Rhein improves renal lesion and ameliorates dyslipidemia in db/db mice with diabetic nephropathy

Planta Medica

Volumn 76, Issue 1, 2010, Pages 27-33

  Gao, Qing ^a   Qin, Wei Song ^a   Jia, Zhong Hui ^a   Zheng, Jing Min ^a   Zeng, Cai Hong ^a   Li, Lei Shi ^a   Liu, Zhi Hong ^a  

^a MEDICAL SCHOOL OF NANJING UNIVERSITY   (China)

Author keywords

Db db mice; Diabetic nephropathy; Dyslipidemia; Polygonaceae; Rhein; Rheum officinale; Simvastatin

Indexed keywords

ALBUMIN; APOLIPOPROTEIN E; CHOLESTEROL; FIBRONECTIN; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; LOW DENSITY LIPOPROTEIN CHOLESTEROL; RHEIN; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA1; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DYSLIPIDEMIA; EXTRACELLULAR MATRIX; IMMUNOHISTOCHEMISTRY; KIDNEY INJURY; MORPHOMETRICS; MOUSE; NONHUMAN; PROTEIN EXPRESSION; RENAL PROTECTION; TRIACYLGLYCEROL BLOOD LEVEL; URINARY EXCRETION;

ALBUMINURIA; ANIMALS; ANTHRAQUINONES; ANTICHOLESTEREMIC AGENTS; CHOLESTEROL; DIABETES MELLITUS, EXPERIMENTAL; DIABETIC NEPHROPATHIES; DRUGS, CHINESE HERBAL; DYSLIPIDEMIAS; EXTRACELLULAR MATRIX; FIBRONECTINS; KIDNEY; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; PHYTOTHERAPY; RHEUM; RHIZOME; SIMVASTATIN; TRANSFORMING GROWTH FACTOR BETA1;

MUS; POLYGONACEAE; RHEUM OFFICINALE; RHEUM X HYBRIDUM;

EID: 74349098549     PISSN: 00320943     EISSN: 14390221     Source Type: Journal    
DOI: 10.1055/s-0029-1185948     Document Type: Article

References (34)

1. Chen Q H. Experimental study and clinical application on rhubara. Chin J Med Pharmacol 1974 8 226-226
2. He Z H., He M F., Ma S C., But P P. Anti-angiogenic effects of rhubarb and its anthraquinone derivatives. J Ethnopharmacol 2009 121 313-317
3. Deffaud J, Kirchmeyer M, Domagala F, Ficheux H, Netter P, Bianchi A. Modulatory effect of rhein on IL-1-induced responses in human chondrocytes: a comparative study between antibody microarrays and specific ELISAs. Biorheology 2008 45 439-455
4. Lin M L., Chung J G., Lu Y C., Yang C Y., Chen S S. Rhein inhibits invasion and migration of human nasopharyngeal carcinoma cells in vitro by down-regulation of matrix metalloproteinases-9 and vascular endothelial growth factor. Oral Oncol 2009 45 531-537
5. Legendre F, Bogdanowicz P, Martin G, Domagala F, Leclercq S, Pujol J P. Rhein, a diacerhein-derived metabolite, modulates the expression of matrix degrading enzymes and the cell proliferation of articular chondrocytes by inhibiting ERK and JNKAP1 dependent pathways. Clin Exp Rheumatol 2007 25 546-555
6. Chen J, Ma M, Lu Y, Wang L, Wu C, Duan H. Rhaponticin from rhubarb rhizomes alleviates liver steatosis and improves blood glucose and lipid profiles in KK/Ay diabetic mice. Planta Med 2009 75 472-477
7. Zhu J M., Liu Z H., Huang Y F., Chen H P., Zhou H, Wang J P., Li L S. Therapeutic effect of rhein on diabetic nephropathy in db/db mice. J Nephrol Dial Transplant 2002 11 3-10
8. Guo X H., Liu Z H., Peng A, Bi Y, Wang J P., Zhou H, Li L S. Rhein retards the progression of type 2 diabetic nephropathy. Chin J Nephrol 2002 18 280-284
9. Jia Z H., Liu Z H., Zheng J M., Zeng C H., Li L S. Combined therapy of rhein and benazepril on the treatment of diabetic nephropathy in db/db mice. Exp Clin Endocrinol Diabetes 2007 115 571-576
10. Huang Y F., Liu Z H., Chen H P., Zhou H, Wang J P., Zhu M Y., Li L S. Improvement of diabetic metabolic disorders ameliorate the renal lesion in db/db mice: comparison between rhein and rosiglitazone. J Nephrol Dial Transplant 2004 13 215-221
11. Usui H, Shikata K, Matsuda M, Okada S, Ogawa D, Yamashita T, Hida K, Satoh M, Wada J, Makino H. HMGCoA reductase inhibitor ameliorates diabetic nephropathy by its pleiotropic effects in rats. Nephrol Dial Transplant 2003 18 265-272
12. Chen H C., Guh J Y., Chang J M., Hsieh M C., Shin S J., Lai Y H. Role of lipid control in diabetic nephropathy. Kidney Int Suppl 2005 94 S60-S62
13. Kanwar Y S., Wada J, Sun L, Xie P, Wallner E I., Chen S, Chugh S, Danesh F R. Diabetic nephropathy: mechanisms of renal disease progression. Exp Biol Med (Maywood) 2008 233 4-11
14. Liu Z H., Li Y J., Chen Z H., Liu D, Li L S. Glucose transporter in human glomerular mesangial cells modulated by transforming growth factor-beta and rhein. Acta Pharmacol Sin 2001 22 169-175
15. Liu Z H., Zhu J M., Huang H D., Chen Z H., Li L S. Effect of rhein on plasminogen activator inhibitor-1 expression of endothelial cells induced by transforming growth factor 1. Chin J Nephrol 2002 18 337-341
16. Pan A, Sun J, Chen Y, Ye X, Li H, Yu Z, Wang Y, Gu W, Zhang X, Chen X, Demark-Wahnefried W, Liu Y, Lin X. Effects of a flaxseed-derived lignan supplement in type 2 diabetic patients: a randomized, double-blind, cross-over trial. PLoS ONE 2007 2 e1148-e1148
17. UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet 1998 352 837-853
18. Macisaac R J., Jerums G. Albuminuric and non-albuminuric pathways to renal impairment in diabetes. Minerva Endocrinol 2005 30 161-177
19. Attia D M., Feron O, Goldschmeding R, Radermakers L H., Vaziri N D., Boer P, Balligand J L., Koomans H A., Joles J A. Hypercholesterolemia in rats induces podocyte stress and decreases renal cortical nitric oxide synthesis via an angiotensin II type 1 receptor-sensitive mechanism. J Am Soc Nephrol 2004 15 949-957
20. Dominguez J H., Tang N, Xu W, Evan A P., Siakotos A N., Agarwal R, Walsh J, Deeg M, Pratt J H., March K L., Monnier V M., Weiss M F., Baynes J W., Peterson R. Studies of renal injury III: lipid-induced nephropathy in type II diabetes. Kidney Int 2000 57 92-104
21. Ji Z Q., Huang C W., Liang C J., Sun W W., Chen B, Tang P R. Effects of rhein on activity of caspase-3 in kidney and cell apoptosis on the progression of renal injury in glomerulosclerosis. Chin J Med 2005 85 1836-1841
22. Shibutani S, Nagasawa T, Yokozawa T, Oura H. Effect of rhubarb (Rhei rhizoma) extract on urea nitrogen and amino acid metabolism after administration. Yakugaku Zasshi 1980 100 434-442
23. Yokozawa T, Zheng P D., Oura H, Nishioka I. Urine composition in rats with adenine-induced renal failure during treatment with rhubarb extract. Chem Pharm Bull (Tokyo) 1984 32 205-212 (Pubitemid 14195358)
24. Li L S. Rheum officinale: a new lead in preventing progression of chronic renal failure. Chin Med J 1996 109 35-37
25. Fried L F., Orchard T J., Kasiske B L. Effect of lipid reduction on the progression of renal disease: a meta-analysis. Kidney Int 2001 59 260-269
26. Mclaughlin K, Jardine A G. Clinical management of diabetic nephropathy. Diabetes Obes Metab 1999 1 307-315
27. Zheng J M., Zhu J M., Li L S., Liu Z H. Rhein reverses the diabetic phenotype of mesangial cells over-expressing the glucose transporter (GLUT1) by inhibiting the hexosamine pathway. Br J Pharmacol 2008 153 1456-1464
28. van Goor H, van der Horst M L., Atmosoerodjo J, Joles J A., van Tol A, Grond J. Renal apolipoproteins in nephrotic rats. Am J Pathol 1993 142 1804-1812
29. Liu Z H., Zheng J M., Wu Y C., Zhu J M., Huang Y F., Li L S. Renal gene expression profiles of db/db mice and its alteration after the treatment with rhein. J Nephrol Dial Transplant 2002 11 201-205
30. Danesh F R., Sadeghi M M., Amro N, Philips C, Zeng L, Lin S, Sahai A, Kanwar Y S. 3-Hydroxy-3-methylglutaryl CoA reductase inhibitors prevent high glucose-induced proliferation of mesangial cells via modulation of Rho GTPase/p21 signaling pathway: implications for diabetic nephropathy. Proc Natl Acad Sci USA 2002 99 8301-8305
31. Guo X H., Liu Z H., Dai C S., Li H, Liu D, Li L S. Rhein inhibits renal tubular epithelial cell hypertrophy and extracellular matrix accumulation induced by transforming growth factor beta1. Acta Pharmacol Sin 2001 22 934-938
32. Watts K L., Spiteri M A. Connective tissue growth factor expression and induction by transforming growth factor-beta is abrogated by simvastatin via a Rho signaling mechanism. Am J Physiol Lung Cell Mol Physiol 2004 287 L1323-L1332
33. Eberlein M, Heusinger-Ribeir O J., Goppelt-Struebe M. Rho-dependent inhibition of the induction connective tissue growth factor (CTGF) by HMG CoA reductase inhibitors (statins). Br J Pharmacol 2001 133 1172-1180
34. Evans T, Deng D X., Chen S, Chakrabarti S. Endothelin receptor blockade prevents augmented extracellular matrix component mRNA expression and capillary basement membrane thickening in the retina of diabetic and galactose-fed rats. Diabetes 2000 49 662-666