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Volumn 26, Issue 5, 2008, Pages 623-638

A killed Leishmania vaccine with sand fly saliva extract and saponin adjuvant displays immunogenicity in dogs

Author keywords

Canine visceral leishmaniasis; Cell and humoral immune response; Flow cytometry

Indexed keywords

ADJUVANT; COMPLEMENT COMPONENT C3D RECEPTOR; LEISHMANIA VACCINE; SALIVA PROTEIN; SAPONIN;

EID: 37849036578     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.vaccine.2007.11.057     Document Type: Article
Times cited : (43)

References (90)
  • 1
    • 0018101169 scopus 로고
    • Epidemiology and ecology of leishmaniasis in Latin-America
    • Lainson R., and Shaw J.J. Epidemiology and ecology of leishmaniasis in Latin-America. Nature 273 5664 (1978) 595-600
    • (1978) Nature , vol.273 , Issue.5664 , pp. 595-600
    • Lainson, R.1    Shaw, J.J.2
  • 2
    • 0025757104 scopus 로고
    • Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice
    • Theodos C.M., Ribeiro J.M., and Titus R.G. Analysis of enhancing effect of sand fly saliva on Leishmania infection in mice. Infect Immun 59 5 (1991) 1592-1598
    • (1991) Infect Immun , vol.59 , Issue.5 , pp. 1592-1598
    • Theodos, C.M.1    Ribeiro, J.M.2    Titus, R.G.3
  • 3
    • 0025812114 scopus 로고
    • Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis
    • Lerner E.A., Ribeiro J.M., Nelson R.J., and Lerner M.R. Isolation of maxadilan, a potent vasodilatory peptide from the salivary glands of the sand fly Lutzomyia longipalpis. J Biol Chem 266 17 (1991) 11234-11236
    • (1991) J Biol Chem , vol.266 , Issue.17 , pp. 11234-11236
    • Lerner, E.A.1    Ribeiro, J.M.2    Nelson, R.J.3    Lerner, M.R.4
  • 4
    • 0033592938 scopus 로고    scopus 로고
    • Toward an understanding of the biochemical and pharmacological complexity of the saliva of a haematophagous sand fly Lutzomyia longipalpis
    • Charlab R., Valenzuela J.G., Rowton E.D., and Ribeiro J.M. Toward an understanding of the biochemical and pharmacological complexity of the saliva of a haematophagous sand fly Lutzomyia longipalpis. Proc Natl Acad Sci USA 96 26 (1999) 15155-15160
    • (1999) Proc Natl Acad Sci USA , vol.96 , Issue.26 , pp. 15155-15160
    • Charlab, R.1    Valenzuela, J.G.2    Rowton, E.D.3    Ribeiro, J.M.4
  • 5
    • 0034046934 scopus 로고    scopus 로고
    • The immunomodulatory factors of blood feeding arthropod saliva
    • Gillespie R.D., Mbow M.L., and Titus R.G. The immunomodulatory factors of blood feeding arthropod saliva. Parasite Immunol 22 7 (2000) 319-331
    • (2000) Parasite Immunol , vol.22 , Issue.7 , pp. 319-331
    • Gillespie, R.D.1    Mbow, M.L.2    Titus, R.G.3
  • 6
    • 0038235210 scopus 로고    scopus 로고
    • Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects
    • Cavalcante R.R., Pereira M.H., and Gontijo N.F. Anti-complement activity in the saliva of phlebotomine sand flies and other haematophagous insects. Parasitology 127 1 (2003) 87-93
    • (2003) Parasitology , vol.127 , Issue.1 , pp. 87-93
    • Cavalcante, R.R.1    Pereira, M.H.2    Gontijo, N.F.3
  • 7
    • 33645108429 scopus 로고    scopus 로고
    • The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission
    • Titus R.G., Bishop J.V., and Mejia J.S. The immunomodulatory factors of arthropod saliva and the potential for these factors to serve as vaccine targets to prevent pathogen transmission. Parasite Immunol 28 4 (2006) 131-141
    • (2006) Parasite Immunol , vol.28 , Issue.4 , pp. 131-141
    • Titus, R.G.1    Bishop, J.V.2    Mejia, J.S.3
  • 8
    • 0023899355 scopus 로고
    • Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity
    • Titus R.G., and Ribeiro J.M. Salivary gland lysates from the sand fly Lutzomyia longipalpis enhance Leishmania infectivity. Science 239 4845 (1988) 1306-1308
    • (1988) Science , vol.239 , Issue.4845 , pp. 1306-1308
    • Titus, R.G.1    Ribeiro, J.M.2
  • 9
    • 0026053944 scopus 로고
    • A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva
    • Samuelson J., Lerner E., Tesh R., and Titus R. A mouse model of Leishmania braziliensis braziliensis infection produced by coinjection with sand fly saliva. J Exp Med 173 1 (1991) 49-54
    • (1991) J Exp Med , vol.173 , Issue.1 , pp. 49-54
    • Samuelson, J.1    Lerner, E.2    Tesh, R.3    Titus, R.4
  • 10
    • 0028782112 scopus 로고
    • Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis
    • Warburg A., Saraiva E., Lanzaro G.C., Titus R.G., and Neva F. Saliva of Lutzomyia longipalpis sibling species differs in its composition and capacity to enhance leishmaniasis. Philos Trans R Soc B 345 1312 (1994) 223-230
    • (1994) Philos Trans R Soc B , vol.345 , Issue.1312 , pp. 223-230
    • Warburg, A.1    Saraiva, E.2    Lanzaro, G.C.3    Titus, R.G.4    Neva, F.5
  • 11
    • 0029825449 scopus 로고    scopus 로고
    • Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice
    • Lima H.C., and Titus R.G. Effects of sand fly vector saliva on development of cutaneous lesions and the immune response to Leishmania braziliensis in BALB/c mice. Infect Immun 64 12 (1996) 5442-5445
    • (1996) Infect Immun , vol.64 , Issue.12 , pp. 5442-5445
    • Lima, H.C.1    Titus, R.G.2
  • 12
    • 0032538905 scopus 로고    scopus 로고
    • Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva pre-exposure on the long-term outcome of Leishmania major infection in the mouse ear dermis
    • Belkaid Y., Kamhawi S., Modi G., Valenzuela J., Noben-Trauth N., Rowton E., et al. Development of a natural model of cutaneous leishmaniasis: powerful effects of vector saliva and saliva pre-exposure on the long-term outcome of Leishmania major infection in the mouse ear dermis. J Exp Med 188 10 (1998) 1941-1953
    • (1998) J Exp Med , vol.188 , Issue.10 , pp. 1941-1953
    • Belkaid, Y.1    Kamhawi, S.2    Modi, G.3    Valenzuela, J.4    Noben-Trauth, N.5    Rowton, E.6
  • 13
    • 0034680892 scopus 로고    scopus 로고
    • Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies
    • Kamhawi S., Belkaid Y., Modi G., Rowton E., and Sacks D. Protection against cutaneous leishmaniasis resulting from bites of uninfected sand flies. Science 290 5495 (2000) 1351-1354
    • (2000) Science , vol.290 , Issue.5495 , pp. 1351-1354
    • Kamhawi, S.1    Belkaid, Y.2    Modi, G.3    Rowton, E.4    Sacks, D.5
  • 14
    • 0035500911 scopus 로고    scopus 로고
    • Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection
    • Morris R.V., Shoemaker C.B., David J.R., Lanzaro G.C., and Titus R.G. Sandfly maxadilan exacerbates infection with Leishmania major and vaccinating against it protects against L. major infection. J Immunol 167 9 (2001) 5226-5230
    • (2001) J Immunol , vol.167 , Issue.9 , pp. 5226-5230
    • Morris, R.V.1    Shoemaker, C.B.2    David, J.R.3    Lanzaro, G.C.4    Titus, R.G.5
  • 15
    • 0035817332 scopus 로고    scopus 로고
    • Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein
    • Valenzuela J.G., Belkaid Y., Garfield M.K., Mendez S., Kamhawi S., Rowton E.D., et al. Toward a defined anti-Leishmania vaccine targeting vector antigens: characterization of a protective salivary protein. J Exp Med 194 3 (2001) 331-342
    • (2001) J Exp Med , vol.194 , Issue.3 , pp. 331-342
    • Valenzuela, J.G.1    Belkaid, Y.2    Garfield, M.K.3    Mendez, S.4    Kamhawi, S.5    Rowton, E.D.6
  • 16
    • 0034623973 scopus 로고    scopus 로고
    • A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (Sao Goncalo do Amaranto RN)
    • da Silva V., Borja-Cabrera G.P., Correia Pontes N.N., de Souza E.P., Luz K.G., Palatnik M., et al. A phase III trial of efficacy of the FML-vaccine against canine kala-azar in an endemic area of Brazil (Sao Goncalo do Amaranto RN). Vaccine 19 9-10 (2000) 1082-1092
    • (2000) Vaccine , vol.19 , Issue.9-10 , pp. 1082-1092
    • da Silva, V.1    Borja-Cabrera, G.P.2    Correia Pontes, N.N.3    de Souza, E.P.4    Luz, K.G.5    Palatnik, M.6
  • 17
    • 0037055992 scopus 로고    scopus 로고
    • Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (Sao Gonçalo do Amarante RN)
    • Borja-Cabrera G.P., Correia Pontes N.N., da Silva V.O., Paraguai de Souza E., Santos W.R., Gomes E.M., et al. Long lasting protection against canine kala-azar using the FML-QuilA saponin vaccine in an endemic area of Brazil (Sao Gonçalo do Amarante RN). Vaccine 20 27-28 (2002) 3277-3284
    • (2002) Vaccine , vol.20 , Issue.27-28 , pp. 3277-3284
    • Borja-Cabrera, G.P.1    Correia Pontes, N.N.2    da Silva, V.O.3    Paraguai de Souza, E.4    Santos, W.R.5    Gomes, E.M.6
  • 18
    • 0037726800 scopus 로고    scopus 로고
    • Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK
    • Ramiro M.J., Zarate J.J., Hanke T., Rodriguez D., Rodriguez J.R., Esteban M., et al. Protection in dogs against visceral leishmaniasis caused by Leishmania infantum is achieved by immunization with a heterologous prime-boost regime using DNA and vaccinia recombinant vectors expressing LACK. Vaccine 21 19-20 (2003) 2474-2484
    • (2003) Vaccine , vol.21 , Issue.19-20 , pp. 2474-2484
    • Ramiro, M.J.1    Zarate, J.J.2    Hanke, T.3    Rodriguez, D.4    Rodriguez, J.R.5    Esteban, M.6
  • 19
    • 4444307813 scopus 로고    scopus 로고
    • Double-blind randomized efficacy field trial of alum precipitated autoclaved Leishmania major vaccine mixed with BCG against canine visceral leishmaniasis in Meshkin-Shahr district I.R. Iran
    • Mohebali M., Khamesipour A., Mobedi I., Zarei Z., and Hashemi-Fesharki R. Double-blind randomized efficacy field trial of alum precipitated autoclaved Leishmania major vaccine mixed with BCG against canine visceral leishmaniasis in Meshkin-Shahr district I.R. Iran. Vaccine 22 29-30 (2004) 4097-4100
    • (2004) Vaccine , vol.22 , Issue.29-30 , pp. 4097-4100
    • Mohebali, M.1    Khamesipour, A.2    Mobedi, I.3    Zarei, Z.4    Hashemi-Fesharki, R.5
  • 20
    • 15244360706 scopus 로고    scopus 로고
    • Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes
    • Lemesre J.L., Holzmuller P., Cavaleyra M., Goncalves R.B., Hottin G., and Papierok G. Protection against experimental visceral leishmaniasis infection in dogs immunized with purified excreted secreted antigens of Leishmania infantum promastigotes. Vaccine 23 22 (2005) 2825-2840
    • (2005) Vaccine , vol.23 , Issue.22 , pp. 2825-2840
    • Lemesre, J.L.1    Holzmuller, P.2    Cavaleyra, M.3    Goncalves, R.B.4    Hottin, G.5    Papierok, G.6
  • 21
    • 24144497414 scopus 로고    scopus 로고
    • Leishmune vaccine blocks the transmission of canine visceral leishmaniasis: absence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogs
    • Nogueira F.S., Moreira M.A., Borja-Cabrera G.P., Santos F.N., Menz I., Parra L.E., et al. Leishmune vaccine blocks the transmission of canine visceral leishmaniasis: absence of Leishmania parasites in blood, skin and lymph nodes of vaccinated exposed dogs. Vaccine 23 40 (2005) 4805-4810
    • (2005) Vaccine , vol.23 , Issue.40 , pp. 4805-4810
    • Nogueira, F.S.1    Moreira, M.A.2    Borja-Cabrera, G.P.3    Santos, F.N.4    Menz, I.5    Parra, L.E.6
  • 22
    • 21044441505 scopus 로고    scopus 로고
    • Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum
    • Rafati S., Nakhaee A., Taheri T., Taslimi Y., Darabi H., Eravani D., et al. Protective vaccination against experimental canine visceral leishmaniasis using a combination of DNA and protein immunization with cysteine proteinases type I and II of L. infantum. Vaccine 23 28 (2005) 3716-3725
    • (2005) Vaccine , vol.23 , Issue.28 , pp. 3716-3725
    • Rafati, S.1    Nakhaee, A.2    Taheri, T.3    Taslimi, Y.4    Darabi, H.5    Eravani, D.6
  • 23
    • 33344468279 scopus 로고    scopus 로고
    • The FML-vaccine (Leishmune) against canine visceral leishmaniasis: a transmission blocking vaccine
    • Saraiva E.M., de Figueiredo B.A., Santos F.N., Borja-Cabrera G.P., Nico D., Souza L.O., et al. The FML-vaccine (Leishmune) against canine visceral leishmaniasis: a transmission blocking vaccine. Vaccine 24 13 (2006) 2423-2431
    • (2006) Vaccine , vol.24 , Issue.13 , pp. 2423-2431
    • Saraiva, E.M.1    de Figueiredo, B.A.2    Santos, F.N.3    Borja-Cabrera, G.P.4    Nico, D.5    Souza, L.O.6
  • 24
    • 34247484942 scopus 로고    scopus 로고
    • Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial
    • Lemesre J.L., Holzmuller P., Goncalves R.B., Bourdoiseau G., Hugnet C., Cavaleyra M., et al. Long-lasting protection against canine visceral leishmaniasis using the LiESAp-MDP vaccine in endemic areas of France: double-blind randomised efficacy field trial. Vaccine 25 21 (2007) 4223-4234
    • (2007) Vaccine , vol.25 , Issue.21 , pp. 4223-4234
    • Lemesre, J.L.1    Holzmuller, P.2    Goncalves, R.B.3    Bourdoiseau, G.4    Hugnet, C.5    Cavaleyra, M.6
  • 25
    • 34447631166 scopus 로고    scopus 로고
    • Immunotherapy against experimental canine visceral leishmaniasis with the saponin enriched-Leishmune vaccine
    • Santos F.N., Borja-Cabrera G.P., Miyashiro L.M., Grechi J., Reis A.B., Moreira M.A., et al. Immunotherapy against experimental canine visceral leishmaniasis with the saponin enriched-Leishmune vaccine. Vaccine 25 33 (2007) 6176-6190
    • (2007) Vaccine , vol.25 , Issue.33 , pp. 6176-6190
    • Santos, F.N.1    Borja-Cabrera, G.P.2    Miyashiro, L.M.3    Grechi, J.4    Reis, A.B.5    Moreira, M.A.6
  • 26
    • 8444241618 scopus 로고    scopus 로고
    • Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi
    • Valenzuela J.G., Garfield M., Rowton E.D., and Pham V.M. Identification of the most abundant secreted proteins from the salivary glands of the sand fly Lutzomyia longipalpis, vector of Leishmania chagasi. J Exp Biol 207 21 (2004) 3717-3729
    • (2004) J Exp Biol , vol.207 , Issue.21 , pp. 3717-3729
    • Valenzuela, J.G.1    Garfield, M.2    Rowton, E.D.3    Pham, V.M.4
  • 27
    • 4444350068 scopus 로고    scopus 로고
    • Progress in vaccine research and possible effector mechanisms in visceral leishmaniasis
    • Ravindran R., and Ali N. Progress in vaccine research and possible effector mechanisms in visceral leishmaniasis. Curr Mol Med 4 6 (2004) 697-709
    • (2004) Curr Mol Med , vol.4 , Issue.6 , pp. 697-709
    • Ravindran, R.1    Ali, N.2
  • 28
    • 0030274707 scopus 로고    scopus 로고
    • Phase I and II open clinical trials of a vaccine against Leishmania chagasi infections in dogs
    • Mayrink W., Genaro O., Silva J.C., da Costa R.T., Tafuri W.L., Toledo V.P., et al. Phase I and II open clinical trials of a vaccine against Leishmania chagasi infections in dogs. Mem Inst Oswaldo Cruz 91 6 (1996) 695-697
    • (1996) Mem Inst Oswaldo Cruz , vol.91 , Issue.6 , pp. 695-697
    • Mayrink, W.1    Genaro, O.2    Silva, J.C.3    da Costa, R.T.4    Tafuri, W.L.5    Toledo, V.P.6
  • 29
    • 0033193856 scopus 로고    scopus 로고
    • Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes
    • Lasri S., Sahibi H., Sadak A., Jaffe C.L., and Rhalem A. Immune responses in vaccinated dogs with autoclaved Leishmania major promastigotes. Vet Res 30 5 (1999) 441-449
    • (1999) Vet Res , vol.30 , Issue.5 , pp. 441-449
    • Lasri, S.1    Sahibi, H.2    Sadak, A.3    Jaffe, C.L.4    Rhalem, A.5
  • 31
    • 43649083892 scopus 로고    scopus 로고
    • Giunchetti RC, Reis AB, Silveira-Lemos D, Martins-Filho OA, Corrêa-Oliveira R, Bethony J, et al. Antigenicity of a whole parasite vaccine as promising candidate against canine leishmaniasis. Res Vet Sci, doi:10.1016/j.rvsc.2007.09.008.
  • 32
    • 32944471240 scopus 로고
    • Reservoirs of Leishmania donovani in Brazil
    • Deane L.M. Reservoirs of Leishmania donovani in Brazil. Rev Assoc Med Bras 7 (1961) 161-169
    • (1961) Rev Assoc Med Bras , vol.7 , pp. 161-169
    • Deane, L.M.1
  • 33
  • 34
    • 0029589761 scopus 로고
    • Experimental models for leishmaniasis and for testing anti-leishmanial vaccines
    • Hommel M., Jaffe C.L., Travi B., and Milon G. Experimental models for leishmaniasis and for testing anti-leishmanial vaccines. Ann Trop Med Parasitol 89 Suppl. 1 (1995) 55-73
    • (1995) Ann Trop Med Parasitol , vol.89 , Issue.SUPPL. 1 , pp. 55-73
    • Hommel, M.1    Jaffe, C.L.2    Travi, B.3    Milon, G.4
  • 35
    • 0035850549 scopus 로고    scopus 로고
    • An update on antileishmanial vaccine candidates and prospects for a canine Leishmania vaccine
    • Gradoni L. An update on antileishmanial vaccine candidates and prospects for a canine Leishmania vaccine. Vet Parasitol 100 1-2 (2001) 87-103
    • (2001) Vet Parasitol , vol.100 , Issue.1-2 , pp. 87-103
    • Gradoni, L.1
  • 38
    • 0021095696 scopus 로고
    • A simple technique for mass rearing Lutzomyia longipalpis and Phlebotomus papatasi (Diptera: Psychodidae) in the laboratory
    • Modi G.B., and Tesh R.B. A simple technique for mass rearing Lutzomyia longipalpis and Phlebotomus papatasi (Diptera: Psychodidae) in the laboratory. J Med Entomol 20 5 (1983) 568-569
    • (1983) J Med Entomol , vol.20 , Issue.5 , pp. 568-569
    • Modi, G.B.1    Tesh, R.B.2
  • 41
    • 33646135059 scopus 로고    scopus 로고
    • Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis
    • Oliveira-Freitas E., Casas C.P., Borja-Cabrera G.P., Santos F.N., Nico D., Souza L.O., et al. Acylated and deacylated saponins of Quillaja saponaria mixture as adjuvants for the FML-vaccine against visceral leishmaniasis. Vaccine 24 18 (2006) 3909-3920
    • (2006) Vaccine , vol.24 , Issue.18 , pp. 3909-3920
    • Oliveira-Freitas, E.1    Casas, C.P.2    Borja-Cabrera, G.P.3    Santos, F.N.4    Nico, D.5    Souza, L.O.6
  • 42
    • 33745881394 scopus 로고    scopus 로고
    • Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in Brazilian dogs naturally infected by Leishmania (Leishmania) chagasi
    • Reis A.B., Teixeira-Carvalho A., Vale A.M., Marques M.J., Giunchetti R.C., Mayrink W., et al. Isotype patterns of immunoglobulins: hallmarks for clinical status and tissue parasite density in Brazilian dogs naturally infected by Leishmania (Leishmania) chagasi. Vet Immunol Immunopathol 112 3-4 (2006) 102-116
    • (2006) Vet Immunol Immunopathol , vol.112 , Issue.3-4 , pp. 102-116
    • Reis, A.B.1    Teixeira-Carvalho, A.2    Vale, A.M.3    Marques, M.J.4    Giunchetti, R.C.5    Mayrink, W.6
  • 43
    • 33644651149 scopus 로고    scopus 로고
    • Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis.
    • Reis A.B., Martins-Filho O.A., Teixeira-Carvalho A., Carvalho M.G., Mayrink W., Franca-Silva J.C., et al. Parasite density and impaired biochemical/hematological status are associated with severe clinical aspects of canine visceral leishmaniasis. Res Vet, Sci 81 1 (2006) 68-75
    • (2006) Res Vet, Sci , vol.81 , Issue.1 , pp. 68-75
    • Reis, A.B.1    Martins-Filho, O.A.2    Teixeira-Carvalho, A.3    Carvalho, M.G.4    Mayrink, W.5    Franca-Silva, J.C.6
  • 44
    • 11144317447 scopus 로고    scopus 로고
    • Establishment of a microplate assay for flow cytometric assessment and it is use for the evaluation of age-related phenotypic changes in canine whole blood leukocytes
    • Reis A.B., Carneiro C.M., Carvalho M.G., Teixeira-Carvalho A., Giunchetti R.C., Mayrink W., et al. Establishment of a microplate assay for flow cytometric assessment and it is use for the evaluation of age-related phenotypic changes in canine whole blood leukocytes. Vet Immunol Immunopathol 103 3-4 (2005) 173-185
    • (2005) Vet Immunol Immunopathol , vol.103 , Issue.3-4 , pp. 173-185
    • Reis, A.B.1    Carneiro, C.M.2    Carvalho, M.G.3    Teixeira-Carvalho, A.4    Giunchetti, R.C.5    Mayrink, W.6
  • 46
    • 0026483214 scopus 로고
    • Simple, rapid method for determining nitrates and nitrites in biological fluids
    • Gutman S.I., and Hollywood C.A. Simple, rapid method for determining nitrates and nitrites in biological fluids. Clin Chem 38 10 (1992) 2152
    • (1992) Clin Chem , vol.38 , Issue.10 , pp. 2152
    • Gutman, S.I.1    Hollywood, C.A.2
  • 47
    • 0021305258 scopus 로고
    • Visceral leishmaniasis in the German shepherd dog. I. Infection, clinical disease, and clinical pathology
    • Keenan C.M., Hendricks L.D., Lightner L., Webster H.K., and Johnson A.J. Visceral leishmaniasis in the German shepherd dog. I. Infection, clinical disease, and clinical pathology. Vet Pathol 21 1 (1984) 74-79
    • (1984) Vet Pathol , vol.21 , Issue.1 , pp. 74-79
    • Keenan, C.M.1    Hendricks, L.D.2    Lightner, L.3    Webster, H.K.4    Johnson, A.J.5
  • 48
    • 0036744994 scopus 로고    scopus 로고
    • Canine leishmaniasis: epidemiological risk and the experimental model
    • Moreno J., and Alvar J. Canine leishmaniasis: epidemiological risk and the experimental model. Trends Parasitol 18 9 (2002) 399-405
    • (2002) Trends Parasitol , vol.18 , Issue.9 , pp. 399-405
    • Moreno, J.1    Alvar, J.2
  • 50
    • 11144322401 scopus 로고    scopus 로고
    • Semi-quantitative analysis of cytokine expression in asymptomatic canine leishmaniasis
    • Chamizo C., Moreno J., and Alvar J. Semi-quantitative analysis of cytokine expression in asymptomatic canine leishmaniasis. Vet Immunol Immunopathol 103 1-2 (2005) 67-75
    • (2005) Vet Immunol Immunopathol , vol.103 , Issue.1-2 , pp. 67-75
    • Chamizo, C.1    Moreno, J.2    Alvar, J.3
  • 51
    • 33750038264 scopus 로고    scopus 로고
    • Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi
    • Reis A.B., Teixeira-Carvalho A., Giunchetti R.C., Guerra L.L., Carvalho M.G., Mayrink W., et al. Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi. Clin Exp Immunol 146 2 (2006) 303-311
    • (2006) Clin Exp Immunol , vol.146 , Issue.2 , pp. 303-311
    • Reis, A.B.1    Teixeira-Carvalho, A.2    Giunchetti, R.C.3    Guerra, L.L.4    Carvalho, M.G.5    Mayrink, W.6
  • 52
    • 33748854435 scopus 로고    scopus 로고
    • Relationship between canine visceral leishmaniosis and the Leishmania (Leishmania) chagasi burden in dermal inflammatory foci
    • Giunchetti R.C., Mayrink W., Genaro O., Carneiro C.M., Correa-Oliveira R., Martins-Filho O.A., et al. Relationship between canine visceral leishmaniosis and the Leishmania (Leishmania) chagasi burden in dermal inflammatory foci. J Comp Pathol 135 2-3 (2006) 100-107
    • (2006) J Comp Pathol , vol.135 , Issue.2-3 , pp. 100-107
    • Giunchetti, R.C.1    Mayrink, W.2    Genaro, O.3    Carneiro, C.M.4    Correa-Oliveira, R.5    Martins-Filho, O.A.6
  • 53
    • 37049038887 scopus 로고    scopus 로고
    • Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis
    • Giunchetti R.C., Mayrink W., Carneiro C.M., Correa-Oliveira R., Martins-Filho O.A., Marques M.J., et al. Histopathological and immunohistochemical investigations of the hepatic compartment associated with parasitism and serum biochemical changes in canine visceral leishmaniasis. Res Vet Sci 84 2 (2008) 269-277
    • (2008) Res Vet Sci , vol.84 , Issue.2 , pp. 269-277
    • Giunchetti, R.C.1    Mayrink, W.2    Carneiro, C.M.3    Correa-Oliveira, R.4    Martins-Filho, O.A.5    Marques, M.J.6
  • 54
  • 56
    • 0037007944 scopus 로고    scopus 로고
    • Chemotherapy of canine leishmaniosis
    • Baneth G., and Shaw S.E. Chemotherapy of canine leishmaniosis. Vet Parasitol 106 4 (2002) 315-324
    • (2002) Vet Parasitol , vol.106 , Issue.4 , pp. 315-324
    • Baneth, G.1    Shaw, S.E.2
  • 57
    • 24644524243 scopus 로고    scopus 로고
    • Treatment of canine Old World visceral leishmaniasis: a systematic review
    • Noli C., and Auxilia S.T. Treatment of canine Old World visceral leishmaniasis: a systematic review. Vet Dermatol 16 4 (2005) 213-232
    • (2005) Vet Dermatol , vol.16 , Issue.4 , pp. 213-232
    • Noli, C.1    Auxilia, S.T.2
  • 58
    • 0028952707 scopus 로고
    • A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice
    • Wilson M.E., Young B.M., Andersen K.P., Weinstock J.V., Metwali A., Ali K.M., et al. A recombinant Leishmania chagasi antigen that stimulates cellular immune responses in infected mice. Infect Immun 63 5 (1995) 2062-2069
    • (1995) Infect Immun , vol.63 , Issue.5 , pp. 2062-2069
    • Wilson, M.E.1    Young, B.M.2    Andersen, K.P.3    Weinstock, J.V.4    Metwali, A.5    Ali, K.M.6
  • 59
    • 0030457804 scopus 로고    scopus 로고
    • Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis
    • Webb J.R., Kaufmann D., Campos-Neto A., and Reed S.G. Molecular cloning of a novel protein antigen of Leishmania major that elicits a potent immune response in experimental murine leishmaniasis. J Immunol 157 11 (1996) 5034-5041
    • (1996) J Immunol , vol.157 , Issue.11 , pp. 5034-5041
    • Webb, J.R.1    Kaufmann, D.2    Campos-Neto, A.3    Reed, S.G.4
  • 60
    • 0031842834 scopus 로고    scopus 로고
    • Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family
    • Webb J.R., Campos-Neto A., Ovendale P.J., Martin T.I., Stromberg E.J., Badaro R., et al. Human and murine immune responses to a novel Leishmania major recombinant protein encoded by members of a multicopy gene family. Infect Immun 66 7 (1998) 3279-3289
    • (1998) Infect Immun , vol.66 , Issue.7 , pp. 3279-3289
    • Webb, J.R.1    Campos-Neto, A.2    Ovendale, P.J.3    Martin, T.I.4    Stromberg, E.J.5    Badaro, R.6
  • 61
    • 0034668153 scopus 로고    scopus 로고
    • Immunization with recombinant LD1 antigens protects against experimental leishmaniasis
    • Dole V.S., Raj V.S., Ghosh A., Madhubala R., Myler P.J., and Stuart K.D. Immunization with recombinant LD1 antigens protects against experimental leishmaniasis. Vaccine 19 4-5 (2000) 423-430
    • (2000) Vaccine , vol.19 , Issue.4-5 , pp. 423-430
    • Dole, V.S.1    Raj, V.S.2    Ghosh, A.3    Madhubala, R.4    Myler, P.J.5    Stuart, K.D.6
  • 62
    • 0035001263 scopus 로고    scopus 로고
    • Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease
    • Campos-Neto A., Porrozzi R., Greeson K., Coler R.N., Webb J.R., Seiky Y., et al. Protection against cutaneous leishmaniasis induced by recombinant antigens in murine and nonhuman primate models of the human disease. Infect Immun 69 6 (2001) 4103-4108
    • (2001) Infect Immun , vol.69 , Issue.6 , pp. 4103-4108
    • Campos-Neto, A.1    Porrozzi, R.2    Greeson, K.3    Coler, R.N.4    Webb, J.R.5    Seiky, Y.6
  • 64
  • 65
    • 20444501804 scopus 로고    scopus 로고
    • Lymphocytes of dogs immunised with purified excreted-secreted antigens of Leishmania infantum co-incubated with Leishmania-infected macrophages produce IFN gamma resulting in nitric oxide-mediated amastigote apoptosis
    • Holzmuller P., Cavaleyra M., Moreaux J., Kovacic R., Vincendeau P., Papierok G., et al. Lymphocytes of dogs immunised with purified excreted-secreted antigens of Leishmania infantum co-incubated with Leishmania-infected macrophages produce IFN gamma resulting in nitric oxide-mediated amastigote apoptosis. Vet Immunol Immunopathol 106 3-4 (2005) 247-257
    • (2005) Vet Immunol Immunopathol , vol.106 , Issue.3-4 , pp. 247-257
    • Holzmuller, P.1    Cavaleyra, M.2    Moreaux, J.3    Kovacic, R.4    Vincendeau, P.5    Papierok, G.6
  • 67
    • 0033635179 scopus 로고    scopus 로고
    • The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections
    • Kamhawi S. The biological and immunomodulatory properties of sand fly saliva and its role in the establishment of Leishmania infections. Microbes Infect 2 14 (2000) 1765-1773
    • (2000) Microbes Infect , vol.2 , Issue.14 , pp. 1765-1773
    • Kamhawi, S.1
  • 68
    • 33746296447 scopus 로고    scopus 로고
    • Is it possible to develop pan-arthropod vaccines?
    • Mejia J.S., Bishop J.V., and Titus R.G. Is it possible to develop pan-arthropod vaccines?. Trends Parasitol 22 8 (2006) 367-370
    • (2006) Trends Parasitol , vol.22 , Issue.8 , pp. 367-370
    • Mejia, J.S.1    Bishop, J.V.2    Titus, R.G.3
  • 69
    • 0022369062 scopus 로고
    • Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis
    • Carvalho E.M., Badaro R., Reed S.G., Jones T.C., and Johnson Jr. W.D. Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis. J Clin Invest 76 (1985) 2066-2069
    • (1985) J Clin Invest , vol.76 , pp. 2066-2069
    • Carvalho, E.M.1    Badaro, R.2    Reed, S.G.3    Jones, T.C.4    Johnson Jr., W.D.5
  • 70
    • 33748682825 scopus 로고    scopus 로고
    • Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon-gamma and interleukin-10 and low frequency of tumour necrosis factor-alpha(+) monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection
    • Peruhype-Magalhaes V., Martins-Filho O.A., Prata A., Silva Lde A., Rabello A., Teixeira-Carvalho A., et al. Mixed inflammatory/regulatory cytokine profile marked by simultaneous raise of interferon-gamma and interleukin-10 and low frequency of tumour necrosis factor-alpha(+) monocytes are hallmarks of active human visceral Leishmaniasis due to Leishmania chagasi infection. Clin Exp Immunol 146 (2006) 124-132
    • (2006) Clin Exp Immunol , vol.146 , pp. 124-132
    • Peruhype-Magalhaes, V.1    Martins-Filho, O.A.2    Prata, A.3    Silva Lde, A.4    Rabello, A.5    Teixeira-Carvalho, A.6
  • 71
    • 0141889064 scopus 로고    scopus 로고
    • Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity
    • Marciani D.J. Vaccine adjuvants: role and mechanisms of action in vaccine immunogenicity. Drug Discov Today 8 20 (2003) 934-943
    • (2003) Drug Discov Today , vol.8 , Issue.20 , pp. 934-943
    • Marciani, D.J.1
  • 72
  • 73
    • 34247117348 scopus 로고    scopus 로고
    • Adjuvant effects of saponins on animal immune responses
    • Rajput Z.I., Hu S.H., Xiao C.W., and Arijo A.G. Adjuvant effects of saponins on animal immune responses. J Zhejiang Univ Sci B 8 3 (2007) 153-161
    • (2007) J Zhejiang Univ Sci B , vol.8 , Issue.3 , pp. 153-161
    • Rajput, Z.I.1    Hu, S.H.2    Xiao, C.W.3    Arijo, A.G.4
  • 74
    • 0037159626 scopus 로고    scopus 로고
    • Saponins IL12 and BCG adjuvant in the FML-vaccine formulation against murine visceral leishmaniasis
    • Santos W.R., de Lima V.M., de Souza E.P., Bernardo R.R., Palatnik M., and Palatnik de Sousa C.B. Saponins IL12 and BCG adjuvant in the FML-vaccine formulation against murine visceral leishmaniasis. Vaccine 21 1-2 (2002) 30-43
    • (2002) Vaccine , vol.21 , Issue.1-2 , pp. 30-43
    • Santos, W.R.1    de Lima, V.M.2    de Souza, E.P.3    Bernardo, R.R.4    Palatnik, M.5    Palatnik de Sousa, C.B.6
  • 75
  • 76
    • 0037111036 scopus 로고    scopus 로고
    • Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity
    • Gomes R.B., Brodskyn C., de Oliveira C.I., Costa J., Miranda J.C., Caldas A., et al. Seroconversion against Lutzomyia longipalpis saliva concurrent with the development of anti-Leishmania chagasi delayed-type hypersensitivity. J Infect Dis 186 10 (2002) 1530-1534
    • (2002) J Infect Dis , vol.186 , Issue.10 , pp. 1530-1534
    • Gomes, R.B.1    Brodskyn, C.2    de Oliveira, C.I.3    Costa, J.4    Miranda, J.C.5    Caldas, A.6
  • 77
    • 33645643110 scopus 로고    scopus 로고
    • Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis
    • Anderson J.M., Oliveira F., Kamhawi S., Mans B.J., Reynoso D., Seitz A.E., et al. Comparative salivary gland transcriptomics of sandfly vectors of visceral leishmaniasis. BMC Genomics 7 52 (2006) 1-23
    • (2006) BMC Genomics , vol.7 , Issue.52 , pp. 1-23
    • Anderson, J.M.1    Oliveira, F.2    Kamhawi, S.3    Mans, B.J.4    Reynoso, D.5    Seitz, A.E.6
  • 78
    • 33749007649 scopus 로고    scopus 로고
    • High degree of conservancy among secreted salivary gland proteins from two geographically distant Phlebotomus duboscqi sandfly populations (Mali and Kenya)
    • Kato H., Anderson J.M., Kamhawi S., Oliveira F., Lawyer P.G., Pham V.M., et al. High degree of conservancy among secreted salivary gland proteins from two geographically distant Phlebotomus duboscqi sandfly populations (Mali and Kenya). BMC Genomics 7 226 (2006) 1-21
    • (2006) BMC Genomics , vol.7 , Issue.226 , pp. 1-21
    • Kato, H.1    Anderson, J.M.2    Kamhawi, S.3    Oliveira, F.4    Lawyer, P.G.5    Pham, V.M.6
  • 79
    • 29044433844 scopus 로고    scopus 로고
    • From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library
    • Oliveira F., Kamhawi S., Seitz A.E., Pham V.M., Guigal P.M., Fischer L., et al. From transcriptome to immunome: identification of DTH inducing proteins from a Phlebotomus ariasi salivary gland cDNA library. Vaccine 24 3 (2006) 374-390
    • (2006) Vaccine , vol.24 , Issue.3 , pp. 374-390
    • Oliveira, F.1    Kamhawi, S.2    Seitz, A.E.3    Pham, V.M.4    Guigal, P.M.5    Fischer, L.6
  • 80
    • 33845773808 scopus 로고    scopus 로고
    • Antibodies from dogs with canine visceral leishmaniasis recognise two proteins from the saliva of Lutzomyia longipalpis
    • Bahia D., Gontijo N.F., Leon I.R., Perales J., Pereira M.H., Oliveira G., et al. Antibodies from dogs with canine visceral leishmaniasis recognise two proteins from the saliva of Lutzomyia longipalpis. Parasitol Res 100 3 (2007) 449-454
    • (2007) Parasitol Res , vol.100 , Issue.3 , pp. 449-454
    • Bahia, D.1    Gontijo, N.F.2    Leon, I.R.3    Perales, J.4    Pereira, M.H.5    Oliveira, G.6
  • 81
    • 0034457550 scopus 로고    scopus 로고
    • Human immune response to sand fly salivary gland antigens: a useful epidemiological marker?
    • Barral A., Honda E., Caldas A., Costa J., Vinhas V., Rowton E.D., et al. Human immune response to sand fly salivary gland antigens: a useful epidemiological marker?. Am J Trop Med Hyg 62 6 (2000) 740-745
    • (2000) Am J Trop Med Hyg , vol.62 , Issue.6 , pp. 740-745
    • Barral, A.1    Honda, E.2    Caldas, A.3    Costa, J.4    Vinhas, V.5    Rowton, E.D.6
  • 82
  • 83
    • 0031556361 scopus 로고    scopus 로고
    • Specific IgG1 and IgG2 antibody and lymphocyte subset levels in naturally Leishmania infantum-infected treated and untreated dogs
    • Bourdoiseau G., Bonnefont C., Hoareau E., Boehringer C., Stolle T., and Chabanne L. Specific IgG1 and IgG2 antibody and lymphocyte subset levels in naturally Leishmania infantum-infected treated and untreated dogs. Vet Immunol Immunopathol 59 1-2 (1997) 21-30
    • (1997) Vet Immunol Immunopathol , vol.59 , Issue.1-2 , pp. 21-30
    • Bourdoiseau, G.1    Bonnefont, C.2    Hoareau, E.3    Boehringer, C.4    Stolle, T.5    Chabanne, L.6
  • 84
    • 0036838280 scopus 로고    scopus 로고
    • Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission
    • Courtenay O., Quinnell R.J., Garcez L.M., Shaw J.J., and Dye C. Infectiousness in a cohort of brazilian dogs: why culling fails to control visceral leishmaniasis in areas of high transmission. J Infect Dis 186 9 (2002) 1314-1320
    • (2002) J Infect Dis , vol.186 , Issue.9 , pp. 1314-1320
    • Courtenay, O.1    Quinnell, R.J.2    Garcez, L.M.3    Shaw, J.J.4    Dye, C.5
  • 85
    • 34248674887 scopus 로고    scopus 로고
    • Immunoglobulin G subclass distribution in canine leishmaniosis: a review and analysis of pitfalls in interpretation
    • Day M.J. Immunoglobulin G subclass distribution in canine leishmaniosis: a review and analysis of pitfalls in interpretation. Vet Parasitol 147 1-2 (2007) 2-8
    • (2007) Vet Parasitol , vol.147 , Issue.1-2 , pp. 2-8
    • Day, M.J.1
  • 86
    • 11144341234 scopus 로고    scopus 로고
    • Cytokines in canine visceral leishmaniasis
    • Schijns V.E.C.J., and Horzinek M.C. (Eds), CAB International, Wallingford
    • Pinelli E. Cytokines in canine visceral leishmaniasis. In: Schijns V.E.C.J., and Horzinek M.C. (Eds). Cytokines in veterinary medicine (1997), CAB International, Wallingford 217-247
    • (1997) Cytokines in veterinary medicine , pp. 217-247
    • Pinelli, E.1
  • 87
    • 0028211827 scopus 로고
    • Monoclonal antibodies that define canine homologues of human CD antigens: Summary of the First International Canine Leukocyte Antigen Workshop (CLAW)
    • Cobbold S., and Metcalfe S. Monoclonal antibodies that define canine homologues of human CD antigens: Summary of the First International Canine Leukocyte Antigen Workshop (CLAW). Tissue Antigens 43 3 (1994) 137-154
    • (1994) Tissue Antigens , vol.43 , Issue.3 , pp. 137-154
    • Cobbold, S.1    Metcalfe, S.2
  • 88
    • 0029294038 scopus 로고
    • Modulation by canine interferon-gamma of major histocompatibility complex and tumor-associated antigen expression in canine mammary tumor and melanoma cell lines
    • Whitley E.M., Bird A.C., Zucker K.E., and Wolfe L.G. Modulation by canine interferon-gamma of major histocompatibility complex and tumor-associated antigen expression in canine mammary tumor and melanoma cell lines. Anticancer Res 15 3 (1995) 923-929
    • (1995) Anticancer Res , vol.15 , Issue.3 , pp. 923-929
    • Whitley, E.M.1    Bird, A.C.2    Zucker, K.E.3    Wolfe, L.G.4
  • 89
    • 0348147560 scopus 로고    scopus 로고
    • Effective suppression of class I major histocompatibility complex expression by the US11 or ICP47 genes can be limited by cell type or interferon-gamma exposure
    • Radosevich T.J., Seregina T., and Link C.J. Effective suppression of class I major histocompatibility complex expression by the US11 or ICP47 genes can be limited by cell type or interferon-gamma exposure. Hum Gene Ther 14 18 (2003) 1765-1775
    • (2003) Hum Gene Ther , vol.14 , Issue.18 , pp. 1765-1775
    • Radosevich, T.J.1    Seregina, T.2    Link, C.J.3
  • 90
    • 0032078521 scopus 로고    scopus 로고
    • Salivary gland lysate from the sand fly Lutzomyia longipalpis suppresses the immune response of mice to sheep red blood cells in vivo and concanavalin A in vitro
    • Titus R.G. Salivary gland lysate from the sand fly Lutzomyia longipalpis suppresses the immune response of mice to sheep red blood cells in vivo and concanavalin A in vitro. Exp Parasitol 89 1 (1998) 133-136
    • (1998) Exp Parasitol , vol.89 , Issue.1 , pp. 133-136
    • Titus, R.G.1


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