Novel inhibitors of the Plasmodium falciparum electron transport chain

Parasitology

Volumn 141, Issue 1, 2014, Pages 50-65

  Stocks, P A ^a   Barton, V ^b   Antoine, T ^a   Biagini, G A ^a   Ward, S A ^a   O'neill, P M ^b  

^a LIVERPOOL SCHOOL OF TROPICAL MEDICINE   (United Kingdom)

^b UNIVERSITY OF LIVERPOOL   (United Kingdom)

Author keywords

Antimalarial; dihydroorotate dehydrogenase; drug development; mitochondrial; PfNADH II; structure activity relationships

Indexed keywords

ANTIMALARIAL AGENT; CYTOCHROME BC1 INHIBITOR; DIHYDROOROTATE DEHYDROGENASE INHIBITOR; PF NDH2 INHIBITOR; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE INHIBITOR; UNCLASSIFIED DRUG; DIHYDROOROTATE DEHYDROGENASE; ENZYME INHIBITOR; OXIDOREDUCTASE; PROTOZOAL PROTEIN; UBIQUINOL CYTOCHROME C REDUCTASE;

AMINO ACID SEQUENCE; ANTIMALARIAL ACTIVITY; ARTICLE; CROSS RESISTANCE; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG OXIDATION; DRUG STRUCTURE; DRUG TARGETING; HIGH THROUGHPUT SCREENING; HYDROPHOBICITY; IN VITRO STUDY; NONHUMAN; PHYSICAL CHEMISTRY; PLASMA PROTEIN BINDING; PLASMODIUM BERGHEI; PLASMODIUM FALCIPARUM; PLASMODIUM YOELII; PRIORITY JOURNAL; PYRIMIDINE SYNTHESIS; RESPIRATORY CHAIN; RHEUMATOID ARTHRITIS; STRUCTURE ACTIVITY RELATION; ANTAGONISTS AND INHIBITORS; CHEMISTRY; DRUG EFFECTS; ELECTRON TRANSPORT; ENZYMOLOGY; HUMAN; MALARIA, FALCIPARUM; METABOLISM; MITOCHONDRION; MOLECULAR DOCKING; PARASITOLOGY;

ANTIMALARIALS; ELECTRON TRANSPORT; ELECTRON TRANSPORT COMPLEX III; ENZYME INHIBITORS; HUMANS; MALARIA, FALCIPARUM; MITOCHONDRIA; MOLECULAR DOCKING SIMULATION; NADH, NADPH OXIDOREDUCTASES; OXIDOREDUCTASES ACTING ON CH-CH GROUP DONORS; PLASMODIUM FALCIPARUM; PROTOZOAN PROTEINS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891889781     PISSN: 00311820     EISSN: 14698161     Source Type: Journal    
DOI: 10.1017/S0031182013001571     Document Type: Article

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