Membrane fluidization by ether, other anesthetics, and certain agents abolishes P-glycoprotein ATPase activity and modulates efflux from multidrug- resistant cells

European Journal of Biochemistry

Volumn 259, Issue 1-2, 1999, Pages 18-24

  Regev, Ronit ^a   Assaraf, Yehuda G ^a   Eytan, Gera D ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

Author keywords

ABC transporters; Anticancer chemotherapy; Membrane fluidity; Multidrug resistance; P glycoprotein

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE; ANESTHETIC AGENT; AZIDOPRAZOSIN; BENZYL ALCOHOL; CHLOROFORM; DOXORUBICIN; ETHER; GLYCOPROTEIN P; GRAMICIDIN D; IODINE 125; POLYSORBATE 20; PRAZOSIN; PROGESTERONE; TRITON X 100; UNCLASSIFIED DRUG; VERAPAMIL;

ANIMAL CELL; ARTICLE; CANCER CHEMOTHERAPY; CHO CELL; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INHIBITION; ION TRANSPORT; MEMBRANE FLUIDITY; MULTIDRUG RESISTANCE; NONHUMAN; PRIORITY JOURNAL; PROTEOLIPOSOME;

ADENOSINE TRIPHOSPHATASES; ANESTHETICS; ANIMALS; BENZYL ALCOHOL; BIOLOGICAL TRANSPORT; CHLOROFORM; CHO CELLS; CRICETINAE; DOSE-RESPONSE RELATIONSHIP, DRUG; DOXORUBICIN; DRUG RESISTANCE, MULTIPLE; ETHER, ETHYL; LIPID BILAYERS; MEMBRANE FLUIDITY; P-GLYCOPROTEIN; POLYSORBATES;

ANIMALIA;

EID: 0033556083     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1327.1999.00037.x     Document Type: Article

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