메뉴 건너뛰기




Volumn 4, Issue DEC, 2013, Pages

Clinical implications of co-inhibitory molecule expression in the tumor microenvironment for DC vaccination: A game of stop and go

Author keywords

Cancer treatment; Checkpoint blockade; DC vaccination; Tumor microenvironment; Tumor specific T cells

Indexed keywords


EID: 84892171528     PISSN: None     EISSN: 16643224     Source Type: Journal    
DOI: 10.3389/fimmu.2013.00417     Document Type: Review
Times cited : (68)

References (138)
  • 1
    • 79953151458 scopus 로고    scopus 로고
    • Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion
    • doi: 10.1126/science.1203486
    • Schreiber RD, Old LJ, Smyth MJ. Cancer immunoediting: integrating immunity's roles in cancer suppression and promotion. Science (2011) 331(6024):1565-70. doi: 10.1126/science.1203486.
    • (2011) Science , vol.331 , Issue.6024 , pp. 1565-1570
    • Schreiber, R.D.1    Old, L.J.2    Smyth, M.J.3
  • 2
    • 84878648470 scopus 로고    scopus 로고
    • The nature of activatory and tolerogenic dendritic cell-derived signal II
    • doi:10.3389/fimmu.2013.00053
    • Bakdash G, Sittig SP, van Dijk T, Figdor CG, de Vries IJ. The nature of activatory and tolerogenic dendritic cell-derived signal II. Front Immunol (2013) 4:53. doi:10.3389/fimmu.2013.00053.
    • (2013) Front Immunol , vol.4 , pp. 53
    • Bakdash, G.1    Sittig, S.P.2    van Dijk, T.3    Figdor, C.G.4    de Vries, I.J.5
  • 3
    • 84858780815 scopus 로고    scopus 로고
    • Cancer immunotherapy via dendritic cells
    • doi:10.1038/nrc3258
    • Palucka K, Banchereau J. Cancer immunotherapy via dendritic cells. Nat Rev Cancer (2012) 12(4):265-77. doi:10.1038/nrc3258.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 265-277
    • Palucka, K.1    Banchereau, J.2
  • 4
    • 84886944286 scopus 로고    scopus 로고
    • Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy
    • doi:10.4161/onci.24440
    • Schreibelt G, Bol KF, Aarntzen EH, Gerritsen WR, Punt CJ, Figdor CG, et al. Importance of helper T-cell activation in dendritic cell-based anticancer immunotherapy. Oncoimmunology (2013) 2(6):e24440. doi:10.4161/onci.24440.
    • (2013) Oncoimmunology , vol.2 , Issue.6
    • Schreibelt, G.1    Bol, K.F.2    Aarntzen, E.H.3    Gerritsen, W.R.4    Punt, C.J.5    Figdor, C.G.6
  • 5
    • 79961166712 scopus 로고    scopus 로고
    • Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity
    • doi:10.1007/s12026-011-8231-0
    • Lee SC, Srivastava RM, López-Albaitero A, Ferrone S, Ferris RL. Natural killer (NK): dendritic cell (DC) cross talk induced by therapeutic monoclonal antibody triggers tumor antigen-specific T cell immunity. Immunol Res (2011) 50(2-3):248-54. doi:10.1007/s12026-011-8231-0.
    • (2011) Immunol Res , vol.50 , Issue.2-3 , pp. 248-254
    • Lee, S.C.1    Srivastava, R.M.2    López-Albaitero, A.3    Ferrone, S.4    Ferris, R.L.5
  • 6
    • 61449146075 scopus 로고    scopus 로고
    • Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells
    • doi:10.4049/jimmunol.0802257
    • Douagi I, Gujer C, Sundling C, Adams WC, Smed-Sörensen A, Seder RA, et al. Human B cell responses to TLR ligands are differentially modulated by myeloid and plasmacytoid dendritic cells. J Immunol (2009) 182(4):1991-2001. doi:10.4049/jimmunol.0802257.
    • (2009) J Immunol , vol.182 , Issue.4 , pp. 1991-2001
    • Douagi, I.1    Gujer, C.2    Sundling, C.3    Adams, W.C.4    Smed-Sörensen, A.5    Seder, R.A.6
  • 7
    • 84859717471 scopus 로고    scopus 로고
    • Dendritic cells the tumor microenvironment and the challenges for an effective antitumor vaccination
    • doi:10.1155/2012/425476
    • Benencia F, Sprague L, McGinty J, Pate M, Muccioli M. Dendritic cells the tumor microenvironment and the challenges for an effective antitumor vaccination. Biomed Res Int (2012) 2012:425476. doi:10.1155/2012/425476.
    • (2012) Biomed Res Int , vol.2012 , pp. 425476
    • Benencia, F.1    Sprague, L.2    McGinty, J.3    Pate, M.4    Muccioli, M.5
  • 8
    • 67650650986 scopus 로고    scopus 로고
    • Dendritic cells in immunotherapy of established cancer: roles of signals 1, 2, 3 and 4
    • Kalinski P. Dendritic cells in immunotherapy of established cancer: roles of signals 1, 2, 3 and 4. Curr Opin Investig Drugs (2009) 10(6):526.
    • (2009) Curr Opin Investig Drugs , vol.10 , Issue.6 , pp. 526
    • Kalinski, P.1
  • 9
    • 0031764104 scopus 로고    scopus 로고
    • Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses
    • doi:10.1016/S0167-5699(98)01346-2
    • Sallusto F, Lanzavecchia A, Mackay CR. Chemokines and chemokine receptors in T-cell priming and Th1/Th2-mediated responses. Immunol Today (1998) 19(12):568-74. doi:10.1016/S0167-5699(98)01346-2.
    • (1998) Immunol Today , vol.19 , Issue.12 , pp. 568-574
    • Sallusto, F.1    Lanzavecchia, A.2    Mackay, C.R.3
  • 10
    • 84858124795 scopus 로고    scopus 로고
    • Targeting costimulatory molecules to improve antitumor immunity
    • doi:10.1155/2012/926321
    • Capece D, Verzella D, Fischietti M, Zazzeroni F, Alesse E. Targeting costimulatory molecules to improve antitumor immunity. J Biomed Biotechnol (2012) 2012:926321. doi:10.1155/2012/926321.
    • (2012) J Biomed Biotechnol , vol.2012 , pp. 926321
    • Capece, D.1    Verzella, D.2    Fischietti, M.3    Zazzeroni, F.4    Alesse, E.5
  • 11
    • 2442647551 scopus 로고    scopus 로고
    • Dendritic cell immunotherapy: mapping the way
    • doi:10.1038/nm1039
    • Figdor CG, de Vries IJ, Lesterhuis WJ, Melief CJ. Dendritic cell immunotherapy: mapping the way. Nat Med (2004) 10(5):475-80. doi:10.1038/nm1039.
    • (2004) Nat Med , vol.10 , Issue.5 , pp. 475-480
    • Figdor, C.G.1    de Vries, I.J.2    Lesterhuis, W.J.3    Melief, C.J.4
  • 12
    • 0031569109 scopus 로고    scopus 로고
    • Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules
    • Shen Z, Reznikoff G, Dranoff G, Rock KL. Cloned dendritic cells can present exogenous antigens on both MHC class I and class II molecules. J Immunol (1997) 158(6):2723-30.
    • (1997) J Immunol , vol.158 , Issue.6 , pp. 2723-2730
    • Shen, Z.1    Reznikoff, G.2    Dranoff, G.3    Rock, K.L.4
  • 13
    • 27844553451 scopus 로고    scopus 로고
    • Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node
    • doi:10.1016/j.smim.2005.09.001
    • Cahalan MD, Parker I, editors. Close encounters of the first and second kind: T-DC and T-B interactions in the lymph node. Semin Immunol (2005) 17(6):442-51. doi:10.1016/j.smim.2005.09.001.
    • (2005) Semin Immunol , vol.17 , Issue.6 , pp. 442-451
    • Cahalan, M.D.1    Parker, I.2
  • 14
    • 18544402305 scopus 로고    scopus 로고
    • Immature dendritic cells acquire Cd8+ cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or-dependent stimuli
    • doi:10.1084/jem.192.1.145
    • Schuurhuis DH, Laban S, Toes RE, Ricciardi-Castagnoli P, Kleijmeer MJ, van der Voort EI, et al. Immature dendritic cells acquire Cd8+ cytotoxic T lymphocyte priming capacity upon activation by T helper cell-independent or-dependent stimuli. J Exp Med (2000) 192(1):145-50. doi:10.1084/jem.192.1.145.
    • (2000) J Exp Med , vol.192 , Issue.1 , pp. 145-150
    • Schuurhuis, D.H.1    Laban, S.2    Toes, R.E.3    Ricciardi-Castagnoli, P.4    Kleijmeer, M.J.5    van der Voort, E.I.6
  • 15
    • 0026558809 scopus 로고
    • Dendritic cells are potent antigen-presenting cells for microbial superantigens
    • doi:10.1084/jem.175.1.267
    • Bhardwaj N, Friedman SM, Cole BC, Nisanian A. Dendritic cells are potent antigen-presenting cells for microbial superantigens. J Exp Med (1992) 175(1):267-73. doi:10.1084/jem.175.1.267.
    • (1992) J Exp Med , vol.175 , Issue.1 , pp. 267-273
    • Bhardwaj, N.1    Friedman, S.M.2    Cole, B.C.3    Nisanian, A.4
  • 16
    • 0028152942 scopus 로고
    • B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells
    • doi:10.1084/jem.180.5.1841
    • Caux C, Vanbervliet B, Massacrier C, Azuma M, Okumura K, Lanier LL, et al. B70/B7-2 is identical to CD86 and is the major functional ligand for CD28 expressed on human dendritic cells. J Exp Med (1994) 180(5):1841-7. doi:10.1084/jem.180.5.1841.
    • (1994) J Exp Med , vol.180 , Issue.5 , pp. 1841-1847
    • Caux, C.1    Vanbervliet, B.2    Massacrier, C.3    Azuma, M.4    Okumura, K.5    Lanier, L.L.6
  • 17
    • 0028500255 scopus 로고
    • Absence of B7-dependent responses in CD28-deficient mice
    • doi:10.1016/1074-7613(94)90092-2
    • Green JM, Noel PJ, Sperling AI, Walunas TL, Gray GS, Bluestone JA, et al. Absence of B7-dependent responses in CD28-deficient mice. Immunity (1994) 1(6):501-8. doi:10.1016/1074-7613(94)90092-2.
    • (1994) Immunity , vol.1 , Issue.6 , pp. 501-508
    • Green, J.M.1    Noel, P.J.2    Sperling, A.I.3    Walunas, T.L.4    Gray, G.S.5    Bluestone, J.A.6
  • 18
    • 77958611660 scopus 로고    scopus 로고
    • Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors
    • doi:10.1111/j.1600-065X.2010.00951.x
    • Zhu J, Paul WE. Peripheral CD4+ T-cell differentiation regulated by networks of cytokines and transcription factors. Immunol Rev (2010) 238(1):247-62. doi:10.1111/j.1600-065X.2010.00951.x.
    • (2010) Immunol Rev , vol.238 , Issue.1 , pp. 247-262
    • Zhu, J.1    Paul, W.E.2
  • 19
    • 50049106591 scopus 로고    scopus 로고
    • Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking
    • doi:10.1038/ni.f.208
    • Sigmundsdottir H, Butcher EC. Environmental cues, dendritic cells and the programming of tissue-selective lymphocyte trafficking. Nat Immunol (2008) 9(9):981-7. doi:10.1038/ni.f.208.
    • (2008) Nat Immunol , vol.9 , Issue.9 , pp. 981-987
    • Sigmundsdottir, H.1    Butcher, E.C.2
  • 20
    • 84866945151 scopus 로고    scopus 로고
    • Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients
    • doi:10.1158/1078-0432.CCR-11-3368
    • Aarntzen EH, Schreibelt G, Bol K, Lesterhuis WJ, Croockewit AJ, de Wilt JH, et al. Vaccination with mRNA-electroporated dendritic cells induces robust tumor antigen-specific CD4+ and CD8+ T cells responses in stage III and IV melanoma patients. Clin Cancer Res (2012) 18(19):5460-70. doi:10.1158/1078-0432.CCR-11-3368.
    • (2012) Clin Cancer Res , vol.18 , Issue.19 , pp. 5460-5470
    • Aarntzen, E.H.1    Schreibelt, G.2    Bol, K.3    Lesterhuis, W.J.4    Croockewit, A.J.5    de Wilt, J.H.6
  • 21
    • 84873460701 scopus 로고    scopus 로고
    • Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients
    • doi:10.1158/0008-5472.CAN-12-2583
    • Tel J, Aarntzen EH, Baba T, Schreibelt G, Schulte BM, Benitez-Ribas D, et al. Natural human plasmacytoid dendritic cells induce antigen-specific T-cell responses in melanoma patients. Cancer Res (2013) 73(3):1063-75. doi:10.1158/0008-5472.CAN-12-2583.
    • (2013) Cancer Res , vol.73 , Issue.3 , pp. 1063-1075
    • Tel, J.1    Aarntzen, E.H.2    Baba, T.3    Schreibelt, G.4    Schulte, B.M.5    Benitez-Ribas, D.6
  • 22
    • 84879228653 scopus 로고    scopus 로고
    • Targeting dendritic cells-why bother?
    • doi:10.1182/blood-2012-09-452078
    • Kreutz M, Tacken PJ, Figdor CG. Targeting dendritic cells-why bother? Blood (2013) 121(15):2836-44. doi:10.1182/blood-2012-09-452078.
    • (2013) Blood , vol.121 , Issue.15 , pp. 2836-2844
    • Kreutz, M.1    Tacken, P.J.2    Figdor, C.G.3
  • 23
    • 84871943629 scopus 로고    scopus 로고
    • Targeting CD4+ T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination
    • doi:10.1158/0008-5472.CAN-12-1127
    • Aarntzen EH, de Vries IJ, Lesterhuis WJ, Schuurhuis D, Jacobs JF, Bol K, et al. Targeting CD4+ T-helper cells improves the induction of antitumor responses in dendritic cell-based vaccination. Cancer Res (2013) 73(1):19-29. doi:10.1158/0008-5472.CAN-12-1127.
    • (2013) Cancer Res , vol.73 , Issue.1 , pp. 19-29
    • Aarntzen, E.H.1    de Vries, I.J.2    Lesterhuis, W.J.3    Schuurhuis, D.4    Jacobs, J.F.5    Bol, K.6
  • 24
    • 68549135290 scopus 로고    scopus 로고
    • Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer
    • doi:10.1002/cncr.24429
    • Higano CS, Schellhammer PF, Small EJ, Burch PA, Nemunaitis J, Yuh L, et al. Integrated data from 2 randomized, double-blind, placebo-controlled, phase 3 trials of active cellular immunotherapy with sipuleucel-T in advanced prostate cancer. Cancer (2009) 115(16):3670-9. doi:10.1002/cncr.24429.
    • (2009) Cancer , vol.115 , Issue.16 , pp. 3670-3679
    • Higano, C.S.1    Schellhammer, P.F.2    Small, E.J.3    Burch, P.A.4    Nemunaitis, J.5    Yuh, L.6
  • 25
    • 77951259112 scopus 로고    scopus 로고
    • Building on dendritic cell subsets to improve cancer vaccines
    • doi:10.1016/j.coi.2010.02.010
    • Palucka K, Ueno H, Zurawski G, Fay J, Banchereau J. Building on dendritic cell subsets to improve cancer vaccines. Curr Opin Immunol (2010) 22(2):258-63. doi:10.1016/j.coi.2010.02.010.
    • (2010) Curr Opin Immunol , vol.22 , Issue.2 , pp. 258-263
    • Palucka, K.1    Ueno, H.2    Zurawski, G.3    Fay, J.4    Banchereau, J.5
  • 26
    • 80052439234 scopus 로고    scopus 로고
    • Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients
    • doi:10.1158/1078-0432.CCR-11-1261
    • Lesterhuis WJ, de Vries IJ, Schreibelt G, Lambeck AJ, Aarntzen EH, Jacobs JF, et al. Route of administration modulates the induction of dendritic cell vaccine-induced antigen-specific T cells in advanced melanoma patients. Clin Cancer Res (2011) 17(17):5725-35. doi:10.1158/1078-0432.CCR-11-1261.
    • (2011) Clin Cancer Res , vol.17 , Issue.17 , pp. 5725-5735
    • Lesterhuis, W.J.1    de Vries, I.J.2    Schreibelt, G.3    Lambeck, A.J.4    Aarntzen, E.H.5    Jacobs, J.F.6
  • 27
    • 34248204110 scopus 로고    scopus 로고
    • DC-based cancer vaccines
    • doi:10.1172/JCI31205
    • Gilboa E. DC-based cancer vaccines. J Clin Invest (2007) 117(5):1195-203. doi:10.1172/JCI31205.
    • (2007) J Clin Invest , vol.117 , Issue.5 , pp. 1195-1203
    • Gilboa, E.1
  • 28
    • 84879045776 scopus 로고    scopus 로고
    • A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer
    • doi:10.1186/1479-5876-11-149
    • Kandalaft LE, Chiang CL, Tanyi J, Motz G, Balint K, Mick R, et al. A Phase I vaccine trial using dendritic cells pulsed with autologous oxidized lysate for recurrent ovarian cancer. J Transl Med (2013) 11(1):149. doi:10.1186/1479-5876-11-149.
    • (2013) J Transl Med , vol.11 , Issue.1 , pp. 149
    • Kandalaft, L.E.1    Chiang, C.L.2    Tanyi, J.3    Motz, G.4    Balint, K.5    Mick, R.6
  • 29
    • 84878002092 scopus 로고    scopus 로고
    • Trial watch: dendritic cell-based interventions for cancer therapy
    • doi:10.4161/onci.21494
    • Galluzzi L, Senovilla L, Vacchelli E, Eggermont A, Fridman WH, Galon J, et al. Trial watch: dendritic cell-based interventions for cancer therapy. Oncoimmunology (2012) 1(7):1111-34. doi:10.4161/onci.21494.
    • (2012) Oncoimmunology , vol.1 , Issue.7 , pp. 1111-1134
    • Galluzzi, L.1    Senovilla, L.2    Vacchelli, E.3    Eggermont, A.4    Fridman, W.H.5    Galon, J.6
  • 30
    • 1542433160 scopus 로고    scopus 로고
    • Letal, a tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells
    • Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, et al. Letal, a tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells. Cancer Biol Ther (2003) 2(4):446-51.
    • (2003) Cancer Biol Ther , vol.2 , Issue.4 , pp. 446-451
    • Conejo-Garcia, J.R.1    Benencia, F.2    Courreges, M.C.3    Khang, E.4    Zhang, L.5    Mohamed-Hadley, A.6
  • 31
    • 40349094954 scopus 로고    scopus 로고
    • Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression
    • doi:10.1186/bcr1746
    • DeNardo DG, Coussens LM. Inflammation and breast cancer. Balancing immune response: crosstalk between adaptive and innate immune cells during breast cancer progression. Breast Cancer Res (2007) 9(4):212. doi:10.1186/bcr1746.
    • (2007) Breast Cancer Res , vol.9 , Issue.4 , pp. 212
    • DeNardo, D.G.1    Coussens, L.M.2
  • 32
    • 36148960830 scopus 로고    scopus 로고
    • Inflammatory cell infiltration of tumors: Jekyll or Hyde
    • doi:10.1007/s10555-007-9072-0
    • Talmadge JE, Donkor M, Scholar E. Inflammatory cell infiltration of tumors: Jekyll or Hyde. Cancer Metastasis Rev (2007) 26(3-4):373-400. doi:10.1007/s10555-007-9072-0.
    • (2007) Cancer Metastasis Rev , vol.26 , Issue.3-4 , pp. 373-400
    • Talmadge, J.E.1    Donkor, M.2    Scholar, E.3
  • 33
    • 33845484234 scopus 로고    scopus 로고
    • Colon cancer and the immune system: the role of tumor invading T cells
    • Waldner M, Schimanski CC, Neurath MF. Colon cancer and the immune system: the role of tumor invading T cells. World J Gastroenterol (2006) 12(45):7233-8.
    • (2006) World J Gastroenterol , vol.12 , Issue.45 , pp. 7233-7238
    • Waldner, M.1    Schimanski, C.C.2    Neurath, M.F.3
  • 34
    • 61349100687 scopus 로고    scopus 로고
    • Myeloid-derived suppressor cells as regulators of the immune system
    • doi:10.1038/nri2506
    • Gabrilovich DI, Nagaraj S. Myeloid-derived suppressor cells as regulators of the immune system. Nat Rev Immunol (2009) 9(3):162-74. doi:10.1038/nri2506.
    • (2009) Nat Rev Immunol , vol.9 , Issue.3 , pp. 162-174
    • Gabrilovich, D.I.1    Nagaraj, S.2
  • 35
    • 84858785703 scopus 로고    scopus 로고
    • Coordinated regulation of myeloid cells by tumours
    • doi:10.1038/nri3175
    • Gabrilovich DI, Ostrand-Rosenberg S, Bronte V. Coordinated regulation of myeloid cells by tumours. Nat Rev Immunol (2012) 12(4):253-68. doi:10.1038/nri3175.
    • (2012) Nat Rev Immunol , vol.12 , Issue.4 , pp. 253-268
    • Gabrilovich, D.I.1    Ostrand-Rosenberg, S.2    Bronte, V.3
  • 36
    • 79952282574 scopus 로고    scopus 로고
    • Biology and clinical observations of regulatory T cells in cancer immunology
    • doi:10.1007/82_2010_50
    • Teng MW, Ritchie DS, Neeson P, Smyth MJ. Biology and clinical observations of regulatory T cells in cancer immunology. Curr Top Microbiol Immunol (2011) 344:61-95. doi:10.1007/82_2010_50.
    • (2011) Curr Top Microbiol Immunol , vol.344 , pp. 61-95
    • Teng, M.W.1    Ritchie, D.S.2    Neeson, P.3    Smyth, M.J.4
  • 37
    • 0026486220 scopus 로고
    • Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes
    • doi:10.1084/jem.176.6.1595
    • Linsley PS, Greene J, Tan P, Bradshaw J, Ledbetter JA, Anasetti C, et al. Coexpression and functional cooperation of CTLA-4 and CD28 on activated T lymphocytes. J Exp Med (1992) 176(6):1595-604. doi:10.1084/jem.176.6.1595.
    • (1992) J Exp Med , vol.176 , Issue.6 , pp. 1595-1604
    • Linsley, P.S.1    Greene, J.2    Tan, P.3    Bradshaw, J.4    Ledbetter, J.A.5    Anasetti, C.6
  • 38
    • 0034679567 scopus 로고    scopus 로고
    • Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+ CD4+ regulatory cells that control intestinal inflammation
    • doi:10.1084/jem.192.2.295
    • Read S, Malmström V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25+ CD4+ regulatory cells that control intestinal inflammation. J Exp Med (2000) 192(2):295-302. doi:10.1084/jem.192.2.295.
    • (2000) J Exp Med , vol.192 , Issue.2 , pp. 295-302
    • Read, S.1    Malmström, V.2    Powrie, F.3
  • 39
    • 65349156913 scopus 로고    scopus 로고
    • Costimulatory and coinhibitory receptors in anti-tumor immunity
    • doi:10.1111/j.1600-065X.2009.00771.x
    • Driessens G, Kline J, Gajewski TF. Costimulatory and coinhibitory receptors in anti-tumor immunity. Immunol Rev (2009) 229(1):126-44. doi:10.1111/j.1600-065X.2009.00771.x.
    • (2009) Immunol Rev , vol.229 , Issue.1 , pp. 126-144
    • Driessens, G.1    Kline, J.2    Gajewski, T.F.3
  • 40
    • 0025830902 scopus 로고
    • CTLA-4 is a second receptor for the B cell activation antigen B7
    • doi:10.1084/jem.174.3.561
    • Linsley PS, Brady W, Urnes M, Grosmaire LS, Damle NK, Ledbetter JA. CTLA-4 is a second receptor for the B cell activation antigen B7. J Exp Med (1991) 174(3):561-9. doi:10.1084/jem.174.3.561.
    • (1991) J Exp Med , vol.174 , Issue.3 , pp. 561-569
    • Linsley, P.S.1    Brady, W.2    Urnes, M.3    Grosmaire, L.S.4    Damle, N.K.5    Ledbetter, J.A.6
  • 41
    • 0029899783 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells
    • doi:10.1084/jem.183.6.2533
    • Krummel MF, Allison JP. CTLA-4 engagement inhibits IL-2 accumulation and cell cycle progression upon activation of resting T cells. J Exp Med (1996) 183(6):2533-40. doi:10.1084/jem.183.6.2533.
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2533-2540
    • Krummel, M.F.1    Allison, J.P.2
  • 42
    • 0029953858 scopus 로고    scopus 로고
    • CTLA-4 ligation blocks CD28-dependent T cell activation
    • doi:10.1084/jem.183.6.2541
    • Walunas TL, Bakker C, Bluestone JA. CTLA-4 ligation blocks CD28-dependent T cell activation. J Exp Med (1996) 183(6):2541-50. doi:10.1084/jem.183.6.2541.
    • (1996) J Exp Med , vol.183 , Issue.6 , pp. 2541-2550
    • Walunas, T.L.1    Bakker, C.2    Bluestone, J.A.3
  • 43
    • 0030443168 scopus 로고    scopus 로고
    • Regulation of surface and intracellular expression of CTLA4 on mouse T cells
    • Alegre M-L, Noel PJ, Eisfelder BJ, Chuang E, Clark MR, Reiner SL, et al. Regulation of surface and intracellular expression of CTLA4 on mouse T cells. J Immunol (1996) 157(11):4762-70.
    • (1996) J Immunol , vol.157 , Issue.11 , pp. 4762-4770
    • Alegre, M.-L.1    Noel, P.J.2    Eisfelder, B.J.3    Chuang, E.4    Clark, M.R.5    Reiner, S.L.6
  • 44
    • 0141925700 scopus 로고    scopus 로고
    • CTLA-4 engagement inhibits Th2 but not Th1 cell polarisation
    • doi:10.1080/10446670310001598519
    • Ubaldi V, Gatta L, Pace L, Doria G, Pioli C. CTLA-4 engagement inhibits Th2 but not Th1 cell polarisation. Clin Dev Immunol (2003) 10(1):13-7. doi:10.1080/10446670310001598519.
    • (2003) Clin Dev Immunol , vol.10 , Issue.1 , pp. 13-17
    • Ubaldi, V.1    Gatta, L.2    Pace, L.3    Doria, G.4    Pioli, C.5
  • 46
    • 0037320926 scopus 로고    scopus 로고
    • CTLA-4 regulates the requirement for cytokine-induced signals in TH2 lineage commitment
    • doi:10.1038/ni884
    • Bour-Jordan H, Grogan JL, Tang Q, Auger JA, Locksley RM, Bluestone JA. CTLA-4 regulates the requirement for cytokine-induced signals in TH2 lineage commitment. Nat Immunol (2003) 4(2):182-8. doi:10.1038/ni884.
    • (2003) Nat Immunol , vol.4 , Issue.2 , pp. 182-188
    • Bour-Jordan, H.1    Grogan, J.L.2    Tang, Q.3    Auger, J.A.4    Locksley, R.M.5    Bluestone, J.A.6
  • 47
    • 0030005099 scopus 로고    scopus 로고
    • Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes
    • doi:10.1093/intimm/8.5.765
    • Agata Y, Kawasaki A, Nishimura H, Ishida Y, Tsubat T, Yagita H, et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int Immunol (1996) 8(5):765-72. doi:10.1093/intimm/8.5.765.
    • (1996) Int Immunol , vol.8 , Issue.5 , pp. 765-772
    • Agata, Y.1    Kawasaki, A.2    Nishimura, H.3    Ishida, Y.4    Tsubat, T.5    Yagita, H.6
  • 48
    • 73949088551 scopus 로고    scopus 로고
    • PD-L1 regulates the development, maintenance, and function of induced regulatory T cells
    • doi:10.1084/jem.20090847
    • Francisco LM, Salinas VH, Brown KE, Vanguri VK, Freeman GJ, Kuchroo VK, et al. PD-L1 regulates the development, maintenance, and function of induced regulatory T cells. J Exp Med (2009) 206(13):3015-29. doi:10.1084/jem.20090847.
    • (2009) J Exp Med , vol.206 , Issue.13 , pp. 3015-3029
    • Francisco, L.M.1    Salinas, V.H.2    Brown, K.E.3    Vanguri, V.K.4    Freeman, G.J.5    Kuchroo, V.K.6
  • 49
    • 0033180181 scopus 로고    scopus 로고
    • Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor
    • doi:10.1016/S1074-7613(00)80089-8
    • Nishimura H, Nose M, Hiai H, Minato N, Honjo T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity (1999) 11(2):141-51. doi:10.1016/S1074-7613(00)80089-8.
    • (1999) Immunity , vol.11 , Issue.2 , pp. 141-151
    • Nishimura, H.1    Nose, M.2    Hiai, H.3    Minato, N.4    Honjo, T.5
  • 50
    • 0034596948 scopus 로고    scopus 로고
    • Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation
    • doi:10.1084/jem.192.7.1027
    • Freeman GJ, Long AJ, Iwai Y, Bourque K, Chernova T, Nishimura H, et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J Exp Med (2000) 192(7):1027-34. doi:10.1084/jem.192.7.1027.
    • (2000) J Exp Med , vol.192 , Issue.7 , pp. 1027-1034
    • Freeman, G.J.1    Long, A.J.2    Iwai, Y.3    Bourque, K.4    Chernova, T.5    Nishimura, H.6
  • 51
    • 42649125225 scopus 로고    scopus 로고
    • PD-1 and its ligands in tolerance and immunity
    • doi:10.1146/annurev.immunol.26.021607.090331
    • Keir ME, Butte MJ, Freeman GJ, Sharpe AH. PD-1 and its ligands in tolerance and immunity. Annu Rev Immunol (2008) 26:677-704. doi:10.1146/annurev.immunol.26.021607.090331.
    • (2008) Annu Rev Immunol , vol.26 , pp. 677-704
    • Keir, M.E.1    Butte, M.J.2    Freeman, G.J.3    Sharpe, A.H.4
  • 52
    • 18544380239 scopus 로고    scopus 로고
    • Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion
    • doi:10.1038/nm0902-1039c
    • Dong H, Strome SE, Salomao DR, Tamura H, Hirano F, Flies DB, et al. Tumor-associated B7-H1 promotes T-cell apoptosis: a potential mechanism of immune evasion. Nat Med (2002) 8(8):793-800. doi:10.1038/nm0902-1039c.
    • (2002) Nat Med , vol.8 , Issue.8 , pp. 793-800
    • Dong, H.1    Strome, S.E.2    Salomao, D.R.3    Tamura, H.4    Hirano, F.5    Flies, D.B.6
  • 53
    • 0032736029 scopus 로고    scopus 로고
    • B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion
    • doi:10.1038/70932
    • Dong H, Zhu G, Tamada K, Chen L. B7-H1, a third member of the B7 family, co-stimulates T-cell proliferation and interleukin-10 secretion. Nat Med (1999) 5(12):1365-9. doi:10.1038/70932.
    • (1999) Nat Med , vol.5 , Issue.12 , pp. 1365-1369
    • Dong, H.1    Zhu, G.2    Tamada, K.3    Chen, L.4
  • 54
    • 5844264920 scopus 로고    scopus 로고
    • PD-L2 is a second ligand for PD-1 and inhibits T cell activation
    • doi:10.1038/85330
    • Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat Immunol (2001) 2(3):261-8. doi:10.1038/85330.
    • (2001) Nat Immunol , vol.2 , Issue.3 , pp. 261-268
    • Latchman, Y.1    Wood, C.R.2    Chernova, T.3    Chaudhary, D.4    Borde, M.5    Chernova, I.6
  • 55
    • 17644425689 scopus 로고    scopus 로고
    • The B7 family revisited
    • doi:10.1146/annurev.immunol.23.021704.115611
    • Greenwald RJ, Freeman GJ, Sharpe AH. The B7 family revisited. Annu Rev Immunol (2005) 23:515-48. doi:10.1146/annurev.immunol.23.021704.115611.
    • (2005) Annu Rev Immunol , vol.23 , pp. 515-548
    • Greenwald, R.J.1    Freeman, G.J.2    Sharpe, A.H.3
  • 56
    • 0038273853 scopus 로고    scopus 로고
    • Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity
    • doi:10.1038/nm863
    • Curiel TJ, Wei S, Dong H, Alvarez X, Cheng P, Mottram P, et al. Blockade of B7-H1 improves myeloid dendritic cell-mediated antitumor immunity. Nat Med (2003) 9(5):562-7. doi:10.1038/nm863.
    • (2003) Nat Med , vol.9 , Issue.5 , pp. 562-567
    • Curiel, T.J.1    Wei, S.2    Dong, H.3    Alvarez, X.4    Cheng, P.5    Mottram, P.6
  • 57
    • 0037126021 scopus 로고    scopus 로고
    • Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade
    • doi:10.1073/pnas.192461099
    • Iwai Y, Ishida M, Tanaka Y, Okazaki T, Honjo T, Minato N. Involvement of PD-L1 on tumor cells in the escape from host immune system and tumor immunotherapy by PD-L1 blockade. Proc Natl Acad Sci U S A (2002) 99(19):12293-7. doi:10.1073/pnas.192461099.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , Issue.19 , pp. 12293-12297
    • Iwai, Y.1    Ishida, M.2    Tanaka, Y.3    Okazaki, T.4    Honjo, T.5    Minato, N.6
  • 58
    • 84886945121 scopus 로고    scopus 로고
    • B7-H1 limits the entry of effector CD8(+) T cells to the memory pool by upregulating Bim
    • doi:10.4161/onci.20850
    • Gibbons RM, Liu X, Pulko V, Harrington SM, Krco CJ, Kwon ED, et al. B7-H1 limits the entry of effector CD8(+) T cells to the memory pool by upregulating Bim. Oncoimmunology (2012) 1(7):1061-73. doi:10.4161/onci.20850.
    • (2012) Oncoimmunology , vol.1 , Issue.7 , pp. 1061-1073
    • Gibbons, R.M.1    Liu, X.2    Pulko, V.3    Harrington, S.M.4    Krco, C.J.5    Kwon, E.D.6
  • 59
    • 34447646310 scopus 로고    scopus 로고
    • Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses
    • doi:10.1016/j.immuni.2007.05.016
    • Butte MJ, Keir ME, Phamduy TB, Sharpe AH, Freeman GJ. Programmed death-1 ligand 1 interacts specifically with the B7-1 costimulatory molecule to inhibit T cell responses. Immunity (2007) 27(1):111-22. doi:10.1016/j.immuni.2007.05.016.
    • (2007) Immunity , vol.27 , Issue.1 , pp. 111-122
    • Butte, M.J.1    Keir, M.E.2    Phamduy, T.B.3    Sharpe, A.H.4    Freeman, G.J.5
  • 60
    • 84861064002 scopus 로고    scopus 로고
    • Programmed death ligand 2 in cancer-induced immune suppression
    • doi:10.1155/2012/656340
    • Rozali EN, Hato SV, Robinson BW, Lake RA, Lesterhuis WJ. Programmed death ligand 2 in cancer-induced immune suppression. Clin Dev Immunol (2012) 2012:656340. doi:10.1155/2012/656340.
    • (2012) Clin Dev Immunol , vol.2012 , pp. 656340
    • Rozali, E.N.1    Hato, S.V.2    Robinson, B.W.3    Lake, R.A.4    Lesterhuis, W.J.5
  • 61
    • 34848831575 scopus 로고    scopus 로고
    • The B7 family and cancer therapy: costimulation and coinhibition
    • doi:10.1158/1078-0432.CCR-07-1030
    • Zang X, Allison JP. The B7 family and cancer therapy: costimulation and coinhibition. Clin Cancer Res (2007) 13(18):5271-9. doi:10.1158/1078-0432.CCR-07-1030.
    • (2007) Clin Cancer Res , vol.13 , Issue.18 , pp. 5271-5279
    • Zang, X.1    Allison, J.P.2
  • 62
    • 84867404126 scopus 로고    scopus 로고
    • A review of B7-H3 and B7-H4 immune molecules and their role in ovarian cancer
    • doi:10.1016/j.ygyno.2012.08.017
    • Fauci JM, Straughn JM, Ferrone S, Buchsbaum DJ. A review of B7-H3 and B7-H4 immune molecules and their role in ovarian cancer. Gynecol Oncol (2012) 127(2):420-5. doi:10.1016/j.ygyno.2012.08.017.
    • (2012) Gynecol Oncol , vol.127 , Issue.2 , pp. 420-425
    • Fauci, J.M.1    Straughn, J.M.2    Ferrone, S.3    Buchsbaum, D.J.4
  • 63
    • 5844252552 scopus 로고    scopus 로고
    • B7-H3: a costimulatory molecule for T cell activation and IFN-γ production
    • doi:10.1038/85339
    • Chapoval AI, Ni J, Lau JS, Wilcox RA, Flies DB, Liu D, et al. B7-H3: a costimulatory molecule for T cell activation and IFN-γ production. Nat Immunol (2001) 2(3):269-74. doi:10.1038/85339.
    • (2001) Nat Immunol , vol.2 , Issue.3 , pp. 269-274
    • Chapoval, A.I.1    Ni, J.2    Lau, J.S.3    Wilcox, R.A.4    Flies, D.B.5    Liu, D.6
  • 64
    • 0038094524 scopus 로고    scopus 로고
    • B7-H4, a molecule of the B7 family, negatively regulates T cell immunity
    • doi:10.1016/S1074-7613(03)00152-3
    • Sica GL, Choi I-H, Zhu G, Tamada K, Wang S-D, Tamura H, et al. B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. Immunity (2003) 18(6):849-61. doi:10.1016/S1074-7613(03)00152-3.
    • (2003) Immunity , vol.18 , Issue.6 , pp. 849-861
    • Sica, G.L.1    Choi, I.-H.2    Zhu, G.3    Tamada, K.4    Wang, S.-D.5    Tamura, H.6
  • 65
    • 77958067744 scopus 로고    scopus 로고
    • Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer
    • doi:10.1007/s00262-010-0900-7
    • Jiang J, Zhu Y, Wu C, Shen Y, Wei W, Chen L, et al. Tumor expression of B7-H4 predicts poor survival of patients suffering from gastric cancer. Cancer Immunol Immunother (2010) 59(11):1707-14. doi:10.1007/s00262-010-0900-7.
    • (2010) Cancer Immunol Immunother , vol.59 , Issue.11 , pp. 1707-1714
    • Jiang, J.1    Zhu, Y.2    Wu, C.3    Shen, Y.4    Wei, W.5    Chen, L.6
  • 66
    • 33745886516 scopus 로고    scopus 로고
    • B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival
    • doi:10.1073/pnas.0600937103
    • Krambeck AE, Thompson RH, Dong H, Lohse CM, Park ES, Kuntz SM, et al. B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. Proc Natl Acad Sci U S A (2006) 103(27):10391-6. doi:10.1073/pnas.0600937103.
    • (2006) Proc Natl Acad Sci U S A , vol.103 , Issue.27 , pp. 10391-10396
    • Krambeck, A.E.1    Thompson, R.H.2    Dong, H.3    Lohse, C.M.4    Park, E.S.5    Kuntz, S.M.6
  • 67
    • 65349130644 scopus 로고    scopus 로고
    • Fine tuning the immune response through B7-H3 and B7-H4
    • doi:10.1111/j.1600-065X.2009.00768.x
    • Yi KH, Chen L. Fine tuning the immune response through B7-H3 and B7-H4. Immunol Rev (2009) 229(1):145-51. doi:10.1111/j.1600-065X.2009.00768.x.
    • (2009) Immunol Rev , vol.229 , Issue.1 , pp. 145-151
    • Yi, K.H.1    Chen, L.2
  • 68
    • 80053597274 scopus 로고    scopus 로고
    • TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14)
    • doi:10.1016/j.coi.2011.08.008
    • Ware CF, Šedỳ JR. TNF Superfamily Networks: bidirectional and interference pathways of the herpesvirus entry mediator (TNFSF14). Curr Opin Immunol (2011) 23(5):627-31. doi:10.1016/j.coi.2011.08.008.
    • (2011) Curr Opin Immunol , vol.23 , Issue.5 , pp. 627-631
    • Ware, C.F.1    Šedỳ, J.R.2
  • 69
    • 80054846953 scopus 로고    scopus 로고
    • Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT
    • doi:10.1016/j.jmb.2011.09.018
    • Kojima R, Kajikawa M, Shiroishi M, Kuroki K, Maenaka K. Molecular basis for herpesvirus entry mediator recognition by the human immune inhibitory receptor CD160 and its relationship to the cosignaling molecules BTLA and LIGHT. J Mol Biol (2011) 413(4):762-72. doi:10.1016/j.jmb.2011.09.018.
    • (2011) J Mol Biol , vol.413 , Issue.4 , pp. 762-772
    • Kojima, R.1    Kajikawa, M.2    Shiroishi, M.3    Kuroki, K.4    Maenaka, K.5
  • 70
    • 19544383401 scopus 로고    scopus 로고
    • The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA
    • doi:10.1016/j.it.2005.03.010
    • Croft M. The evolving crosstalk between co-stimulatory and co-inhibitory receptors: HVEM-BTLA. Trends Immunol (2005) 26(6):292-4. doi:10.1016/j.it.2005.03.010.
    • (2005) Trends Immunol , vol.26 , Issue.6 , pp. 292-294
    • Croft, M.1
  • 71
    • 1842335724 scopus 로고    scopus 로고
    • A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing
    • doi:10.1084/jem.185.10.1743
    • Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, et al. A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing. J Exp Med (1997) 185(10):1743-51. doi:10.1084/jem.185.10.1743.
    • (1997) J Exp Med , vol.185 , Issue.10 , pp. 1743-1751
    • Cella, M.1    Döhring, C.2    Samaridis, J.3    Dessing, M.4    Brockhaus, M.5    Lanzavecchia, A.6
  • 72
    • 0032036434 scopus 로고    scopus 로고
    • Cutting edge: human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules
    • Colonna M, Samaridis J, Cella M, Angman L, Allen RL, O'Callaghan CA, et al. Cutting edge: human myelomonocytic cells express an inhibitory receptor for classical and nonclassical MHC class I molecules. J Immunol (1998) 160(7):3096-100.
    • (1998) J Immunol , vol.160 , Issue.7 , pp. 3096-3100
    • Colonna, M.1    Samaridis, J.2    Cella, M.3    Angman, L.4    Allen, R.L.5    O'Callaghan, C.A.6
  • 73
    • 48249118843 scopus 로고    scopus 로고
    • Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice
    • doi:10.2337/db08-0054
    • Vlad G, D'Agati VD, Zhang Q-Y, Liu Z, Ho EK, Mohanakumar T, et al. Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice. Diabetes (2008) 57(7):1878-86. doi:10.2337/db08-0054.
    • (2008) Diabetes , vol.57 , Issue.7 , pp. 1878-1886
    • Vlad, G.1    D'Agati, V.D.2    Zhang, Q.-Y.3    Liu, Z.4    Ho, E.K.5    Mohanakumar, T.6
  • 74
    • 84879285066 scopus 로고    scopus 로고
    • Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation
    • doi:10.1002/cyto.b.21050
    • Dobrowolska H, Gill KZ, Serban G, Ivan E, Li Q, Qiao P, et al. Expression of immune inhibitory receptor ILT3 in acute myeloid leukemia with monocytic differentiation. Cytometry B Clin Cytom (2013) 84(1):21-9. doi:10.1002/cyto.b.21050.
    • (2013) Cytometry B Clin Cytom , vol.84 , Issue.1 , pp. 21-29
    • Dobrowolska, H.1    Gill, K.Z.2    Serban, G.3    Ivan, E.4    Li, Q.5    Qiao, P.6
  • 75
    • 34249788694 scopus 로고    scopus 로고
    • Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients
    • Suciu-Foca N, Feirt N, Zhang Q-Y, Vlad G, Liu Z, Lin H, et al. Soluble Ig-like transcript 3 inhibits tumor allograft rejection in humanized SCID mice and T cell responses in cancer patients. J Immunol (2007) 178(11):7432-41.
    • (2007) J Immunol , vol.178 , Issue.11 , pp. 7432-7441
    • Suciu-Foca, N.1    Feirt, N.2    Zhang, Q.-Y.3    Vlad, G.4    Liu, Z.5    Lin, H.6
  • 76
    • 84877329134 scopus 로고    scopus 로고
    • Human dendritic cells subsets as targets and vectors for therapy
    • doi:10.1111/nyas.12113
    • Klechevsky E, Banchereau J. Human dendritic cells subsets as targets and vectors for therapy. Ann N Y Acad Sci (2013) 1284(1):24-30. doi:10.1111/nyas.12113.
    • (2013) Ann N Y Acad Sci , vol.1284 , Issue.1 , pp. 24-30
    • Klechevsky, E.1    Banchereau, J.2
  • 77
    • 84859157752 scopus 로고    scopus 로고
    • Tim-3, a negative regulator of anti-tumor immunity
    • doi:10.1016/j.coi.2011.12.005
    • Anderson AC. Tim-3, a negative regulator of anti-tumor immunity. Curr Opin Immunol (2012) 24(2):213-6. doi:10.1016/j.coi.2011.12.005.
    • (2012) Curr Opin Immunol , vol.24 , Issue.2 , pp. 213-216
    • Anderson, A.C.1
  • 78
    • 2142815854 scopus 로고    scopus 로고
    • Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo
    • Workman CJ, Cauley LS, Kim I-J, Blackman MA, Woodland DL, Vignali DA. Lymphocyte activation gene-3 (CD223) regulates the size of the expanding T cell population following antigen activation in vivo. J Immunol (2004) 172(9):5450-5.
    • (2004) J Immunol , vol.172 , Issue.9 , pp. 5450-5455
    • Workman, C.J.1    Cauley, L.S.2    Kim, I.-J.3    Blackman, M.A.4    Woodland, D.L.5    Vignali, D.A.6
  • 79
    • 5644263642 scopus 로고    scopus 로고
    • Role of LAG-3 in regulatory T cells
    • doi:10.1016/j.immuni.2004.08.010
    • Huang C-T, Workman CJ, Flies D, Pan X, Marson AL, Zhou G, et al. Role of LAG-3 in regulatory T cells. Immunity (2004) 21(4):503-13. doi:10.1016/j.immuni.2004.08.010.
    • (2004) Immunity , vol.21 , Issue.4 , pp. 503-513
    • Huang, C.-T.1    Workman, C.J.2    Flies, D.3    Pan, X.4    Marson, A.L.5    Zhou, G.6
  • 80
    • 61449190726 scopus 로고    scopus 로고
    • LAG-3 regulates plasmacytoid dendritic cell homeostasis
    • doi:10.4049/jimmunol.0800185
    • Workman CJ, Wang Y, El Kasmi KC, Pardoll DM, Murray PJ, Drake CG, et al. LAG-3 regulates plasmacytoid dendritic cell homeostasis. J Immunol (2009) 182(4):1885-91. doi:10.4049/jimmunol.0800185.
    • (2009) J Immunol , vol.182 , Issue.4 , pp. 1885-1891
    • Workman, C.J.1    Wang, Y.2    El Kasmi, K.C.3    Pardoll, D.M.4    Murray, P.J.5    Drake, C.G.6
  • 81
    • 77952343328 scopus 로고    scopus 로고
    • Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer
    • doi:10.1073/pnas.1003345107
    • Matsuzaki J, Gnjatic S, Mhawech-Fauceglia P, Beck A, Miller A, Tsuji T, et al. Tumor-infiltrating NY-ESO-1-specific CD8+ T cells are negatively regulated by LAG-3 and PD-1 in human ovarian cancer. Proc Natl Acad Sci U S A (2010) 107(17):7875-80. doi:10.1073/pnas.1003345107.
    • (2010) Proc Natl Acad Sci U S A , vol.107 , Issue.17 , pp. 7875-7880
    • Matsuzaki, J.1    Gnjatic, S.2    Mhawech-Fauceglia, P.3    Beck, A.4    Miller, A.5    Tsuji, T.6
  • 82
    • 33748416499 scopus 로고    scopus 로고
    • Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412
    • doi:10.1056/NEJMoa063842
    • Suntharalingam G, Perry MR, Ward S, Brett SJ, Castello-Cortes A, Brunner MD, et al. Cytokine storm in a phase 1 trial of the anti-CD28 monoclonal antibody TGN1412. N Engl J Med (2006) 355(10):1018-28. doi:10.1056/NEJMoa063842.
    • (2006) N Engl J Med , vol.355 , Issue.10 , pp. 1018-1028
    • Suntharalingam, G.1    Perry, M.R.2    Ward, S.3    Brett, S.J.4    Castello-Cortes, A.5    Brunner, M.D.6
  • 83
    • 84856867834 scopus 로고    scopus 로고
    • Immunotherapy earns its spot in the ranks of cancer therapy
    • doi:10.1084/jem.20112275
    • Pardoll Drew DC. Immunotherapy earns its spot in the ranks of cancer therapy. J Exp Med (2012) 209(2):201-9. doi:10.1084/jem.20112275.
    • (2012) J Exp Med , vol.209 , Issue.2 , pp. 201-209
    • Pardoll Drew, D.C.1
  • 84
    • 78449237499 scopus 로고    scopus 로고
    • Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies
    • doi:10.1053/j.seminoncol.2010.09.008
    • Ascierto PA, Simeone E, Sznol M, Fu Y-X, Melero I, editors. Clinical experiences with anti-CD137 and anti-PD1 therapeutic antibodies. Semin Oncol (2010) 37(5):508-16. doi:10.1053/j.seminoncol.2010.09.008.
    • (2010) Semin Oncol , vol.37 , Issue.5 , pp. 508-516
    • Ascierto, P.A.1    Simeone, E.2    Sznol, M.3    Fu, Y.-X.4    Melero, I.5
  • 85
    • 84884485877 scopus 로고    scopus 로고
    • Brentuximab vedotin (SGN-35) in patients with transplant-naive relapsed/refractory Hodgkin lymphoma
    • doi:10.3109/10428194.2013.775434
    • Sasse S, Rothe A, Goergen H, Eichenauer DA, Lohri A, Kreher S, et al. Brentuximab vedotin (SGN-35) in patients with transplant-naive relapsed/refractory Hodgkin lymphoma. Leuk Lymphoma (2013) 54(10):2144-8. doi:10.3109/10428194.2013.775434.
    • (2013) Leuk Lymphoma , vol.54 , Issue.10 , pp. 2144-2148
    • Sasse, S.1    Rothe, A.2    Goergen, H.3    Eichenauer, D.A.4    Lohri, A.5    Kreher, S.6
  • 86
    • 84877059530 scopus 로고    scopus 로고
    • The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy
    • doi:10.1016/j.coi.2013.01.004
    • Moran AE, Kovacsovics-Bankowski M, Weinberg AD. The TNFRs OX40, 4-1BB, and CD40 as targets for cancer immunotherapy. Curr Opin Immunol (2013) 25(2):230-7. doi:10.1016/j.coi.2013.01.004.
    • (2013) Curr Opin Immunol , vol.25 , Issue.2 , pp. 230-237
    • Moran, A.E.1    Kovacsovics-Bankowski, M.2    Weinberg, A.D.3
  • 87
    • 84875691131 scopus 로고    scopus 로고
    • A phase 1, randomized ascending single-dose study of antagonist anti-human CD40 ASKP1240 in healthy subjects
    • doi:10.1111/ajt.12082
    • Goldwater R, Keirns J, Blahunka P, First R, Sawamoto T, Zhang W, et al. A phase 1, randomized ascending single-dose study of antagonist anti-human CD40 ASKP1240 in healthy subjects. Am J Transplant (2013) 13(4):1040-6. doi:10.1111/ajt.12082.
    • (2013) Am J Transplant , vol.13 , Issue.4 , pp. 1040-1046
    • Goldwater, R.1    Keirns, J.2    Blahunka, P.3    First, R.4    Sawamoto, T.5    Zhang, W.6
  • 88
    • 0028867420 scopus 로고
    • Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4
    • doi:10.1016/1074-7613(95)90125-6
    • Tivol EA, Borriello F, Schweitzer AN, Lynch WP, Bluestone JA, Sharpe AH. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity (1995) 3(5):541-7. doi:10.1016/1074-7613(95)90125-6.
    • (1995) Immunity , vol.3 , Issue.5 , pp. 541-547
    • Tivol, E.A.1    Borriello, F.2    Schweitzer, A.N.3    Lynch, W.P.4    Bluestone, J.A.5    Sharpe, A.H.6
  • 89
    • 0028791059 scopus 로고
    • Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4
    • doi:10.1126/science.270.5238.985
    • Waterhouse P, Penninger JM, Timms E, Wakeham A, Shahinian A, Lee KP, et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science (1995) 270(5238):985-8. doi:10.1126/science.270.5238.985.
    • (1995) Science , vol.270 , Issue.5238 , pp. 985-988
    • Waterhouse, P.1    Penninger, J.M.2    Timms, E.3    Wakeham, A.4    Shahinian, A.5    Lee, K.P.6
  • 90
    • 0029947568 scopus 로고    scopus 로고
    • Enhancement of antitumor immunity by CTLA-4 blockade
    • doi:10.1126/science.271.5256.1734
    • Leach DR, Krummel MF, Allison JP. Enhancement of antitumor immunity by CTLA-4 blockade. Science (1996) 271(5256):1734-6. doi:10.1126/science.271.5256.1734.
    • (1996) Science , vol.271 , Issue.5256 , pp. 1734-1736
    • Leach, D.R.1    Krummel, M.F.2    Allison, J.P.3
  • 91
    • 77954801079 scopus 로고    scopus 로고
    • Improved survival with ipilimumab in patients with metastatic melanoma
    • doi:10.1056/NEJMoa1003466
    • Hodi FS, O'Day SJ, McDermott DF, Weber RW, Sosman JA, Haanen JB, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med (2010) 363(8):711-23. doi:10.1056/NEJMoa1003466.
    • (2010) N Engl J Med , vol.363 , Issue.8 , pp. 711-723
    • Hodi, F.S.1    O'Day, S.J.2    McDermott, D.F.3    Weber, R.W.4    Sosman, J.A.5    Haanen, J.B.6
  • 92
    • 79959772576 scopus 로고    scopus 로고
    • Ipilimumab plus dacarbazine for previously untreated metastatic melanoma
    • doi:10.1056/NEJMoa1104621
    • Robert C, Thomas L, Bondarenko I, O'Day S, Weber J, Garbe C, et al. Ipilimumab plus dacarbazine for previously untreated metastatic melanoma. N Engl J Med (2011) 364(26):2517-26. doi:10.1056/NEJMoa1104621.
    • (2011) N Engl J Med , vol.364 , Issue.26 , pp. 2517-2526
    • Robert, C.1    Thomas, L.2    Bondarenko, I.3    O'Day, S.4    Weber, J.5    Garbe, C.6
  • 93
    • 84874605864 scopus 로고    scopus 로고
    • Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma
    • doi:10.1200/JCO.2012.44.6112
    • Ribas A, Kefford R, Marshall MA, Punt CJ, Haanen JB, Marmol M, et al. Phase III randomized clinical trial comparing tremelimumab with standard-of-care chemotherapy in patients with advanced melanoma. J Clin Oncol (2013) 31(5):616-22. doi:10.1200/JCO.2012.44.6112.
    • (2013) J Clin Oncol , vol.31 , Issue.5 , pp. 616-622
    • Ribas, A.1    Kefford, R.2    Marshall, M.A.3    Punt, C.J.4    Haanen, J.B.5    Marmol, M.6
  • 94
    • 0038153907 scopus 로고    scopus 로고
    • Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
    • doi:10.1073/pnas.1533209100
    • Phan GQ, Yang JC, Sherry RM, Hwu P, Topalian SL, Schwartzentruber DJ, et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci U S A (2003) 100(14):8372-7. doi:10.1073/pnas.1533209100.
    • (2003) Proc Natl Acad Sci U S A , vol.100 , Issue.14 , pp. 8372-8377
    • Phan, G.Q.1    Yang, J.C.2    Sherry, R.M.3    Hwu, P.4    Topalian, S.L.5    Schwartzentruber, D.J.6
  • 95
    • 32644467549 scopus 로고    scopus 로고
    • Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206
    • doi:10.1200/JCO.2005.01.109
    • Ribas A, Camacho LH, Lopez-Berestein G, Pavlov D, Bulanhagui CA, Millham R, et al. Antitumor activity in melanoma and anti-self responses in a phase I trial with the anti-cytotoxic T lymphocyte-associated antigen 4 monoclonal antibody CP-675,206. J Clin Oncol (2005) 23(35):8968-77. doi:10.1200/JCO.2005.01.109.
    • (2005) J Clin Oncol , vol.23 , Issue.35 , pp. 8968-8977
    • Ribas, A.1    Camacho, L.H.2    Lopez-Berestein, G.3    Pavlov, D.4    Bulanhagui, C.A.5    Millham, R.6
  • 96
    • 84858766182 scopus 로고    scopus 로고
    • The blockade of immune checkpoints in cancer immunotherapy
    • doi:10.1038/nrc3239
    • Pardoll DM. The blockade of immune checkpoints in cancer immunotherapy. Nat Rev Cancer (2012) 12(4):252-64. doi:10.1038/nrc3239.
    • (2012) Nat Rev Cancer , vol.12 , Issue.4 , pp. 252-264
    • Pardoll, D.M.1
  • 97
    • 84862769116 scopus 로고    scopus 로고
    • An immune-active tumor microenvironment favors clinical response to ipilimumab
    • doi:10.1007/s00262-011-1172-6
    • Ji RR, Chasalow SD, Wang L, Hamid O, Schmidt H, Cogswell J, et al. An immune-active tumor microenvironment favors clinical response to ipilimumab. Cancer Immunol Immunother (2012) 61(7):1019-31. doi:10.1007/s00262-011-1172-6.
    • (2012) Cancer Immunol Immunother , vol.61 , Issue.7 , pp. 1019-1031
    • Ji, R.R.1    Chasalow, S.D.2    Wang, L.3    Hamid, O.4    Schmidt, H.5    Cogswell, J.6
  • 98
    • 84873129546 scopus 로고    scopus 로고
    • CTLA-4 blockade in tumor models: an overview of preclinical and translational research
    • Grosso JF, Jure-Kunkel MN. CTLA-4 blockade in tumor models: an overview of preclinical and translational research. Cancer Immun (2013) 13:5.
    • (2013) Cancer Immun , vol.13 , pp. 5
    • Grosso, J.F.1    Jure-Kunkel, M.N.2
  • 99
    • 77954899030 scopus 로고    scopus 로고
    • Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates
    • doi:10.1200/JCO.2009.26.7609
    • Brahmer JR, Drake CG, Wollner I, Powderly JD, Picus J, Sharfman WH, et al. Phase I study of single-agent anti-programmed death-1 (MDX-1106) in refractory solid tumors: safety, clinical activity, pharmacodynamics, and immunologic correlates. J Clin Oncol (2010) 28(19):3167-75. doi:10.1200/JCO.2009.26.7609.
    • (2010) J Clin Oncol , vol.28 , Issue.19 , pp. 3167-3175
    • Brahmer, J.R.1    Drake, C.G.2    Wollner, I.3    Powderly, J.D.4    Picus, J.5    Sharfman, W.H.6
  • 100
    • 84872514622 scopus 로고    scopus 로고
    • Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody
    • doi:10.1158/1078-0432.CCR-12-2625
    • Lipson EJ, Sharfman WH, Drake CG, Wollner I, Taube JM, Anders RA, et al. Durable cancer regression off-treatment and effective reinduction therapy with an anti-PD-1 antibody. Clin Cancer Res (2013) 19(2):462-8. doi:10.1158/1078-0432.CCR-12-2625.
    • (2013) Clin Cancer Res , vol.19 , Issue.2 , pp. 462-468
    • Lipson, E.J.1    Sharfman, W.H.2    Drake, C.G.3    Wollner, I.4    Taube, J.M.5    Anders, R.A.6
  • 103
    • 84862859820 scopus 로고    scopus 로고
    • Safety, activity, and immune correlates of anti-PD-1 antibody in cancer
    • doi:10.1056/NEJMoa1200690
    • Topalian SL, Hodi FS, Brahmer JR, Gettinger SN, Smith DC, McDermott DF, et al. Safety, activity, and immune correlates of anti-PD-1 antibody in cancer. N Engl J Med (2012) 366(26):2443-54. doi:10.1056/NEJMoa1200690.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2443-2454
    • Topalian, S.L.1    Hodi, F.S.2    Brahmer, J.R.3    Gettinger, S.N.4    Smith, D.C.5    McDermott, D.F.6
  • 104
    • 84879759020 scopus 로고    scopus 로고
    • Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma
    • doi:10.1056/NEJMoa1305133
    • Hamid O, Robert C, Daud A, Hodi FS, Hwu WJ, Kefford R, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med (2013) 369:134-44. doi:10.1056/NEJMoa1305133.
    • (2013) N Engl J Med , vol.369 , pp. 134-144
    • Hamid, O.1    Robert, C.2    Daud, A.3    Hodi, F.S.4    Hwu, W.J.5    Kefford, R.6
  • 105
    • 49649114804 scopus 로고    scopus 로고
    • Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies
    • doi:10.1158/1078-0432.CCR-07-4079
    • Berger R, Rotem-Yehudar R, Slama G, Landes S, Kneller A, Leiba M, et al. Phase I safety and pharmacokinetic study of CT-011, a humanized antibody interacting with PD-1, in patients with advanced hematologic malignancies. Clin Cancer Res (2008) 14(10):3044-51. doi:10.1158/1078-0432.CCR-07-4079.
    • (2008) Clin Cancer Res , vol.14 , Issue.10 , pp. 3044-3051
    • Berger, R.1    Rotem-Yehudar, R.2    Slama, G.3    Landes, S.4    Kneller, A.5    Leiba, M.6
  • 106
    • 84862903106 scopus 로고    scopus 로고
    • Safety and activity of anti-PD-L1 antibody in patients with advanced cancer
    • doi:10.1056/NEJMoa1200694
    • Brahmer JR, Tykodi SS, Chow LQ, Hwu WJ, Topalian SL, Hwu P, et al. Safety and activity of anti-PD-L1 antibody in patients with advanced cancer. N Engl J Med (2012) 366(26):2455-65. doi:10.1056/NEJMoa1200694.
    • (2012) N Engl J Med , vol.366 , Issue.26 , pp. 2455-2465
    • Brahmer, J.R.1    Tykodi, S.S.2    Chow, L.Q.3    Hwu, W.J.4    Topalian, S.L.5    Hwu, P.6
  • 107
    • 79251582822 scopus 로고    scopus 로고
    • B7-h3 and its role in antitumor immunity
    • doi:10.1155/2010/683875
    • Loos M, Hedderich DM, Friess H, Kleeff J. B7-h3 and its role in antitumor immunity. Clin Dev Immunol (2010) 2010:683875. doi:10.1155/2010/683875.
    • (2010) Clin Dev Immunol , vol.2010 , pp. 683875
    • Loos, M.1    Hedderich, D.M.2    Friess, H.3    Kleeff, J.4
  • 108
    • 33745605153 scopus 로고    scopus 로고
    • B7-H3 and B7-H4 expression in non-small-cell lung cancer
    • doi:10.1016/j.lungcan.2006.05.012
    • Sun Y, Wang Y, Zhao J, Gu M, Giscombe R, Lefvert AK, et al. B7-H3 and B7-H4 expression in non-small-cell lung cancer. Lung Cancer (2006) 53(2):143-51. doi:10.1016/j.lungcan.2006.05.012.
    • (2006) Lung Cancer , vol.53 , Issue.2 , pp. 143-151
    • Sun, Y.1    Wang, Y.2    Zhao, J.3    Gu, M.4    Giscombe, R.5    Lefvert, A.K.6
  • 109
    • 52649160243 scopus 로고    scopus 로고
    • Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma
    • doi:10.1158/1078-0432.CCR-08-0536
    • Crispen PL, Sheinin Y, Roth TJ, Lohse CM, Kuntz SM, Frigola X, et al. Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma. Clin Cancer Res (2008) 14(16):5150-7. doi:10.1158/1078-0432.CCR-08-0536.
    • (2008) Clin Cancer Res , vol.14 , Issue.16 , pp. 5150-5157
    • Crispen, P.L.1    Sheinin, Y.2    Roth, T.J.3    Lohse, C.M.4    Kuntz, S.M.5    Frigola, X.6
  • 110
    • 74549182599 scopus 로고    scopus 로고
    • Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer
    • doi:10.1186/1471-2407-9-463
    • Loos M, Hedderich DM, Ottenhausen M, Giese NA, Laschinger M, Esposito I, et al. Expression of the costimulatory molecule B7-H3 is associated with prolonged survival in human pancreatic cancer. BMC Cancer (2009) 9(1):463. doi:10.1186/1471-2407-9-463.
    • (2009) BMC Cancer , vol.9 , Issue.1 , pp. 463
    • Loos, M.1    Hedderich, D.M.2    Ottenhausen, M.3    Giese, N.A.4    Laschinger, M.5    Esposito, I.6
  • 111
  • 112
    • 84863928141 scopus 로고    scopus 로고
    • Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity
    • doi:10.1158/1078-0432.CCR-12-0715
    • Loo D, Alderson RF, Chen FZ, Huang L, Zhang W, Gorlatov S, et al. Development of an Fc-enhanced anti-B7-H3 monoclonal antibody with potent antitumor activity. Clin Cancer Res (2012) 18(14):3834-45. doi:10.1158/1078-0432.CCR-12-0715.
    • (2012) Clin Cancer Res , vol.18 , Issue.14 , pp. 3834-3845
    • Loo, D.1    Alderson, R.F.2    Chen, F.Z.3    Huang, L.4    Zhang, W.5    Gorlatov, S.6
  • 113
    • 84879123283 scopus 로고    scopus 로고
    • Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model
    • doi:10.4049/jimmunol.1201242
    • Leung J, Suh WK. Host B7-H4 regulates antitumor T cell responses through inhibition of myeloid-derived suppressor cells in a 4T1 tumor transplantation model. J Immunol (2013) 190(12):6651-61. doi:10.4049/jimmunol.1201242.
    • (2013) J Immunol , vol.190 , Issue.12 , pp. 6651-6661
    • Leung, J.1    Suh, W.K.2
  • 114
    • 84881423899 scopus 로고    scopus 로고
    • Novel recombinant human B7-H4 antibodies overcome tumoral immune escape to potentiate T cell anti-tumor responses
    • doi:10.1158/0008-5472.CAN-12-3457
    • Dangaj D, Lanitis E, Zhao A, Joshi S, Cheng Y, Sandaltzopoulos R, et al. Novel recombinant human B7-H4 antibodies overcome tumoral immune escape to potentiate T cell anti-tumor responses. Cancer Res (2013) 73(15):4820-9. doi:10.1158/0008-5472.CAN-12-3457.
    • (2013) Cancer Res , vol.73 , Issue.15 , pp. 4820-4829
    • Dangaj, D.1    Lanitis, E.2    Zhao, A.3    Joshi, S.4    Cheng, Y.5    Sandaltzopoulos, R.6
  • 115
    • 36749067188 scopus 로고    scopus 로고
    • Pancreas cancer and the role of soluble immunoglobulin-like transcript 3 (ILT3)
    • Cortesini R. Pancreas cancer and the role of soluble immunoglobulin-like transcript 3 (ILT3). JOP (2007) 8:697-703.
    • (2007) JOP , vol.8 , pp. 697-703
    • Cortesini, R.1
  • 116
    • 79956103042 scopus 로고    scopus 로고
    • Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors
    • doi:10.1158/0008-5472.CAN-11-0096
    • Ngiow SF, von Scheidt B, Akiba H, Yagita H, Teng MW, Smyth MJ. Anti-TIM3 antibody promotes T cell IFN-γ-mediated antitumor immunity and suppresses established tumors. Cancer Res (2011) 71(10):3540-51. doi:10.1158/0008-5472.CAN-11-0096.
    • (2011) Cancer Res , vol.71 , Issue.10 , pp. 3540-3551
    • Ngiow, S.F.1    von Scheidt, B.2    Akiba, H.3    Yagita, H.4    Teng, M.W.5    Smyth, M.J.6
  • 117
    • 84877817118 scopus 로고    scopus 로고
    • Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas
    • doi:10.1007/s00262-012-1371-9
    • Baghdadi M, Nagao H, Yoshiyama H, Akiba H, Yagita H, Dosaka-Akita H, et al. Combined blockade of TIM-3 and TIM-4 augments cancer vaccine efficacy against established melanomas. Cancer Immunol Immunother (2013) 62(4):629-37. doi:10.1007/s00262-012-1371-9.
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.4 , pp. 629-637
    • Baghdadi, M.1    Nagao, H.2    Yoshiyama, H.3    Akiba, H.4    Yagita, H.5    Dosaka-Akita, H.6
  • 119
    • 84863393290 scopus 로고    scopus 로고
    • CD8+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1
    • doi:10.1158/0008-5472.CAN-11-2637
    • Fourcade J, Sun Z, Pagliano O, Guillaume P, Luescher IF, Sander C, et al. CD8+ T cells specific for tumor antigens can be rendered dysfunctional by the tumor microenvironment through upregulation of the inhibitory receptors BTLA and PD-1. Cancer Res (2012) 72(4):887-96. doi:10.1158/0008-5472.CAN-11-2637.
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 887-896
    • Fourcade, J.1    Sun, Z.2    Pagliano, O.3    Guillaume, P.4    Luescher, I.F.5    Sander, C.6
  • 120
    • 84863115998 scopus 로고    scopus 로고
    • Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape
    • doi:10.1158/0008-5472.CAN-11-1620
    • Woo S-R, Turnis ME, Goldberg MV, Bankoti J, Selby M, Nirschl CJ, et al. Immune inhibitory molecules LAG-3 and PD-1 synergistically regulate T-cell function to promote tumoral immune escape. Cancer Res (2012) 72(4):917-27. doi:10.1158/0008-5472.CAN-11-1620.
    • (2012) Cancer Res , vol.72 , Issue.4 , pp. 917-927
    • Woo, S.-R.1    Turnis, M.E.2    Goldberg, M.V.3    Bankoti, J.4    Selby, M.5    Nirschl, C.J.6
  • 121
    • 0033613173 scopus 로고    scopus 로고
    • In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance
    • doi:10.1073/pnas.96.20.11476
    • Sotomayor EM, Borrello I, Tubb E, Allison JP, Levitsky HI. In vivo blockade of CTLA-4 enhances the priming of responsive T cells but fails to prevent the induction of tumor antigen-specific tolerance. Proc Natl Acad Sci U S A (1999) 96(20):11476-81. doi:10.1073/pnas.96.20.11476.
    • (1999) Proc Natl Acad Sci U S A , vol.96 , Issue.20 , pp. 11476-11481
    • Sotomayor, E.M.1    Borrello, I.2    Tubb, E.3    Allison, J.P.4    Levitsky, H.I.5
  • 122
    • 29844436043 scopus 로고    scopus 로고
    • The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling
    • doi:10.1016/j.canlet.2005.02.005
    • Met O, Wang M, Pedersen AE, Nissen MH, Buus S, Claesson MH. The effect of a therapeutic dendritic cell-based cancer vaccination depends on the blockage of CTLA-4 signaling. Cancer Lett (2006) 231(2):247-56. doi:10.1016/j.canlet.2005.02.005.
    • (2006) Cancer Lett , vol.231 , Issue.2 , pp. 247-256
    • Met, O.1    Wang, M.2    Pedersen, A.E.3    Nissen, M.H.4    Buus, S.5    Claesson, M.H.6
  • 123
    • 0032544067 scopus 로고    scopus 로고
    • CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma
    • doi:10.1073/pnas.95.17.10067
    • Hurwitz AA, Yu TF, Leach DR, Allison JP. CTLA-4 blockade synergizes with tumor-derived granulocyte-macrophage colony-stimulating factor for treatment of an experimental mammary carcinoma. Proc Natl Acad Sci U S A (1998) 95(17):10067-71. doi:10.1073/pnas.95.17.10067.
    • (1998) Proc Natl Acad Sci U S A , vol.95 , Issue.17 , pp. 10067-10071
    • Hurwitz, A.A.1    Yu, T.F.2    Leach, D.R.3    Allison, J.P.4
  • 124
    • 0033517152 scopus 로고    scopus 로고
    • Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (Ctla-4) and granulocyte/macrophage colony-stimulating factor (Gm-Csf)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation
    • van Elsas A, Hurwitz AA, Allison JP. Combination immunotherapy of B16 melanoma using anti-cytotoxic T lymphocyte-associated antigen 4 (Ctla-4) and granulocyte/macrophage colony-stimulating factor (Gm-Csf)-producing vaccines induces rejection of subcutaneous and metastatic tumors accompanied by autoimmune depigmentation. J Exp Med (1999) 190(3):355-66.
    • (1999) J Exp Med , vol.190 , Issue.3 , pp. 355-366
    • van Elsas, A.1    Hurwitz, A.A.2    Allison, J.P.3
  • 125
    • 70349328115 scopus 로고    scopus 로고
    • TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination
    • doi:10.4049/jimmunol.0900974
    • Pulko V, Liu X, Krco CJ, Harris KJ, Frigola X, Kwon ED, et al. TLR3-stimulated dendritic cells up-regulate B7-H1 expression and influence the magnitude of CD8 T cell responses to tumor vaccination. J Immunol (2009) 183(6):3634-41. doi:10.4049/jimmunol.0900974.
    • (2009) J Immunol , vol.183 , Issue.6 , pp. 3634-3641
    • Pulko, V.1    Liu, X.2    Krco, C.J.3    Harris, K.J.4    Frigola, X.5    Kwon, E.D.6
  • 126
    • 77951637543 scopus 로고    scopus 로고
    • Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma
    • doi:10.4049/jimmunol.0904114
    • Pilon-Thomas S, Mackay A, Vohra N, Mulé JJ. Blockade of programmed death ligand 1 enhances the therapeutic efficacy of combination immunotherapy against melanoma. J Immunol (2010) 184(7):3442-9. doi:10.4049/jimmunol.0904114.
    • (2010) J Immunol , vol.184 , Issue.7 , pp. 3442-3449
    • Pilon-Thomas, S.1    Mackay, A.2    Vohra, N.3    Mulé, J.J.4
  • 127
    • 84879783148 scopus 로고    scopus 로고
    • Blockade of PD-1/PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast cancer in hu-SCID mice
    • doi:10.1016/j.canlet.2013.03.010
    • Ge Y, Xi H, Ju S, Zhang X. Blockade of PD-1/PD-L1 immune checkpoint during DC vaccination induces potent protective immunity against breast cancer in hu-SCID mice. Cancer Lett (2013) 336(2):253-9. doi:10.1016/j.canlet.2013.03.010.
    • (2013) Cancer Lett , vol.336 , Issue.2 , pp. 253-259
    • Ge, Y.1    Xi, H.2    Ju, S.3    Zhang, X.4
  • 128
    • 84860436621 scopus 로고    scopus 로고
    • Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial
    • doi:10.1016/S1470-2045(12)70007-4
    • van den Eertwegh AJ, Versluis J, van den Berg HP, Santegoets SJ, van Moorselaar RJ, van der Sluis TM, et al. Combined immunotherapy with granulocyte-macrophage colony-stimulating factor-transduced allogeneic prostate cancer cells and ipilimumab in patients with metastatic castration-resistant prostate cancer: a phase 1 dose-escalation trial. Lancet Oncol (2012) 13(5):509-17. doi:10.1016/S1470-2045(12)70007-4.
    • (2012) Lancet Oncol , vol.13 , Issue.5 , pp. 509-517
    • van den Eertwegh, A.J.1    Versluis, J.2    van den Berg, H.P.3    Santegoets, S.J.4    van Moorselaar, R.J.5    van der Sluis, T.M.6
  • 129
    • 84875785905 scopus 로고    scopus 로고
    • Hepatotoxicity with combination of vemurafenib and ipilimumab
    • doi:10.1056/NEJMc1302338
    • Ribas A, Hodi FS, Callahan M, Konto C, Wolchok J. Hepatotoxicity with combination of vemurafenib and ipilimumab. N Engl J Med (2013) 368(14):1365-6. doi:10.1056/NEJMc1302338.
    • (2013) N Engl J Med , vol.368 , Issue.14 , pp. 1365-1366
    • Ribas, A.1    Hodi, F.S.2    Callahan, M.3    Konto, C.4    Wolchok, J.5
  • 130
    • 84859393995 scopus 로고    scopus 로고
    • CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma
    • doi:10.1158/1078-0432.CCR-11-1823
    • Prieto PA, Yang JC, Sherry RM, Hughes MS, Kammula US, White DE, et al. CTLA-4 blockade with ipilimumab: long-term follow-up of 177 patients with metastatic melanoma. Clin Cancer Res (2012) 18(7):2039-47. doi:10.1158/1078-0432.CCR-11-1823.
    • (2012) Clin Cancer Res , vol.18 , Issue.7 , pp. 2039-2047
    • Prieto, P.A.1    Yang, J.C.2    Sherry, R.M.3    Hughes, M.S.4    Kammula, U.S.5    White, D.E.6
  • 131
    • 34748918373 scopus 로고    scopus 로고
    • Lessons from randomized phase III studies with active cancer immunotherapies-outcomes from the 2006 meeting of the Cancer Vaccine Consortium (CVC)
    • doi:10.1016/j.vaccine.2007.06.067
    • Finke LH, Wentworth K, Blumenstein B, Rudolph NS, Levitsky H, Hoos A. Lessons from randomized phase III studies with active cancer immunotherapies-outcomes from the 2006 meeting of the Cancer Vaccine Consortium (CVC). Vaccine (2007) 25:B97-109. doi:10.1016/j.vaccine.2007.06.067.
    • (2007) Vaccine , vol.25
    • Finke, L.H.1    Wentworth, K.2    Blumenstein, B.3    Rudolph, N.S.4    Levitsky, H.5    Hoos, A.6
  • 132
    • 70349680756 scopus 로고    scopus 로고
    • Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma
    • doi:10.1158/1078-0432.CCR-09-1254
    • Ribas A, Comin-Anduix B, Chmielowski B, Jalil J, de la Rocha P, McCannel TA, et al. Dendritic cell vaccination combined with CTLA4 blockade in patients with metastatic melanoma. Clin Cancer Res (2009) 15(19):6267-76. doi:10.1158/1078-0432.CCR-09-1254.
    • (2009) Clin Cancer Res , vol.15 , Issue.19 , pp. 6267-6276
    • Ribas, A.1    Comin-Anduix, B.2    Chmielowski, B.3    Jalil, J.4    de la Rocha, P.5    McCannel, T.A.6
  • 133
    • 4344714990 scopus 로고    scopus 로고
    • Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy
    • doi:10.1097/00002371-200409000-00004
    • Ribas A, Glaspy JA, Lee Y, Dissette VB, Seja E, Vu HT, et al. Role of dendritic cell phenotype, determinant spreading, and negative costimulatory blockade in dendritic cell-based melanoma immunotherapy. J Immunother (2004) 27(5):354-67. doi:10.1097/00002371-200409000-00004.
    • (2004) J Immunother , vol.27 , Issue.5 , pp. 354-367
    • Ribas, A.1    Glaspy, J.A.2    Lee, Y.3    Dissette, V.B.4    Seja, E.5    Vu, H.T.6
  • 134
    • 84886943680 scopus 로고    scopus 로고
    • Endogenous tumor-reactive CD8(+) T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth
    • doi:10.4161/onci.23972
    • Liu X, Gibbons RM, Harrington SM, Krco CJ, Markovic SN, Kwon ED, et al. Endogenous tumor-reactive CD8(+) T cells are differentiated effector cells expressing high levels of CD11a and PD-1 but are unable to control tumor growth. Oncoimmunology (2013) 2(6):e23972. doi:10.4161/onci.23972.
    • (2013) Oncoimmunology , vol.2 , Issue.6
    • Liu, X.1    Gibbons, R.M.2    Harrington, S.M.3    Krco, C.J.4    Markovic, S.N.5    Kwon, E.D.6
  • 135
    • 68849086119 scopus 로고    scopus 로고
    • Anticancer immunochemotherapy using adjuvants with direct cytotoxic effects
    • doi:10.1172/JCI39991
    • Zitvogel L, Kroemer G. Anticancer immunochemotherapy using adjuvants with direct cytotoxic effects. J Clin Invest (2009) 119(8):2127-30. doi:10.1172/JCI39991.
    • (2009) J Clin Invest , vol.119 , Issue.8 , pp. 2127-2130
    • Zitvogel, L.1    Kroemer, G.2
  • 136
    • 79961016549 scopus 로고    scopus 로고
    • Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice
    • doi:10.1172/JCI43656
    • Lesterhuis WJ, Punt CJ, Hato SV, Eleveld-Trancikova D, Jansen BJ, Nierkens S, et al. Platinum-based drugs disrupt STAT6-mediated suppression of immune responses against cancer in humans and mice. J Clin Invest (2011) 121(8):3100. doi:10.1172/JCI43656.
    • (2011) J Clin Invest , vol.121 , Issue.8 , pp. 3100
    • Lesterhuis, W.J.1    Punt, C.J.2    Hato, S.V.3    Eleveld-Trancikova, D.4    Jansen, B.J.5    Nierkens, S.6
  • 137
    • 84861085067 scopus 로고    scopus 로고
    • STATing the importance of immune modulation by platinum chemotherapeutics
    • doi:10.4161/onci.1.2.18126
    • Hato SV, de Vries IJ, Lesterhuis WJ. STATing the importance of immune modulation by platinum chemotherapeutics. Oncoimmunology (2012) 1(2):234-6. doi:10.4161/onci.1.2.18126.
    • (2012) Oncoimmunology , vol.1 , Issue.2 , pp. 234-236
    • Hato, S.V.1    de Vries, I.J.2    Lesterhuis, W.J.3
  • 138
    • 84877138564 scopus 로고    scopus 로고
    • Novel mechanism of synergistic effects of conventional chemotherapy and immune therapy of cancer
    • doi:10.1007/s00262-012-1390-6
    • Ramakrishnan R, Gabrilovich DI. Novel mechanism of synergistic effects of conventional chemotherapy and immune therapy of cancer. Cancer Immunol Immunother (2013) 62(3):405-10. doi:10.1007/s00262-012-1390-6.
    • (2013) Cancer Immunol Immunother , vol.62 , Issue.3 , pp. 405-410
    • Ramakrishnan, R.1    Gabrilovich, D.I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.