions. J Biol Chem 382:5-14, 2001
5. Dong Y, Kaushal A, Brattsand M, Nicklin J, Clements J: Differential splicing of KLK5 and KLK7 in epithelial ovarian cancer produces novel variants with potential as cancer biomarkers. Clin Cancer Res 9:1710-1720, 2003
6. Egelrud T: Purification and preliminary characterization of stratum corneum chymotryptic enzyme: A proteinase that may be involved in desquamation. J Invest Dermatol 101:200-204, 1993
7. Egelrud T: Desquamation in the stratum corneum. Acta Derm Venereol Suppl 208:44-45, 2000
8. Egelrud T, Lundström A: A chymotrypsin-like proteinase that may be involved in desquamation in plantar stratum corneum. Arch Dermatol Res 283: 108-112, 1991
9. Ekholm E, Brattsand M, Egelrud T: Stratum corneum tryptic enzyme in normal epidermis: A missing link in the desquamation process? J Invest Dermatol 114:56-63, 2000
10. Hachem J-P, Crumrine D, Fluhr J, Brown BE, Feingold KR, Elias PM: pH directly regulates epidermal permeability barrier homeostasis, and stratum corneum integrity/cohesion. J Invest Dermatol 121:345-353, 2003
11. Hansson L, Bäckman A, Ny A, et al: Epidermal overexpression of stratum corneum chymotryptic enzyme in mice: A model for chronic itchy dermatitis. J Invest Dermatol 118:444-449, 2002
12. Hansson L, Strömqvist M, Bäckman A, Wallbrandt P, Carlstein A, Egelrud T: Cloning, expression, and characterization of stratum corneum chymotryptic enzyme. A skin-specific human serine proteinase. J Biol Chem 269:19420-19426, 1994
13. Hooper JD, Bui LT, Rae FK, Harvey TJ, Myers SA, Ashworth LK, Clements JA: Identification and characterization of KLK14, a novel kallikrein serine protease gene located on human chromosome 19q13.4 and expressed in prostate and skeletal muscle. Genomics 73:117-122, 2001
14. Horie H, Fukuyama K, Ito Y, Epstein WL: Detection and characterization of epidermal proteinases by polyacrylamide gel electrophoresis. Comp Biochem Physiol B 77:349-353, 1984
15. Horikoshi T, Arany I, Rajaraman S, et al: Isoforms of cathepsin D and human epidermal differentiation. Biochimie 80:605-612, 1998
16. Huang C, Wong GW, Ghildyal N, et al: The tryptase, mouse mast cell protease 7, exhibits anticoagulant activity in vivo and in vitro due to its ability to degrade fibrinogen in the presence of the diverse array of protease inhibitors in plasma. J Biol Chem 272:31885-31893, 1997
17. Komatsu N, Takata M, Otsuki N, Toyama T, Ohka R, Takehara K, Saijoh K: Expression and localization of tissue kallikrein mRNAs in human epidermis and appendages. J Invest Dermatol 121:542-549, 2003
18. Lundström A, Egelrud T: Stratum corneum chymotryptic enzyme: A proteinase which may be generally present in the stratum corneum and with a possible involvement in desquamation. Acta Derm Venereol 71:471-474, 1991
19. Salvesen G, Nagase H: Inhibition of proteolytic enzymes. In: Reynon RJ, Bond JS (eds). Proteolytic Enzymes, a Practical Approach, 3rd edn. Oxford, England: Oxford University Press, 1994; p 83-104
20. Sondell B, Dyberg P, Anneroth GK, Ostman PO, Egelrud T: Association between expression of stratum corneum chymotryptic enzyme and pathological keratinization in human oral mucosa. Acta Derm Venereol 76:177-181, 1996
21. Suzuki Y, Koyama J, Moro O, Horii I, Kikuchi K, Tanida M, Tagami H: The role of two endogenous proteases of the stratum corneum in degradation of desmoglein-1 and their reduced activity in the skin of ichthyotic patients. Br J Dermatol 134:460-464, 1996
22. Tanimoto H, Underwood LJ, Shigemasa K, Yan Y, Clarke J, Parmley TH, O'Brien TJ: The stratum corneum chymotryptic enzyme that mediates shedding and desquamation of skin cells is highly overexpressed in ovarian tumor cells. Cancer 86:2074-2082, 1999
23. Watkinson A: Stratum corneum thiol protease (SCTP): A novel cysteine protease of late epidermal differentiation. Arch Dermatol Res 291:260-268, 1999
24. Yousef GM, Diamandis EP: The new human tissue kallikrein gene family: Structure, function, and association to disease. Endocrine Rev 22:184-204, 2001
25. Öhman H, Vahlquist A: In vivo studies concerning a pH gradient in human stratum corneum and upper epidermis. Acta Derm Venereol 74:375-379, 1994