Growth hormone stimulates transcription of the fibroblast growth factor 21 gene in the liver through the signal transducer and activator of transcription 5

Endocrinology

Volumn 153, Issue 2, 2012, Pages 750-758

  Yu, Jie ^a,b   Zhao, Lidan ^a   Wang, Aihua ^a   Eleswarapu, Satyanarayana ^a   Ge, Xiaomei ^a   Chen, Daiwen ^b   Jiang, Honglin ^a  

^a VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^b SICHUAN AGRICULTURAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENTARY DNA; FIBROBLAST GROWTH FACTOR 21; GROWTH HORMONE; MESSENGER RNA; RECOMBINANT GROWTH HORMONE; STAT5 PROTEIN;

ANIMAL CELL; ARTICLE; BINDING SITE; CHROMATIN IMMUNOPRECIPITATION; GEL MOBILITY SHIFT ASSAY; GENE EXPRESSION; GENETIC TRANSCRIPTION; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; TATA BOX;

ANIMALS; BASE SEQUENCE; BINDING SITES; CATTLE; CELLS, CULTURED; DELAYED-ACTION PREPARATIONS; FEMALE; FIBROBLAST GROWTH FACTORS; GENE EXPRESSION REGULATION; GROWTH HORMONE; HEPATOCYTES; INJECTIONS, SUBCUTANEOUS; JANUS KINASE 2; LIVER; MICE; PROMOTER REGIONS, GENETIC; PROTEIN BINDING; RECEPTORS, SOMATOTROPIN; RECOMBINANT PROTEINS; RNA, MESSENGER; STAT5 TRANSCRIPTION FACTOR;

EID: 84862958488     PISSN: 00137227     EISSN: 19457170     Source Type: Journal    
DOI: 10.1210/en.2011-1591     Document Type: Article

References (48)

1. de Vos AM, Ultsch M, Kossiakoff AA 1992 Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science 255:306-312
2. Le Roith D, Bondy C, Yakar S, Liu JL, Butler A 2001 The somatomedin hypothesis: 2001. Endocr Rev 22:53-74 (Pubitemid 32187803)
3. Herrington J, Carter-Su C 2001 Signaling pathways activated by the growth hormone receptor. Trends Endocrinol Metab 12:252-257 (Pubitemid 33714215)
4. Brooks AJ, Waters MJ 2010 The growth hormone receptor: mechanism of activation and clinical implications. Nat Rev Endocrinol 6:515-525
5. Zhu T, Goh EL, Graichen R, Ling L, Lobie PE 2001 Signal transduction via the growth hormone receptor. Cell Signal 13:599-616 (Pubitemid 32734097)
6. Okada S, Kopchick JJ 2001 Biological effects of growth hormone and its antagonist. Trends Mol Med 7:126-132 (Pubitemid 32203694)
7. Waxman DJ, O'Connor C 2006 Growth hormone regulation of sex-dependent liver gene expression. Mol Endocrinol 20:2613-2629 (Pubitemid 44833525)
8. Rotwein P, Chia DJ 2010 Gene regulation by growth hormone. Pediatr Nephrol 25:651-658
9. Kofoed EM, Hwa V, Little B, Woods KA, Buckway CK, Tsubaki J, Pratt KL, Bezrodnik L, Jasper H, Tepper A, Heinrich JJ, Rosenfeld RG 2003 Growth hormone insensitivity associated with a STAT5b mutation. N Engl J Med 349:1139-1147 (Pubitemid 37122326)
10. Woelfle J, Chia DJ, Rotwein P 2003 Mechanisms of growth hormone (GH) action. Identification of conserved Stat5 binding sites that mediate GH-induced insulin-like growth factor-I gene activation. J Biol Chem 278:51261-51266 (Pubitemid 38020363)
11. Davey HW, McLachlan MJ, Wilkins RJ, Hilton DJ, Adams TE 1999 STAT5b mediates the GH-induced expression of SOCS-2 and SOCS-3 mRNA in the liver. Mol Cell Endocrinol 158:111-116
12. Vidal OM, Merino R, Rico-Bautista E, Fernandez-Perez L, Chia DJ, Woelfle J, Ono M, Lenhard B, Norstedt G, Rotwein P, Flores-Morales A 2007 In vivo transcript profiling and phylogenetic analysis identifies suppressor of cytokine signaling 2 as a direct signal transducer and activator of transcription 5b target in liver. Mol Endocrinol 21:293-311 (Pubitemid 46041708)
13. Stewart CE, Rotwein P 1996 Growth, differentiation, and survival: multiple physiological functions for insulin-like growth factors. Physiol Rev 76:1005-1026 (Pubitemid 26346814)
14. Jones JI, Clemmons DR 1995 Insulin-like growth factors and their binding proteins: biological actions. Endocr Rev 16:3-34
15. LeRoith D, Roberts Jr CT 1993 Insulin-like growth factors. Ann NY Acad Sci 692:22-32
16. Yakar S, Liu JL, Stannard B, Butler A, Accili D, Sauer B, LeRoith D 1999 Normal growth and development in the absence of hepatic insulin-like growth factor I. Proc Natl Acad Sci USA 96:7324-7329 (Pubitemid 29299660)
17. Sjögren K, Liu JL, Blad K, Skrtic S, Vidal O, Wallenius V, LeRoith D, Törnell J, Isaksson OG, Jansson JO, Ohlsson C 1999 Liver derived insulin-like growth factor I (IGF-I) is the principal source of IGF-I in blood but is not required for postnatal body growth in mice. Proc Natl Acad Sci USA 96:7088-7092 (Pubitemid 29275014)
18. Flores-Morales A, Greenhalgh CJ, Norstedt G, Rico-Bautista E 2006 Negative regulation of growth hormone receptor signaling. Mol Endocrinol 20:241-253 (Pubitemid 43152501)
19. Greenhalgh CJ, Rico-Bautista E, Lorentzon M, Thaus AL, Morgan PO, Willson TA, Zervoudakis P, Metcalf D, Street I, Nicola NA, Nash AD, Fabri LJ, Norstedt G, Ohlsson C, Flores-Morales A, Alexander WS, Hilton DJ 2005 SOCS2 negatively regulates growth hormone action in vitro and in vivo. J Clin Invest 115:397-406 (Pubitemid 40385481)
20. Alexander WS 2002 Suppressors of cytokine signalling (SOCS) in the immune system. Nat Rev Immunol 2:410-416 (Pubitemid 37328748)
21. Turnley AM 2005 Role of SOCS2 in growth hormone actions. Trends Endocrinol Metab 16:53-58 (Pubitemid 40270850)
22. Kralisch S, Fasshauer M 2011 Fibroblast growth factor 21: effects on carbohydrate and lipid metabolism in health and disease. Curr Opin Clin Nutr Metab Care 14:354-359
23. Domouzoglou EM, Maratos-Flier E 2011 Fibroblast growth factor 21 is a metabolic regulator that plays a role in the adaptation to ketosis. Am J Clin Nutr 93:901S-5
24. Kharitonenkov A, Larsen P 2011 FGF21 reloaded: challenges of a rapidly growing field. Trends Endocrinol Metab 22:81-86
25. Nishimura T, Nakatake Y, Konishi M, Itoh N 2000 Identification of a novel FGF, FGF-21, preferentially expressed in the liver. Biochim Biophys Acta 1492:203-206 (Pubitemid 30349198)
26. Kliewer SA, Mangelsdorf DJ 2010 Fibroblast growth factor 21: from pharmacology to physiology. Am J Clin Nutr 91:254S-257S
27. Inagaki T, Lin VY, Goetz R, Mohammadi M, Mangelsdorf DJ, Kliewer SA 2008 Inhibition of growth hormone signaling by the fasting-induced hormone FGF21. Cell Metab 8:77-83
28. Eleswarapu S, Jiang H 2005 Growth hormone regulates the expression of hepatocyte nuclear factor-3 γ and other liver-enriched transcription factors in the bovine liver. J Endocrinol 184:95-105 (Pubitemid 40207565)
29. Wu M, Hall JB, Akers RM, Jiang H 2010 Effect of feeding level on serum IGF1 response to GH injection. J Endocrinol 206:37-45
30. Seglen PO 1976 Preparation of isolated rat liver cells. Methods Cell Biol 13:29-83
31. Eleswarapu S, Gu Z, Jiang H 2008 Growth hormone regulation of insulin-like growth factor-I gene expression may be mediated by multiple distal signal transducer and activator of transcription 5 binding sites. Endocrinology 149:2230-2240
32. Eleswarapu S, Ge X, Wang Y, Yu J, JiangH2009 Growth hormone-activated STAT5 may indirectly stimulate IGF-I gene transcription through HNF-3γ. Mol Endocrinol 23:2026-2037
33. Ariyoshi K, Nosaka T, Yamada K, Onishi M, Oka Y, Miyajima A, Kitamura T 2000 Constitutive activation of STAT5 by a point mutation in the SH2 domain. J Biol Chem 275:24407-24413 (Pubitemid 30626531)
34. Wang Y, Jiang H 2005 Identification of a distal STAT5-binding DNA region that may mediate growth hormone regulation of insulin-like growth factor-I gene expression. J Biol Chem 280:10955-10963
35. Darnell Jr JE 1997 STATs and gene regulation. Science 277:1630-1635 (Pubitemid 27446219)
36. Ehret GB, Reichenbach P, Schindler U, Horvath CM, Fritz S, Nabholz M, Bucher P 2001 DNA binding specificity of different STAT proteins. Comparison of in vitro specificity with natural target sites. J Biol Chem 276:6675-6688
37. Barclay JL, Nelson CN, Ishikawa M, Murray LA, Kerr LM, McPhee TR, Powell EE, Waters MJ 2011 GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism. Endocrinology 152:181-192
38. Woelfle J, Rotwein P 2004 In vivo regulation of growth hormone-stimulated gene transcription by STAT5b. Am J Physiol Endocrinol Metab 286:E393-E401 (Pubitemid 38292689)
39. Kopchick JJ, Andry JM 2000 Growth hormone (GH),GHreceptor, and signal transduction. Mol Genet Metab 71:293-314
40. Davey HW, Xie T, McLachlan MJ, Wilkins RJ, Waxman DJ, Grattan DR 2001 STAT5b is required for GH-induced liver IGF-I gene expression. Endocrinology 142:3836-3841 (Pubitemid 32802654)
41. Frank SJ 2001 Growth hormone signalling and its regulation: preventing too much of a good thing. Growth Horm IGF Res 11:201-212 (Pubitemid 33072259)
42. Fazeli PK, Misra M, Goldstein M, Miller KK, Klibanski A 2010 Fibroblast growth factor-21 may mediate growth hormone resistance in anorexia nervosa. J Clin Endocrinol Metab 95:369-374
43. Kharitonenkov A, Shiyanova TL, Koester A, Ford AM, Micanovic R, Galbreath EJ, Sandusky GE, Hammond LJ, Moyers JS, Owens RA, Gromada J, Brozinick JT, Hawkins ED, Wroblewski VJ, Li DS, Mehrbod F, Jaskunas SR, Shanafelt AB 2005 FGF-21 as a novel metabolic regulator. J Clin Invest 115:1627-1635 (Pubitemid 40814671)
44. Dailey L, Ambrosetti D, Mansukhani A, Basilico C 2005 Mechanisms underlying differential responses to FGF signaling. Cytokine Growth Factor Rev 16:233-247 (Pubitemid 40616120)
45. Vijayakumar A, Novosyadlyy R, Wu Y, Yakar S, LeRoith D 2010 Biological effects of growth hormone on carbohydrate and lipid metabolism. Growth Horm IGF Res 20:1-7
46. Møller N, Jorgensen JO 2009 Effects of growth hormone on glucose, lipid, and protein metabolism in human subjects. Endocr Rev 30: 152-177
47. Xu J, Stanislaus S, Chinookoswong N, Lau YY, Hager T, Patel J, Ge H, Weiszmann J, Lu SC, Graham M, Busby J, Hecht R, Li YS, Li Y, Lindberg RA, Veniant MM 2009 Acute glucose-lowering and insulin-sensitizing action of FGF21 in insulin resistant mouse models-association with liver and adipose tissue effects. Am J Physiol Endocrinol Metab
48. Berglund ED, Li CY, Bina HA, Lynes SE, Michael MD, Shanafelt AB, Kharitonenkov A, Wasserman DH 2009 Fibroblast growth factor 21 controls glycemia via regulation of hepatic glucose flux and insulin sensitivity. Endocrinology 150:4084-4093