메뉴 건너뛰기




Volumn 16, Issue 20, 1998, Pages 2077-2084

Vaccination with recombinant Parasite Surface Antigen 2 from Leishmania major induces a Th1 type of immune response but does not protect against infection

Author keywords

Iscoms; Parasite Surface Antigen 2 vaccine; Th1 responses

Indexed keywords

IMMUNOLOGICAL ADJUVANT; ISCOM; ISCOPREP 703; PARASITE ANTIGEN; UNCLASSIFIED DRUG;

EID: 0032388140     PISSN: 0264410X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0264-410X(98)00075-9     Document Type: Article
Times cited : (79)

References (41)
  • 2
    • 0026806814 scopus 로고
    • Immunology of leishmaniasis. Curr
    • 2 Locksley, R.M. and Louis, J.A. Immunology of leishmaniasis. Curr. Opin. Immunol. 1992, 4, 413-418.
    • (1992) Opin. Immunol. , vol.4 , pp. 413-418
    • Locksley, R.M.1    Louis, J.A.2
  • 3
    • 0030297830 scopus 로고    scopus 로고
    • Leishmania major: Targeting IL-4 in successful immunomodulation of murine infection
    • 3 Wakil, A.E., Wang, Z.-E. and Locksley, R.M. Leishmania major: targeting IL-4 in successful immunomodulation of murine infection. Exp. Parasitol. 1996, 84, 214-222.
    • (1996) Exp. Parasitol. , vol.84 , pp. 214-222
    • Wakil, A.E.1    Wang, Z.-E.2    Locksley, R.M.3
  • 5
    • 0029787798 scopus 로고    scopus 로고
    • IL-4-deficient Balb/c mice resist infection with Leishmania major
    • 5 Kopf, M., Brombacher, F. and Köhler, G. et al. IL-4-deficient Balb/c mice resist infection with Leishmania major. J. Exp. Med. 1996, 184, 1127-1136.
    • (1996) J. Exp. Med. , vol.184 , pp. 1127-1136
    • Kopf, M.1    Brombacher, F.2    Köhler, G.3
  • 6
    • 0027985817 scopus 로고
    • Cytokines in the treatment of leishmaniasis: From studies of immunopathology to patient therapy
    • 6 Ho, J.L., Badaro, R., Hatzigeorgiou, D., Reed, S.G. and Johnson, W.D. Jr.Jr. Cytokines in the treatment of leishmaniasis: from studies of immunopathology to patient therapy. Biotherapy 1994, 7, 223-235.
    • (1994) Biotherapy , vol.7 , pp. 223-235
    • Ho, J.L.1    Badaro, R.2    Hatzigeorgiou, D.3    Reed, S.G.4    Johnson W.D., Jr.5
  • 7
    • 0026354341 scopus 로고
    • Variants of a Leishmania surface antigen derived from a multigenic family
    • 7 Murray, P.J. and Spithill, T.W. Variants of a Leishmania surface antigen derived from a multigenic family. J. Biol. Chem. 1991, 266, 24477-24484.
    • (1991) J. Biol. Chem. , vol.266 , pp. 24477-24484
    • Murray, P.J.1    Spithill, T.W.2
  • 8
    • 0029560098 scopus 로고
    • The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle
    • 8 Handman, E., Osborn, A.M., Symons, F., van Driel, R. and Cappai, R. The Leishmania promastigote surface antigen 2 complex is differentially expressed during the parasite life cycle. Mol. Biochem. Parasitol. 1995, 74, 189-200.
    • (1995) Mol. Biochem. Parasitol. , vol.74 , pp. 189-200
    • Handman, E.1    Osborn, A.M.2    Symons, F.3    Van Driel, R.4    Cappai, R.5
  • 9
    • 0027982231 scopus 로고
    • Characterisation of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species
    • 9 Symons, F.M., Murray, P.J., Osborn, A.H., Cappai, R. and Handman, E. Characterisation of a polymorphic family of integral membrane proteins in promastigotes of different Leishmania species. Mol. Biochem. Parasitol. 1994, 67, 103-113.
    • (1994) Mol. Biochem. Parasitol. , vol.67 , pp. 103-113
    • Symons, F.M.1    Murray, P.J.2    Osborn, A.H.3    Cappai, R.4    Handman, E.5
  • 10
    • 0028876052 scopus 로고
    • Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response
    • 10 Handman, E., Symons, F.M., Baldwin, T.M., Curtis, J.M. and Scheerlinck, J.-P.Y. Protective vaccination with promastigote surface antigen 2 from Leishmania major is mediated by a TH1 type of immune response. Infect. Immun. 1995, 63, 4261-4267.
    • (1995) Infect. Immun. , vol.63 , pp. 4261-4267
    • Handman, E.1    Symons, F.M.2    Baldwin, T.M.3    Curtis, J.M.4    Scheerlinck, J.-P.Y.5
  • 11
    • 0023700905 scopus 로고
    • Membrane glycoprotein M-2 protects against Leishmania amazonensis infection
    • 11 Champsi, J. and McMahon-Pratt, D. Membrane glycoprotein M-2 protects against Leishmania amazonensis infection. Infect. Immun. 1988, 56, 3272-3279.
    • (1988) Infect. Immun. , vol.56 , pp. 3272-3279
    • Champsi, J.1    McMahon-Pratt, D.2
  • 12
    • 0027233931 scopus 로고
    • Recombinant vaccinia viruses expressing GP46/M-2 protect against Leishmania infection
    • 12 McMahon-Pratt, D., Rodriguez, D. and Rodriguez, J.-R. et al. Recombinant vaccinia viruses expressing GP46/M-2 protect against Leishmania infection. Infect. Immun. 1993, 61, 3351-3359.
    • (1993) Infect. Immun. , vol.61 , pp. 3351-3359
    • McMahon-Pratt, D.1    Rodriguez, D.2    Rodriguez, J.-R.3
  • 13
    • 0026044947 scopus 로고
    • Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to gp120
    • 13 Steimer, K.S., Scandella, C.J., Skiles, P.V. and Haigwood, N.L. Neutralization of divergent HIV-1 isolates by conformation-dependent human antibodies to gp120. Science 1991, 254, 105-108.
    • (1991) Science , vol.254 , pp. 105-108
    • Steimer, K.S.1    Scandella, C.J.2    Skiles, P.V.3    Haigwood, N.L.4
  • 14
    • 0029029210 scopus 로고
    • Immunostimulating complexes. Clinical potential in vaccine development
    • 14 Morein, B., Lövgren, K., Rönnberg, B. and Sjölander, A. Immunostimulating complexes. Clinical potential in vaccine development. Clin. Immunother. 1995, 3, 461-475.
    • (1995) Clin. Immunother. , vol.3 , pp. 461-475
    • Morein, B.1    Lövgren, K.2    Rönnberg, B.3    Sjölander, A.4
  • 15
    • 0031081461 scopus 로고    scopus 로고
    • Immunomodulation by Quillaja saponaria adjuvant formulations: In vivo stimulation of interleukin-12 and its effects on the antibody response
    • 15 Villacres-Eriksson, M., Behboudi, S., Morgan, A.J., Trinchieri, G. and Morein, B. Immunomodulation by Quillaja saponaria adjuvant formulations: in vivo stimulation of interleukin-12 and its effects on the antibody response. Cytokine 1997, 9, 73-82.
    • (1997) Cytokine , vol.9 , pp. 73-82
    • Villacres-Eriksson, M.1    Behboudi, S.2    Morgan, A.J.3    Trinchieri, G.4    Morein, B.5
  • 16
    • 0030175481 scopus 로고    scopus 로고
    • Adjuvant activity of iscoms; effect of ratio and co-incorporation of antigen and adjuvant
    • 16 Lövgren Bengtsson, K. and Sjölander, A. Adjuvant activity of iscoms; effect of ratio and co-incorporation of antigen and adjuvant. Vaccine 1996, 14, 753-760.
    • (1996) Vaccine , vol.14 , pp. 753-760
    • Lövgren Bengtsson, K.1    Sjölander, A.2
  • 17
    • 0000195956 scopus 로고
    • Cultures des corps de leishman isoles de la rate dans trois cas d'anemic sptenique infantile
    • 17 Nicolle, C.H. Cultures des corps de Leishman isoles de la rate dans trois cas d'anemic sptenique infantile. Bull. Soc. Pathol. Exot. 1908, 1, 121.
    • (1908) Bull. Soc. Pathol. Exot. , vol.1 , pp. 121
    • Nicolle, C.H.1
  • 18
    • 0020581961 scopus 로고
    • Isolation and characterization of infective and non-infective clones of Leishmania tropica
    • 18 Handman, E., Hocking, R.E., Mitchell, G.F. and Spithill, T.W. Isolation and characterization of infective and non-infective clones of Leishmania tropica. Mol. Biochem. Parasitol. 1983, 7, 111-126.
    • (1983) Mol. Biochem. Parasitol. , vol.7 , pp. 111-126
    • Handman, E.1    Hocking, R.E.2    Mitchell, G.F.3    Spithill, T.W.4
  • 19
    • 0025049856 scopus 로고
    • Gene replacement in parasitic protozoa
    • 19 Cruz, A. and Beverley, S.M. Gene replacement in parasitic protozoa. Nature 1990, 348, 171-173.
    • (1990) Nature , vol.348 , pp. 171-173
    • Cruz, A.1    Beverley, S.M.2
  • 20
    • 0022438406 scopus 로고
    • Leishmania in the old world: 2. Heterogeneity among L. Tropica zymodemes
    • 20 Le Blancq, S. and Peters, W. Leishmania in the Old World: 2. Heterogeneity among L. tropica zymodemes. Trans. R. Soc. Trop. Med. Hyg. 1986, 80, 113-119.
    • (1986) Trans. R. Soc. Trop. Med. Hyg. , vol.80 , pp. 113-119
    • Le Blancq, S.1    Peters, W.2
  • 21
    • 0025650360 scopus 로고
    • Development of a stable Leishmania expression vector and application to the study of parasite surface antigens
    • 21 LeBowitz, J.H., Coburn, C.M., McMahon-Pratt, D. and Beverley, S.M. Development of a stable Leishmania expression vector and application to the study of parasite surface antigens. Proc. Natl Acad. Sci. USA 1990, 87, 9736-9740.
    • (1990) Proc. Natl Acad. Sci. USA , vol.87 , pp. 9736-9740
    • LeBowitz, J.H.1    Coburn, C.M.2    McMahon-Pratt, D.3    Beverley, S.M.4
  • 22
    • 0023806075 scopus 로고
    • Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase
    • 22 Smith, D.B. and Johnson, K.S. Single-step purification of polypeptides expressed in Escherichia coli as fusions with glutathione S-transferase. Gene 1988, 67, 31-40.
    • (1988) Gene , vol.67 , pp. 31-40
    • Smith, D.B.1    Johnson, K.S.2
  • 23
    • 0019800463 scopus 로고
    • Silver stain for proteins in polyacrylamide gels: A modified procedure with enhanced uniform sensitivity
    • 23 Morrisey, J.H. Silver stain for proteins in polyacrylamide gels: a modified procedure with enhanced uniform sensitivity. Analyt. Biochem. 1981, 117, 307-310.
    • (1981) Analyt. Biochem. , vol.117 , pp. 307-310
    • Morrisey, J.H.1
  • 24
    • 0028856624 scopus 로고
    • Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM-matrix
    • 24 Rönnberg, B., Fekadu, M. and Morein, B. Adjuvant activity of non-toxic Quillaja saponaria Molina components for use in ISCOM-matrix. Vaccine 1995, 13, 1375-1382.
    • (1995) Vaccine , vol.13 , pp. 1375-1382
    • Rönnberg, B.1    Fekadu, M.2    Morein, B.3
  • 25
    • 0031562670 scopus 로고    scopus 로고
    • Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-like immune responses
    • 25 Sjölander, A., van't Land, B. and Lövgren Bengtsson, K. Iscoms containing purified Quillaja saponins upregulate both Th1-like and Th2-like immune responses. Cell. Immunol. 1997, 177, 69-76.
    • (1997) Cell. Immunol. , vol.177 , pp. 69-76
    • Sjölander, A.1    Van't Land, B.2    Lövgren Bengtsson, K.3
  • 26
    • 0026697004 scopus 로고
    • Soluble proteins incorporate into iscoms after covalent attachment of fatty acid
    • 26 Reid, G. Soluble proteins incorporate into iscoms after covalent attachment of fatty acid. Vaccine 1992, 9, 597-602.
    • (1992) Vaccine , vol.9 , pp. 597-602
    • Reid, G.1
  • 27
    • 0023882657 scopus 로고
    • The requirement of lipids for the formation of immunostimulating complexes (iscoms)
    • 27 Lövgren, K. and Morein, B. The requirement of lipids for the formation of immunostimulating complexes (iscoms). Biotechnol. Appl. Biochem. 1988, 10, 161-172.
    • (1988) Biotechnol. Appl. Biochem. , vol.10 , pp. 161-172
    • Lövgren, K.1    Morein, B.2
  • 28
    • 0020963862 scopus 로고
    • Leishmania tropica major in mice: Vaccination against cutaneous leishmaniasis in mice of high genetic susceptibility
    • 28 Mitchell, G.F. and Handman, E. Leishmania tropica major in mice: vaccination against cutaneous leishmaniasis in mice of high genetic susceptibility. Aust. J. Exp. Biol. Med. Sci. 1983, 61, 11-25.
    • (1983) Aust. J. Exp. Biol. Med. Sci. , vol.61 , pp. 11-25
    • Mitchell, G.F.1    Handman, E.2
  • 29
    • 0022234330 scopus 로고
    • A limiting dilution assay for quantifying Leishmania major in tissues of infected mice
    • 29 Titus, R.G., Marchand, M., Boon, T. and Louis, J.A. A limiting dilution assay for quantifying Leishmania major in tissues of infected mice. Parasite Immunol. 1985, 7, 545-555.
    • (1985) Parasite Immunol. , vol.7 , pp. 545-555
    • Titus, R.G.1    Marchand, M.2    Boon, T.3    Louis, J.A.4
  • 30
    • 9044251204 scopus 로고    scopus 로고
    • Kinetics, localization and isotype profile of antibody responses to immune stimulating complexes (Iscoms) containing human influenza virus envelope glycoproteins
    • 30 Sjölander, A., Lövgren-Bengtsson, K., Johansson, M. and Morein, B. Kinetics, localization and isotype profile of antibody responses to immune stimulating complexes (Iscoms) containing human influenza virus envelope glycoproteins. Scand. J. Immunol. 1996, 43, 164-172.
    • (1996) Scand. J. Immunol. , vol.43 , pp. 164-172
    • Sjölander, A.1    Lövgren-Bengtsson, K.2    Johansson, M.3    Morein, B.4
  • 32
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon-γ or interleukin-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
    • 32 Heinzel, F.P., Sadick, M.D., Holaday, B.J., Coffman, R.L and Locksley, R.M. Reciprocal expression of interferon-γ or interleukin-4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 1989, 169, 59-72.
    • (1989) J. Exp. Med. , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 33
    • 0025768733 scopus 로고
    • Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis
    • 33 Heinzel, F.P., Sadick, M.D., Mutha, S.S. and Locksley, R.M. Production of interferon gamma, interleukin 2, interleukin 4, and interleukin 10 by CD4+ lymphocytes in vivo during healing and progressive murine leishmaniasis. Proc. Natl Acad. Sci. USA 1991, 88, 7011-7015.
    • (1991) Proc. Natl Acad. Sci. USA , vol.88 , pp. 7011-7015
    • Heinzel, F.P.1    Sadick, M.D.2    Mutha, S.S.3    Locksley, R.M.4
  • 34
    • 0028832241 scopus 로고
    • Induction of Th1 and Th2 CD4+ T cell responses by oral or parenteral immunization with ISCOMS
    • 34 Maloy, K.J., Donachie, A.M. and Mowat, A.M. Induction of Th1 and Th2 CD4+ T cell responses by oral or parenteral immunization with ISCOMS. Eur. J. Immunol. 1995, 25, 2835-2841.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 2835-2841
    • Maloy, K.J.1    Donachie, A.M.2    Mowat, A.M.3
  • 35
    • 0344482144 scopus 로고    scopus 로고
    • Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response is required for generation of immunity to leishmaniasis
    • 35 Sjölander, A., Baldwin, T.M., Curtis, J.M. and Handman, E. Induction of a Th1 immune response and simultaneous lack of activation of a Th2 response is required for generation of immunity to leishmaniasis. J. Immunol. 1998, 160, 3949-3957.
    • (1998) J. Immunol. , vol.160 , pp. 3949-3957
    • Sjölander, A.1    Baldwin, T.M.2    Curtis, J.M.3    Handman, E.4
  • 36
    • 0029052282 scopus 로고
    • A potent, cost-effective RNase inhibitor
    • 36 Murphy, N.R., Leinbach, S.S. and Hellwig, R.J. A potent, cost-effective RNase inhibitor. BioTechniques 1995, 18, 1068-1073.
    • (1995) BioTechniques , vol.18 , pp. 1068-1073
    • Murphy, N.R.1    Leinbach, S.S.2    Hellwig, R.J.3
  • 37
    • 0024793611 scopus 로고
    • The PSA-2 glycoprotein complex of Leishmania major is a glycosylphosphatidylinositol-linked promastigote surface antigen
    • 37 Murray, P.J., Spithill, T.W. and Handman, E. The PSA-2 glycoprotein complex of Leishmania major is a glycosylphosphatidylinositol-linked promastigote surface antigen. J. Immunol. 1989, 143, 4221-4226.
    • (1989) J. Immunol. , vol.143 , pp. 4221-4226
    • Murray, P.J.1    Spithill, T.W.2    Handman, E.3
  • 38
    • 0030059955 scopus 로고    scopus 로고
    • N-linked glycans in the CD4-binding domain of human immunodeficiency virus type I envelope glycoprotein gp160 are essential for the in vivo priming of T cells recognizing an epitope located in their vicinity
    • 38 Sjölander, S., Bolmstedt, A. and Akerblom, L. et al. N-linked glycans in the CD4-binding domain of human immunodeficiency virus type I envelope glycoprotein gp160 are essential for the in vivo priming of T cells recognizing an epitope located in their vicinity. Virology 1996, 215, 124-133.
    • (1996) Virology , vol.215 , pp. 124-133
    • Sjölander, S.1    Bolmstedt, A.2    Akerblom, L.3
  • 39
    • 0027180032 scopus 로고
    • Modulation of CD4+ T-cell recognition of influenza hemagglutinin by carbohydrate side chains located outside a T-cell determinant
    • 39 Drummer, H.E., Jackson, D.C. and Brown, L.E. Modulation of CD4+ T-cell recognition of influenza hemagglutinin by carbohydrate side chains located outside a T-cell determinant. Virology 1993, 192, 282-289.
    • (1993) Virology , vol.192 , pp. 282-289
    • Drummer, H.E.1    Jackson, D.C.2    Brown, L.E.3
  • 40
    • 0005848581 scopus 로고
    • Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein
    • 40 Javaherian, K., Langlois, A.J. and McDanal, C. et al. Principal neutralizing domain of the human immunodeficiency virus type 1 envelope protein. Proc. Natl Acad. Sci. USA 1989, 86, 6768-6772.
    • (1989) Proc. Natl Acad. Sci. USA , vol.86 , pp. 6768-6772
    • Javaherian, K.1    Langlois, A.J.2    McDanal, C.3
  • 41
    • 0025071687 scopus 로고
    • Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant
    • 41 LaRosa, G.J., Davide, J.P. and Weinhold, K. et al. Conserved sequence and structural elements in the HIV-1 principal neutralizing determinant. Science 1990, 249, 932-935.
    • (1990) Science , vol.249 , pp. 932-935
    • LaRosa, G.J.1    Davide, J.P.2    Weinhold, K.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.