Rhein, a natural anthraquinone derivative, attenuates the activation of pancreatic stellate cells and ameliorates pancreatic fibrosis in mice with experimental chronic pancreatitis

PLoS ONE

Volumn 8, Issue 12, 2013, Pages

  Tsang, Siu Wai ^a   Zhang, Hongjie ^a   Lin, Chengyuan ^a   Xiao, Haitao ^a   Wong, Michael ^a   Shang, Hongcai ^b   Yang, Zhi Jun ^a   Lu, Aiping ^a   Yung, Ken Kin Lam ^a   Bian, Zhaoxiang ^a  

^a HONG KONG BAPTIST UNIVERSITY   (Hong Kong)

^b TIANJIN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA SMOOTH MUSCLE ACTIN; CERULETIDE; COLLAGEN TYPE 1; FIBRONECTIN; RHEIN; SONIC HEDGEHOG PROTEIN; TRANSFORMING GROWTH FACTOR BETA; ACTA2 PROTEIN, HUMAN; ACTIN; ALPHA-SMOOTH MUSCLE ACTIN, MOUSE; ANTHRAQUINONE DERIVATIVE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL ACTIVATION; CHRONIC PANCREATITIS; CONTROLLED STUDY; CYSTIC FIBROSIS; DRUG EFFICACY; DRUG MECHANISM; EXOCRINE GLAND; FIBROGENESIS; MALE; MOUSE; NONHUMAN; PANCREATIC STELLATE CELL; PARENCHYMA; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; UPREGULATION; ANIMAL; C57BL MOUSE; CELL LINE; CELL SURVIVAL; DRUG EFFECTS; FIBROSIS; METABOLISM; PANCREAS DISEASE; PANCREATITIS, CHRONIC; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ACTINS; ANIMALS; ANTHRAQUINONES; BLOTTING, WESTERN; CELL LINE; CELL SURVIVAL; FIBRONECTINS; FIBROSIS; MALE; MICE; MICE, INBRED C57BL; PANCREATIC DISEASES; PANCREATIC STELLATE CELLS; PANCREATITIS, CHRONIC; RATS; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84891799378     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0082201     Document Type: Article

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