메뉴 건너뛰기




Volumn 23, Issue 5, 2011, Pages 382-388

Elevated hepatic fatty acid oxidation, high plasma fibroblast growth factor 21, and fasting bile acids in nonalcoholic steatohepatitis

Author keywords

Bile acids; fatty acid oxidation; fibroblast growth factor 21; nonalcoholic steatohepatitis

Indexed keywords

3 HYDROXYBUTYRIC ACID; 8 HYDROXYDEOXYGUANOSINE; ALANINE AMINOTRANSFERASE; BILE ACID; CERAMIDE; FATTY ACID; FIBROBLAST GROWTH FACTOR 21; GLUCOSE; GLYCOCHOLIC ACID; INSULIN; INTRALIPID; LEPTIN; TAUROCHENODEOXYCHOLIC ACID; TAUROCHOLIC ACID;

EID: 79955052166     PISSN: 0954691X     EISSN: None     Source Type: Journal    
DOI: 10.1097/MEG.0b013e328345c8c7     Document Type: Article
Times cited : (106)

References (57)
  • 3
    • 59149104628 scopus 로고    scopus 로고
    • The significance of differences in fatty acid metabolism between obese and nonobese patients with non-alcoholic fatty liver disease
    • Nakamuta M, Kohjima M, Higuchi N, Kato M, Kotoh K, Yoshimoto T, et al. The significance of differences in fatty acid metabolism between obese and nonobese patients with non-alcoholic fatty liver disease. Int J Mol Med 2008; 22:663-667.
    • (2008) Int. J. Mol. Med. , vol.22 , pp. 663-667
    • Nakamuta, M.1    Kohjima, M.2    Higuchi, N.3    Kato, M.4    Kotoh, K.5    Yoshimoto, T.6
  • 5
    • 0028001439 scopus 로고
    • Biochemical diagnosis of fatty acid oxidation disorders by metabolite analysis of postmortem liver
    • DOI 10.1016/0046-8177(94)90240-2
    • Boles RG, Martin SK, Blitzer MG, Rinaldo P. Biochemical diagnosis of fatty acid oxidation disorders by metabolite analysis of postmortem liver. Hum Pathol 1994; 25:735-741. (Pubitemid 24249229)
    • (1994) Human Pathology , vol.25 , Issue.8 , pp. 735-741
    • Boles, R.G.1    Martin, S.K.2    Blitzer, M.G.3    Rinaldo, P.4
  • 6
    • 0034666132 scopus 로고    scopus 로고
    • Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting
    • Hashimoto T, Cook WS, Qi C, Yeldandi AV, Reddy JK, Rao MS. Defect in peroxisome proliferator-activated receptor alpha-inducible fatty acid oxidation determines the severity of hepatic steatosis in response to fasting. J Biol Chem 2000; 275:28918-28928.
    • (2000) J. Biol. Chem. , vol.275 , pp. 28918-28928
    • Hashimoto, T.1    Cook, W.S.2    Qi, C.3    Yeldandi, A.V.4    Reddy, J.K.5    Rao, M.S.6
  • 7
    • 0032546929 scopus 로고    scopus 로고
    • Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-Coa oxidase: Implications for peroxisome proliferator-activated receptor α natural ligand metabolism
    • DOI 10.1074/jbc.273.25.15639
    • Fan CY, Pan J, Usuda N, Yeldandi AV, Rao MS, Reddy JK. Steatohepatitis, spontaneous peroxisome proliferation and liver tumors in mice lacking peroxisomal fatty acyl-CoA oxidase: implications for peroxisome proliferator-activated receptor alpha natural ligand metabolism. J Biol Chem 1998; 273:15639-15645. (Pubitemid 28298179)
    • (1998) Journal of Biological Chemistry , vol.273 , Issue.25 , pp. 15639-15645
    • Fan, C.-Y.1    Pan, J.2    Usuda, N.3    Yeldandi, A.V.4    Rao, M.S.5    Reddy, J.K.6
  • 13
    • 0037315190 scopus 로고    scopus 로고
    • Bile acids induce the expression of the human peroxisome proliferator-activated receptor α gene via activation of the farnesoid X receptor
    • DOI 10.1210/me.2002-0120
    • Pineda TI, Claudel T, Duval C, Kosykh V, Fruchart JC, Staels B. Bile acids induce the expression of the human peroxisome proliferator-activated receptor alpha gene via activation of the farnesoid X receptor. Mol Endocrinol 2003; 17:259-272. (Pubitemid 36183149)
    • (2003) Molecular Endocrinology , vol.17 , Issue.2 , pp. 259-272
    • Torra, I.P.1    Claudel, T.2    Duval, C.3    Kosykh, V.4    Fruchart, J.-C.5    Staels, B.6
  • 14
    • 0034957825 scopus 로고    scopus 로고
    • Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids
    • DOI 10.1042/0300-5127:0290310
    • Louet JF, Le MC, Pegorier JP, Decaux JF, Girard J. Regulation of liver carnitine palmitoyltransferase I gene expression by hormones and fatty acids. Biochem Soc Trans 2001; 29:310-316. (Pubitemid 32587523)
    • (2001) Biochemical Society Transactions , vol.29 , Issue.2 , pp. 310-316
    • Louet, J.-F.1    Le May, C.2    Pegorier, J.-P.3    Decaux, J.-F.4    Girard, J.5
  • 15
    • 53949110053 scopus 로고    scopus 로고
    • Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver
    • Oishi K, Uchida D, Ishida N. Circadian expression of FGF21 is induced by PPARalpha activation in the mouse liver. FEBS Lett 2008; 582:3639-3642.
    • (2008) FEBS Lett. , vol.582 , pp. 3639-3642
    • Oishi, K.1    Uchida, D.2    Ishida, N.3
  • 18
    • 48349146527 scopus 로고    scopus 로고
    • Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans
    • Zhang X, Yeung DC, Karpisek M, Stejskal D, Zhou ZG, Liu F, et al. Serum FGF21 levels are increased in obesity and are independently associated with the metabolic syndrome in humans. Diabetes 2008; 57:1246-1253.
    • (2008) Diabetes , vol.57 , pp. 1246-1253
    • Zhang, X.1    Yeung, D.C.2    Karpisek, M.3    Stejskal, D.4    Zhou, Z.G.5    Liu, F.6
  • 21
    • 66749106885 scopus 로고    scopus 로고
    • Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma-glutamyltransferase but not insulin sensitivity in Chinese subjects
    • Li H, Bao Y, Xu A, Pan X, Lu J,Wu H, et al. Serum fibroblast growth factor 21 is associated with adverse lipid profiles and gamma- glutamyltransferase but not insulin sensitivity in Chinese subjects. J Clin Endocrinol Metab 2009; 94:2151-2156.
    • (2009) J. Clin. Endocrinol. Metab. , vol.94 , pp. 2151-2156
    • Li, H.1    Bao, Y.2    Xu, A.3    Pan, X.4    Lu, J.5    Wu, H.6
  • 23
    • 0029046673 scopus 로고
    • Effects of a 48-h fat infusion on insulin secretion and glucose utilization
    • Boden G, Chen X, Rosner J, Barton M. Effects of a 48-h fat infusion on insulin secretion and glucose utilization. Diabetes 1995; 44:1239-1242.
    • (1995) Diabetes , vol.44 , pp. 1239-1242
    • Boden, G.1    Chen, X.2    Rosner, J.3    Barton, M.4
  • 24
    • 0023882414 scopus 로고
    • Fatty acid-independent inhibition of hepatic ketone body production by insulin in humans
    • Keller U, Gerber PP, Stauffacher W. Fatty acid-independent inhibition of hepatic ketone body production by insulin in humans. Am J Physiol 1988; 254:E694-E699.
    • (1988) Am. J. Physiol. , vol.254
    • Keller, U.1    Gerber, P.P.2    Stauffacher, W.3
  • 26
    • 0036783050 scopus 로고    scopus 로고
    • The metabolic abnormalities associated with non-alcoholic fatty liver disease
    • Haque M, Sanyal AJ. The metabolic abnormalities associated with non-alcoholic fatty liver disease. Best Pract Res Clin Gastroenterol 2002; 16:709-731.
    • (2002) Best Pract. Res. Clin. Gastroenterol. , vol.16 , pp. 709-731
    • Haque, M.1    Sanyal, A.J.2
  • 29
    • 1842330849 scopus 로고    scopus 로고
    • Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: Role of mitochondrial glutathione
    • DOI 10.1074/jbc.272.17.11369
    • Garcia-Ruiz C, Colell A, Mari M, Morales A, Fernandez-Checa JC. Direct effect of ceramide on the mitochondrial electron transport chain leads to generation of reactive oxygen species: role of mitochondrial glutathione. J Biol Chem 1997; 272:11369-11377. (Pubitemid 27184141)
    • (1997) Journal of Biological Chemistry , vol.272 , Issue.17 , pp. 11369-11377
    • Garcia-Ruiz, C.1    Colell, A.2    Mari, M.3    Morales, A.4    Fernandez-Checa, J.C.5
  • 30
    • 33745904468 scopus 로고    scopus 로고
    • In vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease
    • DOI 10.1002/hep.21223
    • Wieckowska A, Zein NN, Yerian LM, Lopez AR, McCullough AJ, Feldstein AE. In-vivo assessment of liver cell apoptosis as a novel biomarker of disease severity in nonalcoholic fatty liver disease. Hepatology 2006; 44:27-33. (Pubitemid 44049136)
    • (2006) Hepatology , vol.44 , Issue.1 , pp. 27-33
    • Wieckowska, A.1    Zein, N.N.2    Yerian, L.M.3    Lopez, A.R.4    McCullough, A.J.5    Feldstein, A.E.6
  • 31
    • 70350747448 scopus 로고    scopus 로고
    • Systematic review: Caspase-cleaved fragments of cytokeratin 18 the promises and challenges of a biomarker for chronic liver disease
    • Yilmaz Y. Systematic review: caspase-cleaved fragments of cytokeratin 18, the promises and challenges of a biomarker for chronic liver disease. Aliment Pharmacol Ther 2009; 30:1103-1109.
    • (2009) Aliment Pharmacol. Ther. , vol.30 , pp. 1103-1109
    • Yilmaz, Y.1
  • 33
    • 71849092184 scopus 로고    scopus 로고
    • Validity of real time ultrasound in the diagnosis of hepatic steatosis: A prospective study
    • Dasarathy S, Dasarathy J, Khiyami A, Joseph R, Lopez R, McCullough AJ. Validity of real time ultrasound in the diagnosis of hepatic steatosis: a prospective study. J Hepatol 2009; 51:1061-1067.
    • (2009) J. Hepatol. , vol.51 , pp. 1061-1067
    • Dasarathy, S.1    Dasarathy, J.2    Khiyami, A.3    Joseph, R.4    Lopez, R.5    McCullough, A.J.6
  • 34
    • 77951091722 scopus 로고    scopus 로고
    • Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry
    • Kasumov T, Huang H, Chung YM, Zhang R, McCullough AJ, Kirwan JP. Quantification of ceramide species in biological samples by liquid chromatography electrospray ionization tandem mass spectrometry. Anal Biochem 2010; 401:154-161.
    • (2010) Anal. Biochem. , vol.401 , pp. 154-161
    • Kasumov, T.1    Huang, H.2    Chung, Y.M.3    Zhang, R.4    McCullough, A.J.5    Kirwan, J.P.6
  • 37
    • 0018864840 scopus 로고
    • Regulation of hepatic fatty acid oxidation and ketone body production
    • McGarry JD, Foster DW. Regulation of hepatic fatty acid oxidation and ketone body production. Annu Rev Biochem 1980; 49:395-420.
    • (1980) Annu. Rev. Biochem. , vol.49 , pp. 395-420
    • McGarry, J.D.1    Foster, D.W.2
  • 38
    • 77956151046 scopus 로고    scopus 로고
    • Fatty acid metabolism in the liver measured by positron emission tomography is increased in obese individuals
    • Iozzo P, Bucci M, Roivainen A, Nagren K, Jarvisalo MJ, Kiss J, et al. Fatty acid metabolism in the liver, measured by positron emission tomography, is increased in obese individuals. Gastroenterology 2010; 139:846-856.
    • (2010) Gastroenterology , vol.139 , pp. 846-856
    • Iozzo, P.1    Bucci, M.2    Roivainen, A.3    Nagren, K.4    Jarvisalo, M.J.5    Kiss, J.6
  • 39
    • 0035865496 scopus 로고    scopus 로고
    • Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor α (PPARα)-independent pathway
    • DOI 10.1042/0264-6021:3540189
    • Louet JF, Chatelain F, Decaux JF, Park EA, Kohl C, Pineau T, et al. Long-chain fatty acids regulate liver carnitine palmitoyltransferase I gene (L-CPT I) expression through a peroxisome-proliferator-activated receptor alpha (PPARalpha)-independent pathway. Biochem J 2001; 354:189-197. (Pubitemid 32183459)
    • (2001) Biochemical Journal , vol.354 , Issue.1 , pp. 189-197
    • Louet, J.-F.1    Chatelain, F.2    Decaux, J.-F.3    Park, E.A.4    Kohl, C.5    Pineau, T.6    Girard, J.7    Pegorier, J.-P.8
  • 40
    • 34249677947 scopus 로고    scopus 로고
    • FGF21: A missing link in the biology of fasting
    • DOI 10.1016/j.cmet.2007.05.010, PII S1550413107001374
    • Reitman ML. FGF21: a missing link in the biology of fasting. Cell Metab 2007; 5:405-407. (Pubitemid 46825502)
    • (2007) Cell Metabolism , vol.5 , Issue.6 , pp. 405-407
    • Reitman, M.L.1
  • 41
    • 67649823642 scopus 로고    scopus 로고
    • FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response
    • U S A
    • Potthoff MJ, Inagaki T, Satapati S, Ding X, He T, Goetz R, et al. FGF21 induces PGC-1alpha and regulates carbohydrate and fatty acid metabolism during the adaptive starvation response. Proc Natl Acad Sci U S A 2009; 106:10853-10858.
    • (2009) Proc. Natl. Acad. Sci. , vol.106 , pp. 10853-10858
    • Potthoff, M.J.1    Inagaki, T.2    Satapati, S.3    Ding, X.4    He, T.5    Goetz, R.6
  • 42
    • 34249711964 scopus 로고    scopus 로고
    • Hepatic Fibroblast Growth Factor 21 Is Regulated by PPARα and Is a Key Mediator of Hepatic Lipid Metabolism in Ketotic States
    • DOI 10.1016/j.cmet.2007.05.002, PII S1550413107001295
    • Badman MK, Pissios P, Kennedy AR, Koukos G, Flier JS, Maratos-Flier E. Hepatic fibroblast growth factor 21 is regulated by PPARalpha and is a key mediator of hepatic lipid metabolism in ketotic states. Cell Metab 2007; 5:426-437. (Pubitemid 46825495)
    • (2007) Cell Metabolism , vol.5 , Issue.6 , pp. 426-437
    • Badman, M.K.1    Pissios, P.2    Kennedy, A.R.3    Koukos, G.4    Flier, J.S.5    Maratos-Flier, E.6
  • 43
  • 45
    • 32644436318 scopus 로고    scopus 로고
    • Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo
    • DOI 10.1210/en.2005-0731
    • Huang W, Dedousis N, Bandi A, Lopaschuk GD, O'Doherty RM. Liver triglyceride secretion and lipid oxidative metabolism are rapidly altered by leptin in vivo. Endocrinology 2006; 147:1480-1487. (Pubitemid 43244383)
    • (2006) Endocrinology , vol.147 , Issue.3 , pp. 1480-1487
    • Huang, W.1    Dedousis, N.2    Bandi, A.3    Lopaschuk, G.D.4    O'Doherty, R.M.5
  • 46
    • 0038890375 scopus 로고    scopus 로고
    • Reduction of plasma leptin concentrations by arginine but not lipid infusion in humans
    • Stingl H, Raffesberg W, Nowotny P, Waldhausl W, Roden M. Reduction of plasma leptin concentrations by arginine but not lipid infusion in humans. Obes Res 2002; 10:1111-1119. (Pubitemid 135686652)
    • (2002) Obesity Research , vol.10 , Issue.11 , pp. 1111-1119
    • Stingl, H.1    Raffesberg, W.2    Nowotny, P.3    Waldhausl, W.4    Roden, M.5
  • 48
    • 0021272481 scopus 로고
    • 2 production following addition of octanoate and oleate in perfused rat liver
    • Scholz R, Schwabe U, Soboll S. Influence of fatty acids on energy metabolism. 1. Stimulation of oxygen consumption, ketogenesis and CO2 production following addition of octanoate and oleate in perfused rat liver. Eur J Biochem 1984; 141:223-230. (Pubitemid 14106271)
    • (1984) European Journal of Biochemistry , vol.141 , Issue.1 , pp. 223-230
    • Scholz, R.1    Schwabe, U.2    Soboll, S.3
  • 49
    • 0021263925 scopus 로고
    • Influence of fatty acids on energy metabolism. 2. Kinetics of changes in metabolic rates and changes in subcellular adenine nucleotide contents and pH gradients following addition of octanoate and oleate in perfused rat liver
    • Soboll S, Grundel S, Schwabe U, Scholz R. Influence of fatty acids on energy metabolism. 2. Kinetics of changes in metabolic rates and changes in subcellular adenine nucleotide contents and pH gradients following addition of octanoate and oleate in perfused rat liver. Eur J Biochem 1984; 141:231-236. (Pubitemid 14106272)
    • (1984) European Journal of Biochemistry , vol.141 , Issue.1 , pp. 231-236
    • Soboll, S.1    Grundel, S.2    Schwabe, U.3    Scholz, R.4
  • 51
    • 34347248400 scopus 로고    scopus 로고
    • Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues
    • DOI 10.1016/j.nut.2007.04.014, PII S0899900707001463
    • Ichi I, Nakahara K, Kiso K, Kojo S. Effect of dietary cholesterol and high fat on ceramide concentration in rat tissues. Nutrition 2007; 23:570-574. (Pubitemid 47002227)
    • (2007) Nutrition , vol.23 , Issue.7-8 , pp. 570-574
    • Ichi, I.1    Nakahara, K.2    Kiso, K.3    Kojo, S.4
  • 52
    • 63249121641 scopus 로고    scopus 로고
    • Hepatic stearoyl-CoA desaturase SCD-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver
    • Kotronen A, Seppanen-Laakso T, Westerbacka J, Kiviluoto T, Arola J, Ruskeepaa AL, et al. Hepatic stearoyl-CoA desaturase (SCD)-1 activity and diacylglycerol but not ceramide concentrations are increased in the nonalcoholic human fatty liver. Diabetes 2009; 58:203-208.
    • (2009) Diabetes , vol.58 , pp. 203-208
    • Kotronen, A.1    Seppanen-Laakso, T.2    Westerbacka, J.3    Kiviluoto, T.4    Arola, J.5    Ruskeepaa, A.L.6
  • 53
    • 4344576754 scopus 로고    scopus 로고
    • Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker
    • DOI 10.1016/j.canlet.2004.06.032, PII S0304383504005002
    • Linder S, Havelka AM, Ueno T, Shoshan MC. Determining tumor apoptosis and necrosis in patient serum using cytokeratin 18 as a biomarker. Cancer Lett 2004; 214:1-9. (Pubitemid 39141193)
    • (2004) Cancer Letters , vol.214 , Issue.1 , pp. 1-9
    • Linder, S.1    Havelka, A.M.2    Ueno, T.3    Shoshan, M.C.4
  • 54
    • 20444504991 scopus 로고    scopus 로고
    • Reversibility of caspase activation and its role during glycochenodeoxycholate-induced hepatocyte apoptosis
    • DOI 10.1074/jbc.M411607200
    • Wang K, Brems JJ, Gamelli RL, Ding J. Reversibility of caspase activation and its role during glycochenodeoxycholate-induced hepatocyte apoptosis. J Biol Chem 2005; 280:23490-23495. (Pubitemid 40884826)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.25 , pp. 23490-23495
    • Wang, K.1    Brems, J.J.2    Gamelli, R.L.3    Ding, J.4
  • 55
    • 0015383455 scopus 로고
    • Apoptosis: A basic biological phenomenon with wide-ranging implications in tissue kinetics
    • Kerr JF, Wyllie AH, Currie AR. Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics. Br J Cancer 1972; 26:239-257.
    • (1972) Br. J. Cancer , vol.26 , pp. 239-257
    • Kerr, J.F.1    Wyllie, A.H.2    Currie, A.R.3
  • 57
    • 0031782291 scopus 로고    scopus 로고
    • Relationships between serum aminotransferase levels, liver histologies and virological status in patients with chronic hepatitis C in Taiwan
    • Luo JC, Hwang SJ, Lai CR, Lu CL, Li CP, Tsay SH, et al. Relationships between serum aminotransferase levels, liver histologies and virological status in patients with chronic hepatitis C in Taiwan. J Gastroenterol Hepatol 1998; 13:685-690.
    • (1998) J. Gastroenterol. Hepatol. , vol.13 , pp. 685-690
    • Luo, J.C.1    Hwang, S.J.2    Lai, C.R.3    Lu, C.L.4    Li, C.P.5    Tsay, S.H.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.