SMG-1 suppresses CDK2 and tumor growth by regulating both the p53 and Cdc25A signaling pathways

Cell Cycle

Volumn 12, Issue 24, 2013, Pages 3770-3780

  Gubanova, Evgenia ^a,b   Issaeva, Natalia ^c,d   Gokturk, Camilla ^b   Djureinovic, Tatjana ^a,e   Helleday, Thomas ^b  

^a STOCKHOLM UNIVERSITY   (Sweden)

^b SCIENCE FOR LIFE LABORATORY   (Sweden)

^c YALE UNIVERSITY   (United States)

^d YALE CANCER CENTER   (United States)

^e UPPSALA UNIVERSITY   (Sweden)

Author keywords

Cdc25A; CDK2; Cell cycle; G1 S checkpoint; p53; SMG 1; Tumor suppressor; Tumorigenesis

Indexed keywords

ALPHA TUBULIN; CDC25A PROTEIN; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYCLIN DEPENDENT KINASE 2; PHOSPHOTRANSFERASE; PROTEIN MDM2; PROTEIN P53; SMG 1 PROTEIN; UNCLASSIFIED DRUG;

ARTICLE; CARCINOGENESIS; CELL CYCLE PROGRESSION; CELL PROLIFERATION; CELL STRAIN HCT116; CONTROLLED STUDY; CYTOTOXICITY; DNA SYNTHESIS; G1 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IMMUNOBLOTTING; IMMUNOPRECIPITATION; IN VITRO STUDY; IONIZING RADIATION; PROTEIN DEGRADATION; PROTEIN DEPLETION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN STABILITY; RADIATION RESPONSE; TUMOR GROWTH; UPREGULATION;

CDC25A; CDK2; CELL CYCLE; G1/S CHECKPOINT; P53; SMG-1; TUMOR SUPPRESSOR; TUMORIGENESIS;

CDC25 PHOSPHATASES; CELL MOVEMENT; CYCLIN-DEPENDENT KINASE 2; G1 PHASE CELL CYCLE CHECKPOINTS; GENE EXPRESSION; HUMANS; NEOPLASMS; PHOSPHATIDYLINOSITOL 3-KINASES; PHOSPHORYLATION; PHOSPHOTRANSFERASES; S PHASE CELL CYCLE CHECKPOINTS; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84891850152     PISSN: 15384101     EISSN: 15514005     Source Type: Journal    
DOI: 10.4161/cc.26660     Document Type: Article

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