The critical role of Th1-dominant immunity in tumor immunology

Cancer Chemotherapy and Pharmacology

Volumn 46, Issue SUPPL., 2000, Pages

  Nishimura, Takashi ^a   Nakui, Minoru ^b   Sato, Marimo ^a   Iwakabe, Kenji ^b   Kitamura, Hidemitsu ^b   Sekimoto, Masashi ^a   Ohta, Akio ^a   Koda, Toshiaki ^a   Nishimura, Shinichiro ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Dendritic cell; Interleukin 12; Natural killer T cell; Th1; Tumor immunotherapy; Galactosylceramide

Indexed keywords

GALACTOSYLCERAMIDE; GAMMA INTERFERON; INTERLEUKIN 12; INTERLEUKIN 4;

ANIMAL CELL; ANTIGEN SPECIFICITY; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER IMMUNOLOGY; CANCER IMMUNOTHERAPY; CELLULAR IMMUNITY; CONTROLLED STUDY; DENDRITIC CELL; FEMALE; GENE THERAPY; IMMUNOLOGICAL MEMORY; IMMUNOMODULATION; MOUSE; NATURAL KILLER CELL; NONHUMAN; PRIORITY JOURNAL; TH1 CELL; TH2 CELL;

EID: 0033759463     PISSN: 03445704     EISSN: None     Source Type: Journal    
DOI: 10.1007/pl00014051     Document Type: Article

References (27)

1. Immunization and curative potential of replicating and nonreplicating murine mammary adenocarcinoma cells engineered with IL-2, IL-4, IL-6, IL-7, IL-10, TNF-α, GM-CSF and IFN-γ gene or admixed with conventonal adjuvants
2. Dendritic cells and the control of immunity
3. Immunotherapy of cancer with dendritic-cell-based vaccines
4. T-cell subsets in anti-tumor responses
5. Expression of the tumor-rejection antigen SART1 in brain tumors
6. Human tumor antigens recognized by T-cells
7. The natural killer T (NKT) cell ligand α-galactosylceramide demonstrates its immunopotentiating effect by inducing IL-12 production by dendritic cells and IL-12 receptor expression on NKT cells
8. Superantigen-induced human helper/killer cell phemenon: Selective induction of Th1 type of helper/killer T cells and application to tumor immunotherapy
9. - subclasses of dendritic cells direct the development of distinct T helper cells in vivo
10. The expanding universe of T-cell subsets: Th1, Th2 and more
11. Natural killer T cell ligand α-galactosylceramide inhibited lymph node metastasis of highly metastatic melanoma cells
12. Distinct role of antigen-specific T helper type 1 (Th1) and Th2 cells in tumor eradication in vivo
13. Protein kinase C is required for cytotoxic T lymphocyte triggering
14. A critical role for antigen-specific Th1 cells in acute liver injury in mice
15. The application of IL-12 to antitumor cytokine and gene therapy
16. Generation and decay of the immune response to a progressive fibrosarcoma 1. Ly-1 + 2- suppressor T cells down-regulate the generation of Ly-1-2+ effector T cells
17. Tumor-specific targeting of T helper type 1 (Th1) cells by anti-CD3 x anti-c-ErbB-2 bispecific antibody
18. + lymphoid dendritic cells
19. Interleukin-12: Role of interferon-γ in IL-12 adverse effects
20. Functional skewing of bone marrow-derived dendritic cells by Th1- or Th2-inducing cytokines
21. Functional heterogeneity among bone marrow-derived dendritic cells conditioned by Th1- and Th2-biasing cytokines for the generation of allogenic cytotoxic lymphocyte
22. Mechanisms of experimental cancer cachexia. Interaction between mononuclear phagocytes and colon-26 carcinoma and its relevance to IL-6-mediated cancer cachexia
23. Murine interleukin-4 displays potent anti-tumor activity in vivo
24. Interleukin-12: A cytokine produced by antigen-presenting cells with immunoregulatory functions in the generation of T-helper cell type 1 and cytotoxic lymphocytes
25. A gene encoding an antigen recognized by cytotoxic T lymphocytes on a human melanoma
26. Vaccination of melanoma patients with peptide- or tumor lysate-pulsed dendritic cells
27. Human tumor antigens for cancer vaccine development