Synthesis, X-ray crystallographic analysis, and antitumor activity of N-(benzothiazole-2-yl)-1-(fluorophenyl)-O,O-dialkyl-α-aminophosphonates

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 6, 2006, Pages 1537-1543

  Jin, Linhong ^a   Song, Baoan ^a   Zhang, Guoping ^a   Xu, Ruiqing ^a   Zhang, Sumei ^a   Gao, Xingwen ^a   Hu, Deyu ^a   Yang, Song ^a  

^a GUIZHOU UNIVERSITY   (China)

Author keywords

Aminophosphonate; Antitumor activity; Benzothiazole moiety; Ionic liquids; Synthesis

Indexed keywords

N BENZOTHIAZOLE 2 YL 1 FLUOROPHENYL O,O DIALKYL ALPHA AMINOPHOSPHONATE DERIVATIVE; PHOSPHONIC ACID DERIVATIVE; UNCLASSIFIED DRUG;

ADDITION REACTION; ANTINEOPLASTIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; INFRARED SPECTROSCOPY; MANNICH REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION TIME; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BENZOTHIAZOLES; CELL PROLIFERATION; CRYSTALLOGRAPHY, X-RAY; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; INHIBITORY CONCENTRATION 50; LUNG NEOPLASMS; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MELANOMA; PHOSPHONIC ACIDS; PROSTATIC NEOPLASMS; SKIN NEOPLASMS; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES; TUMOR CELLS, CULTURED;

EID: 32144455908     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2005.12.041     Document Type: Article

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