Synthesis and antitumor activities of novel rhein α-aminophosphonates conjugates

Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 2, 2014, Pages 501-507

  Yao, Gui Yang ^a,c   Ye, Man Yi ^a   Huang, Ri Zhen ^a   Li, Ya Jun ^a   Pan, Ying Ming ^a   Xu, Qing ^b   Liao, Zhi Xin ^c   Wang, Heng Shan ^a  

^a GUANGXI NORMAL UNIVERSITY   (China)

^b GUILIN MEDICAL UNIVERSITY   (China)

^c SOUTHEAST UNIVERSITY   (China)

Author keywords

Aminophosphonates; Apoptosis; Cytotoxicity; DNA binding; Rhein; Synthesis

Indexed keywords

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CASPASE; DEATH RECEPTOR; DNA; PHOSPHONIC ACID DERIVATIVE; RHEIN; ANTINEOPLASTIC AGENT; FLUOROURACIL; PHOSPHORAMIDIC ACID DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BINDING AFFINITY; CELL CYCLE ASSAY; CELL STRAIN HCT116; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DRUG MECHANISM; DRUG SCREENING; DRUG SYNTHESIS; FLOW CYTOMETRY; FLUORESCENCE; FLUORESCENCE RESONANCE ENERGY TRANSFER; HELA CELL; IN VITRO STUDY; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; SPECTROSCOPY; ULTRAVIOLET RADIATION; CONJUGATE; DRUG BINDING; DRUG CYTOTOXICITY; DRUG DNA INTERACTION; ENZYME ACTIVATION; FEMALE; G1 PHASE CELL CYCLE CHECKPOINT; HCT116 CELL LINE; HELA CELL LINE; HUMAN; HUMAN CELL; MELTING POINT; STAINING;

APOPTOSIS; CYTOTOXICITY; DNA BINDING; RHEIN; SYNTHESIS; Α-AMINOPHOSPHONATES;

ANTHRAQUINONES; ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; HCT116 CELLS; HELA CELLS; HEP G2 CELLS; HUMANS; ORGANOPHOSPHONATES;

EID: 84891881744     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.12.030     Document Type: Article

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