Inhibition mechanism of P-glycoprotein mediated efflux by mPEG-PLA and influence of PLA chain length on P-glycoprotein inhibition activity

Molecular Pharmaceutics

Volumn 11, Issue 1, 2014, Pages 71-80

  Li, Wenjing ^a   Li, Xinru ^a   Gao, Yajie ^a   Zhou, Yanxia ^a   Ma, Shujin ^a   Zhao, Yong ^a   Li, Jinwen ^a   Liu, Yan ^a   Wang, Xinglin ^b   Yin, Dongdong ^b  

^a PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

^b TIANJIN INSTITUTE OF PHARMACEUTICAL RESEARCH   (China)

Author keywords

block copolymer; Caco 2 cells; inhibition mechanism; mPEG PLA; P glycoprotein efflux

Indexed keywords

ADENOSINE TRIPHOSPHATASE; COPOLYMER; MONOMETHOXY MACROGOL LACTIC ACID COPOLYMER; MULTIDRUG RESISTANCE PROTEIN; RHODAMINE 123; UNCLASSIFIED DRUG;

ARTICLE; CELL MEMBRANE; CELL METABOLISM; CELL STRAIN CACO 2; CONTROLLED STUDY; CORRELATION ANALYSIS; DRUG DELIVERY SYSTEM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; FLOW CYTOMETRY; FLUORESCENCE ANALYSIS; HUMAN; HYDROPHILICITY; POLARIZATION; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN STRUCTURE; PROTEIN TRANSPORT;

ADENOSINE TRIPHOSPHATASES; ADENOSINE TRIPHOSPHATE; BIOLOGICAL TRANSPORT; CACO-2 CELLS; CELL MEMBRANE; DRUG DELIVERY SYSTEMS; HUMANS; LACTIC ACID; MEMBRANE FLUIDITY; MEMBRANE POTENTIAL, MITOCHONDRIAL; MICELLES; P-GLYCOPROTEIN; POLYESTERS; POLYETHYLENE GLYCOLS; POLYMERS;

EID: 84891777924     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp4004223     Document Type: Article

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