Acenaphtho[1,2-b]pyrrole derivatives as new family of intercalators: Various DNA binding geometry and interesting antitumor capacity

Bioorganic and Medicinal Chemistry

Volumn 14, Issue 20, 2006, Pages 6962-6970

  Zhang, Zhichao ^a   Yang, Yuanyuan ^a   Zhang, Danni ^a   Wang, Yuanyuan ^a   Qian, Xuhong ^a,b   Liu, Fengyu ^a  

^a DALIAN UNIVERSITY OF TECHNOLOGY   (China)

^b EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY   (China)

Author keywords

Antitumor agents; DNA; Geometry; Intercalation

Indexed keywords

PYRROLE DERIVATIVE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; CONTROLLED STUDY; DNA BINDING; DRUG SYNTHESIS; FLUORESCENCE; GEOMETRY; HUMAN; HUMAN CELL; IC 50; MOLECULAR DYNAMICS; SUBSTITUTION REACTION; TITRIMETRY; TUMOR CELL;

ACENAPHTHENES; ANTINEOPLASTIC AGENTS; APOPTOSIS; BINDING SITES; CELL LINE, TUMOR; CIRCULAR DICHROISM; DNA; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; INTERCALATING AGENTS; MOLECULAR STRUCTURE; NUCLEIC ACID CONFORMATION; PYRROLES; SENSITIVITY AND SPECIFICITY; STRUCTURE-ACTIVITY RELATIONSHIP; TEMPERATURE;

EID: 33748124430     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2006.06.029     Document Type: Article

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