Aminophosphonate inhibitors of dialkylglycine decarboxylase: Structural basis for slow binding inhibition

Biochemistry

Volumn 41, Issue 41, 2002, Pages 12320-12328

  Liu, Wenshe ^a   Rogers, Claude J ^a   Fisher, Andrew J ^a   Toney, Michael D ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INHIBITORS;

AMINO ACIDS; ISOMERIZATION; SUBSTRATES;

BIOCHEMISTRY;

1 AMINO 1 METHYLPROPANEPHOSPHONATE; 1 AMINOETHANEPHOSPHONATE; AMINO ACID; ENZYME INHIBITOR; GLYCINE DEHYDROGENASE (DECARBOXYLATING); GLYCINE DERIVATIVE; PHOSPHORAMIDIC ACID DERIVATIVE; PYRIDOXAL 5 PHOSPHATE; SCHIFF BASE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL BOND; CRYSTAL STRUCTURE; DISSOCIATION; ENZYME ACTIVE SITE; ENZYME BINDING; ENZYME INHIBITION; ENZYME STRUCTURE; INHIBITION KINETICS; ISOMERISM; PRIORITY JOURNAL; STEREOCHEMISTRY; X RAY ANALYSIS;

BINDING, COMPETITIVE; CARBOXY-LYASES; CATALYSIS; COMPUTER SIMULATION; CRYSTALLOGRAPHY, X-RAY; KINETICS; MODELS, MOLECULAR; PHOSPHONIC ACIDS; SCHIFF BASES; SUBSTRATE SPECIFICITY;

EID: 0037108173     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi026318g     Document Type: Article

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