메뉴 건너뛰기




Volumn 27, Issue 2, 2013, Pages 85-102

Development of leishmania vaccines: Predicting the future from past and present experience

Author keywords

Immune response; Immunization; Leishmania; Leishmaniasis; Vaccine

Indexed keywords

ANTIMONY; BCG VACCINE; CPG OLIGODEOXYNUCLEOTIDE; DNA VACCINE; FLUCYTOSINE; FUCOSE MANNOSE LIGAND; GAMMA INTERFERON; GELATINASE B; GLYCOCONJUGATE; GLYCOPROTEIN; IMMUNOLOGICAL ADJUVANT; INTERLEUKIN 2; LEISHMANIA VACCINE; LIGAND; LIPOSOME; LIVE VACCINE; NAKED DNA; NITRIC OXIDE; PARASITE ANTIGEN; PHOSPHORYL LIPID A; PROTEOPHOSPHOGLYCAN; RECOMBINANT PROTEIN; RECOMBINANT VACCINE; SAPONIN; STIBOGLUCONATE SODIUM; SUBUNIT VACCINE; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 84891753022     PISSN: 16748301     EISSN: None     Source Type: Journal    
DOI: 10.7555/JBR.27.20120064     Document Type: Article
Times cited : (72)

References (140)
  • 1
    • 0037449085 scopus 로고    scopus 로고
    • DNA vaccines induce partial protection against Leish mania mexicana
    • Dumonteil E, Jesus MRS, Javier EO, del Rosario MGM. DNA vaccines induce partial protection against Leish mania mexicana. Vaccine 2003; 21: 2161-8.
    • (2003) Vaccine , vol.21 , pp. 2161-2168
    • Dumonteil, E.1    Jesus, M.R.S.2    Javier, E.O.3    del Rosario, M.G.M.4
  • 2
    • 10444254809 scopus 로고    scopus 로고
    • The immunology of Leish mania infection and the implications for vaccine devel opment
    • Vanloubbeeck Y, Jones D. The immunology of Leish mania infection and the implications for vaccine devel opment. Ann N Y Acad Sci 2004; 1026: 267-72.
    • (2004) Ann N Y Acad Sci , vol.1026 , pp. 267-272
    • Vanloubbeeck, Y.1    Jones, D.2
  • 3
    • 84915735358 scopus 로고    scopus 로고
    • Annual report 2009. World Health Organization. TDR/BL10.10 Geneva. 2010.
    • Special program for research and training in tropical dis eases (TDR). Research to support the elimination of vis ceral leishmaniasis. Annual report 2009. World Health Organization. TDR/BL10.10 Geneva. 2010.
    • Research to support the elimination of vis ceral leishmaniasis
  • 4
    • 56149121336 scopus 로고    scopus 로고
    • Complexities of assessing the disease burden attributable to leishmaniasis
    • Bern C, Maguire JH, Alvar J. Complexities of assessing the disease burden attributable to leishmaniasis. PLos Negl Trop Dis 2008; 2: e313.
    • (2008) PLos Negl Trop Dis , vol.2
    • Bern, C.1    Maguire, J.H.2    Alvar, J.3
  • 7
    • 1942445367 scopus 로고    scopus 로고
    • Cutaneous leishmaniasis in red kangaroos: Isolation and characterization of the causa tive organisms
    • Rose K, Curtis J, Baldwin T, Mathis A, Kumar B, Sak thianandeswaren A, et al. Cutaneous leishmaniasis in red kangaroos: Isolation and characterization of the causa tive organisms. Int J Parasitol 2004; 34: 655-64.
    • (2004) Int J Parasitol , vol.34 , pp. 655-664
    • Rose, K.1    Curtis, J.2    Baldwin, T.3    Mathis, A.4    Kumar, B.5    Sakthianandeswaren, A.6
  • 8
    • 84915765211 scopus 로고    scopus 로고
    • Report by the Secretariat; Sixth World Health Assembly. A60/10 Provisional agenta item 12.3. 2007.
    • World Health Organization (WHO). Control of Leish maniasis. Report by the Secretariat; Sixth World Health Assembly. A60/10 Provisional agenta item 12.3. 2007.
    • Control of Leish maniasis
  • 10
    • 35448983199 scopus 로고    scopus 로고
    • Vaccination with plasmid DNA encoding KMPII, TRYP, LACK, and GP63 does not protect dogs against Leishmania infan tum experimental challenge
    • Rodriguez-Cortes A, Ojeda A, Lopez-Fuertez L, Timón M, Altet L, Solano-Gallego L, et al. Vaccination with plasmid DNA encoding KMPII, TRYP, LACK, and GP63 does not protect dogs against Leishmania infan tum experimental challenge. Vaccine 2007; 25: 7962-71.
    • (2007) Vaccine , vol.25 , pp. 7962-7971
    • Rodriguez-Cortes, A.1    Ojeda, A.2    Lopez-Fuertez, L.3    Timón, M.4    Altet, L.5    Solano-Gallego, L.6
  • 12
    • 65949084697 scopus 로고    scopus 로고
    • Canine leishmaniosis in South Ameri ca
    • Dantas-Torres F. Canine leishmaniosis in South Ameri ca. Parasit Vect 2009; 2(S1): 1.
    • (2009) Parasit Vect , vol.2 , Issue.S1 , pp. 1
    • Dantas-Torres, F.1
  • 13
    • 77957937242 scopus 로고    scopus 로고
    • Leishmaniasis in the World Health Organi zation Eastern Mediterranean Region
    • Postigo JAR. Leishmaniasis in the World Health Organi zation Eastern Mediterranean Region. Intern J Antimi crob Agents 2010; 36(S): 62-5.
    • (2010) Intern J Antimi crob Agents , vol.36 , Issue.S , pp. 62-65
    • Postigo, J.A.R.1
  • 14
    • 33947112954 scopus 로고    scopus 로고
    • Balancing immunity and pa thology in visceral leishmaniasis
    • Stanley AC, Engwerda CR. Balancing immunity and pa thology in visceral leishmaniasis. Immunol Cell Biol 2007; 85: 138-47.
    • (2007) Immunol Cell Biol , vol.85 , pp. 138-147
    • Stanley, A.C.1    Engwerda, C.R.2
  • 15
    • 0028933795 scopus 로고
    • The regulation of immunity to Leishmania major
    • Reiner SL, Locksley MR. The regulation of immunity to Leishmania major. Ann Rev Immunol 1995; 13: 151-77.
    • (1995) Ann Rev Immunol , vol.13 , pp. 151-177
    • Reiner, S.L.1    Locksley, M.R.2
  • 16
    • 0023903734 scopus 로고
    • Role of L3T4+ and Lyt-2+ cells in experimental visceral leishmaniasis
    • Stern JJ, Oca MJ, Rubin BY, Anderson SL, Murray HW. Role of L3T4+ and Lyt-2+ cells in experimental visceral leishmaniasis. J Immunol 1988; 140: 3971-77.
    • (1988) J Immunol , vol.140 , pp. 3971-3977
    • Stern, J.J.1    Oca, M.J.2    Rubin, B.Y.3    Anderson, S.L.4    Murray, H.W.5
  • 18
    • 84915784089 scopus 로고    scopus 로고
    • Immune responses to protozo
    • Rich RR, Fleisher TA, Shearer WT, Kotzin BL, Schroder Jr HW, Editors, 2nd Edition. Mosby Intern Limited: Mos by 2001
    • Melby PC, Anstead GM. Immune responses to protozoa. In: Clinical immunology: principles and practices. Rich RR, Fleisher TA, Shearer WT, Kotzin BL, Schroder Jr HW, Editors, 2nd Edition. Mosby Intern Limited: Mos by, 2001; 29: 1-29.13.
    • Clinical immunology: principles and practices , vol.29 , pp. 1-29
    • Melby, P.C.1    Anstead, G.M.2
  • 19
    • 0034671822 scopus 로고    scopus 로고
    • Immunization with a re combinant stage-regulated surface protein from Leish mania donovani induces protection against visceral leishmaniasis
    • Stager S, Smith DF, Kaye PM. Immunization with a re combinant stage-regulated surface protein from Leish mania donovani induces protection against visceral leishmaniasis. J Immunol 2000; 165: 7064-71.
    • (2000) J Immunol , vol.165 , pp. 7064-7071
    • Stager, S.1    Smith, D.F.2    Kaye, P.M.3
  • 20
    • 70849122402 scopus 로고    scopus 로고
    • Recombinant Leishmania taren tolae expressing the A2 virulence gene as a novel can didate vaccine against visceral leishmaniasis
    • Mizbani A, Taheri T, Zahedifard F, Taslimi Y, Azizi H, Azadmanesh K, et al. Recombinant Leishmania taren tolae expressing the A2 virulence gene as a novel can didate vaccine against visceral leishmaniasis. Vaccine 2010; 28: 53-62.
    • (2010) Vaccine , vol.28 , pp. 53-62
    • Mizbani, A.1    Taheri, T.2    Zahedifard, F.3    Taslimi, Y.4    Azizi, H.5    Azadmanesh, K.6
  • 21
    • 78249249268 scopus 로고    scopus 로고
    • Canine visceral leish maniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs
    • Lima LUVR, Carneiro LA, Campos MB, Chagas EJ, Laurenti MD, Corbett CEP, et al. Canine visceral leish maniasis due to Leishmania (L.) infantum chagasi in Amazonian Brazil: comparison of the parasite density from the skin, lymph node and visceral tissues between symptomatic and asymptomatic, seropositive dogs. Rev Instituto Med Trop Sao Paulo 2010; 52: 259-65.
    • (2010) Rev Instituto Med Trop Sao Paulo , vol.52 , pp. 259-265
    • Lima, L.U.V.R.1    Carneiro, L.A.2    Campos, M.B.3    Chagas, E.J.4    Laurenti, M.D.5    Corbett, C.E.P.6
  • 22
    • 33745199610 scopus 로고    scopus 로고
    • Animal models for vaccine studies for visceral leishmaniasis
    • Garg R, Dube A. Animal models for vaccine studies for visceral leishmaniasis. Indian J Med Res 2006; 123: 439-54.
    • (2006) Indian J Med Res , vol.123 , pp. 439-454
    • Garg, R.1    Dube, A.2
  • 23
    • 79960077595 scopus 로고    scopus 로고
    • Immunological perspectives of leishmaniasis
    • Nylen S, Gautam S. Immunological perspectives of leishmaniasis. J Global Infect Dis 2010; 2: 135-46.
    • (2010) J Global Infect Dis , vol.2 , pp. 135-146
    • Nylen, S.1    Gautam, S.2
  • 25
    • 17444429293 scopus 로고    scopus 로고
    • Second generation vaccines against leishmaniasis
    • Coler RN, Reed S. Second generation vaccines against leishmaniasis. Trend Parasitol 2005; 21: 244-9.
    • (2005) Trend Parasitol , vol.21 , pp. 244-249
    • Coler, R.N.1    Reed, S.2
  • 26
    • 33745197847 scopus 로고    scopus 로고
    • The history of leishmaniasis
    • In: Gilles HM, editor. New York & London: Hodder Arnold Publisher
    • Bray RS, Modabber F. The history of leishmaniasis. In: Gilles HM, editor. Protozoal Diseases. New York & London: Hodder Arnold Publisher: 2000; 414-9.
    • (2000) Protozoal Diseases , pp. 414-419
    • Bray, R.S.1    Modabber, F.2
  • 27
    • 0005165843 scopus 로고
    • Artificial infection and immu nization of 368 men with cultures of L. tropica.
    • Senekji HA, Beattie CP. Artificial infection and immu nization of 368 men with cultures of L. tropica. Trans R Soc Trop Med Hyg 1941; 369: 415-9.
    • (1941) Trans R Soc Trop Med Hyg , vol.369 , pp. 415-419
    • Senekji, H.A.1    Beattie, C.P.2
  • 28
    • 0019251264 scopus 로고
    • The present and future of vaccination for cutaneous leishmaniasis
    • In: Mizrahi A, Hertman I, Klingberg MA, Kohn A, editors. New York: Alan R Liss Inc
    • Greenblatt CL. The present and future of vaccination for cutaneous leishmaniasis. In: Mizrahi A, Hertman I, Klingberg MA, Kohn A, editors. New developments with human and veterinary vaccine. New York: Alan R Liss Inc, 1980; 259-85.
    • (1980) New developments with human and veterinary vaccine , pp. 259-285
    • Greenblatt, C.L.1
  • 29
    • 0035067363 scopus 로고    scopus 로고
    • Leishmaniasis: current status of vaccine de velopment
    • Handman E. Leishmaniasis: current status of vaccine de velopment. Clin Microbiol Rev 2001; 14: 229-43.
    • (2001) Clin Microbiol Rev , vol.14 , pp. 229-243
    • Handman, E.1
  • 30
    • 25444511090 scopus 로고    scopus 로고
    • Live non-pathogenic vectors as a candidate vaccine against visceral Leishmaniasis
    • Breton M, Tremblay M, Ouellette M, Papadopoulou B. Live non-pathogenic vectors as a candidate vaccine against visceral Leishmaniasis. Infect Immun 2005; 73: 6372-82.
    • (2005) Infect Immun , vol.73 , pp. 6372-6382
    • Breton, M.1    Tremblay, M.2    Ouellette, M.3    Papadopoulou, B.4
  • 31
    • 33750913168 scopus 로고    scopus 로고
    • Current understandings on the immunol ogy of leishmaniasis and recent developments in pre vention and treatment
    • Roberts MTM. Current understandings on the immunol ogy of leishmaniasis and recent developments in pre vention and treatment. British Med Bullet 2006; 75/76: 115-30.
    • (2006) British Med Bullet , vol.75-76 , pp. 115-130
    • Roberts, M.T.M.1
  • 32
    • 18844445009 scopus 로고
    • Control and prophylaxis of cutaneous leish maniasis in the middle Asia republics of the former USSR
    • Sergiev VP. Control and prophylaxis of cutaneous leish maniasis in the middle Asia republics of the former USSR. Bull Soc Fran Parasit 1992; 10: 183-4.
    • (1992) Bull Soc Fran Parasit , vol.10 , pp. 183-184
    • Sergiev, V.P.1
  • 33
    • 0032619536 scopus 로고    scopus 로고
    • Experience in controlling and preventing zoonotic cutaneous leishmaniasis in Uzbekistan
    • Gafurov IM. Experience in controlling and preventing zoonotic cutaneous leishmaniasis in Uzbekistan. Med Parazitol (Mosk) 1999; 1: 58-9.
    • (1999) Med Parazitol (Mosk) , vol.1 , pp. 58-59
    • Gafurov, I.M.1
  • 35
    • 0033660439 scopus 로고    scopus 로고
    • Safety and immuno genicity of a killed Leishmania (L.) amazonensis vac cine against cutaneous leishmaniasis in Colombia: a randomized controlled trial
    • Velez ID, del Pilar-Agudelo S, Arbelaez MP, Gilchrist K, Robledo SM, Puerta JA, et al. Safety and immuno genicity of a killed Leishmania (L.) amazonensis vac cine against cutaneous leishmaniasis in Colombia: a randomized controlled trial. Trans R Soc Trop Med Hyg 2000; 94: 698-703.
    • (2000) Trans R Soc Trop Med Hyg , vol.94 , pp. 698-703
    • Velez, I.D.1    del Pilar-Agudelo, S.2    Arbelaez, M.P.3    Gilchrist, K.4    Robledo, S.M.5    Puerta, J.A.6
  • 37
    • 1542360794 scopus 로고    scopus 로고
    • Safety, immunogenecity, and ef ficacy of an autoclaved Leishmania amazonensis vac cine plus BCG adjuvant against New World cutaneous leishmaniasis
    • Armijos RX, Weigel MM, Calvopina M, Hidalgo A, Cevallos W, Correa J. Safety, immunogenecity, and ef ficacy of an autoclaved Leishmania amazonensis vac cine plus BCG adjuvant against New World cutaneous leishmaniasis. Vaccine 2004; 22: 1320-6.
    • (2004) Vaccine , vol.22 , pp. 1320-1326
    • Armijos, R.X.1    Weigel, M.M.2    Calvopina, M.3    Hidalgo, A.4    Cevallos, W.5    Correa, J.6
  • 39
    • 0036097079 scopus 로고    scopus 로고
    • Immunochemotherapy for cu taneous leishmaniasis: a controlled trial using killed Leishmania amazonensis vaccine plus antimonial
    • Jackson MP, Pinto J, da Costa CA, Genaro O, Marques MJ, Modabber F, et al. Immunochemotherapy for cu taneous leishmaniasis: a controlled trial using killed Leishmania amazonensis vaccine plus antimonial. Inter J Dermatol 2002; 41: 73-8.
    • (2002) Inter J Dermatol , vol.41 , pp. 73-78
    • Jackson, M.P.1    Pinto, J.2    da Costa, C.A.3    Genaro, O.4    Marques, M.J.5    Modabber, F.6
  • 41
    • 17344374265 scopus 로고    scopus 로고
    • Field trial of a vaccine against New World cutaneous leishmaniasis in an at-risk child population: safety, immunogenicity, and efficacy during the first 12 months of follow-up
    • Armijos RX, Weigel MM, Aviles H, Maldonado R, Racines J. Field trial of a vaccine against New World cutaneous leishmaniasis in an at-risk child population: safety, immunogenicity, and efficacy during the first 12 months of follow-up. J Infect Dis 1998; 177: 1352-7.
    • (1998) J Infect Dis , vol.177 , pp. 1352-1357
    • Armijos, R.X.1    Weigel, M.M.2    Aviles, H.3    Maldonado, R.4    Racines, J.5
  • 42
    • 0030248707 scopus 로고    scopus 로고
    • Comparative safety and immunogenicity trial of two killed Leishmania major vaccines with or without BCG in human volunteers
    • Bahar K, Dowlati Y, Shidani B, Alimohammadian MH, Khamesipour A, Ehsasi S, et al. Comparative safety and immunogenicity trial of two killed Leishmania major vaccines with or without BCG in human volunteers. Clin Dermatol 1996; 14: 489-95.
    • (1996) Clin Dermatol , vol.14 , pp. 489-495
    • Bahar, K.1    Dowlati, Y.2    Shidani, B.3    Alimohammadian, M.H.4    Khamesipour, A.5    Ehsasi, S.6
  • 43
    • 0030249321 scopus 로고    scopus 로고
    • Stepwise safety trial of a killed Leishmania vaccine in Iran
    • Dowlati Y, Ehsasi S, Shidani B, Bahar K. Stepwise safety trial of a killed Leishmania vaccine in Iran. Clin Der matol 1996; 14: 497-502.
    • (1996) Clin Der matol , vol.14 , pp. 497-502
    • Dowlati, Y.1    Ehsasi, S.2    Shidani, B.3    Bahar, K.4
  • 44
    • 0033524709 scopus 로고    scopus 로고
    • A randomized, double blind, controlled trial of a killed L. major vaccine plus BCG against zoonotic cutaneous leishmaniasis in Iran.
    • Momeni AZ, Jalayer T, Emamjomeh M, Khamesipour A, Zicker F, Labaf-Ghasemi R, et al. A randomized, double blind, controlled trial of a killed L. major vaccine plus BCG against zoonotic cutaneous leishmaniasis in Iran. Vaccine 1999; 17: 466-72.
    • (1999) Vaccine , vol.17 , pp. 466-472
    • Momeni, A.Z.1    Jalayer, T.2    Emamjomeh, M.3    Khamesipour, A.4    Zicker, F.5    Labaf-Ghasemi, R.6
  • 45
    • 7144254432 scopus 로고    scopus 로고
    • Randomized vaccine trial of a single dose of killed Leishmania major plus BCG against anthroponotic cutaneous leishmaniasis in Bam, Iran
    • Sharifi I, FeKri A, Aflatonian M, Khamesipour A, Nadim A, Mousavi MRA, et al. Randomized vaccine trial of a single dose of killed Leishmania major plus BCG against anthroponotic cutaneous leishmaniasis in Bam, Iran. Lancet 1998; 351: 1540-3.
    • (1998) Lancet , vol.351 , pp. 1540-1543
    • Sharifi, I.1    FeKri, A.2    Aflatonian, M.3    Khamesipour, A.4    Nadim, A.5    Mousavi, M.R.A.6
  • 46
    • 0034605714 scopus 로고    scopus 로고
    • Autoclaved Leishmania ma jor vaccine for prevention of visceral leishmaniasis: a randomised, double-blind, BCG-controlled trial in Su dan
    • Khalil EA, El Hassan AM, Zijlstra EE, Mukhtar MM, Ghalib HW, Musa B, et al. Autoclaved Leishmania ma jor vaccine for prevention of visceral leishmaniasis: a randomised, double-blind, BCG-controlled trial in Su dan. Lancet 2000; 356: 1565-9.
    • (2000) Lancet , vol.356 , pp. 1565-1569
    • Khalil, E.A.1    El Hassan, A.M.2    Zijlstra, E.E.3    Mukhtar, M.M.4    Ghalib, H.W.5    Musa, B.6
  • 47
    • 0031934169 scopus 로고    scopus 로고
    • Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG.
    • Dube A, Sharma P, Srivastava JK, Misra A, Naik S, Katiyar JC. Vaccination of langur monkeys (Presbytis entellus) against Leishmania donovani with autoclaved L. major plus BCG. Parasitol 1998; 116: 219-21.
    • (1998) Parasitol , vol.116 , pp. 219-221
    • Dube, A.1    Sharma, P.2    Srivastava, J.K.3    Misra, A.4    Naik, S.5    Katiyar, J.C.6
  • 48
    • 0032864099 scopus 로고    scopus 로고
    • Protective immunity using recombinant hu man IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis
    • Kenney RT, Sacks DL, Sypek JP, Vilela L, Gam AA, Davis KE. Protective immunity using recombinant hu man IL-12 and alum as adjuvants in a primate model of cutaneous leishmaniasis. J Immunol 1999; 163: 4481-8.
    • (1999) J Immunol , vol.163 , pp. 4481-4488
    • Kenney, R.T.1    Sacks, D.L.2    Sypek, J.P.3    Vilela, L.4    Gam, A.A.5    Davis, K.E.6
  • 49
    • 0035167274 scopus 로고    scopus 로고
    • Vervet Monkeys vaccinated with killed Leishmania major parasites and Interleukin-12 develop a type 1 immune response but are not protected against challenge infection
    • Gicheru MM, Olobo JO, Anjili CO, Orago AS, Modabber F, Scott P. Vervet Monkeys vaccinated with killed Leishmania major parasites and Interleukin-12 develop a type 1 immune response but are not protected against challenge infection. Infect Immun 2001; 69: 245-51.
    • (2001) Infect Immun , vol.69 , pp. 245-251
    • Gicheru, M.M.1    Olobo, J.O.2    Anjili, C.O.3    Orago, A.S.4    Modabber, F.5    Scott, P.6
  • 50
    • 0035858116 scopus 로고    scopus 로고
    • Successful vaccination against Leishmania donovani infection in Indian langur using alum-precip itated autoclaved Leishmania major with BCG
    • Misra A, Anuradha D, Bindu S, Preeti S, Srivastava JK, Katiyar JC. Successful vaccination against Leishmania donovani infection in Indian langur using alum-precip itated autoclaved Leishmania major with BCG. Vaccine 2001; 19: 3485-92.
    • (2001) Vaccine , vol.19 , pp. 3485-3492
    • Misra, A.1    Anuradha, D.2    Bindu, S.3    Preeti, S.4    Srivastava, J.K.5    Katiyar, J.C.6
  • 51
    • 4444307813 scopus 로고    scopus 로고
    • Double blind randomized efficacy field trial of alum precipitated autoclaved Leishmania major vaccine mixed with BCG against canine visceral leishmaniasis in Meshkin-shahr district I.R. Iran.
    • Mohebalia M, Khamesipour A, Mobedi I, Zareia Z, Hashemi-Fesharki R. Double blind randomized efficacy field trial of alum precipitated autoclaved Leishmania major vaccine mixed with BCG against canine visceral leishmaniasis in Meshkin-shahr district I.R. Iran. Vac cine 2004; 22: 4097-100.
    • (2004) Vac cine , vol.22 , pp. 4097-4100
    • Mohebalia, M.1    Khamesipour, A.2    Mobedi, I.3    Zareia, Z.4    Hashemi-Fesharki, R.5
  • 52
    • 4444327985 scopus 로고    scopus 로고
    • Alum-precipitated autoclaved Leishmania major plus bacille Calmette-Guérrin, a candidate vaccine for visceral leishmaniasis: safety, skin-delayed type hypersensitivity response and dose finding in healthy volunteers
    • Kamil AA, Khalil EAG, Musa AM, Modabber F, Mukhtar MM, Ibrahim ME, et al. Alum-precipitated autoclaved Leishmania major plus bacille Calmette-Guérrin, a candidate vaccine for visceral leishmaniasis: safety, skin-delayed type hypersensitivity response and dose finding in healthy volunteers. Trans R Soc Trop Med Hyg 2003; 97: 365-8.
    • (2003) Trans R Soc Trop Med Hyg , vol.97 , pp. 365-368
    • Kamil, A.A.1    Khalil, E.A.G.2    Musa, A.M.3    Modabber, F.4    Mukhtar, M.M.5    Ibrahim, M.E.6
  • 54
    • 74549123922 scopus 로고    scopus 로고
    • (2009) Montanide ISA 720 is more effective than BCG as an adjuvant for Leishmania killed vaccine in BALB/c mice
    • Mutiso JM, Macharia JC, Kariuki TM, Gicheru MM. (2009) Montanide ISA 720 is more effective than BCG as an adjuvant for Leishmania killed vaccine in BALB/c mice. IJIB 2009; 7: 107-16.
    • (2009) IJIB , vol.7 , pp. 107-116
    • Mutiso, J.M.1    Macharia, J.C.2    Kariuki, T.M.3    Gicheru, M.M.4
  • 55
    • 84857517290 scopus 로고    scopus 로고
    • Leishmania donovani whole cell antigen delivered with adjuvants protects against visceral leishmaniasis in vervet monkeys (Chlorocebus aethiops)
    • Mutiso JM, Macharia JC, Taracha E, Gicheru MM. Leishmania donovani whole cell antigen delivered with adjuvants protects against visceral leishmaniasis in vervet monkeys (Chlorocebus aethiops). J Biomed Res 2012; 26: 8-16.
    • (2012) J Biomed Res , vol.26 , pp. 8-16
    • Mutiso, J.M.1    Macharia, J.C.2    Taracha, E.3    Gicheru, M.M.4
  • 57
    • 0027410174 scopus 로고
    • Leishma nia donovani surface glycoconjugate GP63 is the major immunogen component of the fucose-mannose ligand (FML)
    • Palatnik-de-Sousa CB, Dutra HS, Borojevic R. Leishma nia donovani surface glycoconjugate GP63 is the major immunogen component of the fucose-mannose ligand (FML). Acta Trop 1993; 53: 59-72.
    • (1993) Acta Trop , vol.53 , pp. 59-72
    • Palatnik-de-Sousa, C.B.1    Dutra, H.S.2    Borojevic, R.3
  • 58
    • 0028380624 scopus 로고
    • Experimental murine Leishmania donovani infection: Immunoprotection by the fucose-mannose ligand (FML)
    • Palatnik-de-Sousa CB, Paraguai de Souza E, Gomes EM, Borojevic R. Experimental murine Leishmania donovani infection: Immunoprotection by the fucose-mannose ligand (FML). Braz J Med Biol Res 1994; 27: 547-51.
    • (1994) Braz J Med Biol Res , vol.27 , pp. 547-551
    • Palatnik-de-Sousa, C.B.1    Paraguai De Souza, E.2    Gomes, E.M.3    Borojevic, R.4
  • 60
    • 0030976397 scopus 로고    scopus 로고
    • Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes
    • Afrin F, Ali N. Adjuvanticity and protective immunity elicited by Leishmania donovani antigens encapsulated in positively charged liposomes. Infect Immun 1997; 65: 2371-7.
    • (1997) Infect Immun , vol.65 , pp. 2371-2377
    • Afrin, F.1    Ali, N.2
  • 61
    • 4644242029 scopus 로고    scopus 로고
    • Immunization with Leishmania major exogenous antigens protects susceptible BALB/c mice against challenge infection with L. major.
    • Tonui WK, Mejia JS, Hochberg L, Mbow ML, Ryan JR, Chan AST, et al. Immunization with Leishmania major exogenous antigens protects susceptible BALB/c mice against challenge infection with L. major. Infect Immun 2004;72:5654-61.
    • (2004) Infect Immun , vol.72 , pp. 5654-5661
    • Tonui, W.K.1    Mejia, J.S.2    Hochberg, L.3    Mbow, M.L.4    Ryan, J.R.5    Chan, A.S.T.6
  • 62
    • 32544433906 scopus 로고    scopus 로고
    • Non-PC liposome entrapped promastigote an tigens elicit parasite specific CD8+ and CD4+ T-cell immune response and protect hamsters against visceral leishmaniasis
    • Sharma SK, Dube A, Nadeem A, Khan S, Saleem I, Garg R, et al. Non-PC liposome entrapped promastigote an tigens elicit parasite specific CD8+ and CD4+ T-cell immune response and protect hamsters against visceral leishmaniasis. Vaccine 2006; 24: 1800-10.
    • (2006) Vaccine , vol.24 , pp. 1800-1810
    • Sharma, S.K.1    Dube, A.2    Nadeem, A.3    Khan, S.4    Saleem, I.5    Garg, R.6
  • 63
    • 84861184574 scopus 로고    scopus 로고
    • Liposomal SLA co-incorporated with PO CpG ODNs or PS CpG ODNs induce the same protection against the murine model of leishmaniasis
    • Shargh VH, Jaafari MR, Khamesipour A, Jaafari I, Jalali SA, Abbasi A, et al. Liposomal SLA co-incorporated with PO CpG ODNs or PS CpG ODNs induce the same protection against the murine model of leishmaniasis. Vaccine 2012; 30: 3957-64.
    • (2012) Vaccine , vol.30 , pp. 3957-3964
    • Shargh, V.H.1    Jaafari, M.R.2    Khamesipour, A.3    Jaafari, I.4    Jalali, S.A.5    Abbasi, A.6
  • 64
    • 33750966758 scopus 로고    scopus 로고
    • DNA vaccines: Recent developments and future possibilities
    • Liu MA, Wahren B, Hedestam GBK. DNA vaccines: Recent developments and future possibilities. Human Gene Therapy 2006; 17: 1051-61.
    • (2006) Human Gene Therapy , vol.17 , pp. 1051-1061
    • Liu, M.A.1    Wahren, B.2    Hedestam, G.B.K.3
  • 65
    • 77954990444 scopus 로고    scopus 로고
    • Leishmaniasis Vaccine: Where are we to day?
    • Kedzierski L. Leishmaniasis Vaccine: Where are we to day? J Glob Infect Dis 2010; 2: 177-85.
    • (2010) J Glob Infect Dis , vol.2 , pp. 177-185
    • Kedzierski, L.1
  • 66
    • 0028803795 scopus 로고
    • Vaccination of vervet monkeys against cutaneous leishmaniasis using recombinant Leishmania major surface glycoprotein (gp63)
    • Olobo JO, Anjili CO, Gicheru MM, Mbati PA, Kariuki TM, Githure JI, et al. Vaccination of vervet monkeys against cutaneous leishmaniasis using recombinant Leishmania major surface glycoprotein (gp63). Vet Parasitol 1995; 60: 199-212.
    • (1995) Vet Parasitol , vol.60 , pp. 199-212
    • Olobo, J.O.1    Anjili, C.O.2    Gicheru, M.M.3    Mbati, P.A.4    Kariuki, T.M.5    Githure, J.I.6
  • 67
    • 34447513762 scopus 로고    scopus 로고
    • The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major sur face glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome
    • Jaafari MR, Badiee A, Khamesipour A, Samiei A, Soroush D, Kheiri MT, et al. The role of CpG ODN in enhancement of immune response and protection in BALB/c mice immunized with recombinant major sur face glycoprotein of Leishmania (rgp63) encapsulated in cationic liposome. Vaccine 2007; 25: 6107-17.
    • (2007) Vaccine , vol.25 , pp. 6107-6117
    • Jaafari, M.R.1    Badiee, A.2    Khamesipour, A.3    Samiei, A.4    Soroush, D.5    Kheiri, M.T.6
  • 69
    • 40749103367 scopus 로고    scopus 로고
    • Gp63 in stable cati onic liposemes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania do novani
    • Bhowmick S, Ravindran R, Ali N. Gp63 in stable cati onic liposemes confers sustained vaccine immunity to susceptible BALB/c mice infected with Leishmania do novani. Infect Immun 2008; 76: 1003-15.
    • (2008) Infect Immun , vol.76 , pp. 1003-1015
    • Bhowmick, S.1    Ravindran, R.2    Ali, N.3
  • 70
    • 70349278374 scopus 로고    scopus 로고
    • Enhancement of immune response and protection in BALB/c mice immunized with liposomal recombinant major surface glycoprotein of Leishmania (rgp63): the role of bilayer composition
    • Badiee A, Jaafari MR, Khamesipour A, Samieia A, Soroush D, Kheiric MT, et al. Enhancement of immune response and protection in BALB/c mice immunized with liposomal recombinant major surface glycoprotein of Leishmania (rgp63): the role of bilayer composition. Colloids Surf B Biointerfaces 2009; 74: 37-44.
    • (2009) Colloids Surf B Biointerfaces , vol.74 , pp. 37-44
    • Badiee, A.1    Jaafari, M.R.2    Khamesipour, A.3    Samieia, A.4    Soroush, D.5    Kheiric, M.T.6
  • 71
    • 79551634103 scopus 로고    scopus 로고
    • Potency, efficacy and durability of DNA/DNA, DNA/protein and protein/ protein based vaccination using gp63 against Leish mania donovani in BALB/c mice
    • Mazumder S, Maji M, Das A, Ali N. Potency, efficacy and durability of DNA/DNA, DNA/protein and protein/ protein based vaccination using gp63 against Leish mania donovani in BALB/c mice. PLoS One 2011; 6: e14644.
    • (2011) PLoS One , vol.6 , pp. e14644
    • Mazumder, S.1    Maji, M.2    Das, A.3    Ali, N.4
  • 73
    • 0029560098 scopus 로고
    • The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle
    • Handman E, Osborn AH, Symons F, van Driel R, Cappai R. The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle. Mol Biochem Parasitol 1995; 74: 189-200.
    • (1995) Mol Biochem Parasitol , vol.74 , pp. 189-200
    • Handman, E.1    Osborn, A.H.2    Symons, F.3    van Driel, R.4    Cappai, R.5
  • 74
    • 0032388140 scopus 로고    scopus 로고
    • Vaccination with recombinant parasite surface antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection
    • Sjolander A, Baldwin TM, Curtis JM, Bengtsson LK, Handman E. Vaccination with recombinant parasite surface antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection. Vaccine 1998; 16: 2077-84.
    • (1998) Vaccine , vol.16 , pp. 2077-2084
    • Sjolander, A.1    Baldwin, T.M.2    Curtis, J.M.3    Bengtsson, L.K.4    Handman, E.5
  • 75
    • 1842424610 scopus 로고    scopus 로고
    • A leucine-rich repeat motif of Leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3
    • Kedzierski L, Montgomery J, Bullen D, Curtis J, Gardiner E, Jimenez-Ruiz A, et al. A leucine-rich repeat motif of Leishmania parasite surface antigen 2 binds to macrophages through the complement receptor 3. J Im munol 2004; 172: 4902-6.
    • (2004) J Im munol , vol.172 , pp. 4902-4906
    • Kedzierski, L.1    Montgomery, J.2    Bullen, D.3    Curtis, J.4    Gardiner, E.5    Jimenez-Ruiz, A.6
  • 76
    • 68949108180 scopus 로고    scopus 로고
    • Immunization with the DNA-encoding N-terminal domain of proteophosphoglycan of Leish mania donovani generates Th1-type immunoprotective response against experimental visceral leishmaniasis
    • Samant M, Gupta R, Kumari S, Misra P, Khare P, Kushawaha PK. Immunization with the DNA-encoding N-terminal domain of proteophosphoglycan of Leish mania donovani generates Th1-type immunoprotective response against experimental visceral leishmaniasis. J Immunol 2009; 183: 470-9.
    • (2009) J Immunol , vol.183 , pp. 470-479
    • Samant, M.1    Gupta, R.2    Kumari, S.3    Misra, P.4    Khare, P.5    Kushawaha, P.K.6
  • 77
    • 77958086444 scopus 로고    scopus 로고
    • Vaccination with the Leishmania infantum ribosomal proteins induces protection in BALB/c mice against Leishmania chagasi and Leishmania amazonensis challenge
    • Chávez-Fumagalli MA, Costa MA, Oliveira DM, Ramírez L, Costa LE, Duarte MC, et al. Vaccination with the Leishmania infantum ribosomal proteins induces protection in BALB/c mice against Leishmania chagasi and Leishmania amazonensis challenge. Microbes Infect 2010; 12(12-13): 967-77.
    • (2010) Microbes Infect , vol.12 , Issue.12-13 , pp. 967-977
    • Chávez-Fumagalli, M.A.1    Costa, M.A.2    Oliveira, D.M.3    Ramírez, L.4    Costa, L.E.5    Duarte, M.C.6
  • 78
    • 84858676742 scopus 로고    scopus 로고
    • BALB/c mice vaccinated with Leishma nia major ribosomal proteins extracts combined with CpG oligodeoxynucleotides become resistant to disease caused by a secondary parasite challenge
    • Ramírez L, Iborra S, Cortés J, Bonay P, Alonso C, Barral-Netto M. BALB/c mice vaccinated with Leishma nia major ribosomal proteins extracts combined with CpG oligodeoxynucleotides become resistant to disease caused by a secondary parasite challenge. J Biomed Biotechnol 2010; 181690.
    • (2010) J Biomed Biotechnol , pp. 181690
    • Ramírez, L.1    Iborra, S.2    Cortés, J.3    Bonay, P.4    Alonso, C.5    Barral-Netto, M.6
  • 79
    • 0242333153 scopus 로고    scopus 로고
    • Protec tion against cutaneous leishmaniasis in outbred Vervet Monkeys, using a recombinant Histone-1 antigen
    • Masina S, Gicheru MM, Demotz SO, Fasel NJ. Protec tion against cutaneous leishmaniasis in outbred Vervet Monkeys, using a recombinant Histone-1 antigen. J In fect Dis 2003; 188: 1250-7.
    • (2003) J In fect Dis , vol.188 , pp. 1250-1257
    • Masina, S.1    Gicheru, M.M.2    Demotz, S.O.3    Fasel, N.J.4
  • 80
    • 0029030456 scopus 로고
    • Expression clon ing of a protective Leishmania antigen
    • Mougneau E, Altare F, Wakil AE, et al. Expression clon ing of a protective Leishmania antigen. Science 1995; 268: 563-6.
    • (1995) Science , vol.268 , pp. 563-566
    • Mougneau, E.1    Altare, F.2    Wakil, A.E.3
  • 81
    • 0001123104 scopus 로고    scopus 로고
    • IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice
    • Launois P, Maillard I, Pingel S, Swihart KG, Xénarios I, Acha-Orbea H, et al. IL-4 rapidly produced by V beta 4 V alpha 8 CD4+ T cells instructs Th2 development and susceptibility to Leishmania major in BALB/c mice. Immun 1997; 6: 541-9.
    • (1997) Immun , vol.6 , pp. 541-549
    • Launois, P.1    Maillard, I.2    Pingel, S.3    Swihart, K.G.4    Xénarios, I.5    Acha-Orbea, H.6
  • 82
    • 0030822043 scopus 로고    scopus 로고
    • Vaccination with DNA encod ing the immunodominate LACK parasite antigen confers protective immunity to mice infected with Leishmania major
    • Gurunathan S, Sacks DL, Brown DR, Reiner SL, Charest H, Glaichenhaus N, et al. Vaccination with DNA encod ing the immunodominate LACK parasite antigen confers protective immunity to mice infected with Leishmania major. J Exp Med 1997; 186: 1137-47.
    • (1997) J Exp Med , vol.186 , pp. 1137-1147
    • Gurunathan, S.1    Sacks, D.L.2    Brown, D.R.3    Reiner, S.L.4    Charest, H.5    Glaichenhaus, N.6
  • 83
    • 0029849205 scopus 로고    scopus 로고
    • Resistance to Leishmania major induced by tolerance to a single antigen
    • Julia V, Rassoulzadegan M, Glaichenhaus N. Resistance to Leishmania major induced by tolerance to a single antigen. Science 1996; 18: 421-3.
    • (1996) Science , vol.18 , pp. 421-423
    • Julia, V.1    Rassoulzadegan, M.2    Glaichenhaus, N.3
  • 84
    • 0034911854 scopus 로고    scopus 로고
    • Leish mania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis
    • Melby PC, Yang J, Zhao W, Perez LE, Cheng J. Leish mania donovani p36(LACK) DNA vaccine is highly immunogenic but not protective against experimental visceral leishmaniasis. Infect Immun 2001; 69: 4719-25.
    • (2001) Infect Immun , vol.69 , pp. 4719-4725
    • Melby, P.C.1    Yang, J.2    Zhao, W.3    Perez, L.E.4    Cheng, J.5
  • 85
    • 57749104693 scopus 로고    scopus 로고
    • Altered peptide ligands can modify the Th2 cell response to the im munodominant 161-175 peptide of LACK (Leishmania homolog for the receptor of activated C kinase)
    • Jensen KD, Sercarz EE, Gabaglia CR. Altered peptide ligands can modify the Th2 cell response to the im munodominant 161-175 peptide of LACK (Leishmania homolog for the receptor of activated C kinase). Mol Immunol 2009; 46: 366-74.
    • (2009) Mol Immunol , vol.46 , pp. 366-374
    • Jensen, K.D.1    Sercarz, E.E.2    Gabaglia, C.R.3
  • 86
    • 46249118167 scopus 로고    scopus 로고
    • Kinesin motor do main of Leishmania donovani as a future vaccine candi date
    • Dey A, Sharma P, Redhu N, Singh S. Kinesin motor do main of Leishmania donovani as a future vaccine candi date. Clin Vaccine Immunol 2008; 15: 836-42.
    • (2008) Clin Vaccine Immunol , vol.15 , pp. 836-842
    • Dey, A.1    Sharma, P.2    Redhu, N.3    Singh, S.4
  • 87
    • 77950646645 scopus 로고    scopus 로고
    • In situ immunolocalization and stage-dependent expres sion of a secretory serine protease in Leishmania do novani and its role as a vaccine candidate
    • Choudhury R, Das P, Bhaumik SK, De T, Chakraborti T. In situ immunolocalization and stage-dependent expres sion of a secretory serine protease in Leishmania do novani and its role as a vaccine candidate. Clin Vaccine Immunol 2010; 17: 660-7.
    • (2010) Clin Vaccine Immunol , vol.17 , pp. 660-667
    • Choudhury, R.1    Das, P.2    Bhaumik, S.K.3    De, T.4    Chakraborti, T.5
  • 88
    • 84915765210 scopus 로고    scopus 로고
    • 115 kDa serine protease confers sustained protection to visceral leishmaniasis caused by Leishmania donovani via IFN-γ induced down-regulation of TNF-α mediated MMP-9 activity.
    • [Epub ahead of print] PMID 22440312
    • Choudhury R, Das P, De T, Chakraborti T. 115 kDa serine protease confers sustained protection to visceral leishmaniasis caused by Leishmania donovani via IFN-γ induced down-regulation of TNF-α mediated MMP-9 activity. Immunobiol 2012; [Epub ahead of print] PMID: 22440312.
    • (2012) Immunobiol
    • Choudhury, R.1    Das, P.2    De, T.3    Chakraborti, T.4
  • 89
    • 64449087496 scopus 로고    scopus 로고
    • Leishmania infantum sterol 24-c-methyl transferase formulated with MPL-SE induces cross protection against L. major infection.
    • Goto Y, Bhatia A, Raman VS, Vidal SE, Bertholet S, Coler RN. Leishmania infantum sterol 24-c-methyl transferase formulated with MPL-SE induces cross protection against L. major infection. Vaccine 2009; 27: 2884-90.
    • (2009) Vaccine , vol.27 , pp. 2884-2890
    • Goto, Y.1    Bhatia, A.2    Raman, V.S.3    Vidal, S.E.4    Bertholet, S.5    Coler, R.N.6
  • 90
    • 34748876077 scopus 로고    scopus 로고
    • Protective immunization against visceral leishmaniasis using Leishmania sterol 24-c-methyltransferase formu lated in adjuvant
    • Goto Y, Bogatzki LY, Bertholet S, Coler RN, Reed SG. Protective immunization against visceral leishmaniasis using Leishmania sterol 24-c-methyltransferase formu lated in adjuvant. Vaccine 2007; 25: 7450-8.
    • (2007) Vaccine , vol.25 , pp. 7450-7458
    • Goto, Y.1    Bogatzki, L.Y.2    Bertholet, S.3    Coler, R.N.4    Reed, S.G.5
  • 91
    • 0037055963 scopus 로고    scopus 로고
    • Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant
    • Skeiky YA, Coler RN, Brannon M, Stromberg E, Greeson K, Crane RT, et al. Protective efficacy of a tandemly linked, multi-subunit recombinant leishmanial vaccine (Leish-111f) formulated in MPL adjuvant. Vaccine 2002; 20: 3292-303.
    • (2002) Vaccine , vol.20 , pp. 3292-3303
    • Skeiky, Y.A.1    Coler, R.N.2    Brannon, M.3    Stromberg, E.4    Greeson, K.5    Crane, R.T.6
  • 92
    • 26644448719 scopus 로고    scopus 로고
    • Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals
    • Gradoni L, Manzillo VFV, Pagano A, Piantedosi D, de Luna R, Gramiccia M, Scalone A, et al. Failure of a multi-subunit recombinant leishmanial vaccine (MML) to protect dogs from Leishmania infantum infection and to prevent disease progression in infected animals. Vac cine 2005; 23: 5245-51.
    • (2005) Vac cine , vol.23 , pp. 5245-5251
    • Gradoni, L.1    Manzillo, V.F.V.2    Pagano, A.3    Piantedosi, D.4    de Luna, R.5    Gramiccia, M.6    Scalone, A.7
  • 93
    • 34547870667 scopus 로고    scopus 로고
    • Leish-111f, a recombinant polyprotein vaccine that protects against visceral leishmaniasis by elicitation of CD4+ T cells
    • Coler RN, Goto Y, Lisa B, Raman V, Reed SG. Leish-111f, a recombinant polyprotein vaccine that protects against visceral leishmaniasis by elicitation of CD4+ T cells. Infect Immunol 2007; 75: 4648-54.
    • (2007) Infect Immunol , vol.75 , pp. 4648-4654
    • Coler, R.N.1    Goto, Y.2    Lisa, B.3    Raman, V.4    Reed, S.G.5
  • 94
    • 40049107841 scopus 로고    scopus 로고
    • Evaluation of an immuno-chemother apeutic protocol constituted of N-methyl meglumine an timoniate (Glucantime) and the recombinant Leish-110f + MPL-SE vaccine to treat canine visceral leishmaniasis
    • Miret J, Nascimento E, Sampaio W, França JC, Fujiwara RT, Vale A, et al. Evaluation of an immuno-chemother apeutic protocol constituted of N-methyl meglumine an timoniate (Glucantime) and the recombinant Leish-110f + MPL-SE vaccine to treat canine visceral leishmaniasis. Vaccine 2008; 26: 1585-94 .
    • (2008) Vaccine , vol.26 , pp. 1585-1594
    • Miret, J.1    Nascimento, E.2    Sampaio, W.3    França, J.C.4    Fujiwara, R.T.5    Vale, A.6
  • 95
    • 0029931153 scopus 로고    scopus 로고
    • Gene vaccines
    • Wahren B. Gene vaccines. Immunotechnol 1996; 2: 77-83.
    • (1996) Immunotechnol , vol.2 , pp. 77-83
    • Wahren, B.1
  • 96
    • 0032469359 scopus 로고    scopus 로고
    • DNA vaccines: technology and application as anti-parasite and anti microbial agents
    • Alarcon JB, Waine GW, McManus DP. DNA vaccines: technology and application as anti-parasite and anti microbial agents. Adv Parasitol 1999; 42: 344-410.
    • (1999) Adv Parasitol , vol.42 , pp. 344-410
    • Alarcon, J.B.1    Waine, G.W.2    McManus, D.P.3
  • 97
    • 0033595134 scopus 로고    scopus 로고
    • DNA vaccines-designer vac cines for the 21st century
    • Seder RA, Gurunathan S. DNA vaccines-designer vac cines for the 21st century. N Engl J Med 1999; 341: 277-8.
    • (1999) N Engl J Med , vol.341 , pp. 277-278
    • Seder, R.A.1    Gurunathan, S.2
  • 98
    • 0034086797 scopus 로고    scopus 로고
    • DNA vac cines: a key for inducing long-term cellular immunity
    • Gurunathan S, Wu C, Freidag BL, Seder RA. DNA vac cines: a key for inducing long-term cellular immunity. Curr Opin Immunol 2000; 12: 442-7.
    • (2000) Curr Opin Immunol , vol.12 , pp. 442-447
    • Gurunathan, S.1    Wu, C.2    Freidag, B.L.3    Seder, R.A.4
  • 99
    • 84915763680 scopus 로고    scopus 로고
    • DNA Vaccines again protozoan parasites: Ad vances and challenges
    • Eric D. DNA Vaccines again protozoan parasites: Ad vances and challenges. J Biomed Biotechnol 2007; 10: 1155-66.
    • (2007) J Biomed Biotechnol , vol.10 , pp. 1155-1166
    • Eric, D.1
  • 101
    • 0032171035 scopus 로고    scopus 로고
    • Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis
    • Walker PS, Scharton-Kersten T, Rowton ED, Hengge U, Bouloc A, Udey MC, et al. Genetic immunization with glycoprotein 63 cDNA results in a helper T cell type 1 immune response and protection in a murine model of leishmaniasis. Hum Gene Ther 1998; 9: 1899-907.
    • (1998) Hum Gene Ther , vol.9 , pp. 1899-1907
    • Walker, P.S.1    Scharton-Kersten, T.2    Rowton, E.D.3    Hengge, U.4    Bouloc, A.5    Udey, M.C.6
  • 102
    • 34247605954 scopus 로고    scopus 로고
    • DNA vaccination against the parasite enzyme gamma-glutamylcysteine synthetase confers protection against Leishmania donovani infec tion
    • Carter K, Henriquez F, Campbell S, Roberts CW, Nok A, Mullen AB, McFarlane E. DNA vaccination against the parasite enzyme gamma-glutamylcysteine synthetase confers protection against Leishmania donovani infec tion. Vaccine 2007; 25: 4502-9.
    • (2007) Vaccine , vol.25 , pp. 4502-4509
    • Carter, K.1    Henriquez, F.2    Campbell, S.3    Roberts, C.W.4    Nok, A.5    Mullen, A.B.6    McFarlane, E.7
  • 104
    • 0036783228 scopus 로고    scopus 로고
    • Study of the safety, immuno genicity and efficacy of attenuated and killed Leishma nia major vaccines in a rhesus monkey (Macaca mulat ta) model of the human disease
    • Amaral VF, Teva A, Oliveira-Neto MP, Silva AJ, Pereira MS, Cupolillo E, et al. Study of the safety, immuno genicity and efficacy of attenuated and killed Leishma nia major vaccines in a rhesus monkey (Macaca mulat ta) model of the human disease. Mem Inst Oswaldo Cruz 2002; 97: 1041-8.
    • (2002) Mem Inst Oswaldo Cruz , vol.97 , pp. 1041-1048
    • Amaral, V.F.1    Teva, A.2    Oliveira-Neto, M.P.3    Silva, A.J.4    Pereira, M.S.5    Cupolillo, E.6
  • 105
    • 33646131385 scopus 로고    scopus 로고
    • Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models
    • Saravia NG, Escorcia B, Osorio Y, Valderrama L, Brooks D, Arteaga L, et al. Pathogenicity and protective immunogenicity of cysteine proteinase-deficient mutants of Leishmania mexicana in non-murine models. Vaccine 2006; 24: 4247-59.
    • (2006) Vaccine , vol.24 , pp. 4247-4259
    • Saravia, N.G.1    Escorcia, B.2    Osorio, Y.3    Valderrama, L.4    Brooks, D.5    Arteaga, L.6
  • 106
    • 1542619246 scopus 로고    scopus 로고
    • Vaccina tion with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response
    • Uzonna JE, Spath GF, Beverley SM, Scott P. Vaccina tion with phosphoglycan-deficient Leishmania major protects highly susceptible mice from virulent challenge without inducing a strong Th1 response. J Immunol 2004; 172: 3793-7.
    • (2004) J Immunol , vol.172 , pp. 3793-3797
    • Uzonna, J.E.1    Spath, G.F.2    Beverley, S.M.3    Scott, P.4
  • 107
    • 2542594797 scopus 로고    scopus 로고
    • Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strat egies
    • Spath GF, Lye LF, Segawa H, Turco SJ, Beverley SM. Identification of a compensatory mutant (lpg2-REV) of Leishmania major able to survive as amastigotes within macrophages without LPG2-dependent glycoconjugates and its significance to virulence and immunization strat egies. Infect Immun 2004; 72: 3622-7.
    • (2004) Infect Immun , vol.72 , pp. 3622-3627
    • Spath, G.F.1    Lye, L.F.2    Segawa, H.3    Turco, S.J.4    Beverley, S.M.5
  • 108
    • 2942535893 scopus 로고    scopus 로고
    • Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania
    • Selvapandiyan A, Debrabant A, Duncan R, Muller J, Salotra P, Sreenivas G, et al. Centrin gene disruption impairs stage-specific basal body duplication and cell cycle progression in Leishmania. J Biol Chem 2004; 279: 25703-10.
    • (2004) J Biol Chem , vol.279 , pp. 25703-25710
    • Selvapandiyan, A.1    Debrabant, A.2    Duncan, R.3    Muller, J.4    Salotra, P.5    Sreenivas, G.6
  • 109
    • 68149182303 scopus 로고    scopus 로고
    • Intracellular replication-deficient Leish mania donovani induces long lasting protective im munity against visceral leishmaniasis
    • Selvapandiyan A, Dey R, Nylen S, Duncan R, Sacks D, Nakhasi HL. Intracellular replication-deficient Leish mania donovani induces long lasting protective im munity against visceral leishmaniasis. J Immunol 2009; 183: 1813-20.
    • (2009) J Immunol , vol.183 , pp. 1813-1820
    • Selvapandiyan, A.1    Dey, R.2    Nylen, S.3    Duncan, R.4    Sacks, D.5    Nakhasi, H.L.6
  • 110
    • 81555195734 scopus 로고    scopus 로고
    • Immunity to visceral Leishmaniasis using genetically defined live-attenuated parasites
    • [Epub ahead of print] PMID: 21912560
    • Selvapandiyan A, Dey R, Gannavaram S, Lakhal-Naouar I, Duncan R, Salotra P, et al. Immunity to visceral Leishmaniasis using genetically defined live-attenuated parasites. J Trop Med 2012; 2012: 631460. [Epub ahead of print] PMID: 21912560
    • (2012) J Trop Med , vol.2012 , pp. 631460
    • Selvapandiyan, A.1    Dey, R.2    Gannavaram, S.3    Lakhal-Naouar, I.4    Duncan, R.5    Salotra, P.6
  • 111
    • 58149354341 scopus 로고    scopus 로고
    • Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites
    • Kedzierski L, Curtis JM, Doherty PC, Handman E, Kedzierska K. Decreased IL-10 and IL-13 production and increased CD44hi T cell recruitment contribute to Leishmania major immunity induced by non-persistent parasites. Eur J Immunol 2008; 38: 3090-100.
    • (2008) Eur J Immunol , vol.38 , pp. 3090-3100
    • Kedzierski, L.1    Curtis, J.M.2    Doherty, P.C.3    Handman, E.4    Kedzierska, K.5
  • 112
    • 79960690902 scopus 로고    scopus 로고
    • Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation
    • Carrion J, Folgueira C, Soto M, Fresno M, Requena, JM. Leishmania infantum HSP70-II null mutant as candidate vaccine against leishmaniasis: a preliminary evaluation. Parasit Vect 2011; 4: 150-9.
    • (2011) Parasit Vect , vol.4 , pp. 150-159
    • Carrion, J.1    Folgueira, C.2    Soto, M.3    Fresno, M.4    Requena, J.M.5
  • 113
    • 40649091062 scopus 로고    scopus 로고
    • Vaccines for leishmaniasis in the fore coming 25 years
    • Palatnik-de-Sousa C. Vaccines for leishmaniasis in the fore coming 25 years. Vaccine 2008; 26: 1709-24.
    • (2008) Vaccine , vol.26 , pp. 1709-1724
    • Palatnik-de-Sousa, C.1
  • 114
    • 0242286543 scopus 로고    scopus 로고
    • Recombinant Leishmania major secret ing biologically active granulocyte-macrophage colony stimulating factor survives poorly in macrophages in vitro and delays disease development in mice
    • Dumas C, Muyombwe A, Roy G, Matte C, Ouellette M, Olivier M, et al. Recombinant Leishmania major secret ing biologically active granulocyte-macrophage colony stimulating factor survives poorly in macrophages in vitro and delays disease development in mice. Am Soc Microbiol 2003; 71: 6499-509.
    • (2003) Am Soc Microbiol , vol.71 , pp. 6499-6509
    • Dumas, C.1    Muyombwe, A.2    Roy, G.3    Matte, C.4    Ouellette, M.5    Olivier, M.6
  • 117
    • 73949089714 scopus 로고    scopus 로고
    • Asymptomatic Leishmania infan tum infection in an area of northwestern Italy (Piedmont region) where such infections are traditionally nonen demic
    • Biglino A, Bolla C, Concialdi E, Trisciuoglio A, Romano A, Ferroglio E. Asymptomatic Leishmania infan tum infection in an area of northwestern Italy (Piedmont region) where such infections are traditionally nonen demic. J Clin Microbiol 2010; 48: 131-6.
    • (2010) J Clin Microbiol , vol.48 , pp. 131-136
    • Biglino, A.1    Bolla, C.2    Concialdi, E.3    Trisciuoglio, A.4    Romano, A.5    Ferroglio, E.6
  • 119
    • 77952520609 scopus 로고    scopus 로고
    • Leishmaniasis emergence in Europe
    • Ready PD. Leishmaniasis emergence in Europe. Euro Surveillance 2010; 15: 19505.
    • (2010) Euro Surveillance , vol.15 , pp. 19505
    • Ready, P.D.1
  • 120
    • 0037007944 scopus 로고    scopus 로고
    • Chemotherapy of canine leishmani osis
    • Baneth G, Shaw SE. Chemotherapy of canine leishmani osis. Vet Parasitol 2002; 106: 315-24.
    • (2002) Vet Parasitol , vol.106 , pp. 315-324
    • Baneth, G.1    Shaw, S.E.2
  • 122
    • 0347357682 scopus 로고    scopus 로고
    • Are insecticide-impregnated dog collars a feasible alternative to dog culling as a strategy for controlling canine visceral leishmaniasis in Brazil?
    • Reithinger R, Coleman PG, Alexander B, Vieira EP, Assis G, Davies CR. Are insecticide-impregnated dog collars a feasible alternative to dog culling as a strategy for controlling canine visceral leishmaniasis in Brazil? Intern J Parasitol 2004; 34: 55-62.
    • (2004) Intern J Parasitol , vol.34 , pp. 55-62
    • Reithinger, R.1    Coleman, P.G.2    Alexander, B.3    Vieira, E.P.4    Assis, G.5    Davies, C.R.6
  • 123
    • 0036838280 scopus 로고    scopus 로고
    • Infectiousness in a cohort of Brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission
    • Courtenay O, Quinnell RJ, Garcez LM, Shaw JJ, Dye C. Infectiousness in a cohort of Brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. J Infect Dis 2002; 186: 1314-20.
    • (2002) J Infect Dis , vol.186 , pp. 1314-1320
    • Courtenay, O.1    Quinnell, R.J.2    Garcez, L.M.3    Shaw, J.J.4    Dye, C.5
  • 125
    • 67649470385 scopus 로고    scopus 로고
    • Vaccination of dogs with six different candidate leish maniasis vaccines composed of a chimerical recom binant protein containing ribosomal and histone protein epitopes in combination with different adjuvants
    • Poot J, Janssen LHM, van Kasteren-Westerneng TJ, van der Heijden-Liefkens KHA, Schijns VEJC, Heckeroth A. Vaccination of dogs with six different candidate leish maniasis vaccines composed of a chimerical recom binant protein containing ribosomal and histone protein epitopes in combination with different adjuvants. Vac cine 2009; 27: 4439-46.
    • (2009) Vac cine , vol.27 , pp. 4439-4446
    • Poot, J.1    Janssen, L.H.M.2    van Kasteren-Westerneng, T.J.3    van der Heijden-Liefkens, K.H.A.4    Schijns, V.E.J.C.5    Heckeroth, A.6
  • 126
    • 33845773808 scopus 로고    scopus 로고
    • Antibodies from dogs with canine vis ceral leishmaniasis recognise two proteins from the sa liva of Lutzomyia longipalpis
    • Bahia D, Gontijo NF, León IR, Perales J, Pereira MH, Oliveira G, et al. Antibodies from dogs with canine vis ceral leishmaniasis recognise two proteins from the sa liva of Lutzomyia longipalpis. Parasitol Res 2007; 100: 449-54.
    • (2007) Parasitol Res , vol.100 , pp. 449-454
    • Bahia, D.1    Gontijo, N.F.2    León, I.R.3    Perales, J.4    Pereira, M.H.5    Oliveira, G.6
  • 128
    • 45549097643 scopus 로고    scopus 로고
    • Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of vis ceral leishmaniasis in a hamster model
    • Gomes R, Teixeira C, Teixeira MJ, Oliveira F, Menezes MJ, Silva C, et al. Immunity to a salivary protein of a sand fly vector protects against the fatal outcome of vis ceral leishmaniasis in a hamster model. Proc Nat Ac Sc USA 2008; 105: 7845-50.
    • (2008) Proc Nat Ac Sc USA , vol.105 , pp. 7845-7850
    • Gomes, R.1    Teixeira, C.2    Teixeira, M.J.3    Oliveira, F.4    Menezes, M.J.5    Silva, C.6
  • 129
    • 67249085574 scopus 로고    scopus 로고
    • Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania
    • Collin N, Gomes R, Teixeira C, Cheng L, Laughinghouse A, Ward JM, et al. Sand fly salivary proteins induce strong cellular immunity in a natural reservoir of visceral leishmaniasis with adverse consequences for Leishmania," PLoS Pathogens 2009; 5: e1000441.
    • (2009) PLoS Pathogens , vol.5
    • Collin, N.1    Gomes, R.2    Teixeira, C.3    Cheng, L.4    Laughinghouse, A.5    Ward, J.M.6
  • 130
    • 33748539363 scopus 로고    scopus 로고
    • Leishmune vaccine: the newest tool for prevention and control of canine visceral leishmaniosis and its potential as a transmission-blocking vaccine
    • Dantas-Torres F. Leishmune vaccine: the newest tool for prevention and control of canine visceral leishmaniosis and its potential as a transmission-blocking vaccine. Vet Parasitol 2006; 141: 1-8.
    • (2006) Vet Parasitol , vol.141 , pp. 1-8
    • Dantas-Torres, F.1
  • 131
    • 0034623973 scopus 로고    scopus 로고
    • A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (São Gonçalo do Amaranto, RN)
    • da Silva VO, Borja-Cabrera GP, Correia Pontes NN, de Souza EP, Luz KG, Palatnik M, et al. A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (São Gonçalo do Amaranto, RN). Vaccine 2000; 19: 1082-92.
    • (2000) Vaccine , vol.19 , pp. 1082-1092
    • da Silva, V.O.1    Borja-Cabrera, G.P.2    Correia Pontes, N.N.3    de Souza, E.P.4    Luz, K.G.5    Palatnik, M.6
  • 132
    • 24144497414 scopus 로고    scopus 로고
    • Leishmune vaccine blocks the transmission of canine visceral leishmaniasis: ab sence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogs
    • Nogueira FS, Moreira MA, Borja-Cabrera GP, Santos FN, Menz I, Parra LE, et al. Leishmune vaccine blocks the transmission of canine visceral leishmaniasis: ab sence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogs," Vaccine 2005; 23: 4805-10.
    • (2005) Vaccine , vol.23 , pp. 4805-4810
    • Nogueira, F.S.1    Moreira, M.A.2    Borja-Cabrera, G.P.3    Santos, F.N.4    Menz, I.5    Parra, L.E.6
  • 135
    • 71149106860 scopus 로고    scopus 로고
    • Immunotherapy with the saponin enriched-Leishmune vaccine versus immunochemotherapy in dogs with natural canine vis ceral leishmaniasis
    • Borja-Cabrera GP, Santos FN, Santos FB, de Trivellato FAA, Kawasaki JKA, Costa AC, et al. Immunotherapy with the saponin enriched-Leishmune vaccine versus immunochemotherapy in dogs with natural canine vis ceral leishmaniasis. Vaccine 2010; 28: 597-603.
    • (2010) Vaccine , vol.28 , pp. 597-603
    • Borja-Cabrera, G.P.1    Santos, F.N.2    Santos, F.B.3    de Trivellato, F.A.A.4    Kawasaki, J.K.A.5    Costa, A.C.6
  • 136
    • 67349143961 scopus 로고    scopus 로고
    • Decrease of the incidence of human and canine visceral leishmaniasis after dog vac cination with Leishmune in Brazilian endemic areas
    • Palatnik-de-Sousa CB, Silva-Antunes I, Ade AM, Menz I, Palatnik M, Lavor C. Decrease of the incidence of human and canine visceral leishmaniasis after dog vac cination with Leishmune in Brazilian endemic areas. Vaccine 2009; 27: 3505-12.
    • (2009) Vaccine , vol.27 , pp. 3505-3512
    • Palatnik-de-Sousa, C.B.1    Silva-Antunes, I.2    Ade, A.M.3    Menz, I.4    Palatnik, M.5    Lavor, C.6
  • 137
    • 53449090936 scopus 로고    scopus 로고
    • Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein
    • Fernandes AP, Costa MM, Coelho EA, Michalick MS, de Freitas E, Melo MN, et al. Protective immunity against challenge with Leishmania (Leishmania) chagasi in beagle dogs vaccinated with recombinant A2 protein. Vaccine 2008; 26: 5888-95.
    • (2008) Vaccine , vol.26 , pp. 5888-5895
    • Fernandes, A.P.1    Costa, M.M.2    Coelho, E.A.3    Michalick, M.S.4    de Freitas, E.5    Melo, M.N.6
  • 140
    • 78650508801 scopus 로고    scopus 로고
    • Gentamicin-attenuated Leishma nia infantum: cellular immunity production and protec tion of dogs against experimental canine leishmaniasis
    • Daneshvar H, Molaei MM, Kamiabi H, Burchmore R, Hagan P, Phillips RS. Gentamicin-attenuated Leishma nia infantum: cellular immunity production and protec tion of dogs against experimental canine leishmaniasis. Parasit Immunol 2010; 32: 722-30.
    • (2010) Parasit Immunol , vol.32 , pp. 722-730
    • Daneshvar, H.1    Molaei, M.M.2    Kamiabi, H.3    Burchmore, R.4    Hagan, P.5    Phillips, R.S.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.