Phenylalanine activates the mitochondria-mediated apoptosis through the RhoA/Rho-associated kinase pathway in cortical neurons

European Journal of Neuroscience

Volumn 25, Issue 5, 2007, Pages 1341-1348

  Zhang, Yongjun ^a   Gu, Xuefan ^a   Yuan, Xiaobing ^b  

^a SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b INSTITUTE OF GEOLOGY AND GEOPHYSICS   (China)

Author keywords

Apoptosis; Phenylalanine; Phenylketonuria; Rho associated kinase; RhoA

Indexed keywords

4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; CASPASE 3; EXOENZYME C3; MYOSIN LIGHT CHAIN; PHENYLALANINE; PROTEIN INHIBITOR; RHO KINASE; RHO KINASE INHIBITOR; RHOA GUANINE NUCLEOTIDE BINDING PROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BRAIN CORTEX; BRAIN MITOCHONDRION; BRAIN NERVE CELL; CONTROLLED STUDY; ENZYME ACTIVATION; GENE OVEREXPRESSION; NERVE CELL NECROSIS; NONHUMAN; PHENYLKETONURIA; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; RAT; SIGNAL TRANSDUCTION;

AMINO ACID CHLOROMETHYL KETONES; ANALYSIS OF VARIANCE; ANIMALS; APOPTOSIS; CASPASE 3; CELLS, CULTURED; CEREBRAL CORTEX; EMBRYO; ENZYME INHIBITORS; GREEN FLUORESCENT PROTEINS; IN SITU NICK-END LABELING; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MITOCHONDRIA; NEURONS; NEUROPROTECTIVE AGENTS; PHENYLALANINE; PROTEIN-SERINE-THREONINE KINASES; RATS; RATS, SPRAGUE-DAWLEY; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; TIME FACTORS; TRANSFECTION;

EID: 34147093581     PISSN: 0953816X     EISSN: 14609568     Source Type: Journal    
DOI: 10.1111/j.1460-9568.2007.05404.x     Document Type: Article

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