Reduced system exposures of total rhein and baicalin after combinatory oral administration of rhein, baicalin and berberine to beagle dogs and rats

Journal of Ethnopharmacology

Volumn 145, Issue 2, 2013, Pages 442-449

  Wang, Zhanguo ^a   Hu, Huiling ^b   Chen, Fang ^a   Lan, Ke ^a   Wang, Anqi ^a  

^a SICHUAN UNIVERSITY   (China)

^b CHENGDU UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

Author keywords

Glucuronidase sulfatase; Baicalin; Berberine; Enterohepatic circulation; Rhein

Indexed keywords

BAICALIN; BERBERINE; BETA GLUCURONIDASE; RHEIN; SULFATASE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BLOOD LEVEL; DRUG CONJUGATION; DRUG EXPOSURE; DRUG METABOLISM; DRUG TRANSPORT; IN VITRO STUDY; IN VIVO STUDY; MALE; NONHUMAN; RAT; SMALL INTESTINE;

ANIMALS; ANTHRAQUINONES; BERBERINE; CACO-2 CELLS; DOGS; DRUG INTERACTIONS; FLAVONOIDS; GLUCURONIDES; HUMANS; INTESTINES; MALE; RATS; RATS, WISTAR;

CANIS FAMILIARIS; RATTUS; RATTUS NORVEGICUS;

EID: 84872145462     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2012.11.008     Document Type: Article

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