Triptolide induces apoptosis in human leukemia cells through caspase-3-mediated ROCK1 activation and MLC phosphorylation

Cell Death and Disease

Volumn 4, Issue 12, 2013, Pages

  Liu, L ^a   Li, G ^a   Li, Q ^a   Jin, Z ^a   Zhang, L ^a   Zhou, J ^a   Hu, X ^a   Zhou, T ^a   Chen, J ^a   Gao, N ^a  

^a CHONGQING MEDICAL UNIVERSITY   (China)

Author keywords

apoptosis; leukemia; MLC; MYPT; ROCK1; triptolide

Indexed keywords

1 (5 IODO 1 NAPHTHALENESULFONYL)HEXAHYDRO 1H 1,4 DIAZEPINE; APOPTOSIS INDUCING FACTOR; CASPASE 3; CASPASE 9; CYTOCHROME C; MYOSIN LIGHT CHAIN; MYOSIN LIGHT CHAIN PHOSPHATASE; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN; PROTEIN BAX; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN; ROCK1 PROTEIN; TRIPTOLIDE; UNCLASSIFIED DRUG;

ABSENCE OF SIDE EFFECTS; ACUTE LYMPHOBLASTIC LEUKEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER INHIBITION; CELL DEATH; CELLULAR DISTRIBUTION; CHRONIC LYMPHATIC LEUKEMIA; CHRONIC MYELOID LEUKEMIA; CLINICAL ARTICLE; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE; IMMUNOHISTOCHEMISTRY; IN VIVO STUDY; LEUKEMIA; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; MURINE LEUKEMIA; NONHUMAN; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; WESTERN BLOTTING;

ANIMALS; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; DITERPENES; EPOXY COMPOUNDS; FLUORESCENT ANTIBODY TECHNIQUE; HL-60 CELLS; HUMANS; IMMUNOBLOTTING; LEUKEMIA; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICE; MICE, NUDE; PHENANTHRENES; PHOSPHORYLATION; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN;

EID: 84891795355     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.469     Document Type: Article

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