ER stress, P66shc, and P-Akt/Akt mediate adjuvant-induced inflammation, which is blunted by argirein, a supermolecule and rhein in rats

Inflammation

Volumn 35, Issue 3, 2012, Pages 1031-1040

  Cong, Xiao Dong ^a   Ding, Ming Jian ^a   Dai, De Zai ^b   Wu, You ^a   Zhang, Yun ^a   Dai, Yin ^b  

^a ZHEJIANG CHINESE MEDICAL UNIVERSITY   (China)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Adjuvant arthritis; Argirein; ER stress; p66shc; Rhein

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 6; ANTIINFLAMMATORY AGENT; ARGIREIN; GELATINASE A; IBUPROFEN; P66SHC PROTEIN; PROTEIN KINASE B; PROTEIN P22; PROTEIN P22PHOX; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE PHOSPHATE OXIDASE 2; RHEIN; UNCLASSIFIED DRUG;

ADJUVANT ARTHRITIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG DOSE COMPARISON; DRUG STRUCTURE; ENDOPLASMIC RETICULUM STRESS; FEMALE; INFLAMMATION; MALE; MORNING DOSAGE; NONHUMAN; PAW EDEMA; PROTEIN PHOSPHORYLATION; RAT; UPREGULATION;

ACTIVATING TRANSCRIPTION FACTOR 6; ADJUVANTS, IMMUNOLOGIC; ANIMALS; ANTHRAQUINONES; ANTI-INFLAMMATORY AGENTS; ARTHRITIS, RHEUMATOID; EDEMA; ENDOPLASMIC RETICULUM STRESS; FEMALE; IBUPROFEN; INFLAMMATION; MALE; MATRIX METALLOPROTEINASE 2; MEMBRANE GLYCOPROTEINS; NADPH OXIDASE; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; SHC SIGNALING ADAPTOR PROTEINS;

RATTUS;

EID: 84863789056     PISSN: 03603997     EISSN: 15732576     Source Type: Journal    
DOI: 10.1007/s10753-011-9407-4     Document Type: Article

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